Overview
Background
Professor Wolvetang is an international leader in the area of pluripotent stem cell biology and human functional genomics. he initiated and leads Cell Reprogramming Australia, a collaborative framework that facilitates induced pluripotent stem cell research in Australa and is co-director of the UQ Centre in Stem Cell Ageing and Regenerative Engineering (StemCARE). He has extensive expertise in reprogramming somatic cells, differentiation and tissue engineering with adult, embryonic and induced pluripotent stem cells, genome manipulation with CRISPR, molecular biology, transcriptome analysis, high content image analysis, development and use of microfluidic devices for cell analysis, nanoparticle and scaffold design and delivery, and stem cell and cell-free regenerative medicine approaches.Professor Wolvetang has been instrumental in establishing and enabling the technology for derivation of induced pluripotent stem cells across Australia. Professor Wolvetang made the strategic decision to focus on the generation of induced pluripotent stem from patients with neurological and cardiac disorders because live human cells from such patients can usually not be obtained whereas induced pluripotent stem cells have the ability to generate every cell type of the human brain in unlimited amounts and can recapitulate the disease in the dish. Induced pluripotent stem cells combined with emerging technologies such as CRISPR-based genome editing offers a unique opportunity to study the role of individual genes and combinatorial gene regulatory pathways in the eatiology of monogenic and complex brain disorders. Indeed, combined with RNA-seq and organoid generation we are now for the first time able to gain insight into gene regulatory pathways operational in individual brain cell types of healthy and diseased individuals, investigate the connectivity and function of cells, as well as pinpoint where and when during early development such deregulated pathways lead to pathological changes. Induced pluripotent stem cells further not only provide insight into the underlying pathogenesis of neurological disorders but also constitute a valuable drugscreening platform and, following CRISPR-based gene correction, can form the basis of patient specific cellular therapies for currently incurable diseases.
Professor Wolvetang received his PhD in 1992 from the Department of Biochemistry, University of Amsterdam for his original work on peroxisomal disease (6 papers). He undertook postdoctoral studies at the Department of Biochemistry and the Institute for Reproduction and Development of Monash University, investigating apoptosis, Down syndrome and Ets transcription factors, respectively, obtaining the first evidence for an intra-chromosomal regulatory loop on chromosome 21 involving Ets2 (3 papers), and revealing the role of p53 in immune-suppression in Down syndrome (Hum Mol. Genetics). He then joined Prof Martin Pera in the Australian Stem Cell Centre in 2003 to pioneer human embryonic stem cell research in Australia, resulting in a first author Nature Biotechnology paper in 2006 identifying CD30 as a marker for genetically abnormal hESC (72 cites). He was appointed group leader of the Basic human stem cell biology laboratory in the ASCC research laboratory and senior lecturer in the Department of Anatomy and Cell biology until he accepted his current position as an independent group leader at the AIBN and Professor in stem cell biology at the University of Queensland in 2008. There he started to generate integration-free induced pluripotent stem cells from human neurological diseases such as ataxia-telangiectasia (Stem cells translational medicine). In recognition of his leadership role in this area of research he was appointed leader of the “Reprogramming and Induction of pluripotency” Collaborative Stream of the Australian Stem Cell Centre until the end of that initiative in 2011, coordinating collaborative research between eight stem cell laboratories across Australia. He subsequently initiated and is now the president of Cell Reprogramming Australia, a collaborative framework aiming to facilitate and accelerate iPS cell research in Australia and the Asia pacific region and inform the general public about reprogramming technology. His research continues to combine cell reprogramming technology, genome editing/analysis tools and microfluidic/nanoparticle based detection/ delivery technologies with the aim of creating human in vitro models of disease, unravel the underlying gene regulatory networks and enable novel cell- and delivery-based therapeutics, respectively. He further co-direct the UQ-Centre for stem cell ageing and regenerative engineering (UQ-StemCARE).
Availability
- Professor Ernst Wolvetang is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Amsterdam
- Member, ASSCR, ASSCR
- American Nano society, American Nano society
- Board Member, Australian Functional Genomics Network, Australian Functional Genomics Network
- Australian Neuroscience Society, Australian Neuroscience Society
- Member, Australian Society for Medical Research, Australian Society for Medical Research
- Board Member, CCRM Australia, CCRM Australia
- Member, ISSCR, ISSCR
- Member, NHMRC Research Translation faculty, NHMRC Research Translation faculty
Research interests
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Functional human genomics
Because iPSC can generate every cell type of the body they can be used to model a variety of diseases. CRSIPR assisted technologies can be used for functional genomics approaches. We have a particular interest in neurological diseases and generation of brain organoids from stem cells.
