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Professor Bruno van Swinderen
Professor

Bruno van Swinderen

Email: 
Phone: 
+61 7 334 66332

Overview

Background

Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.

Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.

Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.

Availability

Professor Bruno van Swinderen is:
Available for supervision
Media expert

Fields of research

Qualifications

  • Doctor of Philosophy, Washington University in St Louis

Research interests

  • Attention and memory

    Behavioral choices result from an ongoing interplay between attention and memory. We have developed paradigms to study visual attention and memory in Drosophila, thereby allowing us to investigate this complex problem in a powerful genetic model. Two levels of investigation are involved: behavior and brain electrophysiology. Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. Our goal is to identify mechanisms of visual attention, and to elucidate how these processes interact with memory systems.

  • Anesthesia and sleep

    We all sleep, and many of us require anesthesia during surgery at some point in our lives. However, the function of sleep is unclear, and the mechanism of general anesthesia remains mysterious. Our insight into brain processes modulating visual perception in Drosophila is applied at an electrophysiological level towards understanding sleep and general anesthesia, when perception is lost. We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology.

Works

Search Professor Bruno van Swinderen’s works on UQ eSpace

134 works between 1995 and 2024

1 - 20 of 134 works

2024

Journal Article

Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain

Hines, Adam D., Kewin, Amber B., Van De Poll, Matthew N., Anggono, Victor, Bademosi, Adekunle T. and van Swinderen, Bruno (2024). Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain. The Journal of Neuroscience, 44 (24) e0588232024, 1-18. doi: 10.1523/jneurosci.0588-23.2024

Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain

2024

Journal Article

Time to wake up! The ongoing search for general anesthetic reversal agents

Cylinder, Drew M., van Zundert, André A. J., Solt, Ken and van Swinderen, Bruno (2024). Time to wake up! The ongoing search for general anesthetic reversal agents. Anesthesiology, 140 (3), 610-627. doi: 10.1097/aln.0000000000004846

Time to wake up! The ongoing search for general anesthetic reversal agents

2024

Journal Article

Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies

Jagannathan, Sridhar R., Jeans, Travis, Van De Poll, Matthew N. and van Swinderen, Bruno (2024). Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies. Science Advances, 10 (8) eadj4399. doi: 10.1126/sciadv.adj4399

Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies

2023

Journal Article

Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

Anthoney, Niki, Tainton-Heap, Lucy, Luong, Hang, Notaras, Eleni, Kewin, Amber B., Zhao, Qiongyi, Perry, Trent, Batterham, Philip, Shaw, Paul J. and van Swinderen, Bruno (2023). Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila. eLife, 12 RP88198. doi: 10.7554/elife.88198

Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

2023

Journal Article

Neural ensemble fragmentation in the anesthetized Drosophila brain

Troup, Michael, Tainton-Heap, Lucy A L and van Swinderen, Bruno (2023). Neural ensemble fragmentation in the anesthetized Drosophila brain. The Journal of Neuroscience, 43 (14), 2537-2551. doi: 10.1523/jneurosci.1657-22.2023

Neural ensemble fragmentation in the anesthetized Drosophila brain

2023

Journal Article

Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila

Anthoney, Niki, Tainton-Heap, Lucy A. L., Luong, Hang, Notaras, Eleni, Zhao, Qiongyi, Perry, Trent, Batterham, Philip, Shaw, Paul J. and van Swinderen, Bruno (2023). Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila. eLife, 12. doi: 10.7554/eLife.88198.1

Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila

2022

Journal Article

Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands

Dissel, Stephane, Klose, Markus K., van Swinderen, Bruno, Cao, Lijuan, Ford, Melanie, Periandri, Erica M., Jones, Joseph D., Li, Zhaoyi and Shaw, Paul J. (2022). Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. PLoS Biology, 20 (9) e3001797, 1-25. doi: 10.1371/journal.pbio.3001797

Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands

2022

Journal Article

Anesthesia: Synaptic power failure

van Swinderen, Bruno and Kelz, Max B. (2022). Anesthesia: Synaptic power failure. Current Biology, 32 (14), R781-R783. doi: 10.1016/j.cub.2022.06.043

