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Professor Bruno van Swinderen
Professor

Bruno van Swinderen

Email: 
Phone: 
+61 7 334 66332

Overview

Background

Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.

Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.

Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.

Availability

Professor Bruno van Swinderen is:
Available for supervision
Media expert

Fields of research

Qualifications

  • Doctor of Philosophy, Washington University in St Louis

Research interests

  • Attention and memory

    Behavioral choices result from an ongoing interplay between attention and memory. We have developed paradigms to study visual attention and memory in Drosophila, thereby allowing us to investigate this complex problem in a powerful genetic model. Two levels of investigation are involved: behavior and brain electrophysiology. Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. Our goal is to identify mechanisms of visual attention, and to elucidate how these processes interact with memory systems.

  • Anesthesia and sleep

    We all sleep, and many of us require anesthesia during surgery at some point in our lives. However, the function of sleep is unclear, and the mechanism of general anesthesia remains mysterious. Our insight into brain processes modulating visual perception in Drosophila is applied at an electrophysiological level towards understanding sleep and general anesthesia, when perception is lost. We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology.

Works

Search Professor Bruno van Swinderen’s works on UQ eSpace

137 works between 1995 and 2025

21 - 40 of 137 works

2020

Journal Article

Oscillations in the central brain of Drosophila are phase locked to attended visual features

Grabowska, Martyna J., Jeans, Rhiannon, Steeves, James and Van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. Proceedings of the National Academy of Sciences of the United States of America, 117 (47), 29925-29936. doi: 10.1073/pnas.2010749117

Oscillations in the central brain of Drosophila are phase locked to attended visual features

2020

Journal Article

Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila

Karunanithi, Shanker, Lin, Yong Qi, Odierna, G. Lorenzo, Menon, Hareesh, Gonzalez, Juan Mena, Neely, G Gregory, Noakes, Peter G., Lavidis, Nickolas A., Moorhouse, Andrew J. and van Swinderen, Bruno (2020). Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila. The Journal of Neuroscience, 40 (42), 8025-8041. doi: 10.1523/JNEUROSCI.0349-20.2020

Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila

2020

Journal Article

Turning to Drosophila for help in resolving general anesthesia

van Swinderen, Bruno and Hines, Adam D. (2020). Turning to Drosophila for help in resolving general anesthesia. Proceedings of the National Academy of Sciences, 117 (40), 24627-24628. doi: 10.1073/pnas.2012131117

Turning to Drosophila for help in resolving general anesthesia

2020

Journal Article

Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila

Ertekin, Deniz, Kirszenblat, Leonie, Faville, Richard and van Swinderen, Bruno (2020). Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila. PLOS Biology, 18 (8) 3000548, e3000548. doi: 10.1371/journal.pbio.3000548

Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila

2020

Journal Article

General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila

Muñoz, Roberto N., Leung, Angus, Zecevik, Aidan, Pollock, Felix A., Cohen, Dror, Van Swinderen, Bruno, Tsuchiya, Naotsugu and Modi, Kavan (2020). General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila. Physical Review Research, 2 (2) 023219. doi: 10.1103/PhysRevResearch.2.023219

General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila

2020

Journal Article

Proportional downscaling of glutamatergic release sites by the general anesthetic propofol at Drosophila motor nerve terminals

Karunanithi, Shanker, Cylinder, Drew, Ertekin, Deniz, Zalucki, Oressia H., Marin, Leo, Lavidis, Nickolas A., Atwood, Harold L. and van Swinderen, Bruno (2020). Proportional downscaling of glutamatergic release sites by the general anesthetic propofol at Drosophila motor nerve terminals. eNeuro, 7 (1) ENEURO.0422-19.2020, ENEURO.0422-14. doi: 10.1523/eneuro.0422-19.2020

Proportional downscaling of glutamatergic release sites by the general anesthetic propofol at Drosophila motor nerve terminals

2020

Journal Article

Sleep restores place learning to the adenylyl cyclase mutant rutabaga

Dissel, Stephane, Morgan, Ellen, Duong, Vincent, Chan, Dorothy, van Swinderen, Bruno, Shaw, Paul and Zars, Troy (2020). Sleep restores place learning to the adenylyl cyclase mutant rutabaga. Journal of Neurogenetics, 34 (1), 83-91. doi: 10.1080/01677063.2020.1720674

