Associate Professor Mark Bellingham
Associate Professor

Mark Bellingham

Email: 
Phone: 
+61 7 336 53122

Background

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones.

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice and in vivo preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Projects include :

  • Neurobiology of motor control
  • Motor neuron disease
  • Synaptic transmission in the cochlear nucleus
  • Potassium currents in the brainstem and cerebellum
  • Rhythmic control of breathing movements

Availability

Associate Professor Mark Bellingham is:
Available for supervision

Fields of research

Neurosciences Pharmacology and pharmaceutical sciences Veterinary sciences

Research interests

  • Synaptic transmission in the cochlear nucleus:

    <li>Electrophysiology of postsynaptic AMPA and NMDA receptors and their developmental regulation <li>Single cell RT-PCR with Drs. Joanne Lewohl and Peter Dodd (Biochemistry, UQ) to determine AMPA and NMDA receptor subunits <li>Developmental changes in and mechanisms of short term synaptic plasticity <li>Calcium imaging in single presynaptic terminals

  • Potassium currents in the brainstem and cerebellum:

    <li>Muscarinic receptor regulation of potassium channels in hypoglossal motor neurones - neuropharmacology and second messenger systems <li>Role of potassium channels in causing cerebellar ataxia in ATM protein knock-out mice (with Dr. Martin Lavin, QIMR) <li>Role of potassium channels in regulating transmitter release from presynaptic terminals contacting hypoglossal motor neurones

  • Rhythmic control of breathing movements:

    <li>Muscarinic responses of hypoglossal motor neurones and rhythm-generating network for breathing movements - may be involved in sleep apnoea and SIDS. <li>Role of ATP receptors in rhythmic breathing movements in normal and transgenic knockout mice (with Dr. Peter Noakes) <li>Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Search Professor Mark Bellingham’s works on UQ eSpace

124 works between 1988 and 2024
All (124) Journal Article (83) Book Chapter (4) Conference Publication (36) Other Outputs (1)

1 - 20 of 124 works

2024

Journal Article

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

Cheung, Sang Won, Willis, Emily F., Simmons, David G., Bellingham, Mark C. and Noakes, Peter G. (2024). Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice. Neurobiology of Disease, 200 106614, 1-13. doi: 10.1016/j.nbd.2024.106614

Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

2024

Journal Article

Timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number SOD1G93A mice

Fogarty, Matthew J., Drieberg-Thompson, Joy R., Bellingham, Mark C. and Noakes, Peter G. (2024). Timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number SOD1G93A mice. Frontiers in Neurology, 15 1422943. doi: 10.3389/fneur.2024.1422943

Timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number SOD1G93A mice

2024

Journal Article

Cover Image, Volume 50, Issue 3

Cheung, Sang Won, Bhavnani, Ekta, Simmons, David G., Bellingham, Mark C. and Noakes, Peter G. (2024). Cover Image, Volume 50, Issue 3. Neuropathology and Applied Neurobiology, 50 (3). doi: 10.1111/nan.12993

Cover Image, Volume 50, Issue 3

2024

Journal Article

Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1<sup>G93A</sup> ALS mouse model

Cheung, Sang Won, Bhavnani, Ekta, Simmons, David G., Bellingham, Mark C. and Noakes, Peter G. (2024). Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1G93A ALS mouse model. Neuropathology and Applied Neurobiology, 50 (3) e12982, e12982. doi: 10.1111/nan.12982

Perineuronal nets are phagocytosed by MMP‐9 expressing microglia and astrocytes in the SOD1<sup>G93A</sup> ALS mouse model

2022

Journal Article

Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease

Qian, Lei, Rawashdeh, Oliver, Kasas, Leda, Milne, Michael R., Garner, Nicholas, Sankorrakul, Kornraviya, Marks, Nicola, Dean, Matthew W., Kim, Pu Reum, Sharma, Aanchal, Bellingham, Mark C. and Coulson, Elizabeth J. (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease. Nature Communications, 13 (1) 6543, 1-18. doi: 10.1038/s41467-022-33624-y

Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease

2022

Journal Article

Investigating the role of GABA in neural development and disease using mice lacking GAD67 or VGAT genes

Bolneo, Erika, Chau, Pak Yan S., Noakes, Peter G. and Bellingham, Mark C. (2022). Investigating the role of GABA in neural development and disease using mice lacking GAD67 or VGAT genes. International Journal of Molecular Sciences, 23 (14) 7965, 1-18. doi: 10.3390/ijms23147965

Investigating the role of GABA in neural development and disease using mice lacking GAD67 or VGAT genes

2022

Conference Publication

Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease

Kotapati, Charan , Bellingham, Mark C. and Cardoso, Fernanda C. (2022). Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease. Pathogens and Natural Toxins e-Conference section Diagnostics and Therapeutics From Natural Toxins, Brisbane, Australia, 1 July - 31 August 2022.

