Defining novel neuroepigenetic pathways that influence learning and memory (2019-2023)
Abstract
Activity-induced gene expression is central to neural plasticity, learning, and memory; however, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. The aim of this proposal is to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and memory formation the findings will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.
