Professor Timothy Bredy
Professor

Timothy Bredy

Email: 
Phone: 
+61 7 344 33005

Background

Research in the Bredy laboratory is aimed at elucidating how the genome is connected to the environment through epigenetic modifications, and how this relationship shapes brain and behaviour throughout life. The group is particularly interested in how epigenetic mechanisms, including DNA methylation, histone modifications. the activity of non-coding RNAs, and RNA modification regulate the formation and maintenance of associative fear-related memory.

Availability

Professor Timothy Bredy is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Cellular nervous system Central nervous system Cognitive and computational psychology Gene and molecular therapy Genetics Medical biotechnology Neurogenetics Neurosciences Psychology

Qualifications

  • Doctor of Philosophy of Neurological Sciences, McGill University

Research interests

  • RNA biology

  • Memory

Search Professor Timothy Bredy’s works on UQ eSpace

86 works between 2004 and 2025
All (86) Journal Article (74) Book Chapter (2) Conference Publication (9) Book (1)

81 - 86 of 86 works

2007

Journal Article

Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

Bredy, Timothy, Wu, Hao, Crego, Cortney, Zellhoefer, Jessica, Sun, Yi E. and Barad, Mark (2007). Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learning & Memory, 14 (4), 268-276. doi: 10.1101/lm.500907

Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

2007

Journal Article

Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus)

Bredy, Timothy W., Brown, Richard E. and Meaney, Michael J. (2007). Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus). European Journal of Neuroscience, 25 (2), 567-575. doi: 10.1111/j.1460-9568.2006.05266.x

Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus)

2007

Book Chapter

Developmental origins of neurobiological vulnerability for PTSD.

Bagot, Rose, Parent, Carine, Bredy, Timothy W., Zhang Tieyuan, Grattan, Alain and Meaney, Michael J. (2007). Developmental origins of neurobiological vulnerability for PTSD.. Understanding trauma : Integrating biological, clinical, and cultural perspectives. (pp. 98-117) edited by Laurence J. Kirmayer, Robert Lemelson and Mark Barad. Cambridge, England, U.K.: Cambridge University Press. doi: 10.1017/CBO9780511500008.009

Developmental origins of neurobiological vulnerability for PTSD.

2006

Journal Article

Behavioural epigenetics and psychiatric disorders

Bredy, Timothy (2006). Behavioural epigenetics and psychiatric disorders. Medical Hypotheses, 68 (2), 453-453. doi: 10.1016/j.mehy.2006.07.009

Behavioural epigenetics and psychiatric disorders

2006

Journal Article

Maternal programming of defensive responses through sustained effects on gene expression

Zhang, Tie-Yuan, Bagot, Rose, Parenta, Carine, Nesbitt, Cathy, Bredy, Timothy W., Caldji, Christian, Fish, Eric, Anisman, Hymie, Szyf, Moshe and Meaney, Michael J. (2006). Maternal programming of defensive responses through sustained effects on gene expression. Biological Psychology, 73 (1), 72-89. doi: 10.1016/j.biopsycho.2006.01.009

Maternal programming of defensive responses through sustained effects on gene expression

2004

Conference Publication

Epigenetic programming of stress responses through variations in maternal care

Fish, Eric W., Shahrokh, Dara, Bagot, Rose, Caldji, Christian, Bredy, Timothy W., Szyf, Moshe and Meaney, Michael J. (2004). Epigenetic programming of stress responses through variations in maternal care. Conference on Scientific Approaches to Youth Violence Prevention, New York, United States, 24-26 April 2004. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1330.011

Epigenetic programming of stress responses through variations in maternal care

Current funding

  • 2024 - 2029
    RNA Mass Spectrometry Platform
    Monash University
    Open grant

Past funding

  • 2022 - 2024
    Discovering new molecular contributors to Prader-Willi syndrome
    Prader Willi Syndrome Research Grant
    Open grant
  • 2021 - 2024
    Dynamic DNA structure states and memory formation
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long noncoding RNA in space and time, and the regulation of fear extinction
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    RNA modifications in space and time: How do they govern fear extinction?
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2023
    Defining novel neuroepigenetic pathways that influence learning and memory
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Toward a deeper understanding of new DNA modifications in fear-related learning.
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Cell-type specific profiling of nascent RNA in the brain during learning
    ARC Discovery Projects
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2022
    Cracking the epigenetic code: understanding the mechanisms of memory associated with anxiety-related disorders and their treatment
    NHMRC Research Fellowship
    Open grant
  • 2018 - 2020
    Novel DNA modifications underlying sex differences in fear-related learning and memory
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Shedding light on the dark matter of the genome: understanding the functional relevance of long non-coding RNAs in the brain and elucidating their role in fear-related anxiety disorders
    Brain and Behavior Research Foundation
    Open grant
  • 2017 - 2022
    Epitranscriptomic mechanisms of fear-related learning and memory (NIH Grant administered by University of California, Irvine)
    University of California, Irvine
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015 - 2017
    Transgenerational impacts of paternal stress on offspring mental health: Epigenetic mechanisms and therapeutic interventions (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2016
    Early development, microRNAs, dendritogenesis and cognition
    NHMRC Project Grant
    Open grant
  • 2014
    Touchscreen-automated cognitive testing for mice
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2019
    The Science of Learning Research Centre
    ARC Special Research Initiative for a Science of Learning Research Centre
    Open grant
  • 2013 - 2015
    MicroRNA regulation of fear-related memory
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Exploring DNA methylation as a mechanism for long-term memory for fear extinction
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Exploring the role of the 6th base: how the Tet family of proteins, DNA hydroxymethylation, and active DNA demethylation contribute to fear-related memory.
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2011 - 2012
    Mass spectrometry platform for high throughput genotyping, epigenetic analysis and validation of genome wide sequencing studies
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011
    Advanced behavioural facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Exploring the role of RNA editing in synaptic plasticity and higher order cognition
    UQ Early Career Researcher
    Open grant
  • 2011 - 2013
    The long term consequences of toluene exposure on the maturing brain (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2010 - 2014
    Epigenetic mechanisms regulating sex differences in fear-related learning and memory
    ARC Discovery Projects
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Timothy Bredy is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Exploring the role of chromatin associated RNAs and trans splicing in learning and memory

    Principal Advisor

    Other advisors: Dr Qiongyi Zhao

  • Doctor Philosophy

    Halo-seq to understand the role of subcompartment specific RNA expression in learning and mermory.

    Principal Advisor

  • Doctor Philosophy

    Exploring the role of vaults and vault associated small noncoding RNAs in learning and memory

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Elucidating the functional roles of m6dA in regulating the neuronal genome in response to learning

    Principal Advisor

  • Doctor Philosophy

    Explore extrachromosomal circular DNA in the brain and in fear-related learning and memory

    Principal Advisor

Completed supervision

Enquiries

Contact Professor Timothy Bredy directly for media enquiries about:

  • Emotion
  • Memory
  • Neuroscience
  • RNA Biology
  • RNA therapys

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