Professor Timothy Bredy
Professor

Timothy Bredy

Email: 
Phone: 
+61 7 344 33005

Background

Research in the Bredy laboratory is aimed at elucidating how the genome is connected to the environment through epigenetic modifications, and how this relationship shapes brain and behaviour throughout life. The group is particularly interested in how epigenetic mechanisms, including DNA methylation, histone modifications. the activity of non-coding RNAs, and RNA modification regulate the formation and maintenance of associative fear-related memory.

Availability

Professor Timothy Bredy is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cellular nervous system Central nervous system Cognitive and computational psychology Gene and molecular therapy Genetics Medical biotechnology Neurogenetics Neurosciences Psychology

Qualifications

  • Doctor of Philosophy of Neurological Sciences, McGill University

Research interests

  • RNA biology

  • Memory

Search Professor Timothy Bredy’s works on UQ eSpace

86 works between 2004 and 2025
All (86) Journal Article (74) Book Chapter (2) Conference Publication (9) Book (1)

61 - 80 of 86 works

2014

Journal Article

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

Li, Xiang, Wei, Wei, Zhao, Qiong-Yi, Widagdo, Jocelyn, Baker-Andresen, Danay, Flavell, Charlotte R., D'Alessio, Ana, Zhang, Yi and Bredy, Timothy W. (2014). Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation. Proceedings of the National Academy of Sciences, 111 (19), 7120-7125. doi: 10.1073/pnas.1318906111

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

2014

Journal Article

Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

Fenton, Georgina E., Pollard, Amelia K, Halliday, David M., Mason, Rob, Bredy, Timothy W. and Stevenson, Carl W. (2014). Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21 (2), 55-60. doi: 10.1101/lm.033514.113

Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

2014

Conference Publication

Prolonged Access to Cocaine Results in Distinct Epigenetic Changes in the Prefrontal Cortex

Ploense, Kyle, Carr, Amanda, Baker-Andresen, Danay, Li, Xiang, Woodward, Nick, Sun, Yi, Bredy, Timothy and Kippin, Tod (2014). Prolonged Access to Cocaine Results in Distinct Epigenetic Changes in the Prefrontal Cortex. Experimental Biology 2014 Meeting, San Diego CA, United States, 26-30 April 2014. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

Prolonged Access to Cocaine Results in Distinct Epigenetic Changes in the Prefrontal Cortex

2013

Journal Article

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Flavell, Charlotte R., Lambert, Elliot A., Winters, Boyer D. and Bredy, Timothy W. (2013). Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. Frontiers in Behavioral Neuroscience, 7 (DEC) 214, 214.1-214.11. doi: 10.3389/fnbeh.2013.00214

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

2013

Journal Article

Exposure to histone deacetylase inhibitors during Pavlovian conditioning enhances subsequent cue-induced reinstatement of operant behavior

Ploense, Kyle L., Kerstetter, Kerry A., Wade, Matthew A., Woodward, Nicholas C., Maliniak, Dan, Reyes, Michael, Uchizono, Russell S., Bredy, Timothy W. and Kippin, Tod E. (2013). Exposure to histone deacetylase inhibitors during Pavlovian conditioning enhances subsequent cue-induced reinstatement of operant behavior. Behavioural Pharmacology, 24 (3), 164-171. doi: 10.1097/FBP.0b013e32836104ea

Exposure to histone deacetylase inhibitors during Pavlovian conditioning enhances subsequent cue-induced reinstatement of operant behavior

2013

Journal Article

The amygdala and medial prefrontal cortex: partners in the fear circuit

Marek, Roger, Strobel, Cornelia, Bredy, Timothy W. and Sah, Pankaj (2013). The amygdala and medial prefrontal cortex: partners in the fear circuit. Journal of Physiology, 591 (10), 2381-2391. doi: 10.1113/jphysiol.2012.248575

The amygdala and medial prefrontal cortex: partners in the fear circuit

2013

Journal Article

Activation of BDNF signaling prevents the return of fear in female mice

Baker-Andresen, Danay, Flavell, Charlotte R., Li, Xiang and Bredy, Timothy W. (2013). Activation of BDNF signaling prevents the return of fear in female mice. Learning & Memory, 20 (5), 237-240. doi: 10.1101/lm.029520.112

