
Overview
Background
Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.
Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.
Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.
Availability
- Professor Bruno van Swinderen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Washington University in St Louis
Research interests
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Attention and memory
Behavioral choices result from an ongoing interplay between attention and memory. We have developed paradigms to study visual attention and memory in Drosophila, thereby allowing us to investigate this complex problem in a powerful genetic model. Two levels of investigation are involved: behavior and brain electrophysiology. Behavioral screening methods allow us to determine visual responsiveness levels resulting from gene mutations or drug treatments, and electrophysiology in individual flies identifies brain processes affected by our manipulations. Our goal is to identify mechanisms of visual attention, and to elucidate how these processes interact with memory systems.
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Anesthesia and sleep
We all sleep, and many of us require anesthesia during surgery at some point in our lives. However, the function of sleep is unclear, and the mechanism of general anesthesia remains mysterious. Our insight into brain processes modulating visual perception in Drosophila is applied at an electrophysiological level towards understanding sleep and general anesthesia, when perception is lost. We approach this problem by targeting candidate molecular systems at the level of molecular lesions and pharmacology.
Works
Search Professor Bruno van Swinderen’s works on UQ eSpace
2020
Journal Article
Oscillations in the central brain of Drosophila are phase locked to attended visual features
Grabowska, Martyna J., Jeans, Rhiannon, Steeves, James and Van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. Proceedings of the National Academy of Sciences of the United States of America, 117 (47), 29925-29936. doi: 10.1073/pnas.2010749117
2020
Journal Article
Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila
Karunanithi, Shanker, Lin, Yong Qi, Odierna, G. Lorenzo, Menon, Hareesh, Gonzalez, Juan Mena, Neely, G Gregory, Noakes, Peter G., Lavidis, Nickolas A., Moorhouse, Andrew J. and van Swinderen, Bruno (2020). Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila. The Journal of Neuroscience, 40 (42), 8025-8041. doi: 10.1523/JNEUROSCI.0349-20.2020
2020
Journal Article
Turning to Drosophila for help in resolving general anesthesia
van Swinderen, Bruno and Hines, Adam D. (2020). Turning to Drosophila for help in resolving general anesthesia. Proceedings of the National Academy of Sciences, 117 (40), 24627-24628. doi: 10.1073/pnas.2012131117
2020
Journal Article
Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila
Ertekin, Deniz, Kirszenblat, Leonie, Faville, Richard and van Swinderen, Bruno (2020). Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila. PLOS Biology, 18 (8) 3000548, e3000548. doi: 10.1371/journal.pbio.3000548
2020
Journal Article
General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila
Muñoz, Roberto N., Leung, Angus, Zecevik, Aidan, Pollock, Felix A., Cohen, Dror, Van Swinderen, Bruno, Tsuchiya, Naotsugu and Modi, Kavan (2020). General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila. Physical Review Research, 2 (2) 023219. doi: 10.1103/PhysRevResearch.2.023219
2020
Journal Article
Proportional downscaling of glutamatergic release sites by the general anesthetic propofol at Drosophila motor nerve terminals
Karunanithi, Shanker, Cylinder, Drew, Ertekin, Deniz, Zalucki, Oressia H., Marin, Leo, Lavidis, Nickolas A., Atwood, Harold L. and van Swinderen, Bruno (2020). Proportional downscaling of glutamatergic release sites by the general anesthetic propofol at Drosophila motor nerve terminals. eNeuro, 7 (1) ENEURO.0422-19.2020, ENEURO.0422-14. doi: 10.1523/eneuro.0422-19.2020
2020
Journal Article
Sleep restores place learning to the adenylyl cyclase mutant rutabaga
Dissel, Stephane, Morgan, Ellen, Duong, Vincent, Chan, Dorothy, van Swinderen, Bruno, Shaw, Paul and Zars, Troy (2020). Sleep restores place learning to the adenylyl cyclase mutant rutabaga. Journal of Neurogenetics, 34 (1), 83-91. doi: 10.1080/01677063.2020.1720674
2020
Journal Article
Perceptual rivalry across animal species
Carter, Olivia, van Swinderen, Bruno, Leopold, David A., Collin, Shaun P. and Maier, Alexander (2020). Perceptual rivalry across animal species. Journal of Comparative Neurology, 528 (17) cne.24939, 3123-3133. doi: 10.1002/cne.24939
2020
Other Outputs
Oscillations in the central brain of Drosophila are phase locked to attended visual features
Grabowska, Martyna and van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. The University of Queensland. (Dataset) doi: 10.14264/43fb51f
2019
Journal Article
Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster
Troup, Michael, Zalucki, Oressia H., Kottler, Benjamin D., Karunanithi, Shanker, Anggono, Victor and van Swinderen, Bruno (2019). Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster. Anesthesiology, 131 (3), 555-568. doi: 10.1097/ALN.0000000000002850
2019
Journal Article
Visual experience drives sleep need in Drosophila
Kirszenblat, Leonie, Yaun, Rebecca and van Swinderen, Bruno (2019). Visual experience drives sleep need in Drosophila. Sleep, 42 (7) zsz102. doi: 10.1093/sleep/zsz102
2019
Other Outputs
Drosophila Sleep Multichannel
van Swinderen, Bruno (2019). Drosophila Sleep Multichannel. The University of Queensland. (Dataset) doi: 10.48610/6b03a7c
2019
Book Chapter
Sleep in Drosophila
Kirszenblat, Leonie and van Swinderen, Bruno (2019). Sleep in Drosophila. Handbook of Sleep Research. (pp. 333-347) edited by Hans C. Dringenberg. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-813743-7.00022-0
2018
Journal Article
Innate visual preferences and behavioral flexibility in Drosophila
Grabowska, Martyna J., Steeves, James, Alpay, Julius, van de Poll, Matthew, Ertekin, Deniz and van Swinderen, Bruno (2018). Innate visual preferences and behavioral flexibility in Drosophila. The Journal of Experimental Biology, 221 (23) jeb185918, jeb185918. doi: 10.1242/jeb.185918
