Professor Timothy Bredy
Professor

Timothy Bredy

Email: 
Phone: 
+61 7 344 33005

Background

Research in the Bredy laboratory is aimed at elucidating how the genome is connected to the environment through epigenetic modifications, and how this relationship shapes brain and behaviour throughout life. The group is particularly interested in how epigenetic mechanisms, including DNA methylation, histone modifications. the activity of non-coding RNAs, and RNA modification regulate the formation and maintenance of associative fear-related memory.

Availability

Professor Timothy Bredy is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cellular nervous system Central nervous system Cognitive and computational psychology Gene and molecular therapy Genetics Medical biotechnology Neurogenetics Neurosciences Psychology

Qualifications

  • Doctor of Philosophy of Neurological Sciences, McGill University

Research interests

  • RNA biology

  • Memory

Search Professor Timothy Bredy’s works on UQ eSpace

86 works between 2004 and 2025
All (86) Journal Article (74) Book Chapter (2) Conference Publication (9) Book (1)

21 - 40 of 86 works

2019

Journal Article

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

Li, Xiang, Zhao, Qiongyi, Wei, Wei, Lin, Quan, Magnan, Christophe, Emami, Michael R., Wearick-Silva, Luis E., Viola, Thiago W., Marshall, Paul R., Yin, Jiayu, Madugalle, Sachithrani U., Wang, Ziqi, Nainar, Sarah, Vågbø, Cathrine Broberg, Leighton, Laura J., Zajaczkowski, Esmi L., Ke, Ke, Grassi-Oliveira, Rodrigo, Bjørås, Magnar, Baldi, Pierre F., Spitale, Robert C. and Bredy, Timothy W. (2019). The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience, 22 (4), 534-544. doi: 10.1038/s41593-019-0339-x

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

2019

Journal Article

The DNA repair-associated protein gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required for the consolidation of associative fear memory

Li, Xiang, Marshall, Paul R., Leighton, Laura J., Zajaczkowski, Esmi L., Wang, Ziqi, Madugalle, Sachithrani U., Yin, Jiayu, Bredy, Timothy W. and Wei, Wei (2019). The DNA repair-associated protein gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required for the consolidation of associative fear memory. The Journal of Neuroscience, 39 (6), 970-983. doi: 10.1523/JNEUROSCI.2024-18.2018

The DNA repair-associated protein gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required for the consolidation of associative fear memory

2019

Journal Article

Neuroepigenetic mechanisms underlying fear extinction: emerging concepts

Marshall, Paul R. and Bredy, Timothy W. (2019). Neuroepigenetic mechanisms underlying fear extinction: emerging concepts. Psychopharmacology, 236 (1), 133-142. doi: 10.1007/s00213-018-5084-4

Neuroepigenetic mechanisms underlying fear extinction: emerging concepts

2019

Journal Article

Postnatal impoverished housing impairs adolescent risk-assessment and increases risk-taking: a sex-specific effect associated with histone epigenetic regulation of Crfr1 in the medial prefrontal cortex

Viola, Thiago Wendt, Wearick-Silva, Luis Eduardo, Creutzberg, Kerstin C., Kestering-Ferreira, Érika, Orso, Rodrigo, Centeno-Silva, Anderson, Albrechet-Souza, Lucas, Marshall, Paul R., Li, Xiang, Bredy, Timothy W., Riva, Marco A. and Grassi-Oliveira, Rodrigo (2019). Postnatal impoverished housing impairs adolescent risk-assessment and increases risk-taking: a sex-specific effect associated with histone epigenetic regulation of Crfr1 in the medial prefrontal cortex. Psychoneuroendocrinology, 99, 8-19. doi: 10.1016/j.psyneuen.2018.08.032

Postnatal impoverished housing impairs adolescent risk-assessment and increases risk-taking: a sex-specific effect associated with histone epigenetic regulation of Crfr1 in the medial prefrontal cortex

2018

Journal Article

Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley rats

Ploense, Kyle L., Li, Xiang, Baker-Andresen, Danay, Carr, Amanda E., Woodward, Nick, Bagley, Jared, Szumlinski, Karen K., Bredy, Timothy W. and Kippin, Tod E. (2018). Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley rats. Neuropharmacology, 143, 299-305. doi: 10.1016/j.neuropharm.2018.09.029

Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley rats

2018

Journal Article

Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling

Zajaczkowski, Esmi L., Zhao, Qiong-Yi, Zhang, Zong Hong, Li, Xiang, Wei, Wei, Marshall, Paul R., Leighton, Laura J., Nainar, Sarah, Feng, Chao, Spitale, Robert C. and Bredy, Timothy W. (2018). Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling. ACS Chemical Neuroscience, 9 (7), 1858-1865. doi: 10.1021/acschemneuro.8b00197

Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling

2018

Journal Article

Functional interplay between small non-coding RNAs and RNA modification in the brain

Leighton, Laura J. and Bredy, Timothy W. (2018). Functional interplay between small non-coding RNAs and RNA modification in the brain. Non-Coding RNA, 4 (2) 15, 15. doi: 10.3390/ncrna4020015

Functional interplay between small non-coding RNAs and RNA modification in the brain

2017

Journal Article

A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons

Leighton, Laura J., Zhao, Qiongyi, Li, Xiang, Dai, Chuanyang, Marshall, Paul R., Liu, Sha, Wang, Yi, Zajaczkowski, Esmi L., Khandelwal, Nitin, Kumar, Arvind, Bredy, Timothy W. and Wei, Wei (2017). A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons. Neuroscience, 369, 248-260. doi: 10.1016/j.neuroscience.2017.11.018

A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons

2017

Journal Article

Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics

Leighton, L. J., Ke, K., Zajaczkowski, E. L., Edmunds, J., Spitale, R. C. and Bredy, T. W. (2017). Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics. Genes, Brain, and Behavior, 17 (3) e12426, e12426. doi: 10.1111/gbb.12426

Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics

2017

Journal Article

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

Lin, Quan, Ponnusamy, Ravikumar, Widagdo, Jocelyn, Choi, Jung A., Ge, Weihong, Probst, Christine, Buckley, Tyler, Lou, Mimi, Bredy, Timothy W., Fanselow, Michael S., Ye, Keqiang and Sun, Yi E. (2017). MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proceedings from the National Academy of Sciences of the United States of America, 114 (34), 9188-9193. doi: 10.1073/pnas.1706069114

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

2017

Journal Article

Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats

Castino, M. R., Baker-Andresen, D., Ratnu, V. S., Shevchenko, G., Morris, K. V., Bredy, T. W., Youngson, N. A. and Clemens, K. J. (2017). Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. Genes, Brain and Behavior, 17 (2), 98-106. doi: 10.1111/gbb.12421

Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats

2017

Journal Article

MotifMap-RNA: a genome-wide map of RBP binding sites

Liu, Yu, Sun, Sha, Bredy, Timothy, Wood, Marcelo, Spitale, Robert C. and Baldi, Pierre (2017). MotifMap-RNA: a genome-wide map of RBP binding sites. Bioinformatics, 33 (13), 2029-2031. doi: 10.1093/bioinformatics/btx087

MotifMap-RNA: a genome-wide map of RBP binding sites

2017

Journal Article

MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice

Murphy, Conor P., Li, Xiang, Maurer, Verena, Oberhauser, Michael, Gstir, Ronald, Wearick-Silva, Luis Eduardo, Viola, Thiago Wendt, Schafferer, Simon, Grassi-Oliverira, Rodrigo, Whittle, Nigel, Huttenhofer, Alexander, Bredy, Timothy W. and Singewald, Nicolas (2017). MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice. Biological Psychiatry, 81 (12), 979-989. doi: 10.1016/j.biopsych.2016.12.021

MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice

2017

Journal Article

Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

de Azeredo, Lucas Araujo, Wearick-Silva, Luis Eduardo, Viola, Thiago Wendt, Tractenberg, Saulo Gantes, Centeno-Silva, Anderson, Orso, Rodrigo, Schroder, Nadja, Bredy, Timothy William and Grassi-Oliveira, Rodrigo (2017). Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice. Neurobiology of Learning and Memory, 141, 157-167. doi: 10.1016/j.nlm.2017.04.006

Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

2017

Journal Article

Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes

Pang, Terence Y. C., Short, Annabel K., Bredy, Timothy W. and Hannan, Anthony J. (2017). Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes. Current Opinion in Behavioral Sciences, 14, 140-147. doi: 10.1016/j.cobeha.2017.02.007

Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes

2017

Journal Article

Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes

Yeshurun, Shlomo, Short, Annabel K., Bredy, Timothy W., Pang, Terence Y. and Hannan, Anthony J. (2017). Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes. Psychoneuroendocrinology, 77, 225-235. doi: 10.1016/j.psyneuen.2016.11.013

Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes

2017

Journal Article

Running during adolescence rescues a maternal separation-induced memory impairment in female mice: Potential role of differential exon-specific BDNF expression

Wearick-Silva, Luis Eduardo, Marshall, Paul, Viola, Thiago Wendt, Centeno-Silva, Anderson, de Azeredo, Lucas Araujo, Orso, Rodrigo, Li, Xiang, Donadio, Marcio V., Bredy, Timothy W. and Grassi-Oliveira, Rodrigo (2017). Running during adolescence rescues a maternal separation-induced memory impairment in female mice: Potential role of differential exon-specific BDNF expression. Developmental Psychobiology, 59 (2), 268-274. doi: 10.1002/dev.21487

