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Professor Bruno van Swinderen
Professor

Bruno van Swinderen

Email: 
Phone: 
+61 7 334 66332

Overview

Background

Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.

Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.

Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.

Availability

Professor Bruno van Swinderen is:
Available for supervision
Media expert

Fields of research

Qualifications

  • Doctor of Philosophy, Washington University in St Louis

Research interests

  • Attention and memory

    Behavioral choices result from an ongoing interplay between attention and memory. We have developed paradigms to study visual attention and memory in Drosophila, thereby allowing us to investigate this complex problem in a powerful genetic model. Two levels of investigation are involved: behavior and brain electrophysiology. Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. Our goal is to identify mechanisms of visual attention, and to elucidate how these processes interact with memory systems.

  • Anesthesia and sleep

    We all sleep, and many of us require anesthesia during surgery at some point in our lives. However, the function of sleep is unclear, and the mechanism of general anesthesia remains mysterious. Our insight into brain processes modulating visual perception in Drosophila is applied at an electrophysiological level towards understanding sleep and general anesthesia, when perception is lost. We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology.

Works

Search Professor Bruno van Swinderen’s works on UQ eSpace

137 works between 1995 and 2025

61 - 80 of 137 works

2015

Journal Article

Behavioral and electrophysiological analysis of general anesthesia in 3 background strains of Drosophila melanogaster

Zalucki, Oressia, Day, Rebecca, Kottler, Benjamin, Karunanithi, Shanker and van Swinderen, Bruno (2015). Behavioral and electrophysiological analysis of general anesthesia in 3 background strains of Drosophila melanogaster. Fly, 9 (1), 7-15. doi: 10.1080/19336934.2015.1072663

Behavioral and electrophysiological analysis of general anesthesia in 3 background strains of Drosophila melanogaster

2015

Journal Article

The yin and yang of sleep and attention

Kirszenblat, Leonie and van Swinderen, Bruno (2015). The yin and yang of sleep and attention. Trends in Neurosciences, 38 (12), 776-786. doi: 10.1016/j.tins.2015.10.001

The yin and yang of sleep and attention

2014

Journal Article

Taking a new look at how flies learn

Kottler, Benjamin and Van Swinderen, Bruno (2014). Taking a new look at how flies learn. Elife, 3 e03978, e03978.1-e03978.3. doi: 10.7554/eLife.03978

Taking a new look at how flies learn

2014

Journal Article

Selective attention in the honeybee optic lobes precedes behavioral choices

Paulk, Angelique C., Stacey, Jacqueline A., Pearson, Thomas W. J., Taylor, Gavin J., Moore, Richard J. D., Srinivasan, Mandyam V. and Van Swinderen, Bruno (2014). Selective attention in the honeybee optic lobes precedes behavioral choices. Proceedings of the National Academy of Sciences of the United States of America, 111 (13), 5006-5011. doi: 10.1073/pnas.1323297111

Selective attention in the honeybee optic lobes precedes behavioral choices

2014

Journal Article

Identification of neurons responsible for feeding behavior in the Drosophila brain

Sun, Fei, Wang, YiJin, Zhou, YanQiong, Van Swinderen, Bruno, Gong, ZheFeng and Liu, Li (2014). Identification of neurons responsible for feeding behavior in the Drosophila brain. Science China-Life Sciences, 57 (4), 391-402. doi: 10.1007/s11427-014-4641-2

Identification of neurons responsible for feeding behavior in the Drosophila brain

2014

Journal Article

FicTrac: A visual method for tracking spherical motion and generating fictive animal paths

Moore, Richard J. D., Taylor, Gavin J., Paulk, Angelique C., Pearson, Thomas, van Swinderen, Bruno and Srinivasan, Mandyam V. (2014). FicTrac: A visual method for tracking spherical motion and generating fictive animal paths. Journal of Neuroscience Methods, 225, 106-119. doi: 10.1016/j.jneumeth.2014.01.010

FicTrac: A visual method for tracking spherical motion and generating fictive animal paths

