Dr Jocelyn Widagdo
Dr

Jocelyn Widagdo

Email: 
Phone: 
+61 7 334 66384

Background

Jocelyn Widagdo received her PhD in 2011 from the University of New South Wales. After a short period of postdoctoral training at the Johns Hopkins University in Baltimore, USA, Dr Widagdo returned to Australia in 2012 and joined the Queensland Brain Institute, the University of Queensland, where she is currently a Research Fellow at the Clem Jones Centre for Ageing Dementia Research. Her research aims to understand how the process of synaptic plasticity, learning and memory are underpinned by dynamic regulation of DNA, RNA and proteins, and consequently, how they contribute towards the pathophysiology of neurodegenerative diseases and neuropsychiatric disorders. Her works were published in journals such as The Proceedings of the National Academy of Sciences USA, Journal of Neuroscience, and Cell Reports, and have attracted more than 2000 citations. Dr Widagdo's research has been supported by the Australian Research Council (Discovery Early Career Researcher Fellowship, 2017; Discovery Project grant, 2023).

Availability

Dr Jocelyn Widagdo is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Neurosciences

Qualifications

  • Doctor of Philosophy, University of New South Wales

Research interests

  • Epigenetic regulation of learning and memory

  • Regulation of glutamate receptor trafficking in synaptic plasticity

Search Professor Jocelyn Widagdo’s works on UQ eSpace

37 works between 2010 and 2024
All (37) Journal Article (34) Conference Publication (3)

1 - 20 of 37 works

Featured

2022

Journal Article

The m6A-epitranscriptome in brain plasticity, learning and memory

Widagdo, Jocelyn, Wong, Justin J.-L. and Anggono, Victor (2022). The m6A-epitranscriptome in brain plasticity, learning and memory. Seminars in Cell and Developmental Biology, 125, 110-121. doi: 10.1016/j.semcdb.2021.05.023

The m6A-epitranscriptome in brain plasticity, learning and memory

Featured

2020

Journal Article

Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease

Huang (黄 河), He, Camats-Perna, Judith, Medeiros, Rodrigo, Anggono, Victor and Widagdo, Jocelyn (2020). Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease. eNeuro, 7 (5) ENEURO.0125-20.2020, ENEURO.0125-20.2020. doi: 10.1523/eneuro.0125-20.2020

Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease

Featured

2018

Journal Article

The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

Widagdo, Jocelyn and Anggono, Victor (2018). The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity. Journal of Neurochemistry, 147 (2), 137-152. doi: 10.1111/jnc.14481

The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

Featured

2018

Journal Article

Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein

Zhu, Tianyi, Yong, Xuan Ling Hilary, Di, Xia, Widagdo, Jocelyn and Anggono, Victor (2018). Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein. Journal of Molecular Biology, 430 (3), 363-371. doi: 10.1016/j.jmb.2017.12.003

Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein

Featured

2016

Journal Article

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016). Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience, 36 (25), 6771-6777. doi: 10.1523/JNEUROSCI.4053-15.2016

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Featured

2015

Journal Article

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015). Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports, 10 (5), 783-795. doi: 10.1016/j.celrep.2015.01.015

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

2024

Journal Article

Global quantitative proteomic analysis of aged mouse hippocampus

Huang, He, van Waardenberg, Ashley J., Graham, Mark E., Anggono, Victor and Widagdo, Jocelyn (2024). Global quantitative proteomic analysis of aged mouse hippocampus. PROTEOMICS, 24 (7) e2300276, 1-6. doi: 10.1002/pmic.202300276

Global quantitative proteomic analysis of aged mouse hippocampus

2023

Journal Article

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

Marshall, Andrew C., Cummins, Jerry, Kobelke, Simon, Zhu, Tianyi, Widagdo, Jocelyn, Anggono, Victor, Hyman, Anthony, Fox, Archa H., Bond, Charles S. and Lee, Mihwa (2023). Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates. Journal of Molecular Biology, 435 (24) 168364, 1-18. doi: 10.1016/j.jmb.2023.168364

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

2023

Journal Article

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Tan, Jing Zhi Anson, Jang, Se Eun, Batallas-Borja, Ana, Bhembre, Nishita, Chandra, Mintu, Zhang, Lingrui, Guo, Huimin, Ringuet, Mitchell T., Widagdo, Jocelyn, Collins, Brett M. and Anggono, Victor (2023). Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis. Cell Reports, 42 (12) 113460, 1-20. doi: 10.1016/j.celrep.2023.113460

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

2023

Journal Article

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

Leiter, Odette, Brici, David, Fletcher, Stephen J., Yong, Xuan Ling Hilary, Widagdo, Jocelyn, Matigian, Nicholas, Schroer, Adam B., Bieri, Gregor, Blackmore, Daniel G., Bartlett, Perry F., Anggono, Victor, Villeda, Saul A. and Walker, Tara L. (2023). Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nature Communications, 14 (1) 4375, 1-20. doi: 10.1038/s41467-023-39873-9

