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Novel role of RNA methylation in neuronal homeostasis (2023-2026)

Abstract

This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise highthroughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mechanistic insights into the molecular processes that control neuronal homeostatic responses. This will elucidate how neural plasticity and network stability are maintained, a process that is critical for our understanding of sensory processing, learning and memory throughout life.

Experts

Dr Jocelyn Widagdo

Affiliate of Centre for RNA in Neuroscience
Centre for RNA in Neuroscience
Faculty of Health, Medicine and Behavioural Sciences
Senior Research Fellow
Queensland Brain Institute
Faculty of Health, Medicine and Behavioural Sciences
Jocelyn Widagdo
Jocelyn Widagdo