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Induced pluripotent stem cells
Any cell from a mature organism can be reprogrammed to a pluripotent stem cell with the ability to generate any cell type of the body. This allows unprecedented possibilities to investigate disease.
Research impacts
Memberships, patents and funding
Professor Wolvetang serves on the editorial board of six stem cell and nanotechnology journals; is listed inventor on four patents in stem cell research; and is the recipient of more than $2.5 million in grant funding in the past five years. He is a senior reprogramming scientist in Stem Cells Ltd,
Awards and plenaries
2016 Scopus Eureka Prize for Excellence in International Scientific Collaboration ,
2014 Recipient of the AON regenerative medicine prize, LSQ.
Professor Wolvetang has given 25 lectures and was invited speaker at 23 platform meetings, including multiple keynote addresses;Functional genomics approaches to human neurological diseases. Australia-China symposium. (Melbourne, October 15-18 2015) andFunctional genomics of trisomy 21. Human Genetics Society of Australia, 12th symposium (Adelaide 18 Sept 2015). He spoke at the International Society for Stem Cell Research (ISSCR) conference in Toronto, Canada in 2006; and the 2nd Annual World Congress of Regenerative Medicine & Stem Cell in Dalian, China in 2009. Professor Wolvetang organised a master-class on iPS cells at The 2nd Annual World Stem Cells & Regenerative Medicine Congress in Seoul, Korea in 2010.
Works
Search Professor Ernst Wolvetang’s works on UQ eSpace
2024
Journal Article
A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy
Rossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 1-11. doi: 10.1111/imcb.12820
2024
Journal Article
Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models
Pietrogrande, Giovanni, Shaker, Mohammed R., Stednitz, Sarah J., Soheilmoghaddam, Farhad, Aguado, Julio, Morrison, Sean D., Zambrano, Samuel, Tabassum, Tahmina, Javed, Ibrahim, Cooper-White, Justin, Davis, Thomas P., O’Brien, Terence J., Scott, Ethan K. and Wolvetang, Ernst J. (2024). Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models. Molecular Psychiatry, 1-13. doi: 10.1038/s41380-024-02732-0
2024
Journal Article
Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress
Leeson, Hannah C., Aguado, Julio, Gómez-Inclán, Cecilia, Chaggar, Harman Kaur, Fard, Atefah Taherian, Hunter, Zoe, Lavin, Martin F., Mackay-Sim, Alan and Wolvetang, Ernst J. (2024). Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress. Neurobiology of Disease, 199 106562, 106562. doi: 10.1016/j.nbd.2024.106562
2024
Journal Article
Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2
Shaker, Mohammed R., Slonchak, Andrii, Al-Mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D.J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2024). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. Science Advances, 10 (23) eadj4735, 1-23. doi: 10.1126/sciadv.adj4735
2024
Journal Article
Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming
Chowdhury, Mohammad Mahfuz, Zimmerman, Samuel, Leeson, Hannah, Nefzger, Christian Maximilian, Mar, Jessica Cara, Laslett, Andrew, Polo, Jose Maria, Wolvetang, Ernst and Cooper-White, Justin (2024). Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming. Biomaterials Research, 28 0025, 0025. doi: 10.34133/bmr.0025
2024
Journal Article
Advances in single-cell long-read sequencing technologies
Gupta, Pallavi, O’Neill, Hannah, Wolvetang, Ernst J, Chatterjee, Aniruddha and Gupta, Ishaan (2024). Advances in single-cell long-read sequencing technologies. NAR Genomics and Bioinformatics, 6 (2) lqae047, lqae047. doi: 10.1093/nargab/lqae047
2024
Journal Article
Autosomal recessive BLOC1S1 variants cause a hypomyelinating leukodystrophy with epileptic encephalopathy
Gonzalez, Carlos Dominguez, Sanderson, Leslie E., Depace, Raffaella, Helman, Guy, Wu, Kaiyuan, Disanza, Brianna, Pizzino, Amy, Schmidt, Johanna, Muirhead, Kayla, Bonkowsky, Joshua, Taft, Ryan, Sannaa, Nouriya, Dias, Patrícia, Mutlu, Mehmet Burak, Bertoli-Avella, Aida M., Maroofian, Reza, Barakat, Tahsin Stefan, Bhoj, Elizabeth, Ahrens-Nicklas, Rebecca, Simons, Cas, Wolvetang, Ernst, Sack, Michael N., van Ham, Tjakko, Hsiao-Sánchez, Nicole, Bonifacino, Juan S. and Vanderver, Adeline (2024). Autosomal recessive BLOC1S1 variants cause a hypomyelinating leukodystrophy with epileptic encephalopathy. Molecular Genetics and Metabolism, 141 (4) 108328, 108328. doi: 10.1016/j.ymgme.2024.108328
2024
Journal Article
A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review
Alani, Maath, Altarturih, Hamza, Pars, Selin, Al-Mhanawi, Bahaa, Wolvetang, Ernst J. and Shaker, Mohammed R. (2024). A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review. International Journal of Stem Cells, 1-16. doi: 10.15283/ijsc23170
