Associate Professor Victor Anggono
Associate Professor

Victor Anggono

Email: 
Phone: 
+61 7 334 66417
Phone: 
+61 7 334 66325

Background

Victor Anggono received his PhD in 2007 from the University of Sydney and undertook his postdoctoral training at the Johns Hopkins University in Baltimore, USA. In 2012, Dr Anggono returned to Australia as an NHMRC CJ Martin Research Fellow and joined the Queensland Brain Institute at the University of Queensland, where he is currently a Senior Research Fellow and Group Leader at the Clem Jones Centre for Ageing Dementia Research. His research aims to understand the molecular mechanisms of synaptic vesicle and glutamate receptor trafficking in neurons, processes that are essential for synaptic transmission, plasticity, learning and memory, and how their dysregulations impact on the pathophysiology of neurodegenerative diseases and neuropsychiatric disorders. Dr Anggono has published in journals such as Nature Neuroscience, Neuron, The Proceedings of the National Academy of Sciences USA, Journal of Neuroscience and Cell Reports, and has attracted more than 1500 citations. For his works, Dr Anggono was awarded the Boomerang Award (Australian Society for Biochemistry and Molecular Biology, 2011), the Young Scientist Award (Federation of Asian and Oceanian Biochemists and Molecular Biologists, 2015), the Science to Art Award (NHMRC, 2015) and more recently the Young Investigator Award (Asian-Pacific Society for Neurochemistry, 2016).

Availability

Associate Professor Victor Anggono is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Sydney

Research interests

  • Neuronal Trafficking

    The molecular basis of vesicles and receptors transports between sub-cellular compartments essential for neuronal communications, learning and memory.

  • Neuroepigenetics

    The molecular mechanisms underlying activity-dependent gene transcription in synaptic plasticity, a cellular correlate of learning and memory.

Research impacts

How neurons communicate with each other in the brain is one of the outstanding and most fascinating questions in modern neuroscience. This basic science research program will provide a detailed understanding of three essential biological processes; (i) presynaptic vesicle recycling, (ii) postsynaptic glutamate receptor trafficking, and (iii) epigenetic regulation of synaptic plasticity. These systems are crucial for virtually all function in the central nervous system. As most of these processes have been implicated in neurological disorders, such as epilepsy, Alzheimer's disease, schizophrenia and bipolar disorder, results from Dr Anggono's research program will also provide insights into the principles underpinning disease aetiology. Understanding of the molecular mechanisms of neuronal communications will allow us to devise potential meaningful and novel therapeutic strategies to target these neurological disorders.

Search Professor Victor Anggono’s works on UQ eSpace

72 works between 2006 and 2024
All (72) Journal Article (63) Book Chapter (4) Conference Publication (5)

1 - 20 of 72 works

Featured

2021

Journal Article

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Yong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M. and Anggono, Victor (2021). Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Cell Reports, 36 (1) 109338, 1-21. doi: 10.1016/j.celrep.2021.109338

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Featured

2020

Journal Article

PICK1 controls activity-dependent synaptic vesicle cargo retrieval

Yong, Xuan Ling Hilary, Cousin, Michael A. and Anggono, Victor (2020). PICK1 controls activity-dependent synaptic vesicle cargo retrieval. Cell Reports, 33 (4) 108312, 108312. doi: 10.1016/j.celrep.2020.108312

PICK1 controls activity-dependent synaptic vesicle cargo retrieval

Featured

2015

Journal Article

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015). Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports, 10 (5), 783-795. doi: 10.1016/j.celrep.2015.01.015

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Featured

2013

Journal Article

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

Anggono, Victor, Koc-Schmitz, Yeliz, Widagdo, Jocelyn, Kormann, Jan, Quan, Annie, Chen, Chih-Ming, Robinson, Phillip J., Choi, Se-Young, Linden, David J., Plomann, Markus and Huganir, Richard L. (2013). PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America, 110 (34), 13976-13981. doi: 10.1073/pnas.1312467110

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

Featured

2012

Journal Article

Regulation of AMPA receptor trafficking and synaptic plasticity

Anggono, Victor and Huganir, Richard L. (2012). Regulation of AMPA receptor trafficking and synaptic plasticity. Current Opinion in Neurobiology, 22 (3), 461-469. doi: 10.1016/j.conb.2011.12.006

Regulation of AMPA receptor trafficking and synaptic plasticity

Featured

2011

Journal Article

Regulation of AMPA receptor function by the human memory-associated gene KIBRA

Makuch, Lauren, Volk, Lenora, Anggono, Victor, Johnson, Richard C., Yu, Yilin, Duning, Kerstin, Kremerskothen, Joachim, Xia, Jun, Takamiya, Kogo and Huganir, Richard L. (2011). Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron, 71 (6), 1022-1029. doi: 10.1016/j.neuron.2011.08.017

