Victor Anggono
- Email:
- v.anggono@uq.edu.au
- Phone:
- +61 7 334 66417
- Phone:
- +61 7 334 66325
Overview
Background
Victor Anggono received his PhD in 2007 from the University of Sydney and undertook his postdoctoral training at the Johns Hopkins University in Baltimore, USA. In 2012, Dr Anggono returned to Australia as an NHMRC CJ Martin Research Fellow and joined the Queensland Brain Institute at the University of Queensland, where he is currently a Senior Research Fellow and Group Leader at the Clem Jones Centre for Ageing Dementia Research. His research aims to understand the molecular mechanisms of synaptic vesicle and glutamate receptor trafficking in neurons, processes that are essential for synaptic transmission, plasticity, learning and memory, and how their dysregulations impact on the pathophysiology of neurodegenerative diseases and neuropsychiatric disorders. Dr Anggono has published in journals such as Nature Neuroscience, Neuron, The Proceedings of the National Academy of Sciences USA, Journal of Neuroscience and Cell Reports, and has attracted more than 1500 citations. For his works, Dr Anggono was awarded the Boomerang Award (Australian Society for Biochemistry and Molecular Biology, 2011), the Young Scientist Award (Federation of Asian and Oceanian Biochemists and Molecular Biologists, 2015), the Science to Art Award (NHMRC, 2015) and more recently the Young Investigator Award (Asian-Pacific Society for Neurochemistry, 2016).
Availability
- Associate Professor Victor Anggono is:
- Available for supervision
Qualifications
- Doctor of Philosophy, University of Sydney
Research interests
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Neuronal Trafficking
The molecular basis of vesicles and receptors transports between sub-cellular compartments essential for neuronal communications, learning and memory.
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Neuroepigenetics
The molecular mechanisms underlying activity-dependent gene transcription in synaptic plasticity, a cellular correlate of learning and memory.
Research impacts
How neurons communicate with each other in the brain is one of the outstanding and most fascinating questions in modern neuroscience. This basic science research program will provide a detailed understanding of three essential biological processes; (i) presynaptic vesicle recycling, (ii) postsynaptic glutamate receptor trafficking, and (iii) epigenetic regulation of synaptic plasticity. These systems are crucial for virtually all function in the central nervous system. As most of these processes have been implicated in neurological disorders, such as epilepsy, Alzheimer's disease, schizophrenia and bipolar disorder, results from Dr Anggono's research program will also provide insights into the principles underpinning disease aetiology. Understanding of the molecular mechanisms of neuronal communications will allow us to devise potential meaningful and novel therapeutic strategies to target these neurological disorders.
Works
Search Professor Victor Anggono’s works on UQ eSpace
2022
Journal Article
The m6A-epitranscriptome in brain plasticity, learning and memory
Widagdo, Jocelyn, Wong, Justin J.-L. and Anggono, Victor (2022). The m6A-epitranscriptome in brain plasticity, learning and memory. Seminars in Cell and Developmental Biology, 125, 110-121. doi: 10.1016/j.semcdb.2021.05.023
2022
Journal Article
Editorial – The Making of Memories
Anggono, Victor and Opazo, Patricio (2022). Editorial – The Making of Memories. Seminars in Cell and Developmental Biology, 125, 66-67. doi: 10.1016/j.semcdb.2022.02.001
2022
Journal Article
The multifaceted effects of YTHDC1-mediated nuclear m6A recognition
Widagdo, Jocelyn, Anggono, Victor and Wong, Justin J.-L. (2022). The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. Trends in Genetics, 38 (4), 325-332. doi: 10.1016/j.tig.2021.11.005
2022
Journal Article
The metalloprotease ADM-4/ADAM17 promotes axonal repair
Ho, Xue Yan, Coakley, Sean, Amor, Rumelo, Anggono, Victor and Hilliard, Massimo A. (2022). The metalloprotease ADM-4/ADAM17 promotes axonal repair. Science Advances, 8 (11) eabm2882, eabm2882. doi: 10.1126/sciadv.abm2882
2020
Journal Article
Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease
Huang (黄 河), He, Camats-Perna, Judith, Medeiros, Rodrigo, Anggono, Victor and Widagdo, Jocelyn (2020). Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease. eNeuro, 7 (5) ENEURO.0125-20.2020, ENEURO.0125-20.2020. doi: 10.1523/eneuro.0125-20.2020
2020
Journal Article
An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor trafficking
