
Overview
Background
Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.
Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.
Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.
Availability
- Professor Bruno van Swinderen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Washington University in St Louis
Research interests
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Attention and memory
Behavioral choices result from an ongoing interplay between attention and memory. We have developed paradigms to study visual attention and memory in Drosophila, thereby allowing us to investigate this complex problem in a powerful genetic model. Two levels of investigation are involved: behavior and brain electrophysiology. Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. Our goal is to identify mechanisms of visual attention, and to elucidate how these processes interact with memory systems.
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Anesthesia and sleep
We all sleep, and many of us require anesthesia during surgery at some point in our lives. However, the function of sleep is unclear, and the mechanism of general anesthesia remains mysterious. Our insight into brain processes modulating visual perception in Drosophila is applied at an electrophysiological level towards understanding sleep and general anesthesia, when perception is lost. We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology.
Works
Search Professor Bruno van Swinderen’s works on UQ eSpace
2015
Journal Article
Behavioral and electrophysiological analysis of general anesthesia in 3 background strains of Drosophila melanogaster
Zalucki, Oressia, Day, Rebecca, Kottler, Benjamin, Karunanithi, Shanker and van Swinderen, Bruno (2015). Behavioral and electrophysiological analysis of general anesthesia in 3 background strains of Drosophila melanogaster. Fly, 9 (1), 7-15. doi: 10.1080/19336934.2015.1072663
2015
Journal Article
The yin and yang of sleep and attention
Kirszenblat, Leonie and van Swinderen, Bruno (2015). The yin and yang of sleep and attention. Trends in Neurosciences, 38 (12), 776-786. doi: 10.1016/j.tins.2015.10.001
2014
Journal Article
Taking a new look at how flies learn
Kottler, Benjamin and Van Swinderen, Bruno (2014). Taking a new look at how flies learn. Elife, 3 e03978, e03978.1-e03978.3. doi: 10.7554/eLife.03978
2014
Journal Article
Selective attention in the honeybee optic lobes precedes behavioral choices
Paulk, Angelique C., Stacey, Jacqueline A., Pearson, Thomas W. J., Taylor, Gavin J., Moore, Richard J. D., Srinivasan, Mandyam V. and Van Swinderen, Bruno (2014). Selective attention in the honeybee optic lobes precedes behavioral choices. Proceedings of the National Academy of Sciences of the United States of America, 111 (13), 5006-5011. doi: 10.1073/pnas.1323297111
2014
Journal Article
Identification of neurons responsible for feeding behavior in the Drosophila brain
Sun, Fei, Wang, YiJin, Zhou, YanQiong, Van Swinderen, Bruno, Gong, ZheFeng and Liu, Li (2014). Identification of neurons responsible for feeding behavior in the Drosophila brain. Science China-Life Sciences, 57 (4), 391-402. doi: 10.1007/s11427-014-4641-2
2014
Journal Article
FicTrac: A visual method for tracking spherical motion and generating fictive animal paths
Moore, Richard J. D., Taylor, Gavin J., Paulk, Angelique C., Pearson, Thomas, van Swinderen, Bruno and Srinivasan, Mandyam V. (2014). FicTrac: A visual method for tracking spherical motion and generating fictive animal paths. Journal of Neuroscience Methods, 225, 106-119. doi: 10.1016/j.jneumeth.2014.01.010
2014
Journal Article
Explaining general anesthesia: A two-step hypothesis linking sleep circuits and the synaptic release machinery
van Swinderen, Bruno and Kottler, Benjamin (2014). Explaining general anesthesia: A two-step hypothesis linking sleep circuits and the synaptic release machinery. BioEssays, 36 (4), 372-381. doi: 10.1002/bies.201300154
2013
Journal Article
Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation
Paulk, Angelique C., Zhou, Yanqiong, Stratton, Peter, Liu, Li and van Swinderen, Bruno (2013). Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation. Journal of Neurophysiology, 110 (7), 1703-1721. doi: 10.1152/jn.00414.2013
2013
Journal Article
A dynamic deep sleep stage in Drosophila
van Alphen, Bart, Yap, Melvyn H. W., Kirszenblat, Leonie, Kottler, Benjamin and van Swinderen, Bruno (2013). A dynamic deep sleep stage in Drosophila. Journal of Neuroscience, 33 (16), 6917-6927. doi: 10.1523/JNEUROSCI.0061-13.2013
2013
Journal Article
A sleep/wake circuit controls isoflurane sensitivity in Drosophila
Kottler, Benjamin, Bao, Hong, Zalucki, Oressia, Imlach, Wendy, Troup, Michael, van Alphen, Bart, Paulk, Angelique, Zhang, Bing and van Swinderen, Bruno (2013). A sleep/wake circuit controls isoflurane sensitivity in Drosophila. Current Biology, 23 (7), 594-598. doi: 10.1016/j.cub.2013.02.021
2013
Journal Article
Drosophila strategies to study psychiatric disorders
van Alphen, Bart and van Swinderen, Bruno (2013). Drosophila strategies to study psychiatric disorders. Brain Research Bulletin, 92, 1-11. doi: 10.1016/j.brainresbull.2011.09.007
2013
Journal Article
Vision in Drosophila: seeing the world through a model's eyes
Paulk, Angelique, Millard, S. Sean and van Swinderen, Bruno (2013). Vision in Drosophila: seeing the world through a model's eyes. Annual Review of Entomology, 58 (1), 313-332. doi: 10.1146/annurev-ento-120811-153715
2013
Journal Article
Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia
Calcagno, B., Eyles, D., van Alphen, B. and van Swinderen, B. (2013). Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia. Translational Psychiatry, 3 (1), e206.1-e206.10. doi: 10.1038/tp.2012.139
2012
Journal Article
Competing visual flicker reveals attention-like rivalry in the fly brain
van Swinderen, Bruno (2012). Competing visual flicker reveals attention-like rivalry in the fly brain. Frontiers in Integrative Neuroscience, 6 (OCTOBER 2012), 96.1-96.2. doi: 10.3389/fnint.2012.00096
2012
Conference Publication
Converging bioaminergic pathways controlling general anaesthesia and sleep in Drosophila
Kottler, B., Zalucki, O., Zhang, B. and Van Swinderen, B. (2012). Converging bioaminergic pathways controlling general anaesthesia and sleep in Drosophila. 2012 European Fly Neurobiology Meeting, Padua, Italy, 3-7 September 2012. Philadelphia, PA, United States: Informa Healthcare.