Idiosyncratic treatment of motor neuron disease: selective inhibition of voltage-gated sodium channels using spider venom peptide (ProTX-III) to treat motor neuron disease

2022

Journal Article

Functional divergence of the two Elongator subcomplexes during neurodevelopment

Gaik, Monika, Kojic, Marija, Stegeman, Megan R., Öncü‐Öner, Tülay, Kościelniak, Anna, Jones, Alun, Mohamed, Ahmed, Chau, Pak Yan Stefanie, Sharmin, Sazia, Chramiec‐Głąbik, Andrzej, Indyka, Paulina, Rawski, Michał, Biela, Anna, Dobosz, Dominika, Millar, Amanda, Chau, Vann, Ünalp, Aycan, Piper, Michael, Bellingham, Mark C., Eichler, Evan E., Nickerson, Deborah A., Güleryüz, Handan, Abbassi, Nour El Hana, Jazgar, Konrad, Davis, Melissa J., Mercimek‐Andrews, Saadet, Cingöz, Sultan, Wainwright, Brandon J. and Glatt, Sebastian (2022). Functional divergence of the two Elongator subcomplexes during neurodevelopment. EMBO Molecular Medicine, 14 (7) e15608, e15608. doi: 10.15252/emmm.202115608

Functional divergence of the two Elongator subcomplexes during neurodevelopment

2022

Journal Article

Complement drives circuit modulation in the adult brain

Parker, Sandra E., Bellingham, Mark C. and Woodruff, Trent M. (2022). Complement drives circuit modulation in the adult brain. Progress in Neurobiology, 214 102282, 102282. doi: 10.1016/j.pneurobio.2022.102282

Complement drives circuit modulation in the adult brain

2022

Other Outputs

Cholinergic basal forebrain degeneration due to sleep-disordered breathing project source data

Coulson, Elizabeth, Qian, Lei, Bellingham, Mark, Georgeson, Thomas, Garner, Nicholas and Dean, Matthew (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing project source data. The University of Queensland. (Dataset) doi: 10.48610/81462a6

Cholinergic basal forebrain degeneration due to sleep-disordered breathing project source data

2021

Journal Article

Size-dependent dendritic maladaptations of hypoglossal motor neurons in SOD1G93A mice

Fogarty, Matthew J., Mu, Erica W. H., Lavidis, Nickolas A., Noakes, Peter G. and Bellingham, Mark C. (2021). Size-dependent dendritic maladaptations of hypoglossal motor neurons in SOD1G93A mice. Anatomical Record, 304 (7), 1562-1581. doi: 10.1002/ar.24542

Size-dependent dendritic maladaptations of hypoglossal motor neurons in SOD1G93A mice

2021

Journal Article

Perineuronal net abnormalities in Slc13a4+/- mice are rescued by postnatal administration of N-acetylcysteine

Sharmin, Sazia, Pradhan, Jonu, Zhang, Zhe, Bellingham, Mark, Simmons, David and Piper, Michael (2021). Perineuronal net abnormalities in Slc13a4+/- mice are rescued by postnatal administration of N-acetylcysteine. Experimental Neurology, 342 113734, 1-16. doi: 10.1016/j.expneurol.2021.113734

Perineuronal net abnormalities in Slc13a4+/- mice are rescued by postnatal administration of N-acetylcysteine

2021

Journal Article

Neurophysiological mechanisms underlying cortical hyper-excitability in amyotrophic lateral sclerosis: a review

Pradhan, Jonu and Bellingham, Mark C. (2021). Neurophysiological mechanisms underlying cortical hyper-excitability in amyotrophic lateral sclerosis: a review. Brain Sciences, 11 (5) 549, 10-10. doi: 10.3390/brainsci11050549

Neurophysiological mechanisms underlying cortical hyper-excitability in amyotrophic lateral sclerosis: a review

2021

Journal Article

Reduced Inhibitory Inputs On Basolateral Amygdala Principal Neurons Following Long-Term Alcohol Consumption

Klenowski, Paul M., Fogarty, Matthew J., Drieberg-Thompson, Joy R., Bellingham, Mark C. and Bartlett, Selena E. (2021). Reduced Inhibitory Inputs On Basolateral Amygdala Principal Neurons Following Long-Term Alcohol Consumption. Neuroscience, 452, 219-227. doi: 10.1016/j.neuroscience.2020.10.039

Reduced Inhibitory Inputs On Basolateral Amygdala Principal Neurons Following Long-Term Alcohol Consumption