Anesthesia: Synaptic power failure

2022

Other Outputs

Isoflurane-mediated trapping of Syntaxin1a into nanoclusters in excitatory but not inhibitory synapses reveals a presynaptic mechanism of general anesthesia

Hines, Adam, van Swinderen, Bruno and Kewin, Amber (2022). Isoflurane-mediated trapping of Syntaxin1a into nanoclusters in excitatory but not inhibitory synapses reveals a presynaptic mechanism of general anesthesia. The University of Queensland. (Dataset) doi: 10.48610/1c00586

Isoflurane-mediated trapping of Syntaxin1a into nanoclusters in excitatory but not inhibitory synapses reveals a presynaptic mechanism of general anesthesia

2021

Journal Article

Balancing prediction and surprise: A role for active sleep at the dawn of consciousness?

Van De Poll, Matthew N. and van Swinderen, Bruno (2021). Balancing prediction and surprise: A role for active sleep at the dawn of consciousness?. Frontiers in Systems Neuroscience, 15 768762, 768762. doi: 10.3389/fnsys.2021.768762

Balancing prediction and surprise: A role for active sleep at the dawn of consciousness?

2021

Journal Article

Tracking single molecule dynamics in the adult Drosophila brain

Hines, Adam D. and van Swinderen, Bruno (2021). Tracking single molecule dynamics in the adult Drosophila brain. eNeuro, 8 (3) ENEURO.0057-21.2021, ENEURO.0057-21.2021. doi: 10.1523/eneuro.0057-21.2021

Tracking single molecule dynamics in the adult Drosophila brain

2021

Journal Article

A conserved role for sleep in supporting Spatial Learning in Drosophila

Melnattur, Krishna, Kirszenblat, Leonie, Morgan, Ellen, Militchin, Valentin, Sakran, Blake, English, Denis, Patel, Rushi, Chan, Dorothy, van Swinderen, Bruno and Shaw, Paul J. (2021). A conserved role for sleep in supporting Spatial Learning in Drosophila. Sleep, 44 (3) zsaa197, 1-14. doi: 10.1093/sleep/zsaa197

A conserved role for sleep in supporting Spatial Learning in Drosophila

2021

Journal Article

Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster

Leung, Angus, Cohen, Dror, Van Swinderen, Bruno and Tsuchiya, Naotsugu (2021). Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster. PLoS Computational Biology, 17 (2) e1008722, e1008722. doi: 10.1371/JOURNAL.PCBI.1008722

Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster

2021

Journal Article

A paradoxical kind of sleep in Drosophila melanogaster

Tainton-Heap, Lucy A.L., Kirszenblat, Leonie C., Notaras, Eleni T., Grabowska, Martyna J., Jeans, Rhiannon, Feng, Kai, Shaw, Paul J. and van Swinderen, Bruno (2021). A paradoxical kind of sleep in Drosophila melanogaster. Current Biology, 31 (3), 578-590.e6. doi: 10.1016/j.cub.2020.10.081

A paradoxical kind of sleep in Drosophila melanogaster

2021

Journal Article

A deep sleep stage in Drosophila with a functional role in waste clearance

van Alphen, Bart, Semenza, Evan R., Yap, Melvyn, van Swinderen, Bruno and Allada, Ravi (2021). A deep sleep stage in Drosophila with a functional role in waste clearance. Science Advances, 7 (4) eabc2999, 1-10. doi: 10.1126/sciadv.abc2999

A deep sleep stage in Drosophila with a functional role in waste clearance

2021

Other Outputs

Tracking single molecule dynamics in the adult Drosophila brain

Hines, Adam D and van Swinderen, Bruno (2021). Tracking single molecule dynamics in the adult Drosophila brain. The University of Queensland. (Dataset) doi: 10.14264/2059dcb

Tracking single molecule dynamics in the adult Drosophila brain

2021

Other Outputs

PALM Imaging and analysis

Hines, Adam and van Swinderen, Bruno (2021). PALM Imaging and analysis. The University of Queensland. (Dataset) doi: 10.14264/2124384

