Skip to menu Skip to content Skip to footer
Professor Ernst Wolvetang
Professor

Ernst Wolvetang

Email: 
Phone: 
+61 7 334 63894

Overview

Background

Professor Wolvetang is an international leader in the area of pluripotent stem cell biology and human functional genomics. he initiated and leads Cell Reprogramming Australia, a collaborative framework that facilitates induced pluripotent stem cell research in Australa and is co-director of the UQ Centre in Stem Cell Ageing and Regenerative Engineering (StemCARE). He has extensive expertise in reprogramming somatic cells, differentiation and tissue engineering with adult, embryonic and induced pluripotent stem cells, genome manipulation with CRISPR, molecular biology, transcriptome analysis, high content image analysis, development and use of microfluidic devices for cell analysis, nanoparticle and scaffold design and delivery, and stem cell and cell-free regenerative medicine approaches.Professor Wolvetang has been instrumental in establishing and enabling the technology for derivation of induced pluripotent stem cells across Australia. Professor Wolvetang made the strategic decision to focus on the generation of induced pluripotent stem from patients with neurological and cardiac disorders because live human cells from such patients can usually not be obtained whereas induced pluripotent stem cells have the ability to generate every cell type of the human brain in unlimited amounts and can recapitulate the disease in the dish. Induced pluripotent stem cells combined with emerging technologies such as CRISPR-based genome editing offers a unique opportunity to study the role of individual genes and combinatorial gene regulatory pathways in the eatiology of monogenic and complex brain disorders. Indeed, combined with RNA-seq and organoid generation we are now for the first time able to gain insight into gene regulatory pathways operational in individual brain cell types of healthy and diseased individuals, investigate the connectivity and function of cells, as well as pinpoint where and when during early development such deregulated pathways lead to pathological changes. Induced pluripotent stem cells further not only provide insight into the underlying pathogenesis of neurological disorders but also constitute a valuable drugscreening platform and, following CRISPR-based gene correction, can form the basis of patient specific cellular therapies for currently incurable diseases.

Professor Wolvetang received his PhD in 1992 from the Department of Biochemistry, University of Amsterdam for his original work on peroxisomal disease (6 papers). He undertook postdoctoral studies at the Department of Biochemistry and the Institute for Reproduction and Development of Monash University, investigating apoptosis, Down syndrome and Ets transcription factors, respectively, obtaining the first evidence for an intra-chromosomal regulatory loop on chromosome 21 involving Ets2 (3 papers), and revealing the role of p53 in immune-suppression in Down syndrome (Hum Mol. Genetics). He then joined Prof Martin Pera in the Australian Stem Cell Centre in 2003 to pioneer human embryonic stem cell research in Australia, resulting in a first author Nature Biotechnology paper in 2006 identifying CD30 as a marker for genetically abnormal hESC (72 cites). He was appointed group leader of the Basic human stem cell biology laboratory in the ASCC research laboratory and senior lecturer in the Department of Anatomy and Cell biology until he accepted his current position as an independent group leader at the AIBN and Professor in stem cell biology at the University of Queensland in 2008. There he started to generate integration-free induced pluripotent stem cells from human neurological diseases such as ataxia-telangiectasia (Stem cells translational medicine). In recognition of his leadership role in this area of research he was appointed leader of the “Reprogramming and Induction of pluripotency” Collaborative Stream of the Australian Stem Cell Centre until the end of that initiative in 2011, coordinating collaborative research between eight stem cell laboratories across Australia. He subsequently initiated and is now the president of Cell Reprogramming Australia, a collaborative framework aiming to facilitate and accelerate iPS cell research in Australia and the Asia pacific region and inform the general public about reprogramming technology. His research continues to combine cell reprogramming technology, genome editing/analysis tools and microfluidic/nanoparticle based detection/ delivery technologies with the aim of creating human in vitro models of disease, unravel the underlying gene regulatory networks and enable novel cell- and delivery-based therapeutics, respectively. He further co-direct the UQ-Centre for stem cell ageing and regenerative engineering (UQ-StemCARE).

