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2025 Journal Article Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicityShaker, Mohammed R., Salloum-Asfar, Salam, Taha, Rowaida Z., Javed, Ibrahim and Wolvetang, Ernst J. (2025). Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity. Molecular Brain, 18 (1) 27. doi: 10.1186/s13041-025-01199-6 |
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2024 Journal Article A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapyRossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 102 (10), 1-11. doi: 10.1111/imcb.12820 |
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2024 Journal Article Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal modelsPietrogrande, Giovanni, Shaker, Mohammed R., Stednitz, Sarah J., Soheilmoghaddam, Farhad, Aguado, Julio, Morrison, Sean D., Zambrano, Samuel, Tabassum, Tahmina, Javed, Ibrahim, Cooper-White, Justin, Davis, Thomas P., O’Brien, Terence J., Scott, Ethan K. and Wolvetang, Ernst J. (2024). Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models. Molecular Psychiatry, 30 (3) 200, 1-13. doi: 10.1038/s41380-024-02732-0 |
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2024 Journal Article Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stressLeeson, Hannah C., Aguado, Julio, Gómez-Inclán, Cecilia, Chaggar, Harman Kaur, Fard, Atefah Taherian, Hunter, Zoe, Lavin, Martin F., Mackay-Sim, Alan and Wolvetang, Ernst J. (2024). Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress. Neurobiology of Disease, 199 106562, 106562. doi: 10.1016/j.nbd.2024.106562 |
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2024 Journal Article Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2Shaker, Mohammed R., Slonchak, Andrii, Al-Mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D.J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2024). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. Science Advances, 10 (23) eadj4735, 1-23. doi: 10.1126/sciadv.adj4735 |
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2024 Journal Article Advances in single-cell long-read sequencing technologiesGupta, Pallavi, O’Neill, Hannah, Wolvetang, Ernst J., Chatterjee, Aniruddha and Gupta, Ishaan (2024). Advances in single-cell long-read sequencing technologies. NAR Genomics and Bioinformatics, 6 (2) lqae047, 1-11. doi: 10.1093/nargab/lqae047 |
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2024 Journal Article Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogrammingChowdhury, Mohammad Mahfuz, Zimmerman, Samuel, Leeson, Hannah, Nefzger, Christian Maximilian, Mar, Jessica Cara, Laslett, Andrew, Polo, Jose Maria, Wolvetang, Ernst and Cooper-White, Justin (2024). Superior induced pluripotent stem cell generation through Phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming. Biomaterials Research, 28 0025, 0025. doi: 10.34133/bmr.0025 |
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2024 Journal Article A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive reviewAlani, Maath, Altarturih, Hamza, Pars, Selin, Al-Mhanawi, Bahaa, Wolvetang, Ernst J. and Shaker, Mohammed R. (2024). A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review. International Journal of Stem Cells, 17 (4), 1-16. doi: 10.15283/ijsc23170 |
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2024 Journal Article Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic deviceOtte, Ellen A., Smith, Taryn N., Glass, Nick, Wolvetang, Ernst J. and Cooper-White, Justin J. (2024). Exploring the cell interactome: deciphering relative impacts of cell–cell communication in cell co-culture using a novel microfluidic device. Lab on a Chip, 24 (3), 537-548. doi: 10.1039/d3lc00670k |
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2023 Journal Article Protocol for generating embedding-free brain organoids enriched with oligodendrocytesAl-mhanawi, Bahaa, Marti, Marta Boira, Morrison, Sean D., Gupta, Pallavi, Alani, Maath, Noakes, Peter G., Wolvetang, Ernst J. and Shaker, Mohammed R. (2023). Protocol for generating embedding-free brain organoids enriched with oligodendrocytes. STAR Protocols, 4 (4) 102725, 1-18. doi: 10.1016/j.xpro.2023.102725 |
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2023 Journal Article Development of physiologically relevant skin organoids from human induced pluripotent stem cellsShafiee, Abbas, Sun, Jane, Ahmed, Imaan A., Phua, Felicia, Rossi, Gustavo R., Lin, Cheng‐Yu, Souza‐Fonseca‐Guimaraes, Fernando, Wolvetang, Ernst J., Brown, Jason and Khosrotehrani, Kiarash (2023). Development of physiologically relevant skin organoids from human induced pluripotent stem cells. Small, 20 (16) e2304879, 1-14. doi: 10.1002/smll.202304879 |
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2023 Journal Article Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologyAguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6 |
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2023 Journal Article CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombinationTabassum, Tahmina, Pietrogrande, Giovanni, Healy, Michael and Wolvetang, Ernst J. (2023). CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination. International Journal of Molecular Sciences, 24 (19) 14701, 1-17. doi: 10.3390/ijms241914701 |
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2023 Journal Article Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutationTracey, Timothy J., Jiang, Leanne, Gill, Melinder K., Ranie, Samara N., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Ngo, Shyuan T. (2023). Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation. Stem Cell Research, 70 103137, 1-6. doi: 10.1016/j.scr.2023.103137 |
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2023 Journal Article Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolutionTaherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 46 (1), 1-17. doi: 10.1007/s11357-023-00829-y |
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2023 Journal Article Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv, 10 (23) eadj4735, eadj4735. doi: 10.1101/2023.06.12.544552 |
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2023 Journal Article Cellular senescence and premature aging in Down SyndromePeng, Lianli, Baradar, Alireza A., Aguado, Julio and Wolvetang, Ernst (2023). Cellular senescence and premature aging in Down Syndrome. Mechanisms of Ageing and Development, 212 111824, 1-9. doi: 10.1016/j.mad.2023.111824 |
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2023 Journal Article Embryonic stem cell-derived neurons as a model system for epigenome maturation during developmentMartin, Sally, Poppe, Daniel, Olova, Nelly, O’Leary, Conor, Ivanova, Elena, Pflueger, Jahnvi, Dechka, Jennifer, Simmons, Rebecca K., Cooper, Helen M., Reik, Wolf, Lister, Ryan and Wolvetang, Ernst J. (2023). Embryonic stem cell-derived neurons as a model system for epigenome maturation during development. Genes, 14 (5) 957. doi: 10.3390/genes14050957 |
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2023 Journal Article Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissueSlonchak, Andrii, Chaggar, Harman, Aguado, Julio, Wolvetang, Ernst and Khromykh, Alexander A. (2023). Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissue. Viruses, 15 (5) 1062, 1062. doi: 10.3390/v15051062 |
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2023 Journal Article Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: a repurposing studyRibaudo, Giovanni, Yun, Xiaoyun, Ongaro, Alberto, Oselladore, Erika, Ng, Jerome P. L., Haynes, Richard K., Law, Betty Yuen Kwan, Memo, Maurizio, Wong, Vincent Kam Wai, Coghi, Paolo and Gianoncelli, Alessandra (2023). Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: a repurposing study. Chemical Biology and Drug Design, 101 (4), 809-818. doi: 10.1111/cbdd.14187 |