2018
Journal Article
Sleep regulates visual selective attention in Drosophila
Kirszenblat, Leonie, Ertekin, Deniz, Goodsell, Joseph, Zhou, Yanqiong, Shaw, Paul J. and van Swinderen, Bruno (2018). Sleep regulates visual selective attention in Drosophila. The Journal of Experimental Biology, 221 (24) jeb191429, jeb.191429. doi: 10.1242/jeb.191429
2018
Journal Article
Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness
Troup, Michael, Yap, Melvyn H. W., Rohrscheib, Chelsie, Grabowska, Martyna J, Ertekin, Deniz, Randeniya, Roshini, Kottler, Benjamin, Larkin, Oife, Munro, Kelly, Shaw, Paul J and van Swinderen, Bruno (2018). Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness. eLife, 7 e37105. doi: 10.7554/eLife.37105
2018
Journal Article
In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal
Bademosi, Adekunle T., Lauwers, Elsa, Amor, Rumelo, Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2018). In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal. Journal of Visualized Experiments, 2018 (131) e56952. doi: 10.3791/56952
2018
Journal Article
Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054
2018
Book Chapter
Using Drosophila to understand general anesthesia: from synapses to behavior
Karunanithi, Shanker, Troup, Michael and van Swinderen, Bruno (2018). Using Drosophila to understand general anesthesia: from synapses to behavior. Chemical and biochemical approaches for the study of anesthetic function, Part A. (pp. 153-176) edited by Roderick G. Eckenhoff and Ivan J. Dmochowski. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.mie.2018.02.003
2018
Journal Article
Isoflurane impairs low-frequency feedback but leaves high-frequency feedforward connectivity intact in the fly brain
Cohen, Dror, van Swinderen, Bruno and Tsuchiya, Naotsugu (2018). Isoflurane impairs low-frequency feedback but leaves high-frequency feedforward connectivity intact in the fly brain. eNeuro, 5 (1) e0329-17.2018, ENEURO.0329-17.2018. doi: 10.1523/ENEURO.0329-17.2018
Funding
Current funding
Supervision
Availability
- Professor Bruno van Swinderen is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Consciousness and Unconsciousness in Brain Organoids
Associate Advisor
Other advisors: Professor Andre Van Zundert, Dr Selin Pars, Professor Ernst Wolvetang
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Doctor Philosophy
Consciousness and Unconsciousness in Brain Organoids
Associate Advisor
Other advisors: Professor Andre Van Zundert, Dr Selin Pars, Professor Ernst Wolvetang
Completed supervision
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2024
Doctor Philosophy
Electrophysiological correlates of predictive processing in the fly brain and their modulation during sleep
Principal Advisor
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2024
Doctor Philosophy
Investigation of circuit level mechanisms of propofol anaesthesia in C. elegans
Principal Advisor
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2023
Doctor Philosophy
A target mechanism for general anaesthesia in the presynaptic release machinery
Principal Advisor
Other advisors: Associate Professor Victor Anggono, Dr Adekunle Bademosi
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2021
Doctor Philosophy
Measures of functional brain connectivity during sleep and general anaesthesia in Drosophila
Principal Advisor
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2020
Doctor Philosophy
The effects of diet on sleep and visual selective attention in Drosophila melanogaster
Principal Advisor
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2019
Master Philosophy
The effects of the general anaesthetic propofol on Drosophila larvae
Principal Advisor
Other advisors: Associate Professor Victor Anggono
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2018
Doctor Philosophy
Mechanisms of Sleep and General Anaesthesia in Drosophila melanogaster: The Unresponsive Brain
Principal Advisor
Other advisors: Associate Professor Sean Millard
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2017
Doctor Philosophy
Electrophysiological Analyses of Sleep States in Drosophila
Principal Advisor
Other advisors: Associate Professor Martin Sale
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2016
Doctor Philosophy
Visual Attention and Sleep Homeostasis in Drosophila
Principal Advisor
Other advisors: Professor Massimo Hilliard, Associate Professor Sean Millard
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2015
Doctor Philosophy
Presynaptic mechanisms of general anaesthesia in Drosophila melanogaster
Principal Advisor
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2021
Doctor Philosophy
Analysing the role of candidate neurological disease genes at synapses in Drosophila
Associate Advisor
Other advisors: Associate Professor Sean Millard
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2020
Doctor Philosophy
Experimental analysis of complex insect flight behaviours inside virtual reality for potential applications in robotics
Associate Advisor
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2018
Doctor Philosophy
Control of neurotransmission by diffusional properties of a presynaptic plasma membrane protein - syntaxin1A
Associate Advisor
Other advisors: Professor Frederic Meunier
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2018
Doctor Philosophy
The influence of selective attention on modal completion in the human visual system
Associate Advisor
Other advisors: Professor Jason Mattingley
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2016
Doctor Philosophy
Analysing visual behaviour in Drosophila Dscam2 mutants using optimised optomotor and operant control assays
Associate Advisor
Other advisors: Associate Professor Sean Millard
Media
Enquiries
Contact Professor Bruno van Swinderen directly for media enquiries about:
- Anaesthesia
- Attention - selective
- Behaviour genetics
- Caenorhabditis elegans
- Drosophila melanogaster
- Evolution
- Genetics - behavious
- Memory - selective
- Model organisms
- Selective attention and memory
- Sleep
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