Availability

Professor Ernst Wolvetang is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Amsterdam
  • Member, ASSCR, ASSCR
  • American Nano society, American Nano society
  • Board Member, Australian Functional Genomics Network, Australian Functional Genomics Network
  • Australian Neuroscience Society, Australian Neuroscience Society
  • Member, Australian Society for Medical Research, Australian Society for Medical Research
  • Board Member, CCRM Australia, CCRM Australia
  • Member, ISSCR, ISSCR
  • Member, NHMRC Research Translation faculty, NHMRC Research Translation faculty

Research interests

  • Functional human genomics

    Because iPSC can generate every cell type of the body they can be used to model a variety of diseases. CRSIPR assisted technologies can be used for functional genomics approaches. We have a particular interest in neurological diseases and generation of brain organoids from stem cells.

  • Induced pluripotent stem cells

    Any cell from a mature organism can be reprogrammed to a pluripotent stem cell with the ability to generate any cell type of the body. This allows unprecedented possibilities to investigate disease.

Research impacts

Memberships, patents and funding

Professor Wolvetang serves on the editorial board of six stem cell and nanotechnology journals; is listed inventor on four patents in stem cell research; and is the recipient of more than $2.5 million in grant funding in the past five years. He is a senior reprogramming scientist in Stem Cells Ltd,

Awards and plenaries

2016 Scopus Eureka Prize for Excellence in International Scientific Collaboration ,

2014 Recipient of the AON regenerative medicine prize, LSQ.

Professor Wolvetang has given 25 lectures and was invited speaker at 23 platform meetings, including multiple keynote addresses;Functional genomics approaches to human neurological diseases. Australia-China symposium. (Melbourne, October 15-18 2015) andFunctional genomics of trisomy 21. Human Genetics Society of Australia, 12th symposium (Adelaide 18 Sept 2015). He spoke at the International Society for Stem Cell Research (ISSCR) conference in Toronto, Canada in 2006; and the 2nd Annual World Congress of Regenerative Medicine & Stem Cell in Dalian, China in 2009. Professor Wolvetang organised a master-class on iPS cells at The 2nd Annual World Stem Cells & Regenerative Medicine Congress in Seoul, Korea in 2010.

Works

Search Professor Ernst Wolvetang’s works on UQ eSpace

242 works between 1987 and 2024

1 - 20 of 242 works

2024

Journal Article

A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy

Rossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 1-11. doi: 10.1111/imcb.12820

A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy

2024

Journal Article

Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models

Pietrogrande, Giovanni, Shaker, Mohammed R., Stednitz, Sarah J., Soheilmoghaddam, Farhad, Aguado, Julio, Morrison, Sean D., Zambrano, Samuel, Tabassum, Tahmina, Javed, Ibrahim, Cooper-White, Justin, Davis, Thomas P., O’Brien, Terence J., Scott, Ethan K. and Wolvetang, Ernst J. (2024). Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models. Molecular Psychiatry, 1-13. doi: 10.1038/s41380-024-02732-0

Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models

2024

Journal Article

Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress

Leeson, Hannah C., Aguado, Julio, Gómez-Inclán, Cecilia, Chaggar, Harman Kaur, Fard, Atefah Taherian, Hunter, Zoe, Lavin, Martin F., Mackay-Sim, Alan and Wolvetang, Ernst J. (2024). Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress. Neurobiology of Disease, 199 106562, 106562. doi: 10.1016/j.nbd.2024.106562

Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress

2024

Journal Article

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

Shaker, Mohammed R., Slonchak, Andrii, Al-Mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D.J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2024). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. Science Advances, 10 (23) eadj4735, 1-23. doi: 10.1126/sciadv.adj4735

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

2024

Journal Article

Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming

Chowdhury, Mohammad Mahfuz, Zimmerman, Samuel, Leeson, Hannah, Nefzger, Christian Maximilian, Mar, Jessica Cara, Laslett, Andrew, Polo, Jose Maria, Wolvetang, Ernst and Cooper-White, Justin (2024). Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming. Biomaterials Research, 28 0025, 0025. doi: 10.34133/bmr.0025

Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming

2024

Journal Article

Advances in single-cell long-read sequencing technologies

Gupta, Pallavi, O’Neill, Hannah, Wolvetang, Ernst J, Chatterjee, Aniruddha and Gupta, Ishaan (2024). Advances in single-cell long-read sequencing technologies. NAR Genomics and Bioinformatics, 6 (2) lqae047, lqae047. doi: 10.1093/nargab/lqae047

Advances in single-cell long-read sequencing technologies

2024

Journal Article

Autosomal recessive BLOC1S1 variants cause a hypomyelinating leukodystrophy with epileptic encephalopathy

Gonzalez, Carlos Dominguez, Sanderson, Leslie E., Depace, Raffaella, Helman, Guy, Wu, Kaiyuan, Disanza, Brianna, Pizzino, Amy, Schmidt, Johanna, Muirhead, Kayla, Bonkowsky, Joshua, Taft, Ryan, Sannaa, Nouriya, Dias, Patrícia, Mutlu, Mehmet Burak, Bertoli-Avella, Aida M., Maroofian, Reza, Barakat, Tahsin Stefan, Bhoj, Elizabeth, Ahrens-Nicklas, Rebecca, Simons, Cas, Wolvetang, Ernst, Sack, Michael N., van Ham, Tjakko, Hsiao-Sánchez, Nicole, Bonifacino, Juan S. and Vanderver, Adeline (2024). Autosomal recessive BLOC1S1 variants cause a hypomyelinating leukodystrophy with epileptic encephalopathy. Molecular Genetics and Metabolism, 141 (4) 108328, 108328. doi: 10.1016/j.ymgme.2024.108328

Autosomal recessive BLOC1S1 variants cause a hypomyelinating leukodystrophy with epileptic encephalopathy

2024

Journal Article

A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review

Alani, Maath, Altarturih, Hamza, Pars, Selin, Al-Mhanawi, Bahaa, Wolvetang, Ernst J. and Shaker, Mohammed R. (2024). A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review. International Journal of Stem Cells, 1-16. doi: 10.15283/ijsc23170

A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review

2024

Conference Publication

How the Australian Functional Genomics Network (AFGN) contributes to improved patient care

Scott, Hamish S., Matotek, Ebony, Mattiske, Tessa, Bryson-Richardson, Robert J., Smyth, Ian, Gecz, Jozef, Christodoulou, John, Palpant, Nathan, Smith, Kelly, Warr, Coral, Bennetts, Bruce, Thomas, Paul, Bowles, Josephine, Hilliard, Massimo, Hime, Gary, Hool, Livia, Quinn, Leonie, Wolvetang, Ernst, Jamieson, Robyn, Baynam, Gareth, Dudding-Byth, Tracy, Tan, Tiong Yang, Milnes, Di, Wallis, Mathew, Palmer, Elizabeth, Patel, Chirag, Jones, Kristi, Tam, Patrick, Stark, Zornitza ... Sinclair, Andrew (2024). How the Australian Functional Genomics Network (AFGN) contributes to improved patient care. Pathology Update 2024, Adelaide, SA, Australia, 1-3 March 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2023.12.084

How the Australian Functional Genomics Network (AFGN) contributes to improved patient care

2024

Journal Article

Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device

Otte, Ellen A., Smith, Taryn N., Glass, Nick, Wolvetang, Ernst J. and Cooper-White, Justin J. (2024). Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device. Lab on a Chip, 24 (3), 537-548. doi: 10.1039/d3lc00670k

Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device

2023

Journal Article

Protocol for generating embedding-free brain organoids enriched with oligodendrocytes