2014

Journal Article

Explaining general anesthesia: A two-step hypothesis linking sleep circuits and the synaptic release machinery

van Swinderen, Bruno and Kottler, Benjamin (2014). Explaining general anesthesia: A two-step hypothesis linking sleep circuits and the synaptic release machinery. BioEssays, 36 (4), 372-381. doi: 10.1002/bies.201300154

Explaining general anesthesia: A two-step hypothesis linking sleep circuits and the synaptic release machinery

2013

Journal Article

Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation

Paulk, Angelique C., Zhou, Yanqiong, Stratton, Peter, Liu, Li and van Swinderen, Bruno (2013). Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation. Journal of Neurophysiology, 110 (7), 1703-1721. doi: 10.1152/jn.00414.2013

Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation

2013

Journal Article

A dynamic deep sleep stage in Drosophila

van Alphen, Bart, Yap, Melvyn H. W., Kirszenblat, Leonie, Kottler, Benjamin and van Swinderen, Bruno (2013). A dynamic deep sleep stage in Drosophila. Journal of Neuroscience, 33 (16), 6917-6927. doi: 10.1523/JNEUROSCI.0061-13.2013

A dynamic deep sleep stage in Drosophila

2013

Journal Article

A sleep/wake circuit controls isoflurane sensitivity in Drosophila

Kottler, Benjamin, Bao, Hong, Zalucki, Oressia, Imlach, Wendy, Troup, Michael, van Alphen, Bart, Paulk, Angelique, Zhang, Bing and van Swinderen, Bruno (2013). A sleep/wake circuit controls isoflurane sensitivity in Drosophila. Current Biology, 23 (7), 594-598. doi: 10.1016/j.cub.2013.02.021

A sleep/wake circuit controls isoflurane sensitivity in Drosophila

2013

Journal Article

Drosophila strategies to study psychiatric disorders

van Alphen, Bart and van Swinderen, Bruno (2013). Drosophila strategies to study psychiatric disorders. Brain Research Bulletin, 92, 1-11. doi: 10.1016/j.brainresbull.2011.09.007

Drosophila strategies to study psychiatric disorders

2013

Journal Article

Vision in Drosophila: seeing the world through a model's eyes

Paulk, Angelique, Millard, S. Sean and van Swinderen, Bruno (2013). Vision in Drosophila: seeing the world through a model's eyes. Annual Review of Entomology, 58 (1), 313-332. doi: 10.1146/annurev-ento-120811-153715

Vision in Drosophila: seeing the world through a model's eyes

2013

Journal Article

Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia

Calcagno, B., Eyles, D., van Alphen, B. and van Swinderen, B. (2013). Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia. Translational Psychiatry, 3 (1), e206.1-e206.10. doi: 10.1038/tp.2012.139

Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia

2012

Journal Article

Competing visual flicker reveals attention-like rivalry in the fly brain

van Swinderen, Bruno (2012). Competing visual flicker reveals attention-like rivalry in the fly brain. Frontiers in Integrative Neuroscience, 6 (OCTOBER 2012), 96.1-96.2. doi: 10.3389/fnint.2012.00096

Competing visual flicker reveals attention-like rivalry in the fly brain

2012

Conference Publication

Converging bioaminergic pathways controlling general anaesthesia and sleep in Drosophila

Kottler, B., Zalucki, O., Zhang, B. and Van Swinderen, B. (2012). Converging bioaminergic pathways controlling general anaesthesia and sleep in Drosophila. 2012 European Fly Neurobiology Meeting, Padua, Italy, 3-7 September 2012. Philadelphia, PA, United States: Informa Healthcare.

Converging bioaminergic pathways controlling general anaesthesia and sleep in Drosophila

2012

Journal Article

Attentional switching in humans and flies: rivalry in large and miniature brains

Miller, Steven Mark, Ngo, Trung Thanh and van Swinderen, Bruno (2012). Attentional switching in humans and flies: rivalry in large and miniature brains. Frontiers in Human Neuroscience, 5 (JANUARY 2012) 188, 1-17. doi: 10.3389/fnhum.2011.00188

Attentional switching in humans and flies: rivalry in large and miniature brains

2011

Journal Article

Single fly tethered paradigms

van Swinderen, Bruno (2011). Single fly tethered paradigms. Cold Spring Harbor Protocol, 2011 (12), 1488-1491. doi: 10.1101/pdb.prot066910

