Professor Timothy Bredy
Professor

Timothy Bredy

Email: 
Phone: 
+61 7 344 33005

Background

Research in the Bredy laboratory is aimed at elucidating how the genome is connected to the environment through epigenetic modifications, and how this relationship shapes brain and behaviour throughout life. The group is particularly interested in how epigenetic mechanisms, including DNA methylation, histone modifications. the activity of non-coding RNAs, and RNA modification regulate the formation and maintenance of associative fear-related memory.

Availability

Professor Timothy Bredy is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cellular nervous system Central nervous system Cognitive and computational psychology Gene and molecular therapy Genetics Medical biotechnology Neurogenetics Neurosciences Psychology

Qualifications

  • Doctor of Philosophy of Neurological Sciences, McGill University

Research interests

  • RNA biology

  • Memory

Search Professor Timothy Bredy’s works on UQ eSpace

84 works between 2004 and 2024
All (84) Journal Article (72) Book Chapter (2) Conference Publication (9) Book (1)

1 - 20 of 84 works

2024

Journal Article

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

Chen, Claire C., Han, Joseph, Chinn, Carlene A., Rounds, Jacob S., Li, Xiang, Nikan, Mehran, Myszka, Marie, Tong, Liqi, Passalacqua, Luiz F. M., Bredy, Timothy, Wood, Marcelo A. and Luptak, Andrej (2024). Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory. eLife, 13 e90116. doi: 10.7554/elife.90116

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

2024

Journal Article

DNA G-quadruplex is a transcriptional control device that regulates memory

Marshall, Paul R., Davies, Joshua, Zhao, Qiongyi, Liau, Wei-Siang, Lee, Yujin, Basic, Dean, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Kielar, Marcin, Brueckner, Arie Maeve, Gong, Hao, Ren, Haobin, Walsh, Alexander, Kaczmarczyk, Lech, Jackson, Walker S., Chen, Alon, Spitale, Robert C. and Bredy, Timothy W. (2024). DNA G-quadruplex is a transcriptional control device that regulates memory. The Journal of Neuroscience, 44 (15) e0093232024, e0093232024. doi: 10.1523/jneurosci.0093-23.2024

DNA G-quadruplex is a transcriptional control device that regulates memory

2024

Journal Article

Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding RNAs spanning learning, memory and adaptive immunity

Musgrove, Mason R. B., Mikhaylova, Marina and Bredy, Timothy W. (2024). Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding RNAs spanning learning, memory and adaptive immunity. Journal of Neurochemistry, 168 (6), 961-976. doi: 10.1111/jnc.16071

Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding RNAs spanning learning, memory and adaptive immunity

2023

Journal Article

Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours

Hoffmann, L. B., Li, B., Wei, W., Zhao, Q., Leighton, L. J., Bredy, T. W., Pang, T. Y. and Hannan, A. J. (2023). Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours. Molecular Psychiatry, 29 (3), 590-601. doi: 10.1038/s41380-023-02350-2

Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours

2023

Journal Article

Huntingtin decreases susceptibility to a spontaneous seizure disorder in FVN/B mice

Van Raamsdonk, Jeremy M., Al-Shekaili, Hilal H., Wagner, Laura, Bredy, Tim W., Chan, Laura, Pearson, Jacqueline, Schwab, Claudia, Murphy, Zoe, Devon, Rebecca S., Lu, Ge, Kobor, Michael S., Hayden, Michael R. and Leavitt, Blair R. (2023). Huntingtin decreases susceptibility to a spontaneous seizure disorder in FVN/B mice. Aging and Disease, 14 (6), 2249-2266. doi: 10.14336/AD.2023.0423

Huntingtin decreases susceptibility to a spontaneous seizure disorder in FVN/B mice

2023

Journal Article

Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

Liau, Wei-Siang, Zhao, Qiongyi, Bademosi, Adekunle, Gormal, Rachel S., Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Madugalle, Sachithrani U., Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason, Davies, Joshua, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Li, Xiang, Wei, Wei, Meunier, Frédéric A., Fernández-Moya, Sandra M., Kiebler, Michael A., Srinivasan, Balakumar, Banerjee, Sourav, Clark, Michael, Spitale, Robert C. and Bredy, Timothy W. (2023). Fear extinction is regulated by the activity of long noncoding RNAs at the synapse. Nature Communications, 14 (1) 7616, 1-16. doi: 10.1038/s41467-023-43535-1

Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

2023

Journal Article

Synapse-enriched m<sup>6</sup>A-modified Malat1 interacts with the novel m<sup>6</sup>A reader, DPYSL2, and is required for fear-extinction memory