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

2023

Journal Article

Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility

Guntupalli, Sumasri, Park, Pojeong, Han, Dae Hee, Zhang, Lingrui, Yong, Xuan Ling Hilary, Ringuet, Mitchell, Blackmore, Daniel G., Jhaveri, Dhanisha J., Koentgen, Frank, Widagdo, Jocelyn, Kaang, Bong-Kiun and Anggono, Victor (2023). Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility. The Journal of Neuroscience, 43 (30), 5448-5457. doi: 10.1523/jneurosci.1542-22.2023

Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility

2023

Journal Article

Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

Radford, Rowan A. W., Rayner, Stephanie L., Szwaja, Paulina, Morsch, Marco, Cheng, Flora, Zhu, Tianyi, Widagdo, Jocelyn, Anggono, Victor, Pountney, Dean L., Chung, Roger and Lee, Albert (2023). Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission. Journal of Neurochemistry, 165 (4), 563-586. doi: 10.1111/jnc.15796

Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

2023

Journal Article

The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus

Huang, He, Song, Renhua, Wong, Justin J.‐L., Anggono, Victor and Widagdo, Jocelyn (2023). The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus. Aging Cell, 22 (1) e13755, 1-8. doi: 10.1111/acel.13755

The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus

2022

Journal Article

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Widagdo, Jocelyn, Udagedara, Saumya, Bhembre, Nishita, Tan, Jing Zhi Anson, Neureiter, Lara, Huang, Jie, Anggono, Victor and Lee, Mihwa (2022). Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons. Open Biology, 12 (9) 220187, 1-12. doi: 10.1098/rsob.220187

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

2022

Journal Article

The multifaceted effects of YTHDC1-mediated nuclear m6A recognition

Widagdo, Jocelyn, Anggono, Victor and Wong, Justin J.-L. (2022). The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. Trends in Genetics, 38 (4), 325-332. doi: 10.1016/j.tig.2021.11.005

The multifaceted effects of YTHDC1-mediated nuclear m6A recognition

2021

Journal Article

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Yong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M. and Anggono, Victor (2021). Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Cell Reports, 36 (1) 109338, 1-21. doi: 10.1016/j.celrep.2021.109338

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

2020

Journal Article

Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester

Widagdo, Jocelyn, Kerk, Jun Wei, Guntupalli, Sumasri, Huganir, Richard L. and Anggono, Victor (2020). Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester. Cellular and Molecular Neurobiology, 40 (7), 1213-1222. doi: 10.1007/s10571-020-00809-2

Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester

2020

Journal Article

The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease

Bamford, Rosemary A., Widagdo, Jocelyn, Takamura, Natsuki, Eve, Madeline, Anggono, Victor and Oguro-Ando, Asami (2020). The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease. Neuroscience, 424, 184-202. doi: 10.1016/j.neuroscience.2019.10.006

The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease

2019

Journal Article

NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone

Zalucki, Oressia, Harris, Lachlan, Harvey, Tracey J., Harkins, Danyon, Widagdo, Jocelyn, Oishi, Sabrina, Matuzelski, Elise, Yong, Xuan Ling Hilary, Schmidt, Hannes, Anggono, Victor, Burne, Thomas H. J., Gronostajski, Richard M. and Piper, Michael (2019). NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone. Cerebral Cortex, 29 (8), 3590-3604. doi: 10.1093/cercor/bhy233

NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone

2017

Journal Article

Regulation of AMPA receptor trafficking by protein ubiquitination

Widagdo, Jocelyn, Guntupalli, Sumasri, Jang, Se E. and Anggono, Victor (2017). Regulation of AMPA receptor trafficking by protein ubiquitination. Frontiers in Molecular Neuroscience, 10 347, 347. doi: 10.3389/fnmol.2017.00347

Regulation of AMPA receptor trafficking by protein ubiquitination

Current funding

  • 2024 - 2025
    Characterisation of a de novo WDR26 rare genetic variant associated with neurodevelopmental disorders
    Australian Functional Genomics Network
    Open grant
  • 2023 - 2026
    Novel role of RNA methylation in neuronal homeostasis
    ARC Discovery Projects
    Open grant

Past funding

  • 2021 - 2022
    Molecular mechanisms underlying the cytoplasmic aggregation of the RNA binding protein, SFPQ, in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019 - 2021
    Dr Jocelyn Widagdo - AQ WRAP
    Advance Queensland Women's Research Assistance Program
    Open grant
  • 2019 - 2020
    UQ AWARE - Dr Jocelyn Widagdo
    UQ Amplify Women's Academic Research Equity
    Open grant
  • 2018
    To atttend the 48th Annual Meeting of the Society for Neuroscience (SFN), 3-7 November 2018
    The Cass Foundation Limited
    Open grant
  • 2018
    The epitranscripttomic landscape in ageing and dementia
    UQ Early Career Researcher
    Open grant
  • 2017 - 2020
    Epitranscriptomic regulation of learning and memory
    ARC Discovery Early Career Researcher Award
    Open grant

Availability

Dr Jocelyn Widagdo is:
Available for supervision

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Available projects

  • Novel role of RNA methylation in neuronal homeostasis

Supervision history

Current supervision

Completed supervision

Enquiries

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