Dr Jocelyn Widagdo
Dr

Jocelyn Widagdo

Email: 
Phone: 
+61 7 334 66384

Background

Jocelyn Widagdo received her PhD in 2011 from the University of New South Wales. After a short period of postdoctoral training at the Johns Hopkins University in Baltimore, USA, Dr Widagdo returned to Australia in 2012 and joined the Queensland Brain Institute, the University of Queensland, where she is currently a Research Fellow at the Clem Jones Centre for Ageing Dementia Research. Her research aims to understand how the process of synaptic plasticity, learning and memory are underpinned by dynamic regulation of DNA, RNA and proteins, and consequently, how they contribute towards the pathophysiology of neurodegenerative diseases and neuropsychiatric disorders. Her works were published in journals such as The Proceedings of the National Academy of Sciences USA, Journal of Neuroscience, and Cell Reports, and have attracted more than 2000 citations. Dr Widagdo's research has been supported by the Australian Research Council (Discovery Early Career Researcher Fellowship, 2017; Discovery Project grant, 2023).

Availability

Dr Jocelyn Widagdo is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Neurosciences

Qualifications

  • Doctor of Philosophy, University of New South Wales

Research interests

  • Epigenetic regulation of learning and memory

  • Regulation of glutamate receptor trafficking in synaptic plasticity

Search Professor Jocelyn Widagdo’s works on UQ eSpace

37 works between 2010 and 2024
All (37) Journal Article (34) Conference Publication (3)

21 - 37 of 37 works

2017

Journal Article

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

Lin, Quan, Ponnusamy, Ravikumar, Widagdo, Jocelyn, Choi, Jung A., Ge, Weihong, Probst, Christine, Buckley, Tyler, Lou, Mimi, Bredy, Timothy W., Fanselow, Michael S., Ye, Keqiang and Sun, Yi E. (2017). MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proceedings from the National Academy of Sciences of the United States of America, 114 (34), 9188-9193. doi: 10.1073/pnas.1706069114

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

2017

Journal Article

GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Guntupalli, Sumasri, Jang, Se Eun, Zhu, Tianyi, Huganir, Richard L., Widagdo, Jocelyn and Anggono, Victor (2017). GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Journal of Biological Chemistry, 292 (20), 8186-8194. doi: 10.1074/jbc.M116.774554

GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

2017

Journal Article

The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons

Tan, Men C., Widagdo, Jocelyn, Chau, Yu Q., Zhu, Tianyi, Wong, Justin J.-L, Cheung, Allen and Anggono, Victor (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11 124, 124.1-124.12. doi: 10.3389/fncel.2017.00124

The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons

2017

Conference Publication

Activity-dependent RNA methylation in learning and memory

Widagdo, J. (2017). Activity-dependent RNA methylation in learning and memory. ISN-ESN 2017 Meeting, Paris, France, 20-24 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.14090

Activity-dependent RNA methylation in learning and memory

2016

Journal Article

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology, 23 (10), 921-932. doi: 10.1038/nsmb.3290

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

2016

Journal Article

PACSIN1 regulates the dynamics of AMPA receptor trafficking

Widagdo, Jocelyn, Fang, Huaqiang, Jang, Se Eun and Anggono, Victor (2016). PACSIN1 regulates the dynamics of AMPA receptor trafficking. Scientific Reports, 6 (31070) 31070, 1-9. doi: 10.1038/srep31070

PACSIN1 regulates the dynamics of AMPA receptor trafficking

2016

Journal Article

Amyloid-β-induced dysregulation of AMPA receptor trafficking

Guntupalli, Sumasri, Widagdo, Jocelyn and Anggono, Victor (2016). Amyloid-β-induced dysregulation of AMPA receptor trafficking. Neural Plasticity, 2016 3204519, 1-12. doi: 10.1155/2016/3204519

Amyloid-β-induced dysregulation of AMPA receptor trafficking

2015

Journal Article

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation

Carmona-Mora, Paulina, Widagdo, Jocelyn, Tomasetig, Florence, Canales, Cesar P, Cha, Yeojoon, Lee, Wei, Alshawaf, Abdullah, Dottori, Mirella, Whan, Renee M, Hardeman, Edna C and Palmer, Stephen J (2015). The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Human Genetics, 134 (10), 1099-1115. doi: 10.1007/s00439-015-1591-0

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation

2015

Journal Article

Ubiquitin signals the demise of AMPA receptors

Widagdo, Jocelyn and Anggono, Victor (2015). Ubiquitin signals the demise of AMPA receptors. Oncotarget, 6 (18), 15718-15719. doi: 10.18632/oncotarget.4645

