Overview
Background
Professor Geoff Hill MBChB MD BHB FRCPA FRACP geoffH@qimr.edu.au
NHMRC Australia and QLD Health Senior Clinical Research Fellow
Coordinator, Cancer Programme, QIMR Berghofer
Head, Bone Marrow Transplantation Laboratory, QIMR Berghofer
Director of Research, Cancer Care Services, Royal Brisbane & Womens’ Hospital
Bone Marrow Transplant Physician and Haematologist, Royal Brisbane & Womens’ Hospital
Geoff Hill is a medical graduate of the University of Auckland and Haematologist, training in New Zealand, The Dana Farber Cancer Institute in Boston. He is a NHMRC Australia Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory T cells during transplantation.
Professor Hill was the 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award and the 2014 Translational Research Institute National Prize for excellence within basic and clinical research in the transplant field. He was also awarded a Queensland Health Senior Clinical Research Fellowship in 2010 to translate new cytokine and cell based therapies into clinic practice.
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, The University of Auckland
- Masters (Coursework) of Medicine Surgery, The University of Auckland
- Doctoral Diploma of Medicine, The University of Auckland
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
Works
Search Professor Geoffrey Hill’s works on UQ eSpace
2024
Journal Article
CMV Reactivation during Pre-Transplantation Evaluation: A Novel Risk Factor for Post-Transplantation CMV Reactivation
Zamora, Danniel, Xie, Hu, Sadowska-Klasa, Alicja, Kampouri, Eleftheria, Biernacki, Melinda A, Ueda Oshima, Masumi, Duke, Elizabeth R, Green, Margaret L., Kimball, Louise, Holmberg, Leona A, Waghmare, Alpana, Greninger, Alexander L, Jerome, Keith R, Hill, Geoffrey R, Hill, Joshua A, Leisenring, Wendy M and Boeckh, Michael J (2024). CMV Reactivation during Pre-Transplantation Evaluation: A Novel Risk Factor for Post-Transplantation CMV Reactivation. Blood Advances, 8 (17), 4568-4580. doi: 10.1182/bloodadvances.2023012234
2024
Journal Article
Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation
Yeh, Albert C., Koyama, Motoko, Waltner, Olivia G., Minnie, Simone A., Boiko, Julie R., Shabaneh, Tamer B., Takahashi, Shuichiro, Zhang, Ping, Ensbey, Kathleen S., Schmidt, Christine R., Legg, Samuel R.W., Sekiguchi, Tomoko, Nelson, Ethan, Bhise, Shruti S., Stevens, Andrew R., Goodpaster, Tracy, Chakka, Saranya, Furlan, Scott N., Markey, Kate A., Bleakley, Marie E., Elson, Charles O., Bradley, Philip H. and Hill, Geoffrey R. (2024). Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation. Immunity, 57 (7), 1648-1664.e9. doi: 10.1016/j.immuni.2024.05.018
2024
Journal Article
IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation
Zhang, Ping, Fleming, Peter, Andoniou, Christopher E., Waltner, Olivia G., Bhise, Shruti S., Martins, Jose Paulo, McEnroe, Benjamin A., Voigt, Valentina, Daly, Sheridan, Kuns, Rachel D., Ekwe, Adaeze P., Henden, Andrea S., Saldan, Alda, Olver, Stuart, Varelias, Antiopi, Smith, Corey, Schmidt, Christine R., Ensbey, Kathleen S., Legg, Samuel R.W., Sekiguchi, Tomoko, Minnie, Simone A., Gradwell, Mark, Wagenaar, Irma, Clouston, Andrew D., Koyama, Motoko, Furlan, Scott N., Kennedy, Glen A., Ward, E Sally, Degli-Esposti, Mariapia A. ... Tey, Siok-Keen (2024). IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation. Journal of Clinical Investigation, 134 (7) e174184. doi: 10.1172/jci174184
2024
Journal Article
Clinical grade multiparametric cell sorting and gene-marking of regulatory T cells
Ekwe, Adaeze Precious, Au, Raymond, Zhang, Ping, McEnroe, Benjamin, Tan, Mei Ling, Saldan, Alda, Henden, Andrea S., Hutchins, Cheryl, Henderson, Ashleigh, Mudie, Kari, Kerr, Keri, Fuery, Madonna, Kennedy, Glen A., Hill, Geoffrey R. and Tey, Siok-Keen (2024). Clinical grade multiparametric cell sorting and gene-marking of regulatory T cells. Cytotherapy, 26 (7), 719-728. doi: 10.1016/j.jcyt.2024.02.023
2024
Journal Article
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2024). Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 25 (4), 716-716. doi: 10.1038/s41590-024-01770-8
2024
Journal Article
Autophagy prevents graft failure during murine Graft versus Host Disease
Lineburg, Katie E, Leveque-El Mouttie, Lucie, Hunter, Christopher R., Le Texier, Laeitia, McGirr, Crystal, Teal, Bianca, Blazar, Bruce R., Lane, Steven W, Hill, Geoffrey R, Levesque, Jean-Pierre and MacDonald, Kelli P.A. (2024). Autophagy prevents graft failure during murine Graft versus Host Disease. Blood Advances, 8 (8), 2032-2043. doi: 10.1182/bloodadvances.2023010972
