Associate Professor Victor Anggono
Associate Professor

Victor Anggono

Email: 
Phone: 
+61 7 334 66417
Phone: 
+61 7 334 66325

Background

Victor Anggono received his PhD in 2007 from the University of Sydney and undertook his postdoctoral training at the Johns Hopkins University in Baltimore, USA. In 2012, Dr Anggono returned to Australia as an NHMRC CJ Martin Research Fellow and joined the Queensland Brain Institute at the University of Queensland, where he is currently a Senior Research Fellow and Group Leader at the Clem Jones Centre for Ageing Dementia Research. His research aims to understand the molecular mechanisms of synaptic vesicle and glutamate receptor trafficking in neurons, processes that are essential for synaptic transmission, plasticity, learning and memory, and how their dysregulations impact on the pathophysiology of neurodegenerative diseases and neuropsychiatric disorders. Dr Anggono has published in journals such as Nature Neuroscience, Neuron, The Proceedings of the National Academy of Sciences USA, Journal of Neuroscience and Cell Reports, and has attracted more than 1500 citations. For his works, Dr Anggono was awarded the Boomerang Award (Australian Society for Biochemistry and Molecular Biology, 2011), the Young Scientist Award (Federation of Asian and Oceanian Biochemists and Molecular Biologists, 2015), the Science to Art Award (NHMRC, 2015) and more recently the Young Investigator Award (Asian-Pacific Society for Neurochemistry, 2016).

Availability

Associate Professor Victor Anggono is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Sydney

Research interests

  • Neuronal Trafficking

    The molecular basis of vesicles and receptors transports between sub-cellular compartments essential for neuronal communications, learning and memory.

  • Neuroepigenetics

    The molecular mechanisms underlying activity-dependent gene transcription in synaptic plasticity, a cellular correlate of learning and memory.

Research impacts

How neurons communicate with each other in the brain is one of the outstanding and most fascinating questions in modern neuroscience. This basic science research program will provide a detailed understanding of three essential biological processes; (i) presynaptic vesicle recycling, (ii) postsynaptic glutamate receptor trafficking, and (iii) epigenetic regulation of synaptic plasticity. These systems are crucial for virtually all function in the central nervous system. As most of these processes have been implicated in neurological disorders, such as epilepsy, Alzheimer's disease, schizophrenia and bipolar disorder, results from Dr Anggono's research program will also provide insights into the principles underpinning disease aetiology. Understanding of the molecular mechanisms of neuronal communications will allow us to devise potential meaningful and novel therapeutic strategies to target these neurological disorders.

Search Professor Victor Anggono’s works on UQ eSpace

70 works between 2006 and 2024
All (70) Journal Article (62) Book Chapter (4) Conference Publication (4)

41 - 60 of 70 works

2017

Journal Article

G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity

May, Linda M., Anggono, Victor, Gooch, Helen M., Jang, Se E., Matusica, Dusan, Kerbler, Georg M., Meunier, Frederic A., Sah, Pankaj and Coulson, Elizabeth J. (2017). G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity. Frontiers in Neuroscience, 11 (455) 455. doi: 10.3389/fnins.2017.00455

G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity

2017

Journal Article

GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Guntupalli, Sumasri, Jang, Se Eun, Zhu, Tianyi, Huganir, Richard L., Widagdo, Jocelyn and Anggono, Victor (2017). GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Journal of Biological Chemistry, 292 (20), 8186-8194. doi: 10.1074/jbc.M116.774554

GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

2017

Journal Article

The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons

Tan, Men C., Widagdo, Jocelyn, Chau, Yu Q., Zhu, Tianyi, Wong, Justin J.-L, Cheung, Allen and Anggono, Victor (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11 124, 124.1-124.12. doi: 10.3389/fncel.2017.00124

The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons

2017

Conference Publication

Pacsin regulates the dynamics of AMPA receptor trafficking and synaptic plasticity

Anggono, V. (2017). Pacsin regulates the dynamics of AMPA receptor trafficking and synaptic plasticity. ISN-ESN 2017 Meeting, Paris, France, 20-24 August, 2017. HOBOKEN: Wiley.