2024
Conference Publication
How the Australian Functional Genomics Network (AFGN) contributes to improved patient care
Scott, Hamish S., Matotek, Ebony, Mattiske, Tessa, Bryson-Richardson, Robert J., Smyth, Ian, Gecz, Jozef, Christodoulou, John, Palpant, Nathan, Smith, Kelly, Warr, Coral, Bennetts, Bruce, Thomas, Paul, Bowles, Josephine, Hilliard, Massimo, Hime, Gary, Hool, Livia, Quinn, Leonie, Wolvetang, Ernst, Jamieson, Robyn, Baynam, Gareth, Dudding-Byth, Tracy, Tan, Tiong Yang, Milnes, Di, Wallis, Mathew, Palmer, Elizabeth, Patel, Chirag, Jones, Kristi, Tam, Patrick, Stark, Zornitza ... Sinclair, Andrew (2024). How the Australian Functional Genomics Network (AFGN) contributes to improved patient care. Pathology Update 2024, Adelaide, SA, Australia, 1-3 March 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2023.12.084
2024
Journal Article
Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device
Otte, Ellen A., Smith, Taryn N., Glass, Nick, Wolvetang, Ernst J. and Cooper-White, Justin J. (2024). Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device. Lab on a Chip, 24 (3), 537-548. doi: 10.1039/d3lc00670k
2023
Journal Article
Protocol for generating embedding-free brain organoids enriched with oligodendrocytes
Al-mhanawi, Bahaa, Marti, Marta Boira, Morrison, Sean D., Gupta, Pallavi, Alani, Maath, Noakes, Peter G., Wolvetang, Ernst J. and Shaker, Mohammed R. (2023). Protocol for generating embedding-free brain organoids enriched with oligodendrocytes. STAR Protocols, 4 (4) 102725, 1-18. doi: 10.1016/j.xpro.2023.102725
2023
Journal Article
Development of physiologically relevant skin organoids from human induced pluripotent stem cells
Shafiee, Abbas, Sun, Jane, Ahmed, Imaan A., Phua, Felicia, Rossi, Gustavo R., Lin, Cheng‐Yu, Souza‐Fonseca‐Guimaraes, Fernando, Wolvetang, Ernst J., Brown, Jason and Khosrotehrani, Kiarash (2023). Development of physiologically relevant skin organoids from human induced pluripotent stem cells. Small, 20 (16) e2304879, 1-14. doi: 10.1002/smll.202304879
2023
Journal Article
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6
2023
Journal Article
CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination
Tabassum, Tahmina, Pietrogrande, Giovanni, Healy, Michael and Wolvetang, Ernst J. (2023). CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination. International Journal of Molecular Sciences, 24 (19) 14701, 1-17. doi: 10.3390/ijms241914701
2023
Journal Article
Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation
Tracey, Timothy J., Jiang, Leanne, Gill, Melinder K., Ranie, Samara N., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Ngo, Shyuan T. (2023). Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation. Stem Cell Research, 70 103137, 1-6. doi: 10.1016/j.scr.2023.103137
2023
Conference Publication
Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties
Morrison, Sean, Shaker, Mohammed, Pietrogrande, Giovanni, Wolvetang, Ernst and Noakes, Peter (2023). Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties. ISN‐ESN 2023 Meeting, Porto, Portugal, 8‐11 August 2023. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
2023
Journal Article
Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution
Taherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 46 (1), 1-17. doi: 10.1007/s11357-023-00829-y
2023
Journal Article
Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2
Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv, 10 (23) eadj4735, eadj4735. doi: 10.1101/2023.06.12.544552
2023
Journal Article
Cellular senescence and premature aging in Down Syndrome
Peng, Lianli, Baradar, Alireza A., Aguado, Julio and Wolvetang, Ernst (2023). Cellular senescence and premature aging in Down Syndrome. Mechanisms of Ageing and Development, 212 111824, 1-9. doi: 10.1016/j.mad.2023.111824
2023
Journal Article
Embryonic stem cell-derived neurons as a model system for epigenome maturation during development
Martin, Sally, Poppe, Daniel, Olova, Nelly, O’Leary, Conor, Ivanova, Elena, Pflueger, Jahnvi, Dechka, Jennifer, Simmons, Rebecca K., Cooper, Helen M., Reik, Wolf, Lister, Ryan and Wolvetang, Ernst J. (2023). Embryonic stem cell-derived neurons as a model system for epigenome maturation during development. Genes, 14 (5) 957. doi: 10.3390/genes14050957
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ernst Wolvetang is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Safer gene editing tools for Australian livestock and biotech industries
Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this we created a novel genome editing platform technology t that is almost 100% accurate, while retaining the efficiency of the classical Cas9 system.
