Honorary Professor Geoffrey Hill
Honorary Professor

Geoffrey Hill

Email: 

Background

Professor Geoff Hill MBChB MD BHB FRCPA FRACP geoffH@qimr.edu.au

NHMRC Australia and QLD Health Senior Clinical Research Fellow

Coordinator, Cancer Programme, QIMR Berghofer

Head, Bone Marrow Transplantation Laboratory, QIMR Berghofer

Director of Research, Cancer Care Services, Royal Brisbane & Womens’ Hospital

Bone Marrow Transplant Physician and Haematologist, Royal Brisbane & Womens’ Hospital

Geoff Hill is a medical graduate of the University of Auckland and Haematologist, training in New Zealand, The Dana Farber Cancer Institute in Boston. He is a NHMRC Australia Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory T cells during transplantation.

Professor Hill was the 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award and the 2014 Translational Research Institute National Prize for excellence within basic and clinical research in the transplant field. He was also awarded a Queensland Health Senior Clinical Research Fellowship in 2010 to translate new cytokine and cell based therapies into clinic practice.

Availability

Honorary Professor Geoffrey Hill is:
Available for supervision

Fields of research

Clinical sciences Immunology

Qualifications

  • Bachelor, The University of Auckland
  • Masters (Coursework) of Medicine Surgery, The University of Auckland
  • Doctoral Diploma of Medicine, The University of Auckland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians
  • Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia

Search Professor Geoffrey Hill’s works on UQ eSpace

278 works between 1996 and 2024
All (278) Journal Article (250) Book Chapter (2) Conference Publication (26)

61 - 80 of 278 works

2019

Journal Article

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Gartlan, Kate H., Koyama, Motoko, Lineburg, Katie E., Chang, Karshing, Ensbey, Kathleen S., Kuns, Rachel D., Henden, Andrea S., Samson, Luke D., Clouston, Andrew D., Lopez, Angel F., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract. Blood Advances, 3 (19), 2859-2865. doi: 10.1182/bloodadvances.2019000053

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

2019

Journal Article

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, Asim, Taylor, Patricia A., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Osborn, Mark J., Feser, Colby J., Thangavelu, Govindarajan, Melchinger, Wolfgang, Refaeli, Yosef, Hill, Geoffrey R., Munn, David H., Murphy, William J., Serody, Jonathan S., Maillard, Ivan, Kreymborg, Katharina, van den Brink, Marcel, Dong, Chen, Huang, Shuyu, Zang, Xingxing, Allison, James P., Zeiser, Robert and Blazar, Bruce R. (2019). Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality. JCI insight, 4 (19) e127716. doi: 10.1172/jci.insight.127716

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

2019

Journal Article

IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling

Wilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H. and Hill, Geoffrey R. (2019). IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling. Blood, 134 (23), 2092-2106. doi: 10.1182/blood.2019000396

IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling

2019

Journal Article

Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo

Spicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Giddens, Anna C., Jaiswal, Jagdish K., Jamieson, Stephen M. F., Bull, Matthew R., Denny, William A., Akhlaghi, Hedieh, Trapani, Joseph A., Hill, Geoff R., Chang, Karshing and Gartlan, Kate H. (2019). Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo. Journal of Medicinal Chemistry, 63 (5) acs.jmedchem.9b00881, 2229-2239. doi: 10.1021/acs.jmedchem.9b00881

Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo

2019

Journal Article

Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic intervention

Zhang, Ping and Hill, Geoffrey R. (2019). Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic intervention. Seminars in Immunology, 44 101322, 101322. doi: 10.1016/j.smim.2019.101322

Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic intervention

2019

Journal Article

Adult related haematopoietic stem cell donor care: views of transplant nurses

Zomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2019). Adult related haematopoietic stem cell donor care: views of transplant nurses. European Journal of Oncology Nursing, 41, 56-63. doi: 10.1016/j.ejon.2019.05.012