2024
Journal Article
Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation
Takahashi, Shuichiro, Minnie, Simone A., Ensbey, Kathleen S., Schmidt, Christine R., Sekiguchi, Tomoko, Legg, Samuel R. W., Zhang, Ping, Koyama, Motoko, Olver, Stuart D., Collinge, Alika D., Keshmiri, Sara, Comstock, Melissa L., Varelias, Antiopi, Green, Damian J. and Hill, Geoffrey R. (2024). Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Blood, 143 (16), 1656-1669. doi: 10.1182/blood.2023022000
2023
Journal Article
CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice
Adams, Rachael C, Carter-Cusack, Dylan, Llanes, Genesis T, Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R, Furlan, Scott N, Zeiser, Robert and MacDonald, Kelli P.A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice. Blood Journal, 142 (Supplement 1), 2052-2052. doi: 10.1182/blood.2023022040
2023
Conference Publication
CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice
Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P. A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice. 65th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 9-12 December 2023. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2023-184841
2023
Journal Article
Chronic GvHD NIH consensus project biology task force: evolving path to personalized treatment of chronic GvHD
Buxbaum, Nataliya Prokopenko, Socié, Gerard, Hill, Geoffrey R, MacDonald, Kelli PA, Tkachev, Victor, Teshima, Takanori, Lee, Stephanie J, Ritz, Jerome, Sarantopoulos, Stefanie, Luznik, Leo, Zeng, Defu, Paczesny, Sophie, Martin, Paul J., Pavletic, Steven Z, Schultz, Kirk R and Blazar, Bruce R. (2023). Chronic GvHD NIH consensus project biology task force: evolving path to personalized treatment of chronic GvHD. Blood Advances, 7 (17), 4886-4902. doi: 10.1182/bloodadvances.2022007611
2023
Journal Article
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity
Koyama, Motoko, Hippe, Daniel S., Srinivasan, Sujatha, Proll, Sean C., Miltiadous, Oriana, Li, Naisi, Zhang, Ping, Ensbey, Kathleen S., Hoffman, Noah G., Schmidt, Christine R., Yeh, Albert C., Minnie, Simone A., Strenk, Susan M., Fiedler, Tina L., Hattangady, Namita, Kowalsky, Jacob, Grady, Willian M., Degli-Esposti, Mariapia A., Varelias, Antiopi, Clouston, Andrew D., van den Brink, Marcel R.M., Dey, Neelendu, Randolph, Timothy W., Markey, Kate A., Fredricks, David N. and Hill, Geoffrey R. (2023). Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity. Immunity, 56 (8), 1876-1893.e8. doi: 10.1016/j.immuni.2023.06.024
2023
Journal Article
Treg amelioration of GVHD following allo/xeno-HSCT using mobilized mouse and human peripheral blood donors
Barreras, Henry, Copsel, Sabrina N., Bader, Cameron S., Ding, Ying, Wolf, Dietlinde, Cash, Charles, Stacey, Caleb J., Benjamin, Cara, Seavey, Mathew M, Wolf, Jeffrey, Jasuja, Rahul R, Pfeiffer, Brent, Hill, Geoffrey R., Komanduri, Krishna V., Jurecic, Roland, Malek, Thomas R. and Levy, Robert B. (2023). Treg amelioration of GVHD following allo/xeno-HSCT using mobilized mouse and human peripheral blood donors. Transplantation and Cellular Therapy, 29 (5), 341.e1-341.e9. doi: 10.1016/j.jtct.2023.02.015
2023
Conference Publication
Type-1 regulatory T cells are critical for curative immunotherapy outcomes
Zhang, Ping, Gartlan, Kate H., Minnie, Simone A., Yeh, Albert, Takahashi, Shuichiro, Atilla, Erden, Nemychenkov, Nicole S., Boiko, Julie R., Schmidt, Christine R., Legg, Samuel R.W., Sekiguchi, Tomoko, Ensbey, Kathleen S., Koyama, Motoko, Furlan, Scott N. and Hill, Geoffrey R. (2023). Type-1 regulatory T cells are critical for curative immunotherapy outcomes. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.173.11
2023
Journal Article
Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation
Ueda Oshima, Masumi, Xie, Hu, Zamora, Danniel, Flowers, Mary E., Hill, Geoffrey R, Mielcarek, Marco, Sandmaier, Brenda M, Gooley, Theodore A and Boeckh, Michael J. (2023). Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation. Blood Advances, 7 (8), 1394-1403. doi: 10.1182/bloodadvances.2022009112
2023
Journal Article
Oncogenic drivers dictate immune control of acute myeloid leukemia
Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W. and Bywater, Megan J. (2023). Oncogenic drivers dictate immune control of acute myeloid leukemia. Nature Communications, 14 (1) 2155, 1-14. doi: 10.1038/s41467-023-37592-9
2023
Journal Article
Infection induces tissue-resident memory NK cells that safeguard tissue health