Mota Vieira, Marta, Nguyen, Thien A., Wu, Kunwei, Badger, John D., Collins, Brett M., Anggono, Victor, Lu, Wei and Roche, Katherine W. (2020). An epilepsy-associated GRIN2A rare variant disrupts CaMKIIα phosphorylation of GluN2A and NMDA receptor trafficking. Cell Reports, 32 (9) 108104, 108104. doi: 10.1016/j.celrep.2020.108104
2020
Journal Article
Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ
Huang, Jie, Ringuet, Mitchell, Whitten, Andrew E, Caria, Sofia, Lim, Yee Wa, Badhan, Rahul, Anggono, Victor and Lee, Mihwa (2020). Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ. Nucleic Acids Research, 48 (6), 3356-3365. doi: 10.1093/nar/gkaa076
2020
Journal Article
Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester
Widagdo, Jocelyn, Kerk, Jun Wei, Guntupalli, Sumasri, Huganir, Richard L. and Anggono, Victor (2020). Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester. Cellular and Molecular Neurobiology, 40 (7), 1213-1222. doi: 10.1007/s10571-020-00809-2
2020
Journal Article
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
Vieira, Marta, Yong, Xuan Ling Hilary, Roche, Katherine W. and Anggono, Victor (2020). Regulation of NMDA glutamate receptor functions by the GluN2 subunits. Journal of Neurochemistry, 154 (2) jnc.14970, 121-143. doi: 10.1111/jnc.14970
2020
Journal Article
The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease
Bamford, Rosemary A., Widagdo, Jocelyn, Takamura, Natsuki, Eve, Madeline, Anggono, Victor and Oguro-Ando, Asami (2020). The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease. Neuroscience, 424, 184-202. doi: 10.1016/j.neuroscience.2019.10.006
2019
Journal Article
Co-expression of synaptic genes in the sponge Amphimedon queenslandica uncovers ancient neural submodules
Wong, Eunice, Mölter, Jan, Anggono, Victor, Degnan, Sandie M. and Degnan, Bernard M. (2019). Co-expression of synaptic genes in the sponge Amphimedon queenslandica uncovers ancient neural submodules. Scientific Reports, 9 (1) 15781, 15781. doi: 10.1038/s41598-019-51282-x
2019
Journal Article
1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex
Gooch, Helen, Cui, Xiaoying, Anggono, Victor, Trzaskowski, Maciej, Tan, Men Chee, Eyles, Darryl W., Burne, Thomas H. J., Jang, Se Eun, Mattheisen, Manuel, Hougaard, David M., Pedersen, Bent Nørgaard, Cohen, Arieh, Mortensen, Preben B., Sah, Pankaj and McGrath, John J. (2019). 1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex. Translational Psychiatry, 9 (1) 281, 281. doi: 10.1038/s41398-019-0626-z
2019
Journal Article
Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster
Troup, Michael, Zalucki, Oressia H., Kottler, Benjamin D., Karunanithi, Shanker, Anggono, Victor and van Swinderen, Bruno (2019). Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster. Anesthesiology, 131 (3), 555-568. doi: 10.1097/ALN.0000000000002850
2019
Journal Article
NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone
Zalucki, Oressia, Harris, Lachlan, Harvey, Tracey J., Harkins, Danyon, Widagdo, Jocelyn, Oishi, Sabrina, Matuzelski, Elise, Yong, Xuan Ling Hilary, Schmidt, Hannes, Anggono, Victor, Burne, Thomas H. J., Gronostajski, Richard M. and Piper, Michael (2019). NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone. Cerebral Cortex, 29 (8), 3590-3604. doi: 10.1093/cercor/bhy233
2018
Journal Article
The association between neonatal vitamin D status and risk of schizophrenia
Eyles, Darryl W., Trzaskowski, Maciej, Vinkhuyzen, Anna A. E., Mattheisen, Manuel, Meier, Sandra, Gooch, Helen, Anggono, Victor, Cui, Xiaoying, Tan, Men Chee, Burne, Thomas H. J., Jang, Se Eun, Kvaskoff, David, Hougaard, David M., Nørgaard-Pedersen, Bent, Cohen, Arieh, Agerbo, Esben, Pedersen, Carsten B., Børglum, Anders D., Mors, Ole, Sah, Pankaj, Wray, Naomi R., Mortensen, Preben B. and McGrath, John J. (2018). The association between neonatal vitamin D status and risk of schizophrenia. Scientific Reports, 8 (1) 17692, 17692. doi: 10.1038/s41598-018-35418-z
2018
Journal Article
The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity
Widagdo, Jocelyn and Anggono, Victor (2018). The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity. Journal of Neurochemistry, 147 (2), 137-152. doi: 10.1111/jnc.14481
2018
Journal Article
Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein
Zhu, Tianyi, Yong, Xuan Ling Hilary, Di, Xia, Widagdo, Jocelyn and Anggono, Victor (2018). Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein. Journal of Molecular Biology, 430 (3), 363-371. doi: 10.1016/j.jmb.2017.12.003
2018
Journal Article
Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054