Ubiquitin signals the demise of AMPA receptors

2015

Journal Article

Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice

Spadaro, Paola A., Flavell, Charlotte R., Widagdo, Jocelyn, Ratnu, Vikram S., Troup, Michael, Ragan, Chikako, Mattick, John S. and Bredy, Timothy W. (2015). Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice. Biological Psychiatry, 78 (12), 848-859. doi: 10.1016/j.biopsych.2015.02.004

Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice

2015

Conference Publication

Epitranscriptomic mechanisms of memory stability

Bredy, T., Widagdo, J. and Zhao, Q.-Y. (2015). Epitranscriptomic mechanisms of memory stability. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185

Epitranscriptomic mechanisms of memory stability

2015

Conference Publication

Activity-dependent RNA methylation in learning and memory

Widagdo, J., Zhao, Q. -Y., Anggono, V. and Bredy, T. (2015). Activity-dependent RNA methylation in learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Activity-dependent RNA methylation in learning and memory

2014

Journal Article

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

Li, Xiang, Wei, Wei, Zhao, Qiong-Yi, Widagdo, Jocelyn, Baker-Andresen, Danay, Flavell, Charlotte R., D'Alessio, Ana, Zhang, Yi and Bredy, Timothy W. (2014). Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation. Proceedings of the National Academy of Sciences, 111 (19), 7120-7125. doi: 10.1073/pnas.1318906111

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

2013

Journal Article

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

Anggono, Victor, Koc-Schmitz, Yeliz, Widagdo, Jocelyn, Kormann, Jan, Quan, Annie, Chen, Chih-Ming, Robinson, Phillip J., Choi, Se-Young, Linden, David J., Plomann, Markus and Huganir, Richard L. (2013). PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America, 110 (34), 13976-13981. doi: 10.1073/pnas.1312467110

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

2012

Journal Article

SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation

Widagdo, Jocelyn, Taylor, Kylie M., Gunning, Peter W., Hardeman, Edna C. and Palmer, Stephen J. (2012). SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation. PLoS One, 7 (11) e49283, e49283. doi: 10.1371/journal.pone.0049283

SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation

2012

Journal Article

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members

Palmer, Stephen J., Taylor, Kylie M., Santucci, Nicole, Widagdo, Jocelyn, Chan, Yee-Ka Agnes, Yeo, Jen-Li, Adams, Merritt, Gunning, Peter W. and Hardeman, Edna C. (2012). GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members. Journal of Cell Science, 125 (21), 5040-5050. doi: 10.1242/jcs.102798

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members

2010

Journal Article

Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism

Palmer, Stephen J., Santucci, Nicole, Widagdo, Jocelyn, Bontempo, Sara J., Taylor, Kylie M., Tay, Enoch S. E., Hook, Jeff, Lemckert, Frances, Gunning, Peter W. and Hardeman, Edna C. (2010). Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism. Journal of Biological Chemistry, 285 (7), 4715-4724. doi: 10.1074/jbc.M109.086660

Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism

Current funding

  • 2024 - 2025
    Characterisation of a de novo WDR26 rare genetic variant associated with neurodevelopmental disorders
    Australian Functional Genomics Network
    Open grant
  • 2023 - 2026
    Novel role of RNA methylation in neuronal homeostasis
    ARC Discovery Projects
    Open grant

Past funding

  • 2021 - 2022
    Molecular mechanisms underlying the cytoplasmic aggregation of the RNA binding protein, SFPQ, in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2019 - 2021
    Dr Jocelyn Widagdo - AQ WRAP
    Advance Queensland Women's Research Assistance Program
    Open grant
  • 2019 - 2020
    UQ AWARE - Dr Jocelyn Widagdo
    UQ Amplify Women's Academic Research Equity
    Open grant
  • 2018
    To atttend the 48th Annual Meeting of the Society for Neuroscience (SFN), 3-7 November 2018
    The Cass Foundation Limited
    Open grant
  • 2018
    The epitranscripttomic landscape in ageing and dementia
    UQ Early Career Researcher
    Open grant
  • 2017 - 2020
    Epitranscriptomic regulation of learning and memory
    ARC Discovery Early Career Researcher Award
    Open grant

Availability

Dr Jocelyn Widagdo is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Novel role of RNA methylation in neuronal homeostasis

Supervision history

Current supervision

Completed supervision

Enquiries

For media enquiries about Dr Jocelyn Widagdo's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au