Pacsin regulates the dynamics of AMPA receptor trafficking and synaptic plasticity

2016

Journal Article

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology, 23 (10), 921-932. doi: 10.1038/nsmb.3290

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

2016

Journal Article

PACSIN1 regulates the dynamics of AMPA receptor trafficking

Widagdo, Jocelyn, Fang, Huaqiang, Jang, Se Eun and Anggono, Victor (2016). PACSIN1 regulates the dynamics of AMPA receptor trafficking. Scientific Reports, 6 (31070) 31070, 1-9. doi: 10.1038/srep31070

PACSIN1 regulates the dynamics of AMPA receptor trafficking

Featured

2016

Journal Article

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016). Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience, 36 (25), 6771-6777. doi: 10.1523/JNEUROSCI.4053-15.2016

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

2016

Journal Article

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

Goldschmidt, Hana L., Tu-Sekine, Becky, Volk, Lenora, Anggono, Victor, Huganir, Richard L. and Raben, Daniel M. (2016). DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses. Cell Reports, 14 (2), 200-207. doi: 10.1016/j.celrep.2015.12.022

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

2016

Journal Article

Amyloid-β-induced dysregulation of AMPA receptor trafficking

Guntupalli, Sumasri, Widagdo, Jocelyn and Anggono, Victor (2016). Amyloid-β-induced dysregulation of AMPA receptor trafficking. Neural Plasticity, 2016 3204519, 1-12. doi: 10.1155/2016/3204519

Amyloid-β-induced dysregulation of AMPA receptor trafficking

2016

Journal Article

Glutamate receptors in alzheimer's disease: mechanisms and therapies

Anggono, Victor, Tsai, Li-Huei and Goetz, Juergen (2016). Glutamate receptors in alzheimer's disease: mechanisms and therapies. Neural Plasticity, 2016 8256196, 8256196-2. doi: 10.1155/2016/8256196

Glutamate receptors in alzheimer's disease: mechanisms and therapies

2015

Journal Article

Ubiquitin signals the demise of AMPA receptors

Widagdo, Jocelyn and Anggono, Victor (2015). Ubiquitin signals the demise of AMPA receptors. Oncotarget, 6 (18), 15718-15719. doi: 10.18632/oncotarget.4645

Ubiquitin signals the demise of AMPA receptors

2015

Conference Publication

Regulation of AMPA receptor function by protein ubiquitination

Anggono, V. (2015). Regulation of AMPA receptor function by protein ubiquitination. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13187

Regulation of AMPA receptor function by protein ubiquitination

2015

Conference Publication

Activity-dependent RNA methylation in learning and memory

Widagdo, J., Zhao, Q. -Y., Anggono, V. and Bredy, T. (2015). Activity-dependent RNA methylation in learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Activity-dependent RNA methylation in learning and memory

2015

Conference Publication

Depolarization-dependent syndapin i phosphorylation in nerve terminals

Quan, A., Xue, J., Rao, S., Anggono, V., Larsen, M., Graham, M. and Robinson, P. (2015). Depolarization-dependent syndapin i phosphorylation in nerve terminals. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 20155. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Depolarization-dependent syndapin i phosphorylation in nerve terminals

2014

Journal Article

Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs

Hussain, Natasha K., Diering, Graham H., Sole, Jonathan, Anggono, Victor and Huganir, Richard L. (2014). Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. Proceedings of the National Academy of Sciences of the United States of America, 111 (32), 11840-11845. doi: 10.1073/pnas.1412415111

Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs

2013

Journal Article

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons

Rathje, Mette, Fang, Huaqiang, Bachman, Julia L., Anggono, Victor, Gether, Ulrik, Huganir, Richard L. and Madsen, Kenneth L. (2013). AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 110 (35), 14426-14431. doi: 10.1073/pnas.1312982110

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons

2012

Journal Article

Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation

Quana, Annie, Xue, Jing, Wielens, Jerome, Smillie, Karen J., Anggono, Victor, Parker, Michael W., Cousin, Michael A., Graham, Mark E. and Robinson, Phillip J. (2012). Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proceedings of the National Academy of Sciences of the United States of America, 109 (10), 3760-3765. doi: 10.1073/pnas.1108294109

Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation

2011

Journal Article

Phosphorylation of dynamin II at serine-764 is associated with cytokinesis

Chircop, Megan, Sarcevic, Boris, Larsen, Martin R., Malladi, Chandra S., Chau, Ngoc, Zavortink, Michael, Smith, Charlotte M., Quan, Annie, Anggono, Victor, Hains, Peter G., Graham, Mark E. and Robinson, Phillip J. (2011). Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. Biochimica Et Biophysica Acta-Molecular Cell Research, 1813 (10), 1689-1699. doi: 10.1016/j.bbamcr.2010.12.018

