Professor Timothy Bredy
Professor

Timothy Bredy

Email: 
Phone: 
+61 7 344 33005

Background

Research in the Bredy laboratory is aimed at elucidating how the genome is connected to the environment through epigenetic modifications, and how this relationship shapes brain and behaviour throughout life. The group is particularly interested in how epigenetic mechanisms, including DNA methylation, histone modifications. the activity of non-coding RNAs, and RNA modification regulate the formation and maintenance of associative fear-related memory.

Availability

Professor Timothy Bredy is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cellular nervous system Central nervous system Cognitive and computational psychology Gene and molecular therapy Genetics Medical biotechnology Neurogenetics Neurosciences Psychology

Qualifications

  • Doctor of Philosophy of Neurological Sciences, McGill University

Research interests

  • RNA biology

  • Memory

Search Professor Timothy Bredy’s works on UQ eSpace

86 works between 2004 and 2025
All (86) Journal Article (74) Book Chapter (2) Conference Publication (9) Book (1)

41 - 60 of 86 works

2017

Book Chapter

What does the future hold for the study of nucleic acid modifications in the brain?

Marshall, P. R. and Bredy, T. W. (2017). What does the future hold for the study of nucleic acid modifications in the brain?. DNA modifications in the brain: Neuroepigenetic Regulation of Gene Expression. (pp. 149-159) edited by Timothy W. Bredy. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-801596-4.00009-5

What does the future hold for the study of nucleic acid modifications in the brain?

2016

Journal Article

Evolving insights into RNA modifications and their functional diversity in the brain

Nainar, Sarah, Marshall, Paul R., Tyler, Christina R., Spitale, Robert C. and Bredy, Timothy W. (2016). Evolving insights into RNA modifications and their functional diversity in the brain. Nature Neuroscience, 19 (10), 1292-1298. doi: 10.1038/nn.4378

Evolving insights into RNA modifications and their functional diversity in the brain

2016

Journal Article

Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB/c mice: the role of cortical BDNF, microRNA-212, and MeCP2

Viola, Thiago Wendt, Wearick-Silva, Luis Eduardo, De Azeredo, Lucas Araujo, Centeno-Silva, Anderson, Murphy, Conor, Marshall, Paul, Li, Xiang, Singewald, Nicolas, Garcia, Frederico, Bredy, Timothy W. and Grassi-Oliveira, Rodrigo (2016). Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB/c mice: the role of cortical BDNF, microRNA-212, and MeCP2. Psychopharmacology, 233 (17), 3279-3288. doi: 10.1007/s00213-016-4373-z

Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB/c mice: the role of cortical BDNF, microRNA-212, and MeCP2

2016

Journal Article

Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?

Marshall, Paul and Bredy, Timothy W. (2016). Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?. n p j Science of Learning, 1 (1) 16014, 16014. doi: 10.1038/npjscilearn.2016.14

Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?

2016

Journal Article

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016). Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience, 36 (25), 6771-6777. doi: 10.1523/JNEUROSCI.4053-15.2016

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

2016

Journal Article

Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex

Fenton, Georgina E., Halliday, David M., Mason, Rob, Bredy, Timothy W. and Stevenson, Carl W. (2016). Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex. Neurobiology of Learning and Memory, 135, 66-72. doi: 10.1016/j.nlm.2016.06.019

Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex

2016

Journal Article

The role of active DNA demethylation and Tet enzyme function in memory formation and cocaine action

Alaghband, Yasaman, Bredy, Timothy W. and Wood, Marcelo A. (2016). The role of active DNA demethylation and Tet enzyme function in memory formation and cocaine action. Neuroscience Letters, 625, 40-46. doi: 10.1016/j.neulet.2016.01.023

The role of active DNA demethylation and Tet enzyme function in memory formation and cocaine action

2016

Journal Article

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

Short, A. K., Fennell, K. A., Perreau, V. M., Fox, A., O'Bryan, M. K., Kim, J. H., Bredy, T. W., Pang, T. Y. and Hannan, A. J. (2016). Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring. Translational Psychiatry, 6 (6) e837, e837-e837. doi: 10.1038/tp.2016.109