Regulation of AMPA receptor function by the human memory-associated gene KIBRA

Featured

2006

Journal Article

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

Anggono, V, Smillie, KJ, Graham, ME, Valova, VA, Cousin, MA and Robinson, PJ (2006). Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nature Neuroscience, 9 (6), 752-760. doi: 10.1038/nn1695

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

2024

Journal Article

Learning-induced remodelling of inhibitory synapses in the motor cortex

Bhembre, Nishita, Paolino, Annalisa, Das, Sooraj S., Guntupalli, Sumasri, Fenlon, Laura R. and Anggono, Victor (2024). Learning-induced remodelling of inhibitory synapses in the motor cortex. Open Biology, 14 (11) 240109, 1-9. doi: 10.1098/rsob.240109

Learning-induced remodelling of inhibitory synapses in the motor cortex

2024

Conference Publication

Photocontrollable probes for the investigation of neuropeptide signalling

Raabe, Konstantin, Kalaba, Predrag, Yong, Xuan Ling Hilary, Keimpema, Erik, Anggono, Victor and Muttenthaler, Markus (2024). Photocontrollable probes for the investigation of neuropeptide signalling. HOBOKEN: WILEY.

Photocontrollable probes for the investigation of neuropeptide signalling

2024

Journal Article

Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain

Hines, Adam D., Kewin, Amber B., Van De Poll, Matthew N., Anggono, Victor, Bademosi, Adekunle T. and van Swinderen, Bruno (2024). Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain. The Journal of Neuroscience, 44 (24) e0588232024, 1-18. doi: 10.1523/jneurosci.0588-23.2024

Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain

2024

Journal Article

Global quantitative proteomic analysis of aged mouse hippocampus

Huang, He, van Waardenberg, Ashley J., Graham, Mark E., Anggono, Victor and Widagdo, Jocelyn (2024). Global quantitative proteomic analysis of aged mouse hippocampus. PROTEOMICS, 24 (7) e2300276, 1-6. doi: 10.1002/pmic.202300276

Global quantitative proteomic analysis of aged mouse hippocampus

2024

Journal Article

Editorial: The role of trafficking in synaptic development, maintenance, and plasticity

Hoerndli, Frederic J., Kurshan, Peri T. and Anggono, Victor (2024). Editorial: The role of trafficking in synaptic development, maintenance, and plasticity. Frontiers in Cellular Neuroscience, 18 1362676. doi: 10.3389/fncel.2024.1362676

Editorial: The role of trafficking in synaptic development, maintenance, and plasticity

2023

Journal Article

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

Marshall, Andrew C., Cummins, Jerry, Kobelke, Simon, Zhu, Tianyi, Widagdo, Jocelyn, Anggono, Victor, Hyman, Anthony, Fox, Archa H., Bond, Charles S. and Lee, Mihwa (2023). Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates. Journal of Molecular Biology, 435 (24) 168364, 1-18. doi: 10.1016/j.jmb.2023.168364

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

2023

Journal Article

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Tan, Jing Zhi Anson, Jang, Se Eun, Batallas-Borja, Ana, Bhembre, Nishita, Chandra, Mintu, Zhang, Lingrui, Guo, Huimin, Ringuet, Mitchell T., Widagdo, Jocelyn, Collins, Brett M. and Anggono, Victor (2023). Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis. Cell Reports, 42 (12) 113460, 1-20. doi: 10.1016/j.celrep.2023.113460

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

2023

Journal Article

GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms

Ragnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776

GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms

2023

Journal Article

Structural basis for enhanced cytoplasmic aggregation of familial ALS-associated SFPQ mutants

Widagdo, J., Udagedara, S., Bhembre, N., Tan, J. Z. A., Neureiter, L., Huang, J., Anggono, V. and Lee, M. (2023). Structural basis for enhanced cytoplasmic aggregation of familial ALS-associated SFPQ mutants. Acta Crystallographica Section A Foundations and Advances, 79 (a2), C7-C7. doi: 10.1107/s2053273323096018

Structural basis for enhanced cytoplasmic aggregation of familial ALS-associated SFPQ mutants

2023

Journal Article

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

Leiter, Odette, Brici, David, Fletcher, Stephen J., Yong, Xuan Ling Hilary, Widagdo, Jocelyn, Matigian, Nicholas, Schroer, Adam B., Bieri, Gregor, Blackmore, Daniel G., Bartlett, Perry F., Anggono, Victor, Villeda, Saul A. and Walker, Tara L. (2023). Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nature Communications, 14 (1) 4375, 1-20. doi: 10.1038/s41467-023-39873-9