Adult related haematopoietic stem cell donor care: views of transplant nurses

2019

Journal Article

Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model

Guillerey, Camille, Nakamura, Kyohei, Pichler, Andrea C., Barkauskas, Deborah, Krumeich, Sophie, Stannard, Kimberley, Miles, Kim, Harjunpää, Heidi, Yu, Yuan, Casey, Mika, Doban, Alina I., Lazar, Mircea, Hartel, Gunter, Smith, David, Vuckovic, Slavica, Teng, Michele W.L., Bergsagel, P. Leif, Chesi, Marta, Hill, Geoffrey R., Martinet, Ludovic and Smyth, Mark J. (2019). Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model. JCI Insight, 4 (14) :e125932. doi: 10.1172/jci.insight.125932

Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model

2019

Conference Publication

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology. Immunology 2019™ Meeting, San Diego, CA United States, 9-13 May 2019. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.202.supp.69.38

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

2019

Conference Publication

B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality

Saha, Asim, Taylor, Patricia A., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Osborn, Mark J., Feser, Colby J., Thangavelu, Govindarajan, Melchinger, Wolfgang, Refaeli, Yosef, Hill, Geoffrey R., Munn, David H., Serody, Jonathan S., Maillard, Ivan, Kreymborg, Katharina, van den Brink, Marcel, Dong, Chen, Huang, Shuyu, Zang, Xingxing, Allison, James P, Zeiser, Robert and Blazar, Bruce R. (2019). B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality. Immunology 2019™ Meeting, San Diego, CA United States, 9-13 May 2019. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.202.supp.69.10

B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality

2019

Journal Article

Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature review

Zomerdijk, Nienke, Turner, Jane M. and Hill, Geoffrey R. (2019). Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature review. European Journal of Cancer Care, 28 (3) e12932, 1-15. doi: 10.1111/ecc.12932

Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature review

2019

Conference Publication

Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation

Zaiken, Michael C., Flynn, Ryan, Paz, Katelyn, Rhee, Stephanie, Park, Paul, Hemming, Matthew, Sage, Peter, Sharpe, Arlene, Luznik, Leonard, Mailard, Ivan, Hill, Geoffrey R., MacDonald, Kelli, Serody, Jonathon, Cutler, Corey, Koreth, John, Miklos, David, Antin, Joseph, Soiffer, Robert, Ritz, Jerome, Bradner, Jay, Qi, Jun and Blazar, Bruce R. (2019). Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation. Immunology 2019™ Meeting, San Diego, CA United States, 9-13 May 2019. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.202.supp.69.42

Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation

2019

Journal Article

Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer

Zhang, Ping, Curley, Cameron I., Mudie, Kari, Nakagaki, Midori, Hill, Geoffrey R., Roberts, Jason A. and Tey, Siok-Keen (2019). Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer. Bone Marrow Transplantation, 54 (12), 2110-2116. doi: 10.1038/s41409-019-0505-5

Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer

2019

Journal Article

Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization

Varelias, Antiopi, Gartlan, Kate H., Wilkinson, Andrew N., Olver, Stuart D., Samson, Luke D., Tey, Siok-Keen, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization. Blood Advances, 3 (5), 718-723. doi: 10.1182/bloodadvances.2018025601

Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization

2019

Journal Article

Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential and long-term persistence of transgenic T cells

Zhang, Ping, Raju, Jyothy, Ullah, Md Ashik, Au, Raymond, Varelias, Antiopi, Gartlan, Kate H, Olver, Stuart D., Samson, Luke D., Sturgeon, Elise, Zomerdijk, Nienke, Avery, Judy, Gargett, Tessa, Brown, Michael P., Coin, Lachlan J., Ganesamoorthy, Devika, Hutchins, Cheryl, Pratt, Gary R, Kennedy, Glen A., Morton, A. James, Curley, Cameron I., Hill, Geoffrey R. and Tey, Siok-Keen (2019). Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential and long-term persistence of transgenic T cells. Clinical Cancer Research, 25 (6), 1749-1755. doi: 10.1158/1078-0432.CCR-18-3069

Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential and long-term persistence of transgenic T cells

2019

Journal Article

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Martins, Jose Paulo, Andoniou, Christopher E., Fleming, Peter, Kuns, Rachel D., Schuster, Iona S., Voigt, Valentina, Daly, Sheridan, Varelias, Antiopi, Tey, Siok-Keen, Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation. Science, 363 (6424), 288-293. doi: 10.1126/science.aat0066