Activation of BDNF signaling prevents the return of fear in female mice

2013

Journal Article

Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation

Baker-Andresen, Danay, Ratnu, Vikram and Bredy, Timothy (2013). Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation. Trends In Neurosciences, 36 (1), 3-13. doi: 10.1016/j.tins.2012.09.003

Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation

2013

Journal Article

On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory

Li, Xiang, Wei, Wei, Ratnu, Vikram and Bredy, Timothy (2013). On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory. Neurobiology of Learning and Memory, 105, 125-132. doi: 10.1016/j.nlm.2013.06.009

On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory

2013

Journal Article

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

Barry, Guy, Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Vikram Ratnu, Nayler, S. P., Nones, K., Hu, J., Timothy Bredy, Nakagawa, S., Rigo, F., Taft, R. J., Cairns, M. J., Blackshaw, S., Wolvetang, E. J. and Mattick, J. S. (2013). The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molecular Psychiatry, 19 (4), 486-494. doi: 10.1038/mp.2013.45

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

2012

Journal Article

p300/CBP-associated factor selectively regulates the extinction of conditioned fear

Wei, Wei, Coelho, Carlos M., Li, Xiang, Marek, Roger, Yan, Shanzhi, Anderson, Shawn, Meyers, David, Mukherjee, Chandrani, Sbardella, Gianluca, Castellano, Sabrina, Milite, Ciro, Rotili, Dante, Mai, Antonello, Cole, Philip A., Sah, Pankaj, Kobor, Michael S. and Bredy, Timothy W. (2012). p300/CBP-associated factor selectively regulates the extinction of conditioned fear. Journal of Neuroscience, 32 (35), 11930-11941. doi: 10.1523/JNEUROSCI.0178-12.2012

p300/CBP-associated factor selectively regulates the extinction of conditioned fear

2012

Journal Article

Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders

Spadaro, Paola A. and Bredy, Timothy W. (2012). Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Frontiers in Genetics, 3 (JUL) Article 132, 132.1-132.16. doi: 10.3389/fgene.2012.00132

Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders

2011

Journal Article

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Lin, Quan, Wei, Wei, Coelho, Carlos M., Li, Xiang, Baker-Andresen, Dannay, Dudley, Kevin, Ratnu, Vikram S., Boskovic, Zoran, Kobor, Michael S., Sun, Yi E. and Bredy, Timothy W. (2011). The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nature Neuroscience, 14 (9), 1115-1117. doi: 10.1038/nn.2891

The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

2011

Journal Article

MicroRNA regulation of neural plasticity and memory

Bredy, Timothy W., Lin, Quan, Wei, Wei, Baker-Andresen, Danay and Mattick, John S. (2011). MicroRNA regulation of neural plasticity and memory. Neurobiology of Learning and Memory, 96 (1), 89-94. doi: 10.1016/j.nlm.2011.04.004

MicroRNA regulation of neural plasticity and memory

2011

Journal Article

Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders

Dudley, Kevin J., Li, Xiang, Kobor, Michael S., Kippin, Tod E. and Bredy, Timothy W. (2011). Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. Neuroscience and Biobehavioral Reviews, 35 (7), 1544-1551. doi: 10.1016/j.neubiorev.2010.12.016

Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders

2011

Journal Article

Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300

Marek, Roger, Coelho, Carlos M., Sullivan, Robert K. P., Baker-Andresen, Danay, Li, Xiang, Ratnu, Vikram, Dudley, Kevin J., Meyers, David, Mukherjee, Chandrani, Cole, Philip A., Sah, Pankaj and Bredy, Timothy W. (2011). Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. Journal of Neuroscience, 31 (20), 7486-7491. doi: 10.1523/JNEUROSCI.0133-11.2011

Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300

2010

Journal Article

How the epigenome contributes to the development of psychiatric disorders

Bredy, Timothy W., Sun, Yi E. and Kobor, Michael S. (2010). How the epigenome contributes to the development of psychiatric disorders. Developmental Psychobiology, 52 (4), 331-342. doi: 10.1002/dev.20424

How the epigenome contributes to the development of psychiatric disorders

2009

Journal Article

Paternal deprivation during infancy results in dendrite- and time-specific changes of dendritic development and spine formation in the orbitofrontal cortex of the biparental rodent Octodon degus