Sleep restores place learning to the adenylyl cyclase mutant rutabaga

2020

Journal Article

Perceptual rivalry across animal species

Carter, Olivia, van Swinderen, Bruno, Leopold, David A., Collin, Shaun P. and Maier, Alexander (2020). Perceptual rivalry across animal species. Journal of Comparative Neurology, 528 (17) cne.24939, 3123-3133. doi: 10.1002/cne.24939

Perceptual rivalry across animal species

2020

Other Outputs

Oscillations in the central brain of Drosophila are phase locked to attended visual features

Grabowska, Martyna and van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. The University of Queensland. (Dataset) doi: 10.14264/43fb51f

Oscillations in the central brain of Drosophila are phase locked to attended visual features

2019

Journal Article

Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster

Troup, Michael, Zalucki, Oressia H., Kottler, Benjamin D., Karunanithi, Shanker, Anggono, Victor and van Swinderen, Bruno (2019). Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster. Anesthesiology, 131 (3), 555-568. doi: 10.1097/ALN.0000000000002850

Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster

2019

Journal Article

Visual experience drives sleep need in Drosophila

Kirszenblat, Leonie, Yaun, Rebecca and van Swinderen, Bruno (2019). Visual experience drives sleep need in Drosophila. Sleep, 42 (7) zsz102. doi: 10.1093/sleep/zsz102

Visual experience drives sleep need in Drosophila

2019

Other Outputs

Drosophila Sleep Multichannel

van Swinderen, Bruno (2019). Drosophila Sleep Multichannel. The University of Queensland. (Dataset) doi: 10.48610/6b03a7c

Drosophila Sleep Multichannel

2019

Book Chapter

Sleep in Drosophila

Kirszenblat, Leonie and van Swinderen, Bruno (2019). Sleep in Drosophila. Handbook of Sleep Research. (pp. 333-347) edited by Hans C. Dringenberg. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-813743-7.00022-0

Sleep in Drosophila

2018

Journal Article

Innate visual preferences and behavioral flexibility in Drosophila

Grabowska, Martyna J., Steeves, James, Alpay, Julius, van de Poll, Matthew, Ertekin, Deniz and van Swinderen, Bruno (2018). Innate visual preferences and behavioral flexibility in Drosophila. The Journal of Experimental Biology, 221 (23) jeb185918, jeb185918. doi: 10.1242/jeb.185918

Innate visual preferences and behavioral flexibility in Drosophila

2018

Journal Article

Sleep regulates visual selective attention in Drosophila

Kirszenblat, Leonie, Ertekin, Deniz, Goodsell, Joseph, Zhou, Yanqiong, Shaw, Paul J. and van Swinderen, Bruno (2018). Sleep regulates visual selective attention in Drosophila. The Journal of Experimental Biology, 221 (24) jeb191429, jeb.191429. doi: 10.1242/jeb.191429

Sleep regulates visual selective attention in Drosophila

2018

Journal Article

Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness

Troup, Michael, Yap, Melvyn H. W., Rohrscheib, Chelsie, Grabowska, Martyna J, Ertekin, Deniz, Randeniya, Roshini, Kottler, Benjamin, Larkin, Oife, Munro, Kelly, Shaw, Paul J and van Swinderen, Bruno (2018). Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness. eLife, 7 e37105. doi: 10.7554/eLife.37105

Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness

2018

Journal Article

In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal

Bademosi, Adekunle T., Lauwers, Elsa, Amor, Rumelo, Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2018). In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal. Journal of Visualized Experiments, 2018 (131) e56952. doi: 10.3791/56952

In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal

2018

Journal Article

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

2018

Book Chapter

Using Drosophila to understand general anesthesia: from synapses to behavior

Karunanithi, Shanker, Troup, Michael and van Swinderen, Bruno (2018). Using Drosophila to understand general anesthesia: from synapses to behavior. Chemical and biochemical approaches for the study of anesthetic function, Part A. (pp. 153-176) edited by Roderick G. Eckenhoff and Ivan J. Dmochowski. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.mie.2018.02.003