PALM Imaging and analysis

2020

Journal Article

Oscillations in the central brain of Drosophila are phase locked to attended visual features

Grabowska, Martyna J., Jeans, Rhiannon, Steeves, James and Van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. Proceedings of the National Academy of Sciences of the United States of America, 117 (47), 29925-29936. doi: 10.1073/pnas.2010749117

Oscillations in the central brain of Drosophila are phase locked to attended visual features

2020

Journal Article

Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila

Karunanithi, Shanker, Lin, Yong Qi, Odierna, G. Lorenzo, Menon, Hareesh, Gonzalez, Juan Mena, Neely, G Gregory, Noakes, Peter G., Lavidis, Nickolas A., Moorhouse, Andrew J. and van Swinderen, Bruno (2020). Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila. The Journal of Neuroscience, 40 (42), 8025-8041. doi: 10.1523/JNEUROSCI.0349-20.2020

Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila

2020

Journal Article

Turning to Drosophila for help in resolving general anesthesia

van Swinderen, Bruno and Hines, Adam D. (2020). Turning to Drosophila for help in resolving general anesthesia. Proceedings of the National Academy of Sciences, 117 (40), 24627-24628. doi: 10.1073/pnas.2012131117

Turning to Drosophila for help in resolving general anesthesia

Funding

Current funding

  • 2024
    Investigating a working anaesthesia reversal agent
    Australian and New Zealand College of Anaesthestists
    Open grant
  • 2024 - 2026
    Quiet sleep is for repair, active sleep is for learning
    ARC Discovery Projects
    Open grant
  • 2023 - 2024
    Discovering anaesthesia recovery treatments (DART): A super-resolution microscopy approach to uncovering reversal agents
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2021 - 2024
    A role for sleep in optimising attention
    ARC Discovery Projects
    Open grant
  • 2019 - 2024
    Presynaptic control of general anaesthesia
    NHMRC Project Grant
    Open grant

Past funding

  • 2019 - 2022
    ActiveAI - active learning and selective attention for robust, transparent and efficient AI (EPSRC International Centre-to-Centre Research Collaborations application submitted by University of Sussex)
    University of Sussex
    Open grant
  • 2019 - 2022
    Bridging the gap between electrical and molecular sleep functions in the brain
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Closing the loop between salience and brain activity (ARC Discovery Project administered by Flinders University)
    Flinders University
    Open grant
  • 2018
    A multifunctional platform for monitoring and manipulating neural activities with freely behaving small animals
    NHMRC Equipment Grant
    Open grant
  • 2018 - 2020
    Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    4-Dimensional multi-photon microscopy for understanding neural circuits and behaviour
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    How the dosage of a Down syndrome candidate gene affects neural circuitry and behaviour
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Molecular mechanisms underlying recovery from general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Sleep and wakefulness in the fly brain
    UQ Fellowships
    Open grant
  • 2014 - 2017
    Discovering deep sleep genes and determining their roles for preserving cognitive functions
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Dopaminergic mechanisms of visual selective attention in the fly
    ARC Discovery Projects
    Open grant
  • 2014
    Two-photon microscopy for live and fixed imaging in model organisms and thick tissue
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    A virtual environment for the study of multisensory learning, adaptation and control
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Neurexin and Neuroligin: A Code for Synaptic Development
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Perceptual suppression mechanisms in the Drosophila brain
    ARC Future Fellowships
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Presynaptic mechanisms of general anaesthesia in the fly brain
    ARC Discovery Projects
    Open grant
  • 2008
    Behavioural Facility for Genetically Modified Insects
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Professor Bruno van Swinderen is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Consciousness and Unconsciousness in Brain Organoids

    Associate Advisor

    Other advisors: Professor Ernst Wolvetang

Completed supervision

Media

Enquiries

Contact Professor Bruno van Swinderen directly for media enquiries about:

  • Anaesthesia
  • Attention - selective
  • Behaviour genetics
  • Caenorhabditis elegans
  • Drosophila melanogaster
  • Evolution
  • Genetics - behavious
  • Memory - selective
  • Model organisms
  • Selective attention and memory
  • Sleep

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