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

2015

Journal Article

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Bjorge, Monica D., Hildrestrand, Gunn A., Scheffler, Katja, Suganthan, Rajikala, Rolseth, Veslemoy, Kusnierczyk, Anna, Rowe, Alexander D., Vagbo, Cathrine B., Vetlesen, Susanne, Eide, Lars, Slupphaug, Geir, Nakabeppu, Yusaku, Bredy, Timothy W., Klungland, Arne and Bjoras, Magnar (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell Reports, 13 (12), 2671-2678. doi: 10.1016/j.celrep.2015.12.001

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

2015

Journal Article

Persistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice

Baker-Andresen, Danay, Zhao, Qiongyi, Li, Xiang, Jupp, Bianca, Chesworth, Rose, Lawrence, Andrew J. and Bredy, Timothy (2015). Persistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice. Neuroepigenetics, 4, 1-11. doi: 10.1016/j.nepig.2015.10.001

Persistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice

2015

Conference Publication

Transcriptional and epigenetic factors underlying the extinction of nicotine-seeking behaviour in the rat

Castino, M., Youngson, N., Baker-Andresen, D., Ratnu, V., Bredy, T. and Clemens, K. (2015). Transcriptional and epigenetic factors underlying the extinction of nicotine-seeking behaviour in the rat. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Transcriptional and epigenetic factors underlying the extinction of nicotine-seeking behaviour in the rat

2015

Journal Article

Extended Cocaine Access Results in a Distinct Epigenetic Alterations to the Homer2 Gene in the Dorsal Medial Prefrontal Cortex

Ploense, Kyle, Carr, Amanda, Baker‐Andresen, Danay, Li, Xiang, Sun, Yi, Bredy, Timothy and Kippin, Tod (2015). Extended Cocaine Access Results in a Distinct Epigenetic Alterations to the Homer2 Gene in the Dorsal Medial Prefrontal Cortex. The FASEB Journal, 29 (S1). doi: 10.1096/fasebj.29.1_supplement.705.11

Extended Cocaine Access Results in a Distinct Epigenetic Alterations to the Homer2 Gene in the Dorsal Medial Prefrontal Cortex

2015

Conference Publication

Epitranscriptomic mechanisms of memory stability

Bredy, T., Widagdo, J. and Zhao, Q.-Y. (2015). Epitranscriptomic mechanisms of memory stability. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185

Epitranscriptomic mechanisms of memory stability

2015

Journal Article

Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice

Spadaro, Paola A., Flavell, Charlotte R., Widagdo, Jocelyn, Ratnu, Vikram S., Troup, Michael, Ragan, Chikako, Mattick, John S. and Bredy, Timothy W. (2015). Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice. Biological Psychiatry, 78 (12), 848-859. doi: 10.1016/j.biopsych.2015.02.004

Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice

2015

Conference Publication

Activity-dependent RNA methylation in learning and memory

Widagdo, J., Zhao, Q. -Y., Anggono, V. and Bredy, T. (2015). Activity-dependent RNA methylation in learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Activity-dependent RNA methylation in learning and memory

2015

Conference Publication

Enhancing TRK mediated trophic signalling to augment cognitive processes

Camara, M. Iou, Matusica, D., Qian, L., Bredy, T., Nykjaer, A. and Coulson, E. (2015). Enhancing TRK mediated trophic signalling to augment cognitive processes. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13189

Enhancing TRK mediated trophic signalling to augment cognitive processes

2015

Conference Publication

Exploring the role of histone demethylase, UTX, in mediating sex differences in fear-related learning and memory

Ratnu, V., Li, X., Emami, M., Zhao, Q. -Y. and Bredy, T. (2015). Exploring the role of histone demethylase, UTX, in mediating sex differences in fear-related learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Exploring the role of histone demethylase, UTX, in mediating sex differences in fear-related learning and memory

2015

Conference Publication

Dissociable roles of GADD45A/B in the rat perirhinal cortex and hippocampus for object memory: different forms of dna methylation?

Mitchnick, K., Wei, W., Creighton, S., Kalisch, B., Bredy, T. and Winters, B. (2015). Dissociable roles of GADD45A/B in the rat perirhinal cortex and hippocampus for object memory: different forms of dna methylation?. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Dissociable roles of GADD45A/B in the rat perirhinal cortex and hippocampus for object memory: different forms of dna methylation?

