Overview
Background
Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.
Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.
Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.
Availability
- Professor Bruno van Swinderen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Washington University in St Louis
Research interests
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Attention and memory
Behavioral choices result from an ongoing interplay between attention and memory. We have developed paradigms to study visual attention and memory in Drosophila, thereby allowing us to investigate this complex problem in a powerful genetic model. Two levels of investigation are involved: behavior and brain electrophysiology. Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. Our goal is to identify mechanisms of visual attention, and to elucidate how these processes interact with memory systems.
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Anesthesia and sleep
We all sleep, and many of us require anesthesia during surgery at some point in our lives. However, the function of sleep is unclear, and the mechanism of general anesthesia remains mysterious. Our insight into brain processes modulating visual perception in Drosophila is applied at an electrophysiological level towards understanding sleep and general anesthesia, when perception is lost. We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology.
Works
Search Professor Bruno van Swinderen’s works on UQ eSpace
2024
Journal Article
Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain
Hines, Adam D., Kewin, Amber B., Van De Poll, Matthew N., Anggono, Victor, Bademosi, Adekunle T. and van Swinderen, Bruno (2024). Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain. The Journal of Neuroscience, 44 (24) e0588232024, 1-18. doi: 10.1523/jneurosci.0588-23.2024
2024
Journal Article
Time to wake up! The ongoing search for general anesthetic reversal agents
Cylinder, Drew M., van Zundert, André A. J., Solt, Ken and van Swinderen, Bruno (2024). Time to wake up! The ongoing search for general anesthetic reversal agents. Anesthesiology, 140 (3), 610-627. doi: 10.1097/aln.0000000000004846
2024
Journal Article
Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies
Jagannathan, Sridhar R., Jeans, Travis, Van De Poll, Matthew N. and van Swinderen, Bruno (2024). Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies. Science Advances, 10 (8) eadj4399. doi: 10.1126/sciadv.adj4399
2023
Journal Article
Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila
Anthoney, Niki, Tainton-Heap, Lucy, Luong, Hang, Notaras, Eleni, Kewin, Amber B., Zhao, Qiongyi, Perry, Trent, Batterham, Philip, Shaw, Paul J. and van Swinderen, Bruno (2023). Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila. eLife, 12 RP88198. doi: 10.7554/elife.88198
2023
Journal Article
Neural ensemble fragmentation in the anesthetized Drosophila brain
Troup, Michael, Tainton-Heap, Lucy A L and van Swinderen, Bruno (2023). Neural ensemble fragmentation in the anesthetized Drosophila brain. The Journal of Neuroscience, 43 (14), 2537-2551. doi: 10.1523/jneurosci.1657-22.2023
2023
Journal Article
Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila
Anthoney, Niki, Tainton-Heap, Lucy A. L., Luong, Hang, Notaras, Eleni, Zhao, Qiongyi, Perry, Trent, Batterham, Philip, Shaw, Paul J. and van Swinderen, Bruno (2023). Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila. eLife, 12. doi: 10.7554/eLife.88198.1
2022
Journal Article
Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands
Dissel, Stephane, Klose, Markus K., van Swinderen, Bruno, Cao, Lijuan, Ford, Melanie, Periandri, Erica M., Jones, Joseph D., Li, Zhaoyi and Shaw, Paul J. (2022). Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. PLoS Biology, 20 (9) e3001797, 1-25. doi: 10.1371/journal.pbio.3001797
2022
Journal Article
Anesthesia: Synaptic power failure
van Swinderen, Bruno and Kelz, Max B. (2022). Anesthesia: Synaptic power failure. Current Biology, 32 (14), R781-R783. doi: 10.1016/j.cub.2022.06.043
2022
Other Outputs
Isoflurane-mediated trapping of Syntaxin1a into nanoclusters in excitatory but not inhibitory synapses reveals a presynaptic mechanism of general anesthesia
Hines, Adam, van Swinderen, Bruno and Kewin, Amber (2022). Isoflurane-mediated trapping of Syntaxin1a into nanoclusters in excitatory but not inhibitory synapses reveals a presynaptic mechanism of general anesthesia. The University of Queensland. (Dataset) doi: 10.48610/1c00586
2021
Journal Article
Balancing prediction and surprise: A role for active sleep at the dawn of consciousness?