This project will exemplify the capabilities of the novel gene targeting platform in cell types used by the biotechnology and livestock sectors, ensuring its global uptake by these industries and delivering significant economic benefits for Australia.
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Modelling epilepsy related cortical dysplasia with human stem cell derived brain organoids
In this MRFF funded project we will use induced pluripotent stem cell with patient specific and CRISPR-introduced mutations to create brain organoids. Using a combination of lineage tracing, advanced imaging modalities and multi-electrode arrays we aim to gain insight into the molecular processes that underlie cortical dysplasias and discover how this relates to differential drug responsiveness between patients.
Supervision history
Current supervision
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Doctor Philosophy
Disease modelling of epilepsy using patient-derived brain organoids
Principal Advisor
Other advisors: Associate Professor Lata Vadlamudi, Dr Hannah Leeson, Dr Selin Pars
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Doctor Philosophy
Consciousness and Unconsciousness in Brain Organoids
Principal Advisor
Other advisors: Professor Bruno van Swinderen
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Doctor Philosophy
Elucidating the impact of micro-exon splicing defects in epilepsy with human iPSC-derived brain organoids
Principal Advisor
Other advisors: Dr Hannah Leeson
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Doctor Philosophy
Multiomics and AI for Hypoxic Ischemic Encephalopathy (HIE) Biomarker and Treatment Discovery with Human Brain Organoids
Principal Advisor
Other advisors: Associate Professor Jessica Mar, Dr Giovanni Pietrogrande
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Doctor Philosophy
'Safer gene editing tools in human stem cell models'
Principal Advisor
Other advisors: Dr Giovanni Pietrogrande
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Doctor Philosophy
Identifying the mechanism of regeneration in early brain development
Principal Advisor
Other advisors: Dr Giovanni Pietrogrande, Dr Selin Pars
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Doctor Philosophy
Elucidating the role of Human Aminoacyl multi- tRNA synthetase complex (MSC) in Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
Principal Advisor
Other advisors: Associate Professor Jessica Mar, Professor Stefan Thor, Dr Mohammed Shaker
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Doctor Philosophy
Generating complex brain organoids from human stem cells
Associate Advisor
Other advisors: Professor Michael Piper, Professor Stefan Thor
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Doctor Philosophy
Understanding neuromuscular synaptic loss in motor neuron disease
Associate Advisor
Other advisors: Dr Giovanni Pietrogrande, Dr Mohammed Shaker, Associate Professor Peter Noakes
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Doctor Philosophy
Developing an in vitro human sleep system
Associate Advisor
Other advisors: Professor Michael Piper, Professor Stefan Thor
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Doctor Philosophy
Enhancing recovery post traumatic brain injury with reparative hydrogels
Associate Advisor
Other advisors: Professor Justin Cooper-White
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Doctor Philosophy
Generating hypothalamic neurons from human stem cells
Associate Advisor
Other advisors: Professor Michael Piper, Professor Stefan Thor
Completed supervision
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2023
Doctor Philosophy
Stem Cell Derived Models to Investigate Age-Related Diseases
Principal Advisor
Other advisors: Associate Professor Shyuan Ngo, Dr Giovanni Pietrogrande
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2018
Doctor Philosophy
Uncovering novel aspects of human neural crest biology using multiomic approaches
Principal Advisor
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2016
Doctor Philosophy
CRISPR/Cas9-mediated traceless gene correction and activation of the HBB locus in iPSCs with the beta thalassaemia mutation
Principal Advisor
Other advisors: Associate Professor Deanne Whitworth
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2015
Doctor Philosophy
Generation of intestinal stem cells from human pluripotent stem cells and partially reprogrammed mouse fibroblast using a novel LGR5 promoter-based reporter
Principal Advisor
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2015
Doctor Philosophy
Regulation of Mitochondrial Biogenesis in Human Embryonic Stem Cells
Principal Advisor
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2014
Doctor Philosophy
Investigation of NFKB Signaling in Human Pluripotent Stem Cells
Principal Advisor
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2024
Doctor Philosophy
Understanding transcriptomic heterogeneity in ageing and organoids through the application of bioinformatic tools
Associate Advisor
Other advisors: Associate Professor Jessica Mar
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2023
Doctor Philosophy
Refining for Rarity: Evaluation and Adaptation of Single-cell Data Analysis for Improved Performance on Rare and Subtly-Defined Cell Populations