2014

Journal Article

Activation-induced cytidine deaminase regulates activity-dependent BDNF expression in post-mitotic cortical neurons

Ratnu, Vikram S., Wei, Wei and Bredy, Timothy W. (2014). Activation-induced cytidine deaminase regulates activity-dependent BDNF expression in post-mitotic cortical neurons. European Journal of Neuroscience, 40 (7), 3032-3039. doi: 10.1111/ejn.12678

Activation-induced cytidine deaminase regulates activity-dependent BDNF expression in post-mitotic cortical neurons

2014

Journal Article

Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation

Li, X., Baker-Andresen, D., Zhao, Q., Marshall, V. and Bredy, T. W. (2014). Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation. Genes, Brain and Behavior, 13 (7), 721-731. doi: 10.1111/gbb.12150

Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation

Current funding

  • 2024 - 2029
    RNA Mass Spectrometry Platform
    Monash University
    Open grant

Past funding

  • 2022 - 2024
    Discovering new molecular contributors to Prader-Willi syndrome
    Prader Willi Syndrome Research Grant
    Open grant
  • 2021 - 2024
    Dynamic DNA structure states and memory formation
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long noncoding RNA in space and time, and the regulation of fear extinction
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    RNA modifications in space and time: How do they govern fear extinction?
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2023
    Defining novel neuroepigenetic pathways that influence learning and memory
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Toward a deeper understanding of new DNA modifications in fear-related learning.
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Cell-type specific profiling of nascent RNA in the brain during learning
    ARC Discovery Projects
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2022
    Cracking the epigenetic code: understanding the mechanisms of memory associated with anxiety-related disorders and their treatment
    NHMRC Research Fellowship
    Open grant
  • 2018 - 2020
    Novel DNA modifications underlying sex differences in fear-related learning and memory
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Shedding light on the dark matter of the genome: understanding the functional relevance of long non-coding RNAs in the brain and elucidating their role in fear-related anxiety disorders
    Brain and Behavior Research Foundation
    Open grant
  • 2017 - 2022
    Epitranscriptomic mechanisms of fear-related learning and memory (NIH Grant administered by University of California, Irvine)
    University of California, Irvine
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015 - 2017
    Transgenerational impacts of paternal stress on offspring mental health: Epigenetic mechanisms and therapeutic interventions (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2016
    Early development, microRNAs, dendritogenesis and cognition
    NHMRC Project Grant
    Open grant
  • 2014
    Touchscreen-automated cognitive testing for mice
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2019
    The Science of Learning Research Centre
    ARC Special Research Initiative for a Science of Learning Research Centre
    Open grant
  • 2013 - 2015
    MicroRNA regulation of fear-related memory
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Exploring DNA methylation as a mechanism for long-term memory for fear extinction
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Exploring the role of the 6th base: how the Tet family of proteins, DNA hydroxymethylation, and active DNA demethylation contribute to fear-related memory.
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2011 - 2012
    Mass spectrometry platform for high throughput genotyping, epigenetic analysis and validation of genome wide sequencing studies
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011
    Advanced behavioural facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Exploring the role of RNA editing in synaptic plasticity and higher order cognition
    UQ Early Career Researcher
    Open grant
  • 2011 - 2013
    The long term consequences of toluene exposure on the maturing brain (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2010 - 2014
    Epigenetic mechanisms regulating sex differences in fear-related learning and memory
    ARC Discovery Projects
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Timothy Bredy is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Exploring the role of vaults and vault associated small noncoding RNAs in learning and memory

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Explore extrachromosomal circular DNA in the brain and in fear-related learning and memory

    Principal Advisor

  • Doctor Philosophy

    Exploring the role of chromatin associated RNAs and trans splicing in learning and memory

    Principal Advisor

    Other advisors: Dr Qiongyi Zhao

  • Doctor Philosophy

    Halo-seq to understand the role of subcompartment specific RNA expression in learning and mermory.

    Principal Advisor

Completed supervision

Enquiries

Contact Professor Timothy Bredy directly for media enquiries about:

  • Emotion
  • Memory
  • Neuroscience
  • RNA Biology
  • RNA therapys

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