Van De Poll, Matthew N. and van Swinderen, Bruno (2021). Balancing prediction and surprise: A role for active sleep at the dawn of consciousness?. Frontiers in Systems Neuroscience, 15 768762, 768762. doi: 10.3389/fnsys.2021.768762
2021
Journal Article
Tracking single molecule dynamics in the adult Drosophila brain
Hines, Adam D. and van Swinderen, Bruno (2021). Tracking single molecule dynamics in the adult Drosophila brain. eNeuro, 8 (3) ENEURO.0057-21.2021, ENEURO.0057-21.2021. doi: 10.1523/eneuro.0057-21.2021
2021
Journal Article
A conserved role for sleep in supporting Spatial Learning in Drosophila
Melnattur, Krishna, Kirszenblat, Leonie, Morgan, Ellen, Militchin, Valentin, Sakran, Blake, English, Denis, Patel, Rushi, Chan, Dorothy, van Swinderen, Bruno and Shaw, Paul J. (2021). A conserved role for sleep in supporting Spatial Learning in Drosophila. Sleep, 44 (3) zsaa197, 1-14. doi: 10.1093/sleep/zsaa197
2021
Journal Article
Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster
Leung, Angus, Cohen, Dror, Van Swinderen, Bruno and Tsuchiya, Naotsugu (2021). Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster. PLoS Computational Biology, 17 (2) e1008722, e1008722. doi: 10.1371/JOURNAL.PCBI.1008722
2021
Journal Article
A paradoxical kind of sleep in Drosophila melanogaster
Tainton-Heap, Lucy A.L., Kirszenblat, Leonie C., Notaras, Eleni T., Grabowska, Martyna J., Jeans, Rhiannon, Feng, Kai, Shaw, Paul J. and van Swinderen, Bruno (2021). A paradoxical kind of sleep in Drosophila melanogaster. Current Biology, 31 (3), 578-590.e6. doi: 10.1016/j.cub.2020.10.081
2021
Journal Article
A deep sleep stage in Drosophila with a functional role in waste clearance
van Alphen, Bart, Semenza, Evan R., Yap, Melvyn, van Swinderen, Bruno and Allada, Ravi (2021). A deep sleep stage in Drosophila with a functional role in waste clearance. Science Advances, 7 (4) eabc2999, 1-10. doi: 10.1126/sciadv.abc2999
2021
Other Outputs
Tracking single molecule dynamics in the adult Drosophila brain
Hines, Adam D and van Swinderen, Bruno (2021). Tracking single molecule dynamics in the adult Drosophila brain. The University of Queensland. (Dataset) doi: 10.14264/2059dcb
2021
Other Outputs
PALM Imaging and analysis
Hines, Adam and van Swinderen, Bruno (2021). PALM Imaging and analysis. The University of Queensland. (Dataset) doi: 10.14264/2124384
2020
Journal Article
Oscillations in the central brain of Drosophila are phase locked to attended visual features
Grabowska, Martyna J., Jeans, Rhiannon, Steeves, James and Van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. Proceedings of the National Academy of Sciences of the United States of America, 117 (47), 29925-29936. doi: 10.1073/pnas.2010749117
2020
Journal Article
Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila
Karunanithi, Shanker, Lin, Yong Qi, Odierna, G. Lorenzo, Menon, Hareesh, Gonzalez, Juan Mena, Neely, G Gregory, Noakes, Peter G., Lavidis, Nickolas A., Moorhouse, Andrew J. and van Swinderen, Bruno (2020). Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila. The Journal of Neuroscience, 40 (42), 8025-8041. doi: 10.1523/JNEUROSCI.0349-20.2020
2020
Journal Article
Turning to Drosophila for help in resolving general anesthesia
van Swinderen, Bruno and Hines, Adam D. (2020). Turning to Drosophila for help in resolving general anesthesia. Proceedings of the National Academy of Sciences, 117 (40), 24627-24628. doi: 10.1073/pnas.2012131117
Funding
Current funding
Supervision
Availability
- Professor Bruno van Swinderen is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Consciousness and Unconsciousness in Brain Organoids
Associate Advisor
Other advisors: Professor Ernst Wolvetang
Completed supervision
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2024
Doctor Philosophy
Electrophysiological correlates of predictive processing in the fly brain and their modulation during sleep
Principal Advisor
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2024
Doctor Philosophy
Investigation of circuit level mechanisms of propofol anaesthesia in C. elegans
Principal Advisor
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2023
Doctor Philosophy
A target mechanism for general anaesthesia in the presynaptic release machinery
Principal Advisor
Other advisors: Associate Professor Victor Anggono, Dr Adekunle Bademosi
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2021
Doctor Philosophy
Measures of functional brain connectivity during sleep and general anaesthesia in Drosophila
Principal Advisor
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2020
Doctor Philosophy
The effects of diet on sleep and visual selective attention in Drosophila melanogaster
Principal Advisor
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2019
Master Philosophy
The effects of the general anaesthetic propofol on Drosophila larvae
Principal Advisor
Other advisors: Associate Professor Victor Anggono
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2018
Doctor Philosophy
Mechanisms of Sleep and General Anaesthesia in Drosophila melanogaster: The Unresponsive Brain
Principal Advisor
Other advisors: Associate Professor Sean Millard
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2017
Doctor Philosophy
Electrophysiological Analyses of Sleep States in Drosophila
Principal Advisor
Other advisors: Associate Professor Martin Sale
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2016
Doctor Philosophy
Visual Attention and Sleep Homeostasis in Drosophila
Principal Advisor
Other advisors: Professor Massimo Hilliard, Associate Professor Sean Millard
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2015
Doctor Philosophy
Presynaptic mechanisms of general anaesthesia in Drosophila melanogaster
Principal Advisor
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2021
Doctor Philosophy
Analysing the role of candidate neurological disease genes at synapses in Drosophila
Associate Advisor
Other advisors: Associate Professor Sean Millard
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2020
Doctor Philosophy
Experimental analysis of complex insect flight behaviours inside virtual reality for potential applications in robotics
Associate Advisor
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2018
Doctor Philosophy
Control of neurotransmission by diffusional properties of a presynaptic plasma membrane protein - syntaxin1A
Associate Advisor
Other advisors: Professor Frederic Meunier
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2018
Doctor Philosophy
The influence of selective attention on modal completion in the human visual system
Associate Advisor
Other advisors: Professor Jason Mattingley
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2016
Doctor Philosophy
Analysing visual behaviour in Drosophila Dscam2 mutants using optimised optomotor and operant control assays
Associate Advisor
Other advisors: Associate Professor Sean Millard
Media
Enquiries
Contact Professor Bruno van Swinderen directly for media enquiries about:
- Anaesthesia
- Attention - selective
- Behaviour genetics
- Caenorhabditis elegans
- Drosophila melanogaster
- Evolution
- Genetics - behavious
- Memory - selective
- Model organisms
- Selective attention and memory
- Sleep
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