Al-mhanawi, Bahaa, Marti, Marta Boira, Morrison, Sean D., Gupta, Pallavi, Alani, Maath, Noakes, Peter G., Wolvetang, Ernst J. and Shaker, Mohammed R. (2023). Protocol for generating embedding-free brain organoids enriched with oligodendrocytes. STAR Protocols, 4 (4) 102725, 1-18. doi: 10.1016/j.xpro.2023.102725

Protocol for generating embedding-free brain organoids enriched with oligodendrocytes

2023

Journal Article

Development of physiologically relevant skin organoids from human induced pluripotent stem cells

Shafiee, Abbas, Sun, Jane, Ahmed, Imaan A., Phua, Felicia, Rossi, Gustavo R., Lin, Cheng‐Yu, Souza‐Fonseca‐Guimaraes, Fernando, Wolvetang, Ernst J., Brown, Jason and Khosrotehrani, Kiarash (2023). Development of physiologically relevant skin organoids from human induced pluripotent stem cells. Small, 20 (16) e2304879, 1-14. doi: 10.1002/smll.202304879

Development of physiologically relevant skin organoids from human induced pluripotent stem cells

2023

Journal Article

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

2023

Journal Article

CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination

Tabassum, Tahmina, Pietrogrande, Giovanni, Healy, Michael and Wolvetang, Ernst J. (2023). CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination. International Journal of Molecular Sciences, 24 (19) 14701, 1-17. doi: 10.3390/ijms241914701

CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination

2023

Journal Article

Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation

Tracey, Timothy J., Jiang, Leanne, Gill, Melinder K., Ranie, Samara N., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Ngo, Shyuan T. (2023). Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation. Stem Cell Research, 70 103137, 1-6. doi: 10.1016/j.scr.2023.103137

Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation

2023

Conference Publication

Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties

Morrison, Sean, Shaker, Mohammed, Pietrogrande, Giovanni, Wolvetang, Ernst and Noakes, Peter (2023). Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties. ISN‐ESN 2023 Meeting, Porto, Portugal, 8‐11 August 2023. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties

2023

Journal Article

Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution

Taherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 46 (1), 1-17. doi: 10.1007/s11357-023-00829-y

Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution

2023

Journal Article

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv, 10 (23) eadj4735, eadj4735. doi: 10.1101/2023.06.12.544552

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

2023

Journal Article

Cellular senescence and premature aging in Down Syndrome

Peng, Lianli, Baradar, Alireza A., Aguado, Julio and Wolvetang, Ernst (2023). Cellular senescence and premature aging in Down Syndrome. Mechanisms of Ageing and Development, 212 111824, 1-9. doi: 10.1016/j.mad.2023.111824

Cellular senescence and premature aging in Down Syndrome

2023

Journal Article

Embryonic stem cell-derived neurons as a model system for epigenome maturation during development

Martin, Sally, Poppe, Daniel, Olova, Nelly, O’Leary, Conor, Ivanova, Elena, Pflueger, Jahnvi, Dechka, Jennifer, Simmons, Rebecca K., Cooper, Helen M., Reik, Wolf, Lister, Ryan and Wolvetang, Ernst J. (2023). Embryonic stem cell-derived neurons as a model system for epigenome maturation during development. Genes, 14 (5) 957. doi: 10.3390/genes14050957

Embryonic stem cell-derived neurons as a model system for epigenome maturation during development

Funding

Current funding

  • 2024 - 2028
    Spider venom peptides: precision therapy for genetic epilepsies
    NHMRC MRFF Stem Cells Therapies Mission
    Open grant
  • 2024 - 2027
    Creating a non-invasive window into the mind
    ARC Discovery Projects
    Open grant
  • 2023 - 2025
    Moon's Mission: creating a replicable therapeutic framework for hereditary spastic paraplegias.
    NHMRC MRFF Stem Cells Therapies Mission
    Open grant
  • 2023 - 2025
    A human brain organoid model of acute prenatal hypoxia enables biomarker discovery and drug screening for hypoxic-ischemic encephalopathy.
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2028
    Phenomics Australia national Non-Animal Technologies Service (NATS) at UQ
    Australian National University
    Open grant
  • 2021 - 2024
    Repairing catalase function in A-T patients using a CAT-SKL therapeutic
    National Stem Cell Foundation of Australia Matched Funding Program
    Open grant
  • 2021 - 2030
    Hereditary Spastic Paraplegia Research Model
    The Trustee for Moon Atlas Trust
    Open grant
  • 2021 - 2026
    The Australian Functional Genomics Network (Administered by Murdoch Children's Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2021 - 2024
    Safer gene editing tools for Australian livestock and biotech industries
    ARC Discovery Projects
    Open grant
  • 2020 - 2025
    Ataxia-telangiectasia: treating mitochondrial dysfunction with a novel form of anaplerosis
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant

Past funding

  • 2022 - 2024
    Deciphering disease heterogeneity: Spatiotemporal analysis of molecular and cellular pathology in HBSL
    ELA International
    Open grant
  • 2021 - 2024
    ABOLISH Neuroblastoma (MRFF Childhood Cancer Research Grant led by University of South Australia)
    University of South Australia
    Open grant
  • 2021 - 2024
    Identification and assessment of new treatment options for the childhood cancer Neuroblastoma (MRFF Stem Cell Therapies led by Uni South Australia)
    University of South Australia
    Open grant
  • 2021 - 2024
    Transforming the paradigm of epilepsy care with precision medicine
    NHMRC MRFF Stem Cells Therapies Mission
    Open grant
  • 2020 - 2022
    A functional genomics approach to personalise refractory epilepsy management
    Metro North Hospital and Health Service
    Open grant
  • 2019 - 2022
    Mimicking the perivascular niche with boronolectin-based biomaterials
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Leukodystrophy Flagship (MRFF Accelerated Research, administered by Murdoch Children's Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2018 - 2019
    AutoStem: A high performance, automated stem cell bioengineering facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2018 - 2021
    Defective repair of neuronal activity-induced DNA double strand breaks: A novel pathogenic mechanism for neurodegeneration in ataxia-telangiectasia
    NHMRC Project Grant
    Open grant
  • 2018 - 2020
    Hyperactive mobile DNA in schizophrenia
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    Targeting neuromuscular stability in motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2017 - 2019
    (Re)wiring a stem cell: Deciphering the molecular mechanism underpinning lineage propensity (NHMRC Project Grant led by the University of Sydney)
    University of Sydney
    Open grant
  • 2017 - 2020
    Leveraging genomics strategies to generate adult neurons from iPSCs and somatic cells (NHMRC Project Grant administered by University of Western Australia)
    University of Western Australia
    Open grant
  • 2016 - 2021
    Preparing Australia for Genomic Medicine: A proposal by the Australian Genomics Health Alliance (NHMRC Targeted Call for Research administered by Murdoch Children's Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Single Cell Transcriptomic Laboratory
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2017
    Deciphering the role of atypical DNA methylation in neural genome regulation and neurological disorders (NHMRC project grant administered by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2015
    Directed differentiation of human embryonic stem cells to kidney progenitors (NHMRC Project Grant administered by MCRI)
    Murdoch Childrens Research Institute
    Open grant
  • 2015
    The role of altered neuromuscular activity and mRNA transport in modifying the progression of Motor Neuron Disease
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2015
    The role of altered neuronal activity and mRNA transport in modifying the progression Motor Neuron Disease (MND)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2014 - 2015
    Brain cells transformed from blood: a cell model for investigating autism
    CRC for Living with Autism Spectrum Disorders (Autism CRC Limited)
    Open grant
  • 2014 - 2018
    From iPSC based disease discovery for HBSL to novel therapeutic approaches for leukodystrophies
    Mission Massimo Foundation
    Open grant
  • 2014 - 2018
    A stem cell-based approach to the treatment of devil facial tumour disease in the Tasmanian devil (Sarcophilus harrisii)
    Morris Animal Foundation
    Open grant
  • 2014 - 2016
    Elucidation of the gene regulatory networks that cause Alzheimer's disease in Down Syndrome
    NHMRC Project Grant
    Open grant
  • 2014
    Establishment of a core facility in reproductive technology including cell micromanipulation and stem cells to improve research capacity and benefit animal health at the Gatton campus
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    Mitochondrial analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2021
    Targeting cerebellar degeneration in Ataxia-Telangiectasia using induced pluripotent stem cells