2019

Journal Article

Size-dependent vulnerability of lumbar motor neuron dendritic degeneration in SOD1(G93A) mice

Fogarty, Matthew J., Mu, Erica W. H., Lavidis, Nickolas A., Noakes, Peter G. and Bellingham, Mark C. (2019). Size-dependent vulnerability of lumbar motor neuron dendritic degeneration in SOD1(G93A) mice. The Anatomical Record, 303 (5) ar.24255, 1455-1471. doi: 10.1002/ar.24255

Size-dependent vulnerability of lumbar motor neuron dendritic degeneration in SOD1(G93A) mice

2019

Journal Article

The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis

Pradhan, Jonu, Noakes, Peter G. and Bellingham, Mark C. (2019). The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis. Frontiers in Cellular Neuroscience, 13 368, 368. doi: 10.3389/fncel.2019.00368

The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis

2019

Journal Article

Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism

Thakre, Prajwal P. and Bellingham, Mark C. (2019). Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism. Journal of Neurophysiology, 121 (4), 1535-1542. doi: 10.1152/jn.00059.2019

Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism

2019

Journal Article

Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons

Lau, Cora, Thakre, Prajwal P. and Bellingham, Mark C. (2019). Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons. Frontiers in Cellular Neuroscience, 13 100, 100. doi: 10.3389/fncel.2019.00100

Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons

2019

Journal Article

Central inspiratory activity rhythmically activates synaptic currents of airway vagal preganglionic neurons in neonatal rats

Hou, Lili, Bellingham, Mark C., Huang, Yong, Zhang, Pengyu, Zhou, Xin and Zhang, Min (2019). Central inspiratory activity rhythmically activates synaptic currents of airway vagal preganglionic neurons in neonatal rats. Neuroscience Letters, 694, 231-237. doi: 10.1016/j.neulet.2018.11.024

Central inspiratory activity rhythmically activates synaptic currents of airway vagal preganglionic neurons in neonatal rats

2018

Conference Publication

IVT-14 Layer V pyramidal neurons showing synaptic hyper-excitability has altered TrkB receptor signaling in SOD1G3A mouse model of ALS

Pradhan, Jonu, Noakes, Peter G. and Bellingham, Mark C. (2018). IVT-14 Layer V pyramidal neurons showing synaptic hyper-excitability has altered TrkB receptor signaling in SOD1G3A mouse model of ALS. 29th International Symposium on ALS/MND, Glasgow, Scotland, 7-9 December 2018. Abingdon, Oxfordshire, United Kingdom: Taylor & Francis. doi: 10.1080/21678421.2018.1510569

IVT-14 Layer V pyramidal neurons showing synaptic hyper-excitability has altered TrkB receptor signaling in SOD1G3A mouse model of ALS

Current funding

  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Linking synaptic hyperexcitability to corticospinal neuron death in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    In search of novel MND therapeutics: Investigating the role of selective KATP channel activators on cortical hyperexcitability, corticospinal circuit degeneration, and cortical bioenergetics
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Orexin/Hypocretin Receptors in Self- Administration and Stress-Induced Reinstatement of Ethanol Seeking (NHMRC Project Grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2014 - 2015
    Respiratory motor dysfunction and treatment in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Sleep disturbance and cholinergic degeneration in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    A multi-channel, multi-animal facility for recording brain and muscle activity in awake behaving animals
    NHMRC Equipment Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2010
    Plant derived odours reducing the adverse affects of chronic stress on the hiccocampus
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006
    Glutamate receptors and ion currents controlling in vivo excitability of motor neurons resistant and susceptible to death in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2004
    Mechanisms underlying motor neurone death due to glutamate-receptor evoked calcium influx
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    Interactions between phenome and genome at developing CNS synapses during synaptic refinement
    ARC Discovery Projects
    Open grant
  • 2002
    Cholinergic modulation of central respiratory activity
    UQ External Support Enabling Grant
    Open grant
  • 2002 - 2003
    Epigenetic and genetic factors involved in regulation of developmental changes in central synaptic transmission
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Mechanisms underlying motor neuron death due to glutamate receptor-evoked calcium influx in vitro
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2001
    Fast photometric measurement of calcium entry into single central synaptic terminals
    Ramaciotti Foundation
    Open grant
  • 2000
    (1) Quantifying the relationship betwen presynaptic calcium influx and transmitter release at a single central synapse. (2) The cellular basis for cholinergic control of respiratory muscle activity.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000 - 2001
    Mechanisms controlling transmitter release at a central synapse
    ARC Australian Research Fellowship/QEII F/ship
    Open grant
  • 2000
    Quantifying the Relationship Between Presynaptic Calcium Influx and Transmitter Release at a Single Central Synapse.
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Associate Professor Mark Bellingham is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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