2012
Journal Article
Attentional switching in humans and flies: rivalry in large and miniature brains
Miller, Steven Mark, Ngo, Trung Thanh and van Swinderen, Bruno (2012). Attentional switching in humans and flies: rivalry in large and miniature brains. Frontiers in Human Neuroscience, 5 (JANUARY 2012) 188, 1-17. doi: 10.3389/fnhum.2011.00188
2011
Journal Article
Single fly tethered paradigms
van Swinderen, Bruno (2011). Single fly tethered paradigms. Cold Spring Harbor Protocol, 2011 (12), 1488-1491. doi: 10.1101/pdb.prot066910
2011
Journal Article
Conditioning to colors: a population assay for visual learning in Drosophila
van Swinderen, Bruno (2011). Conditioning to colors: a population assay for visual learning in Drosophila. Cold Spring Harbor Protocols, 6 (11), 1334-1336. doi: 10.1101/pdb.prot066522
2011
Journal Article
The optomotor maze: a population assay for visual perception in Drosophila
van Swinderen, Bruno (2011). The optomotor maze: a population assay for visual perception in Drosophila. Cold Spring Harbor Protocols, 6 (11), 1337-1339. doi: 10.1101/pdb.prot066530
2011
Journal Article
The aversive phototaxic suppression assay for individual adult Drosophila
van Swinderen. Bruno (2011). The aversive phototaxic suppression assay for individual adult Drosophila. Cold Spring Harbor Protocols, 6 (10), 1203-1205. doi: 10.1101/pdb.prot065896
Funding
Current funding
Supervision
Availability
- Professor Bruno van Swinderen is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Consciousness and Unconsciousness in Brain Organoids
Associate Advisor
Other advisors: Professor Andre Van Zundert, Dr Selin Pars, Professor Ernst Wolvetang
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Doctor Philosophy
Consciousness and Unconsciousness in Brain Organoids
Associate Advisor
Other advisors: Professor Andre Van Zundert, Dr Selin Pars, Professor Ernst Wolvetang
Completed supervision
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2024
Doctor Philosophy
Investigation of circuit level mechanisms of propofol anaesthesia in C. elegans
Principal Advisor
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2024
Doctor Philosophy
Electrophysiological correlates of predictive processing in the fly brain and their modulation during sleep
Principal Advisor
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2023
Doctor Philosophy
A target mechanism for general anaesthesia in the presynaptic release machinery
Principal Advisor
Other advisors: Associate Professor Victor Anggono, Dr Adekunle Bademosi
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2021
Doctor Philosophy
Measures of functional brain connectivity during sleep and general anaesthesia in Drosophila
Principal Advisor
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2020
Doctor Philosophy
The effects of diet on sleep and visual selective attention in Drosophila melanogaster
Principal Advisor
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2019
Master Philosophy
The effects of the general anaesthetic propofol on Drosophila larvae
Principal Advisor
Other advisors: Associate Professor Victor Anggono
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2018
Doctor Philosophy
Mechanisms of Sleep and General Anaesthesia in Drosophila melanogaster: The Unresponsive Brain
Principal Advisor
Other advisors: Associate Professor Sean Millard
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2017
Doctor Philosophy
Electrophysiological Analyses of Sleep States in Drosophila
Principal Advisor
Other advisors: Associate Professor Martin Sale
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2016
Doctor Philosophy
Visual Attention and Sleep Homeostasis in Drosophila
Principal Advisor
Other advisors: Professor Massimo Hilliard, Associate Professor Sean Millard
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2015
Doctor Philosophy
Presynaptic mechanisms of general anaesthesia in Drosophila melanogaster
Principal Advisor
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2021
Doctor Philosophy
Analysing the role of candidate neurological disease genes at synapses in Drosophila
Associate Advisor
Other advisors: Associate Professor Sean Millard
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2020
Doctor Philosophy
Experimental analysis of complex insect flight behaviours inside virtual reality for potential applications in robotics
Associate Advisor
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2018
Doctor Philosophy
Control of neurotransmission by diffusional properties of a presynaptic plasma membrane protein - syntaxin1A
Associate Advisor
Other advisors: Professor Frederic Meunier
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2018
Doctor Philosophy
The influence of selective attention on modal completion in the human visual system
Associate Advisor
Other advisors: Professor Jason Mattingley
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2016
Doctor Philosophy
Analysing visual behaviour in Drosophila Dscam2 mutants using optimised optomotor and operant control assays
Associate Advisor
Other advisors: Associate Professor Sean Millard
Media
Enquiries
Contact Professor Bruno van Swinderen directly for media enquiries about:
- Anaesthesia
- Attention - selective
- Behaviour genetics
- Caenorhabditis elegans
- Drosophila melanogaster
- Evolution
- Genetics - behavious
- Memory - selective
- Model organisms
- Selective attention and memory
- Sleep
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