Using Drosophila to understand general anesthesia: from synapses to behavior

2018

Journal Article

Isoflurane impairs low-frequency feedback but leaves high-frequency feedforward connectivity intact in the fly brain

Cohen, Dror, van Swinderen, Bruno and Tsuchiya, Naotsugu (2018). Isoflurane impairs low-frequency feedback but leaves high-frequency feedforward connectivity intact in the fly brain. eNeuro, 5 (1) e0329-17.2018, ENEURO.0329-17.2018. doi: 10.1523/ENEURO.0329-17.2018

Isoflurane impairs low-frequency feedback but leaves high-frequency feedforward connectivity intact in the fly brain

Funding

Current funding

  • 2025 - 2028
    Tracking mistakes in the fly brain: understanding consciousness from the bottom up
    Open grant
  • 2025 - 2026
    Human brain organoid models to investigate anaesthesia induction and reversal agents
    Australian and New Zealand College of Anaesthestists
    Open grant
  • 2025 - 2028
    Time to wake up! Reversing a presynaptic anaesthetic mechanism
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2026
    Quiet sleep is for repair, active sleep is for learning
    ARC Discovery Projects
    Open grant

Past funding

  • 2024
    Investigating a working anaesthesia reversal agent
    Australian and New Zealand College of Anaesthestists
    Open grant
  • 2023 - 2024
    Discovering anaesthesia recovery treatments (DART): A super-resolution microscopy approach to uncovering reversal agents
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2021 - 2024
    A role for sleep in optimising attention
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    ActiveAI - active learning and selective attention for robust, transparent and efficient AI (EPSRC International Centre-to-Centre Research Collaborations application submitted by University of Sussex)
    University of Sussex
    Open grant
  • 2019 - 2022
    Bridging the gap between electrical and molecular sleep functions in the brain
    NHMRC Project Grant
    Open grant
  • 2019 - 2024
    Presynaptic control of general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Closing the loop between salience and brain activity (ARC Discovery Project administered by Flinders University)
    Flinders University
    Open grant
  • 2018
    A multifunctional platform for monitoring and manipulating neural activities with freely behaving small animals
    NHMRC Equipment Grant
    Open grant
  • 2018 - 2020
    Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    4-Dimensional multi-photon microscopy for understanding neural circuits and behaviour
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    How the dosage of a Down syndrome candidate gene affects neural circuitry and behaviour
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Molecular mechanisms underlying recovery from general anaesthesia
    NHMRC Project Grant
    Open grant
  • 2016 - 2018
    Sleep and wakefulness in the fly brain
    UQ Fellowships
    Open grant
  • 2014 - 2017
    Discovering deep sleep genes and determining their roles for preserving cognitive functions
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Dopaminergic mechanisms of visual selective attention in the fly
    ARC Discovery Projects
    Open grant
  • 2014
    Two-photon microscopy for live and fixed imaging in model organisms and thick tissue
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    A virtual environment for the study of multisensory learning, adaptation and control
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    An automated liquid handling platform for High-throughput Preparation of multiplexed targeted sequence capture DNA libraries for Next-Generation DNA Sequencing (NGS)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Neurexin and Neuroligin: A Code for Synaptic Development
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Perceptual suppression mechanisms in the Drosophila brain
    ARC Future Fellowships
    Open grant
  • 2010
    Next-generation DNA sequencer to accelerate discovery in molecular and cellular research programs at QBI
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Presynaptic mechanisms of general anaesthesia in the fly brain
    ARC Discovery Projects
    Open grant
  • 2008
    Behavioural Facility for Genetically Modified Insects
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Professor Bruno van Swinderen is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Professor Bruno van Swinderen directly for media enquiries about:

  • Anaesthesia
  • Attention - selective
  • Behaviour genetics
  • Caenorhabditis elegans
  • Drosophila melanogaster
  • Evolution
  • Genetics - behavious
  • Memory - selective
  • Model organisms
  • Selective attention and memory
  • Sleep

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