Running during adolescence rescues a maternal separation-induced memory impairment in female mice: Potential role of differential exon-specific BDNF expression

2017

Journal Article

Cell-selective bioorthogonal metabolic labeling of RNA

Nguyen, Kim, Fazio, Michael, Kubota, Miles, Nainar, Sarah, Feng, Chao, Li, Xiang, Atwood, Scott X., Bredy, Timothy W. and Spitale, Robert C. (2017). Cell-selective bioorthogonal metabolic labeling of RNA. Journal of the American Chemical Society, 139 (6), 2148-2151. doi: 10.1021/jacs.6b11401

Cell-selective bioorthogonal metabolic labeling of RNA

2017

Book Chapter

What does the future hold for the study of nucleic acid modifications in the brain?

Marshall, P. R. and Bredy, T. W. (2017). What does the future hold for the study of nucleic acid modifications in the brain?. DNA modifications in the brain: Neuroepigenetic Regulation of Gene Expression. (pp. 149-159) edited by Timothy W. Bredy. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-801596-4.00009-5

What does the future hold for the study of nucleic acid modifications in the brain?

2017

Journal Article

Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

Ratnu, Vikram S., Emami, Michael R. and Bredy, Timothy W. (2017). Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain. Journal of Neuroscience Research, 95 (1-2), 301-310. doi: 10.1002/jnr.23886

Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

Current funding

  • 2024 - 2029
    RNA Mass Spectrometry Platform
    Monash University
    Open grant

Past funding

  • 2022 - 2024
    Discovering new molecular contributors to Prader-Willi syndrome
    Prader Willi Syndrome Research Grant
    Open grant
  • 2021 - 2024
    Dynamic DNA structure states and memory formation
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long noncoding RNA in space and time, and the regulation of fear extinction
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    RNA modifications in space and time: How do they govern fear extinction?
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2023
    Defining novel neuroepigenetic pathways that influence learning and memory
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Toward a deeper understanding of new DNA modifications in fear-related learning.
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Cell-type specific profiling of nascent RNA in the brain during learning
    ARC Discovery Projects
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2022
    Cracking the epigenetic code: understanding the mechanisms of memory associated with anxiety-related disorders and their treatment
    NHMRC Research Fellowship
    Open grant
  • 2018 - 2020
    Novel DNA modifications underlying sex differences in fear-related learning and memory
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Shedding light on the dark matter of the genome: understanding the functional relevance of long non-coding RNAs in the brain and elucidating their role in fear-related anxiety disorders
    Brain and Behavior Research Foundation
    Open grant
  • 2017 - 2022
    Epitranscriptomic mechanisms of fear-related learning and memory (NIH Grant administered by University of California, Irvine)
    University of California, Irvine
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015 - 2017
    Transgenerational impacts of paternal stress on offspring mental health: Epigenetic mechanisms and therapeutic interventions (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2016
    Early development, microRNAs, dendritogenesis and cognition
    NHMRC Project Grant
    Open grant
  • 2014
    Touchscreen-automated cognitive testing for mice
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2019
    The Science of Learning Research Centre
    ARC Special Research Initiative for a Science of Learning Research Centre
    Open grant
  • 2013 - 2015
    MicroRNA regulation of fear-related memory
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Exploring DNA methylation as a mechanism for long-term memory for fear extinction
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Exploring the role of the 6th base: how the Tet family of proteins, DNA hydroxymethylation, and active DNA demethylation contribute to fear-related memory.
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2011 - 2012
    Mass spectrometry platform for high throughput genotyping, epigenetic analysis and validation of genome wide sequencing studies
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011
    Advanced behavioural facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Exploring the role of RNA editing in synaptic plasticity and higher order cognition
    UQ Early Career Researcher
    Open grant
  • 2011 - 2013
    The long term consequences of toluene exposure on the maturing brain (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2010 - 2014
    Epigenetic mechanisms regulating sex differences in fear-related learning and memory
    ARC Discovery Projects
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Timothy Bredy is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Exploring the role of chromatin associated RNAs and trans splicing in learning and memory

    Principal Advisor

    Other advisors: Dr Qiongyi Zhao

  • Doctor Philosophy

    Halo-seq to understand the role of subcompartment specific RNA expression in learning and mermory.

    Principal Advisor

  • Doctor Philosophy

    Exploring the role of vaults and vault associated small noncoding RNAs in learning and memory

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Explore extrachromosomal circular DNA in the brain and in fear-related learning and memory

    Principal Advisor

Completed supervision

Enquiries

Contact Professor Timothy Bredy directly for media enquiries about:

  • Emotion
  • Memory
  • Neuroscience
  • RNA Biology
  • RNA therapys

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