Madugalle, Sachithrani U., Liau, Wei-Siang, Zhao, Qiongyi, Li, Xiang, Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason R. B., Davies, Joshua W. A., Kim, Gwangmin, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Fulopova, Barbora, Fletcher, Lee N., Williams, Stephen R., Spitale, Robert C. and Bredy, Timothy W. (2023). Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory. The Journal of Neuroscience, 43 (43), 7084-7100. doi: 10.1523/jneurosci.0943-23.2023

Synapse-enriched m<sup>6</sup>A-modified Malat1 interacts with the novel m<sup>6</sup>A reader, DPYSL2, and is required for fear-extinction memory

2023

Journal Article

Localised Cdr1as activity is required for fear extinction memory

Lau Zajaczkowski, Esmi, Zhao, Qiongyi, Liau, Wei-Siang, Gong, Hao, Madugalle, Sachithrani Umanda, Periyakaruppiah, Ambika, Leighton, Laura Jane, Musgrove, Mason, Ren, Haobin, Davies, Joshua, Marshall, Paul Robert and Bredy, Timothy William (2023). Localised Cdr1as activity is required for fear extinction memory. Neurobiology of Learning and Memory, 203 107777, 107777. doi: 10.1016/j.nlm.2023.107777

Localised Cdr1as activity is required for fear extinction memory

2022

Journal Article

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

Wei, Wei, Zhao, Qiongyi, Wang, Ziqi, Liau, Wei-Siang, Basic, Dean, Ren, Haobin, Marshall, Paul R., Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Periyakaruppiah, Ambika, Shi, Jichun, Zhang, Jianjian, Mattick, John S., Mercer, Timothy R., Spitale, Robert C., Li, Xiang and Bredy, Timothy W. (2022). ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3. Cell Reports, 38 (12) 110546, 110546. doi: 10.1016/j.celrep.2022.110546

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

2021

Journal Article

From circuits to chromatin: the emerging role of epigenetics in mental health

Mews, Philipp, Calipari, Erin S., Day, Jeremy, Lobo, Mary Kay, Bredy, Timothy and Abel, Ted (2021). From circuits to chromatin: the emerging role of epigenetics in mental health. The Journal of Neuroscience, 41 (5), 873-882. doi: 10.1523/jneurosci.1649-20.2020

From circuits to chromatin: the emerging role of epigenetics in mental health

2021

Journal Article

On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain

Liau, Wei-Siang, Samaddar, Sarbani, Banerjee, Sourav and Bredy, Timothy W. (2021). On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain. RNA Biology, 18 (7), 1-12. doi: 10.1080/15476286.2020.1868165

On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain

2020

Journal Article

RNA N6-methyladenosine and the regulation of RNA localization and function in the brain

Madugalle, Sachithrani U., Meyer, Kate, Wang, Dan Ohtan and Bredy, Timothy W. (2020). RNA N6-methyladenosine and the regulation of RNA localization and function in the brain. Trends in Neurosciences, 43 (12), 1011-1023. doi: 10.1016/j.tins.2020.09.005

RNA N6-methyladenosine and the regulation of RNA localization and function in the brain

2020

Journal Article

Circular RNAs in the brain: a possible role in memory?

Zajaczkowski, Esmi L. and Bredy, Timothy W. (2020). Circular RNAs in the brain: a possible role in memory?. The Neuroscientist, 27 (5), 1073858420963028-486. doi: 10.1177/1073858420963028

Circular RNAs in the brain: a possible role in memory?

2020

Journal Article

Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis

Chen, Min, Zhao, Qiong-Yi, Edson, Janette, Zhang, Zong Hong, Li, Xiang, Wei, Wei, Bredy, Timothy and Reutens, David C. (2020). Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis. Epilepsy Research, 166 106400, 106400. doi: 10.1016/j.eplepsyres.2020.106400

Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis

2020

Journal Article

Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex

Dick, Alec L. W., Zhao, Qiongyi, Crossin, Rose, Baker-Andresen, Danay, Li, Xiang, Edson, Janette, Roeh, Simone, Marshall, Victoria, Bredy, Timothy W., Lawrence, Andrew J. and Duncan, Jhodie R. (2020). Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex. Addiction Biology, 26 (3) e12937, e12937. doi: 10.1111/adb.12937

Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex

2020

Journal Article

Publisher Correction: Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

Marshall, Paul R., Zhao, Qiongyi, Li, Xiang, Wei, Wei, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Basic, Dean, Wang, Ziqi, Yin, Jiayu, Liau, Wei-Siang, Gupte, Ankita, Walkley, Carl R. and Bredy, Timothy W. (2020). Publisher Correction: Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction. Nature Neuroscience, 23 (8), 1034-1034. doi: 10.1038/s41593-020-0669-8

Publisher Correction: Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

2020

Journal Article

Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

Marshall, Paul R., Zhao, Qiongyi, Li, Xiang, Wei, Wei, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Basic, Dean, Wang, Ziqi, Yin, Jiayu, Liau, Wei-Siang, Gupte, Ankita, Walkley, Carl R. and Bredy, Timothy W. (2020). Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction. Nature Neuroscience, 23 (6), 718-729. doi: 10.1038/s41593-020-0627-5

Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

2019

Conference Publication

RNA modifications and memory

Bredy, T. (2019). RNA modifications and memory. ISN-ASN Meeting, Montreal, Canada, 4-8 August 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

RNA modifications and memory

2019

Journal Article

Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice

Leighton, Laura J., Wei, Wei, Marshall, Paul R., Ratnu, Vikram Singh, Li, Xiang, Zajaczkowski, Esmi L., Spadaro, Paola A., Khandelwal, Nitin, Kumar, Arvind and Bredy, Timothy W. (2019). Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice. Neurobiology of Learning and Memory, 161, 202-209. doi: 10.1016/j.nlm.2019.04.002

Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice

2019

Journal Article

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

Li, Xiang, Zhao, Qiongyi, Wei, Wei, Lin, Quan, Magnan, Christophe, Emami, Michael R., Wearick-Silva, Luis E., Viola, Thiago W., Marshall, Paul R., Yin, Jiayu, Madugalle, Sachithrani U., Wang, Ziqi, Nainar, Sarah, Vågbø, Cathrine Broberg, Leighton, Laura J., Zajaczkowski, Esmi L., Ke, Ke, Grassi-Oliveira, Rodrigo, Bjørås, Magnar, Baldi, Pierre F., Spitale, Robert C. and Bredy, Timothy W. (2019). The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience, 22 (4), 534-544. doi: 10.1038/s41593-019-0339-x

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

Past funding

  • 2022 - 2024
    Discovering new molecular contributors to Prader-Willi syndrome
    Prader Willi Syndrome Research Grant
    Open grant
  • 2021 - 2024
    Dynamic DNA structure states and memory formation
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long noncoding RNA in space and time, and the regulation of fear extinction
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    RNA modifications in space and time: How do they govern fear extinction?
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2023
    Defining novel neuroepigenetic pathways that influence learning and memory
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Toward a deeper understanding of new DNA modifications in fear-related learning.
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Cell-type specific profiling of nascent RNA in the brain during learning
    ARC Discovery Projects
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2022
    Cracking the epigenetic code: understanding the mechanisms of memory associated with anxiety-related disorders and their treatment
    NHMRC Research Fellowship
    Open grant
  • 2018 - 2020
    Novel DNA modifications underlying sex differences in fear-related learning and memory
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Shedding light on the dark matter of the genome: understanding the functional relevance of long non-coding RNAs in the brain and elucidating their role in fear-related anxiety disorders
    Brain and Behavior Research Foundation
    Open grant
  • 2017 - 2022
    Epitranscriptomic mechanisms of fear-related learning and memory (NIH Grant administered by University of California, Irvine)
    University of California, Irvine
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015 - 2017
    Transgenerational impacts of paternal stress on offspring mental health: Epigenetic mechanisms and therapeutic interventions (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2016
    Early development, microRNAs, dendritogenesis and cognition
    NHMRC Project Grant
    Open grant
  • 2014
    Touchscreen-automated cognitive testing for mice
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2019
    The Science of Learning Research Centre
    ARC Special Research Initiative for a Science of Learning Research Centre
    Open grant
  • 2013 - 2015
    MicroRNA regulation of fear-related memory
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Exploring DNA methylation as a mechanism for long-term memory for fear extinction
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Exploring the role of the 6th base: how the Tet family of proteins, DNA hydroxymethylation, and active DNA demethylation contribute to fear-related memory.
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2011 - 2012
    Mass spectrometry platform for high throughput genotyping, epigenetic analysis and validation of genome wide sequencing studies
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011
    Advanced behavioural facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Exploring the role of RNA editing in synaptic plasticity and higher order cognition
    UQ Early Career Researcher
    Open grant
  • 2011 - 2013
    The long term consequences of toluene exposure on the maturing brain (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2010 - 2014
    Epigenetic mechanisms regulating sex differences in fear-related learning and memory
    ARC Discovery Projects
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Timothy Bredy is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Exploring the role of chromatin associated RNAs and trans splicing in learning and memory

    Principal Advisor

    Other advisors: Dr Qiongyi Zhao

  • Doctor Philosophy

    Halo-seq to understand the role of subcompartment specific RNA expression in learning and mermory.

    Principal Advisor

  • Doctor Philosophy

    Exploring the role of vaults and vault associated small noncoding RNAs in learning and memory

    Principal Advisor

    Other advisors: Dr Wei-Siang Liau

Completed supervision

Enquiries

Contact Professor Timothy Bredy directly for media enquiries about:

  • Emotion
  • Memory
  • Neuroscience
  • RNA Biology
  • RNA therapys

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