2017
Journal Article
Regulation of AMPA receptor trafficking by protein ubiquitination
Widagdo, Jocelyn, Guntupalli, Sumasri, Jang, Se E. and Anggono, Victor (2017). Regulation of AMPA receptor trafficking by protein ubiquitination. Frontiers in Molecular Neuroscience, 10 347, 347. doi: 10.3389/fnmol.2017.00347
2017
Journal Article
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
Mahadevan, Vivek, Khademullah, C. Sahara, Dargaei, Zahra, Chevrier, Jonah, Uvarov, Pavel, Kwan, Julian, Bagshaw, Richard D., Pawson, Tony, Emili, Andrew, De Koninck, Yves, Anggono, Victor, Airaksinen, Matti and Woodin, Melanie A. (2017). Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. eLife, 6 e28270. doi: 10.7554/eLife.28270
Funding
Current funding
Supervision
Availability
- Associate Professor Victor Anggono is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Regulation of sorting nexin 27 by protein phosphorylation
Principal Advisor
Other advisors: Professor Brett Collins
-
Doctor Philosophy
Regulation of synapse to nucleus signalling during synaptic plasticity
Principal Advisor
Other advisors: Dr Jocelyn Widagdo, Dr Anson Tan
-
Doctor Philosophy
APP interacting protein as a key target of neuronal activity regulator in healthy aging
Principal Advisor
-
Doctor Philosophy
Photocontrollable probes to study neuropeptide-mediated memory formation
Associate Advisor
Other advisors: Associate Professor Markus Muttenthaler
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Doctor Philosophy
The effects of lifestyle interventions in adult neurogenesis and cognition
Associate Advisor
Other advisors: Dr Tara Walker
-
Doctor Philosophy
Revealing memory formation using whole-brain calcium imaging
Associate Advisor
Other advisors: Dr Zhaoyu Li
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Doctor Philosophy
Understanding the epitranscriptomes of the diseased neurons
Associate Advisor
Other advisors: Dr Jocelyn Widagdo
Completed supervision
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2024
Doctor Philosophy
Phosphorylation of GluN2B at Ser-1480 controls activity-induced degradation of NMDARs and spine stability.
Principal Advisor
Other advisors: Dr Jocelyn Widagdo
-
2024
Doctor Philosophy
Defining the mechanisms of Copine-6 lipid-binding properties in regulating the activity-dependent trafficking of glutamate receptors
Principal Advisor
Other advisors: Dr Anson Tan
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2024
Doctor Philosophy
Activity-dependent trafficking of NMDA receptors in mammalian central neurons
Principal Advisor
Other advisors: Professor Jürgen Götz
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2023
Doctor Philosophy
Role of FTO in DNA damage response
Principal Advisor
Other advisors: Dr Jocelyn Widagdo
-
2020
Doctor Philosophy
The regulation of AMPA receptor trafficking by protein ubiquitination and its role in the pathogenesis of Alzheimer's disease
Principal Advisor
Other advisors: Dr Jocelyn Widagdo
-
2019
Doctor Philosophy
Characterisation and roles of the postsynaptic Ca2+ sensor Copine-6 in primary neurons
Principal Advisor
Other advisors: Professor Brett Collins
-
2023
Doctor Philosophy
A target mechanism for general anaesthesia in the presynaptic release machinery
Associate Advisor
Other advisors: Professor Bruno van Swinderen, Dr Adekunle Bademosi
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2023
Doctor Philosophy
Chemosensory Communication in the Crown-of-Thorns Starfish: Towards a Green and Species-specific Biocontrol program
Associate Advisor
Other advisors: Professor Bernard Degnan, Professor Sandie Degnan
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2022
Doctor Philosophy
Epitranscriptomic Regulation of Normal and Pathological Ageing in the Hippocampus
Associate Advisor
Other advisors: Dr Jocelyn Widagdo
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2022
Doctor Philosophy
Regulation of Cadherin adhesion by Neogenin
Associate Advisor
Other advisors: Professor Helen Cooper
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2020
Doctor Philosophy
Early evolution of the nervous system: Insights from synaptic sub-machineries and sensory behaviour in the aneural sponge, Amphimedon queenslandica
Associate Advisor
Other advisors: Professor Sandie Degnan, Professor Bernard Degnan
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2019
Master Philosophy
The effects of the general anaesthetic propofol on Drosophila larvae
Associate Advisor
Other advisors: Professor Bruno van Swinderen
Media
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