Single fly tethered paradigms

2011

Journal Article

Conditioning to colors: a population assay for visual learning in Drosophila

van Swinderen, Bruno (2011). Conditioning to colors: a population assay for visual learning in Drosophila. Cold Spring Harbor Protocols, 6 (11), 1334-1336. doi: 10.1101/pdb.prot066522

Conditioning to colors: a population assay for visual learning in Drosophila

2011

Journal Article

The optomotor maze: a population assay for visual perception in Drosophila

van Swinderen, Bruno (2011). The optomotor maze: a population assay for visual perception in Drosophila. Cold Spring Harbor Protocols, 6 (11), 1337-1339. doi: 10.1101/pdb.prot066530

The optomotor maze: a population assay for visual perception in Drosophila

2011

Journal Article

The aversive phototaxic suppression assay for individual adult Drosophila

van Swinderen. Bruno (2011). The aversive phototaxic suppression assay for individual adult Drosophila. Cold Spring Harbor Protocols, 6 (10), 1203-1205. doi: 10.1101/pdb.prot065896

The aversive phototaxic suppression assay for individual adult Drosophila

Funding

Current funding

  • 2025 - 2028
    Tracking mistakes in the fly brain: understanding consciousness from the bottom up
    Open grant
  • 2025 - 2026
    Human brain organoid models to investigate anaesthesia induction and reversal agents
    Australian and New Zealand College of Anaesthestists
    Open grant
  • 2025 - 2028
    Time to wake up! Reversing a presynaptic anaesthetic mechanism
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2026
    Quiet sleep is for repair, active sleep is for learning
    ARC Discovery Projects
    Open grant

Past funding

  • 2024
    Investigating a working anaesthesia reversal agent
    Australian and New Zealand College of Anaesthestists
    Open grant
  • 2023 - 2024
    Discovering anaesthesia recovery treatments (DART): A super-resolution microscopy approach to uncovering reversal agents
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2021 - 2024
    A role for sleep in optimising attention
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    ActiveAI - active learning and selective attention for robust, transparent and efficient AI (EPSRC International Centre-to-Centre Research Collaborations application submitted by University of Sussex)
    University of Sussex
    Open grant
  • 2019 - 2022
    Bridging the gap between electrical and molecular sleep functions in the brain
    NHMRC Project Grant
    Open grant
  • 2019 - 2024
    Presynaptic control of general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Closing the loop between salience and brain activity (ARC Discovery Project administered by Flinders University)
    Flinders University
    Open grant
  • 2018
    A multifunctional platform for monitoring and manipulating neural activities with freely behaving small animals
    NHMRC Equipment Grant
    Open grant
  • 2018 - 2020
    Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    4-Dimensional multi-photon microscopy for understanding neural circuits and behaviour
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    How the dosage of a Down syndrome candidate gene affects neural circuitry and behaviour
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Molecular mechanisms underlying recovery from general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Sleep and wakefulness in the fly brain
    UQ Fellowships
    Open grant
  • 2014 - 2017
    Discovering deep sleep genes and determining their roles for preserving cognitive functions
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Dopaminergic mechanisms of visual selective attention in the fly
    ARC Discovery Projects
    Open grant
  • 2014
    Two-photon microscopy for live and fixed imaging in model organisms and thick tissue
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    A virtual environment for the study of multisensory learning, adaptation and control
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Neurexin and Neuroligin: A Code for Synaptic Development
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Perceptual suppression mechanisms in the Drosophila brain
    ARC Future Fellowships
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Presynaptic mechanisms of general anaesthesia in the fly brain
    ARC Discovery Projects
    Open grant
  • 2008
    Behavioural Facility for Genetically Modified Insects
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Professor Bruno van Swinderen is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Professor Bruno van Swinderen directly for media enquiries about:

  • Anaesthesia
  • Attention - selective
  • Behaviour genetics
  • Caenorhabditis elegans
  • Drosophila melanogaster
  • Evolution
  • Genetics - behavious
  • Memory - selective
  • Model organisms
  • Selective attention and memory
  • Sleep

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