Phosphorylation of dynamin II at serine-764 is associated with cytokinesis

2011

Journal Article

Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism

Mejias, Rebeca, Adamczyk, Abby, Anggono, Victor, Niranjan, Tejasvi, Thomas, Gareth M., Sharma, Kamal, Skinner, Cindy, Schwartz, Charles E., Stevenson, Roger E., Fallin, M. Daniele, Kaufmann, Walter, Pletnikov, Mikhail, Valle, David, Huganir, Richard L. and Wang, Tao (2011). Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proceedings of the National Academy of Sciences of the United States of America, 108 (12), 4920-4925. doi: 10.1073/pnas.1102233108

Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism

2011

Journal Article

PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling

Anggono, Victor, Clem, Roger L. and Huganir, Richard L. (2011). PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling. Journal of Neuroscience, 31 (6), 2188-2196. doi: 10.1523/JNEUROSCI.5633-10.2011

PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling

Current funding

  • 2024 - 2025
    Characterisation of a de novo WDR26 rare genetic variant associated with neurodevelopmental disorders
    Australian Functional Genomics Network
    Open grant
  • 2024 - 2027
    Unraveling the physiological and disease-enabling functions of Tau protein
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2026
    Molecular basis of glutamate receptor trafficking in neuronal plasticity
    ARC Future Fellowships
    Open grant
  • 2022 - 2025
    Regulation of activity-induced glutamate receptor trafficking in neurons
    ARC Discovery Projects
    Open grant

Past funding

  • 2021 - 2022
    Molecular mechanisms underlying the cytoplasmic aggregation of the RNA binding protein, SFPQ, in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019 - 2022
    Regulation of glutamate receptor dynamics in mammalian central neurons
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
    NHMRC Project Grant
    Open grant
  • 2017
    Australia-China Young Scientists Exchange Program 2017
    Australian Academy of Technological Sciences and Engineering
    Open grant
  • 2017 - 2019
    Regulation of synaptic vesicle endocytosis by membrane-sensing proteins
    ARC Discovery Projects
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016
    Travel Award for the 39th Annual Meeting of the Japan Neuroscience Society
    Japan Neuroscience Society
    Open grant
  • 2016 - 2018
    Molecular mechanisms underlying recovery from general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015 - 2016
    Ubiquitinomic profiling of synaptic proteins in Alzheimer's Disease
    Alzheimer's Australia Dementia Research Foundation
    Open grant
  • 2015 - 2018
    Targeting the synaptic actin cytoskeleton in Alzheimer's Disease (NHMRC Project Grant administered by UNSW)
    University of New South Wales
    Open grant
  • 2014
    Transcriptional Profiling of Long Non-coding RNAs in Synaptic Plasticity
    UQ Early Career Researcher
    Open grant
  • 2012 - 2013
    The role of synaptotagmin-1 ubiquitination in synaptic transmission
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2012 - 2014
    NHMRC Training Fellowship (CJ Martin): The role of stargazin and TARP phosphorylation in synaptic plasticity
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Availability

Associate Professor Victor Anggono is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    APP interacting protein as a key target of neuronal activity regulator in healthy aging

    Principal Advisor

  • Doctor Philosophy

    Regulation of sorting nexin 27 by protein phosphorylation

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Regulation of synapse to nucleus signalling during synaptic plasticity

    Principal Advisor

    Other advisors: Dr Jocelyn Widagdo, Dr Anson Tan

  • Doctor Philosophy

    Revealing memory formation using whole-brain calcium imaging

    Associate Advisor

    Other advisors: Dr Zhaoyu Li

  • Doctor Philosophy

    Understanding the epitranscriptomes of the diseased neurons

    Associate Advisor

    Other advisors: Dr Jocelyn Widagdo

  • Doctor Philosophy

    Photocontrollable probes to study neuropeptide-mediated memory formation

    Associate Advisor

    Other advisors: Associate Professor Markus Muttenthaler

  • Doctor Philosophy

    The effects of lifestyle interventions in adult neurogenesis and cognition

    Associate Advisor

    Other advisors: Dr Tara Walker

Completed supervision

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