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

2019

Journal Article

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, Katelyn, Flynn, Ryan, Du, Jing, Qi, Jun, Luznik, Leo, Maillard, Ivan, MacDonald, Kelli P., Hill, Geoffrey R., Serody, Jonathan S., Murphy, William J., Sage, Peter T., Sharpe, Arlene H., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Bradner, James E., Melnick, Ari M. and Blazar, Bruce R. (2019). Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease. Blood, 133 (1), 94-99. doi: 10.1182/blood-2018-03-839993

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

2019

Journal Article

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, Katelyn, Flynn, Ryan, Du, Jing, Tannheimer, Stacey, Johnson, Amy J., Dong, Shuai, Stark, Anne-Katrien, Okkenhaug, Klaus, Panoskaltsis-Mortari, Angela, Sage, Peter T., Sharpe, Arlene H., Luznik, Leo, Ritz, Jerome, Soiffer, Robert J., Cutler, Corey S., Koreth, John, Antin, Joseph H., Miklos, David B., MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Serody, Jonathan S., Murphy, William J., Munn, David H., Feser, Colby, Zaiken, Michael, Vanhaesebroeck, Bart, Turka, Laurence A., Byrd, John C. and Blazar, Bruce R. (2019). Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease. American Journal of Transplantation, 19 (6) ajt.15305, 1820-1830. doi: 10.1111/ajt.15305

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

2018

Journal Article

Distinct roles for CD4+ Foxp3+ regulatory T cells and IL-10–mediated immunoregulatory mechanisms during experimental visceral Leishmaniasis caused by Leishmania donovani

Bunn, Patrick T., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Kumar, Rajiv, Ng, Susanna S., Edwards, Chelsea L., Faleiro, Rebecca J., Sheel, Meru, Amante, Fiona H., Frame, Teija C. M., Muller, Werner, Haque, Ashraful, Uzonna, Jude E., Hill, Geoffrey R. and Engwerda, Christian R. (2018). Distinct roles for CD4+ Foxp3+ regulatory T cells and IL-10–mediated immunoregulatory mechanisms during experimental visceral Leishmaniasis caused by Leishmania donovani. The Journal of Immunology, 201 (11), 3362-3372. doi: 10.4049/jimmunol.1701582

Distinct roles for CD4+ Foxp3+ regulatory T cells and IL-10–mediated immunoregulatory mechanisms during experimental visceral Leishmaniasis caused by Leishmania donovani

2018

Book Chapter

Monocytes, macrophages, and dendritic cells

Collin, Matthew and Hill, Geoffrey R. (2018). Monocytes, macrophages, and dendritic cells. Wintrobe's Clinical Hematology: Fourteenth Edition. (pp. 616-683) Philadelphia, PA United States: Wolters Kluwer.

Monocytes, macrophages, and dendritic cells

2018

Journal Article

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Jacquelin, Sebastien, Straube, Jasmin, Cooper, Leanne, Vu, Therese, Song, Axia, Bywater, Megan, Baxter, Eva, Heidecker, Matthew, Wackrow, Brad, Porter, Amy, Ling, Victoria, Green, Joanne, Austin, Rebecca, Kazakoff, Stephen, Waddell, Nicola, Hesson, Luke B., Pimanda, John E., Stegelmann, Frank, Bullinger, Lars, Döhner, Konstanze, Rampal, Raajit K., Heckl, Dirk, Hill, Geoffrey R. and Lane, Steven W. (2018). Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation. Blood, 132 (26), blood-2018. doi: 10.1182/blood-2018-04-846220

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Current funding

  • 2024 - 2027
    Harnessing the gut microbiome to improve stem cell transplant outcome (NHMRC Ideas 2023 Administered by The Council of the Queensland Institute of Medical Research)
    Queensland Institute of Medical Research
    Open grant

Past funding

  • 2015 - 2016
    Developing new ways to predict infection in patients undergoing chemotherapy and bone marrow transplantation
    UQ Academic Title Holder Research Fund
    Open grant
  • 2010 - 2014
    Immunological therapies for cancer, chronic infection and autoimmunity
    NHMRC Program Grant
    Open grant
  • 2005 - 2009
    Immunological therapies for cancer and autoimmunity
    NHMRC Program Grant
    Open grant
  • 2003 - 2004
    Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
    NHMRC Project Grant
    Open grant

Availability

Honorary Professor Geoffrey Hill is:
Available for supervision

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Supervision history

Completed supervision

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