Associate Advisor
Other advisors: Associate Professor Jessica Mar
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2023
Doctor Philosophy
Developing novel statistical methods to investigate heterogeneity in single-cell multi-omics data
Associate Advisor
Other advisors: Associate Professor Jessica Mar
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2023
Doctor Philosophy
An in vitro human iPSC-based model to decipher cellular contributions to age-related heart failure
Associate Advisor
Other advisors: Dr Joan Li, Professor Justin Cooper-White
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2022
Doctor Philosophy
Bioengineering and Bioprocessing Approaches to Direct Protein Encapsidation by Virus-Like Particles
Associate Advisor
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2021
Doctor Philosophy
Understanding the endogenous stem/ progenitor cell response to spinal cord injury, and exploring the use of iPSC-derived propriospinal interneuron transplants to restore connectivity across the lesion site
Associate Advisor
Other advisors: Professor Marc Ruitenberg
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2020
Doctor Philosophy
Exploring the neurometabolic component of amyotrophic lateral sclerosis through the generation of human cell-derived in vitro models
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo
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2020
Doctor Philosophy
A stem cell-based approach to the treatment of devil facial tumour disease (DFTD) in the Tasmanian devil (Sarcophilus harrisii)
Associate Advisor
Other advisors: Associate Professor Deanne Whitworth
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2020
Doctor Philosophy
A pre-clinical trial using bio-material-based delivery of in vitro-derived mesenchymal stem cells to effect cartilage repair in a canine model of osteoarthritis
Associate Advisor
Other advisors: Associate Professor Deanne Whitworth
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2020
Doctor Philosophy
A versatile microfluidic platform for vector free intracellular delivery
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2019
Doctor Philosophy
L1 is dynamic during neurogenesis
Associate Advisor
Other advisors: Dr Sandra Richardson, Professor Geoff Faulkner
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2019
Doctor Philosophy
The role of TDP-43 and neuromuscular junction stability in modifying the progression of amyotrophic lateral sclerosis
Associate Advisor
Other advisors: Associate Professor Mark Bellingham, Professor Massimo Hilliard, Associate Professor Peter Noakes
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2019
Doctor Philosophy
In vitro optimization of osteogenic differentiation outcomes from human mesenchymal stem cells
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2018
Doctor Philosophy
Variability is a hallmark of human pluripotent stem cells and embryogenesis.
Associate Advisor
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2017
Doctor Philosophy
Exploring the role of C5a-C5aR1 signalling in development through pluripotent stem cell modelling
Associate Advisor
Other advisors: Dr David Simmons, Professor Trent Woodruff
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2016
Doctor Philosophy
Stem Cell Therapies and Radiological Imaging in Ataxia Telangiectasia
Associate Advisor
Other advisors: Honorary Professor Geoffrey Hill
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2016
Doctor Philosophy
Analysis of the recreation, maintenance and differentiation of nephron progenitors for use in disease modelling
Associate Advisor
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2016
Doctor Philosophy
Marvellous complexity: Characterising the transcriptome of the mammalian nervous system using RNA sequencing
Associate Advisor
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2016
Doctor Philosophy
A Self-Assembling, Targeted Biomaterial Delivery System for Cardiac Regeneration
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2015
Doctor Philosophy
In Vitro Ischemia-Reperfusion Injury Model for Pharmacological Post Conditioning of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2014
Doctor Philosophy
Induced Pluripotent Stem Cells from patients with Ataxia-Telangiectasia
Associate Advisor
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2013
Doctor Philosophy
Cartilage tissue engineering using mesenchymal stromal cells
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2011
Doctor Philosophy
Microbioreactor Arrays for Screening and Controlling Pluripotent Stem Cell Expansion, Maintenance and Differentiation
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2011
Doctor Philosophy
Development of Functional Myocardium for Regenerative Treatment of Heart Disease
Associate Advisor
Other advisors: Professor Justin Cooper-White
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2011
Doctor Philosophy
Modulation of Mesenchymal Stem Cell Behaviour via Integrin- Extracellular Matrix Interactions
Associate Advisor
Other advisors: Professor Justin Cooper-White
Media
Enquiries
Contact Professor Ernst Wolvetang directly for media enquiries about:
- Down syndrome
- Induced pluripotent stem cells
- Leukodystrophies
- Regenerative medicine
- Stem cells
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