Helmekea, C., Seidel, K., Poeggel, G., Bredy, Timothy, Abraham, A. and Braun, K. (2009). Paternal deprivation during infancy results in dendrite- and time-specific changes of dendritic development and spine formation in the orbitofrontal cortex of the biparental rodent Octodon degus. Neuroscience, 163 (3), 790-798. doi: 10.1016/j.neuroscience.2009.07.008

Paternal deprivation during infancy results in dendrite- and time-specific changes of dendritic development and spine formation in the orbitofrontal cortex of the biparental rodent Octodon degus

2009

Journal Article

Social modulation of associative fear learning by pheromone communication

Bredy, Timothy W. and Barad, Mark (2009). Social modulation of associative fear learning by pheromone communication. Learning and Memory, 16 (1), 12-18. doi: 10.1101/lm.1226009

Social modulation of associative fear learning by pheromone communication

2008

Journal Article

The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

Timothy, Bredy and Barad, Mark (2008). The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear. Learning & Memory, 15 (1), 39-45. doi: 10.1101/lm.801108

The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

Current funding

  • 2024 - 2029
    RNA Mass Spectrometry Platform
    Monash University
    Open grant

Past funding

  • 2022 - 2024
    Discovering new molecular contributors to Prader-Willi syndrome
    Prader Willi Syndrome Research Grant
    Open grant
  • 2021 - 2024
    Dynamic DNA structure states and memory formation
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long noncoding RNA in space and time, and the regulation of fear extinction
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    RNA modifications in space and time: How do they govern fear extinction?
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2023
    Defining novel neuroepigenetic pathways that influence learning and memory
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Toward a deeper understanding of new DNA modifications in fear-related learning.
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Cell-type specific profiling of nascent RNA in the brain during learning
    ARC Discovery Projects
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2022
    Cracking the epigenetic code: understanding the mechanisms of memory associated with anxiety-related disorders and their treatment
    NHMRC Research Fellowship
    Open grant
  • 2018 - 2020
    Novel DNA modifications underlying sex differences in fear-related learning and memory
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Shedding light on the dark matter of the genome: understanding the functional relevance of long non-coding RNAs in the brain and elucidating their role in fear-related anxiety disorders
    Brain and Behavior Research Foundation
    Open grant
  • 2017 - 2022
    Epitranscriptomic mechanisms of fear-related learning and memory (NIH Grant administered by University of California, Irvine)
    University of California, Irvine
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015 - 2017
    Transgenerational impacts of paternal stress on offspring mental health: Epigenetic mechanisms and therapeutic interventions (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2016
    Early development, microRNAs, dendritogenesis and cognition
    NHMRC Project Grant
    Open grant
  • 2014
    Touchscreen-automated cognitive testing for mice
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2019
    The Science of Learning Research Centre
    ARC Special Research Initiative for a Science of Learning Research Centre
    Open grant
  • 2013 - 2015
    MicroRNA regulation of fear-related memory
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Exploring DNA methylation as a mechanism for long-term memory for fear extinction
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Exploring the role of the 6th base: how the Tet family of proteins, DNA hydroxymethylation, and active DNA demethylation contribute to fear-related memory.
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2011 - 2012
    Mass spectrometry platform for high throughput genotyping, epigenetic analysis and validation of genome wide sequencing studies
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011
    Advanced behavioural facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Exploring the role of RNA editing in synaptic plasticity and higher order cognition
    UQ Early Career Researcher
    Open grant
  • 2011 - 2013
    The long term consequences of toluene exposure on the maturing brain (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2010 - 2014
    Epigenetic mechanisms regulating sex differences in fear-related learning and memory
    ARC Discovery Projects
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Timothy Bredy is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Exploring the role of chromatin associated RNAs and trans splicing in learning and memory

    Principal Advisor

    Other advisors: Dr Qiongyi Zhao

  • Doctor Philosophy

    Halo-seq to understand the role of subcompartment specific RNA expression in learning and mermory.

    Principal Advisor

  • Doctor Philosophy

    Exploring the role of vaults and vault associated small noncoding RNAs in learning and memory

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Explore extrachromosomal circular DNA in the brain and in fear-related learning and memory

    Principal Advisor

Completed supervision

Enquiries

Contact Professor Timothy Bredy directly for media enquiries about:

  • Emotion
  • Memory
  • Neuroscience
  • RNA Biology
  • RNA therapys

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