Schuster, Iona S., Sng, Xavier Y. X., Lau, Colleen M., Powell, David R., Weizman, Orr-El, Fleming, Peter, Neate, Georgia E. G., Voigt, Valentina, Sheppard, Sam, Maraskovsky, Andreas I., Daly, Sheridan, Koyama, Motoko, Hill, Geoffrey R., Turner, Stephen J., O’Sullivan, Timothy E., Sun, Joseph C., Andoniou, Christopher E. and Degli-Esposti, Mariapia A. (2023). Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity, 56 (3), 531-546.e6. doi: 10.1016/j.immuni.2023.01.016
2023
Journal Article
A novel RIPK1 inhibitor attenuates GVHD
Hill, Geoffrey R. and Koyama, Motoko (2023). A novel RIPK1 inhibitor attenuates GVHD. Blood, 141 (9), 969-970. doi: 10.1182/blood.2022019019
2023
Journal Article
Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity
Larson, Jemma H., Jin, Sujeong, Loschi, Michael, Wagers, Sara Bolivar, Thangavelu, Govindarajan, Zaiken, Michael C., McDonald-Hyman, Cameron, Saha, Asim, Aguilar, Ethan G., Koehn, Brent, Osborn, Mark J., Panoskaltsis-Mortari, Angela, Macdonald, Kelli P.A., Hill, Geoffrey R., Murphy, William J., Serody, Jonathan S, Maillard, Ivan, Kean, Leslie S., Kim, Sangwon V., Littman, Dan R. and Blazar, Bruce R. (2023). Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity. American Journal of Transplantation, 23 (8), 1102-1115. doi: 10.1016/j.ajt.2023.01.030
2023
Conference Publication
Single Cell RNA Sequencing Identifies IL-17- and CSF-1-Associated Pathologic Gene Expression Signatures in Blood during Chronic Graft-Versus-Host Disease
Boiko, Julie R., Ensbey, Kathleen S., Schmidt, Christine R., Waltner, Olivia G., Minnie, Simone A., Furlan, Scott N. and Hill, Geoffrey R. (2023). Single Cell RNA Sequencing Identifies IL-17- and CSF-1-Associated Pathologic Gene Expression Signatures in Blood during Chronic Graft-Versus-Host Disease. 2023 Tandem Meetings of ASTCT and CIBMTR, Orlando, FL United States, 15-19 February 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/s2666-6367(23)00389-5
2023
Conference Publication
Pilot Trial of Interferon-γ and Donor Lymphocyte Infusion to Treat Relapsed Myeloblastic Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation
Geramita, Emily, Ventura, Kedwin, Bhise, Shruti, Moore, Erika, Krakow, Elizabeth F., Hill, Geoffrey R., Furlan, Scott N., Shlomchik, Warren D. and Ito, Sawa (2023). Pilot Trial of Interferon-γ and Donor Lymphocyte Infusion to Treat Relapsed Myeloblastic Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation. 2023 Tandem Meetings of ASTCT and CIBMTR, Orlando, FL United States, 15-19 February 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/s2666-6367(23)00122-7
Supervision
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
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Supervision history
Completed supervision
-
2019
Doctor Philosophy
Understanding the role of IL-6 signalling in Graft-Versus-Host Disease (GVHD)
Principal Advisor
Other advisors: Associate Professor Kate Gartlan
-
2019
Doctor Philosophy
Restoring myeloma-immune equilibrium by stem cell transplantation
Principal Advisor
-
2019
Doctor Philosophy
Anti-leukaemia effect of Interferons
Principal Advisor
Other advisors: Professor Steven Lane, Associate Professor Kate Gartlan
-
2012
Doctor Philosophy
Mechanisms of Immune Modulation after Stem Cell Transplantation
Principal Advisor
-
2021
Doctor Philosophy
Interplay between cytomegalovirus infection and graft-versus-leukaemia effect
Associate Advisor
-
2019
Doctor Philosophy
The Psychosocial Impact of Haematopoietic Stem Cell Donation on Adult Related Donors
Associate Advisor
-
2019
Doctor Philosophy
The contribution of cytokine signals, autophagy and antigen presentation to complications associated with allogeneic stem cell transplantation
Associate Advisor
-
2017
Doctor Philosophy
Maintenance of blood stem cells and the development of haematological malignancies
Associate Advisor
Other advisors: Professor Steven Lane
-
2016
Doctor Philosophy
Stem Cell Therapies and Radiological Imaging in Ataxia Telangiectasia
Associate Advisor
Other advisors: Professor Ernst Wolvetang
-
2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
-
2012
Doctor Philosophy
T cell immune response to human cytomegalovirus in latency and reactivation
Associate Advisor
-
2012
Doctor Philosophy
Self-renewal pathways in leukaemia stem cells and haematopoietic stem cells
Associate Advisor
-
2011
Doctor Philosophy
Antigen Presentation and Inflammation in Allogeneic Bone Marrow Transplantation
Associate Advisor
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Associate Advisor
Other advisors: Professor Ian Frazer
Media
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