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

2023

Journal Article

Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility

Guntupalli, Sumasri, Park, Pojeong, Han, Dae Hee, Zhang, Lingrui, Yong, Xuan Ling Hilary, Ringuet, Mitchell, Blackmore, Daniel G., Jhaveri, Dhanisha J., Koentgen, Frank, Widagdo, Jocelyn, Kaang, Bong-Kiun and Anggono, Victor (2023). Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility. The Journal of Neuroscience, 43 (30), 5448-5457. doi: 10.1523/jneurosci.1542-22.2023

Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility

2023

Journal Article

Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

Radford, Rowan A. W., Rayner, Stephanie L., Szwaja, Paulina, Morsch, Marco, Cheng, Flora, Zhu, Tianyi, Widagdo, Jocelyn, Anggono, Victor, Pountney, Dean L., Chung, Roger and Lee, Albert (2023). Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission. Journal of Neurochemistry, 165 (4), 563-586. doi: 10.1111/jnc.15796

Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

2023

Journal Article

The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus

Huang, He, Song, Renhua, Wong, Justin J.‐L., Anggono, Victor and Widagdo, Jocelyn (2023). The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus. Aging Cell, 22 (1) e13755, 1-8. doi: 10.1111/acel.13755

The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus

Current funding

  • 2024 - 2025
    Characterisation of a de novo WDR26 rare genetic variant associated with neurodevelopmental disorders
    Australian Functional Genomics Network
    Open grant
  • 2024 - 2027
    Unraveling the physiological and disease-enabling functions of Tau protein
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2026
    Molecular basis of glutamate receptor trafficking in neuronal plasticity
    ARC Future Fellowships
    Open grant
  • 2022 - 2025
    Regulation of activity-induced glutamate receptor trafficking in neurons
    ARC Discovery Projects
    Open grant

Past funding

  • 2021 - 2022
    Molecular mechanisms underlying the cytoplasmic aggregation of the RNA binding protein, SFPQ, in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019 - 2022
    Regulation of glutamate receptor dynamics in mammalian central neurons
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
    NHMRC Project Grant
    Open grant
  • 2017
    Australia-China Young Scientists Exchange Program 2017
    Australian Academy of Technological Sciences and Engineering
    Open grant
  • 2017 - 2019
    Regulation of synaptic vesicle endocytosis by membrane-sensing proteins
    ARC Discovery Projects
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016
    Travel Award for the 39th Annual Meeting of the Japan Neuroscience Society
    Japan Neuroscience Society
    Open grant
  • 2016 - 2018
    Molecular mechanisms underlying recovery from general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2016
    Ubiquitinomic profiling of synaptic proteins in Alzheimer's Disease
    Alzheimer's Australia Dementia Research Foundation
    Open grant
  • 2015 - 2018
    Targeting the synaptic actin cytoskeleton in Alzheimer's Disease (NHMRC Project Grant administered by UNSW)
    University of New South Wales
    Open grant
  • 2014
    Transcriptional Profiling of Long Non-coding RNAs in Synaptic Plasticity
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    The role of synaptotagmin-1 ubiquitination in synaptic transmission
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2012 - 2014
    NHMRC Training Fellowship (CJ Martin): The role of stargazin and TARP phosphorylation in synaptic plasticity
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Availability

Associate Professor Victor Anggono is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    APP interacting protein as a key target of neuronal activity regulator in healthy aging

    Principal Advisor

  • Doctor Philosophy

    Regulation of sorting nexin 27 by protein phosphorylation

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Regulation of synapse to nucleus signalling during synaptic plasticity

    Principal Advisor

    Other advisors: Dr Jocelyn Widagdo, Dr Anson Tan

  • Doctor Philosophy

    APP interacting protein as a key target of neuronal activity regulator in healthy aging

    Principal Advisor

  • Doctor Philosophy

    The Neural Network Function during Aging and Death in Caenorhabditis elegans

    Associate Advisor

    Other advisors: Dr Zhaoyu Li

  • Doctor Philosophy

    Use of transcriptomic, epitranscriptomic, and genomic approaches to understand neuronal homeostatic plasticity and disease

    Associate Advisor

    Other advisors: Dr Jocelyn Widagdo

  • Doctor Philosophy

    Epigenetic Regulation of Learning and Memory

    Associate Advisor

    Other advisors: Dr Anson Tan, Dr Jocelyn Widagdo

  • Doctor Philosophy

    Photocontrollable probes to study neuropeptide-mediated memory formation

    Associate Advisor

    Other advisors: Associate Professor Markus Muttenthaler

  • Doctor Philosophy

    Understanding pathomechanisms in Alzheimer's disease

    Associate Advisor

    Other advisors: Dr Pranesh Padmanabhan

  • Doctor Philosophy

    The effects of lifestyle interventions in adult neurogenesis and cognition

    Associate Advisor

    Other advisors: Dr Tara Walker

Completed supervision

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