    Research Donation Generic
    Open grant
  • 2013 - 2014
    Directed differentiation of human embryonic stem cells to kidney progenitors
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2016
    Investigation of processed snoRNAs as cryptic regulators of the imprinted Prader-Willi syndrome locus
    NHMRC Project Grant
    Open grant
  • 2012 - 2014
    In vitro-derived mesenchymal cells as a therapeutic resource for treating osteoarthritis - a clinical trial
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2012 - 2014
    Production of next-generation defined culture surfaces for stem cell culture
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2012
    An intergrated fluidic circuit system for digital PCR analysis, single-cell gene- expression, and high-throughput preparation of next-generation sequencing libraries.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2015
    Reprogramming of Ataxia Telangiectasia fibroblasts to generate iPS cells
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    Scanning electron microscope to house 3-Dimensional Sectioning Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Use of induced pluripotent stem cells to define genetic factors involved in abnormal myeloproliferation and leukaemia in Down syndrome patients
    Fondation Jerome Lejeune
    Open grant
  • 2011 - 2019
    Stem Cells Australia (ARC Special Research Initiative administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2011 - 2013
    Towards curing of beta-thalassemia with iPS cells
    University of Dammam
    Open grant
  • 2011 - 2012
    Applying Inducible Pluripotent Stem (iPS) Cell Technology to Study Breast Lineage Differentiation and Tumourigensis
    Royal Brisbane and Women's Hospital
    Open grant
  • 2010 - 2012
    Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis
    ARC Discovery Projects
    Open grant
  • 2009 - 2011
    AIBN BioReactor Program (ASCC Collaborative Stream 1 - Module 2)
    Australian Stem Cell Centre
    Open grant
  • 2009 - 2011
    Novel Methods of Reprogramming (ASCC Collaborative Stream 2, Module 1)
    Australian Stem Cell Centre
    Open grant
  • 2009 - 2011
    Primitive iPS-derived MSC for Bone Repair (ASCC Collaborative Stream 2 - Module 7)
    Australian Stem Cell Centre
    Open grant
  • 2009 - 2011
    Safe and Efficient Expansion of Genetically Stable hESC (ASCC Collaborative Stream 1 - Module 6)
    Australian Stem Cell Centre
    Open grant
  • 2008 - 2011
    The generation of primary DS neurons from induced pluripotent cells
    Fondation Jerome Lejeune
    Open grant
  • 2008 - 2010
    Safe and efficient expansion of genetically stable hESC under defined conditions (ASCC Project P090)
    Australian Stem Cell Centre
    Open grant

Supervision

Availability

Professor Ernst Wolvetang is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Safer gene editing tools for Australian livestock and biotech industries

    Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this we created a novel genome editing platform technology t that is almost 100% accurate, while retaining the efficiency of the classical Cas9 system.

    This project will exemplify the capabilities of the novel gene targeting platform in cell types used by the biotechnology and livestock sectors, ensuring its global uptake by these industries and delivering significant economic benefits for Australia.

  • Modelling epilepsy related cortical dysplasia with human stem cell derived brain organoids

    In this MRFF funded project we will use induced pluripotent stem cell with patient specific and CRISPR-introduced mutations to create brain organoids. Using a combination of lineage tracing, advanced imaging modalities and multi-electrode arrays we aim to gain insight into the molecular processes that underlie cortical dysplasias and discover how this relates to differential drug responsiveness between patients.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Professor Ernst Wolvetang directly for media enquiries about:

  • Down syndrome
  • Induced pluripotent stem cells
  • Leukodystrophies
  • Regenerative medicine
  • Stem cells

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au