Associate Professor Mark Bellingham
Associate Professor

Mark Bellingham

Email: 
Phone: 
+61 7 336 53122

Background

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones.

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice and in vivo preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Projects include :

  • Neurobiology of motor control
  • Motor neuron disease
  • Synaptic transmission in the cochlear nucleus
  • Potassium currents in the brainstem and cerebellum
  • Rhythmic control of breathing movements

Availability

Associate Professor Mark Bellingham is:
Available for supervision

Fields of research

Neurosciences Pharmacology and pharmaceutical sciences Veterinary sciences

Research interests

  • Synaptic transmission in the cochlear nucleus:

    <li>Electrophysiology of postsynaptic AMPA and NMDA receptors and their developmental regulation <li>Single cell RT-PCR with Drs. Joanne Lewohl and Peter Dodd (Biochemistry, UQ) to determine AMPA and NMDA receptor subunits <li>Developmental changes in and mechanisms of short term synaptic plasticity <li>Calcium imaging in single presynaptic terminals

  • Potassium currents in the brainstem and cerebellum:

    <li>Muscarinic receptor regulation of potassium channels in hypoglossal motor neurones - neuropharmacology and second messenger systems <li>Role of potassium channels in causing cerebellar ataxia in ATM protein knock-out mice (with Dr. Martin Lavin, QIMR) <li>Role of potassium channels in regulating transmitter release from presynaptic terminals contacting hypoglossal motor neurones

  • Rhythmic control of breathing movements:

    <li>Muscarinic responses of hypoglossal motor neurones and rhythm-generating network for breathing movements - may be involved in sleep apnoea and SIDS. <li>Role of ATP receptors in rhythmic breathing movements in normal and transgenic knockout mice (with Dr. Peter Noakes) <li>Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Search Professor Mark Bellingham’s works on UQ eSpace

124 works between 1988 and 2024
All (124) Journal Article (83) Book Chapter (4) Conference Publication (36) Other Outputs (1)

41 - 60 of 124 works

2015

Journal Article

Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1G93A mouse model of amyotrophic lateral sclerosis

Fogarty, Matthew J., Noakes, Peter G. and Bellingham, Mark C. (2015). Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 35 (2), 643-647. doi: 10.1523/JNEUROSCI.3483-14.2015

Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1G93A mouse model of amyotrophic lateral sclerosis

2015

Journal Article

Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development

Fogarty, Matthew J., Yanagawa, Yuchio, Obata, Kunihiko, Bellingham, Mark C. and Noakes, Peter G. (2015). Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development. Brain Structure and Function, 220 (1), 525-540. doi: 10.1007/s00429-013-0673-9

Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development

2015

Conference Publication

Cholinergic dysfunction of mesopontine tegmentum is involved in the development of Alzheimer's disease

Qian, L., Marks, N., Sharma, A., Bellingham, M. and Coulson, E. (2015). Cholinergic dysfunction of mesopontine tegmentum is involved in the development of Alzheimer's disease. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13189

Cholinergic dysfunction of mesopontine tegmentum is involved in the development of Alzheimer's disease

2013

Journal Article

Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice

Steyn, F. J., Lee, Kevin, Fogarty, M. J., Veldhuis, J. D., McCombe, P. A,, Bellingham, M. C., Ngo, S. T. and Chen, C (2013). Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice. Endocrinology, 154 (12), 4695-4706. doi: 10.1210/en.2013-1570

Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice

2013

Journal Article

Plasma pharmacokinetics of alfaxalone after a single intraperitoneal or intravenous injection of Alfaxan((R)) in rats

Lau, C., Ranasinghe, M. G., Shiels, I., Keates, H., Pasloske, K. and Bellingham, M. C. (2013). Plasma pharmacokinetics of alfaxalone after a single intraperitoneal or intravenous injection of Alfaxan((R)) in rats. Journal of Veterinary Pharmacology and Therapeutics, 36 (5), 516-520. doi: 10.1111/jvp.12055

Plasma pharmacokinetics of alfaxalone after a single intraperitoneal or intravenous injection of Alfaxan((R)) in rats

2013

Journal Article

A method for the three-dimensional reconstruction of Neurobiotin(TM)-filled neurons and the location of their synaptic inputs

Fogarty, Matthew J., Hammond, Luke A., Kanjhan, Refik, Bellingham, Mark C. and Noakes, Peter G. (2013). A method for the three-dimensional reconstruction of Neurobiotin(TM)-filled neurons and the location of their synaptic inputs. Frontiers in Neural Circuits, 7 (OCT) 153, 1-18. doi: 10.3389/fncir.2013.00153

A method for the three-dimensional reconstruction of Neurobiotin(TM)-filled neurons and the location of their synaptic inputs

2013

Journal Article

Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole

Bellingham, Mark C. (2013). Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole. Journal of Neurophysiology, 110 (5), 1047-1061. doi: 10.1152/jn.00587.2012

Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole

2013

Journal Article

Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development

Fogarty, Matthew J., Smallcombe, Karen L., Yanagawa, Yuchio, Obata, Kunihiko, Bellingham, Mark C. and Noakes, Peter G. (2013). Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development. PLoS One, 8 (2) e56257, e56257. doi: 10.1371/journal.pone.0056257

Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development

2013

Book Chapter

Pharmacological dissection of G protein-mediated second messenger cascades in neurons

Bellingham, Mark C. (2013). Pharmacological dissection of G protein-mediated second messenger cascades in neurons. Stimulation and inhibition of neurons. (pp. 61-106) edited by Pilowsky, Paul M., Farnham, Melissa M. J. and Fong, Angelina Y.. New York, NY, United States: Humana Press. doi: 10.1007/978-1-62703-233-9_5

Pharmacological dissection of G protein-mediated second messenger cascades in neurons

2013

Conference Publication

Investigating the Contribution of Beta1 Adrenoceptors in the Development of Alcohol Dependence

Klenowski, Paul, Holgate, Joan, Bellingham, Mark, Molenaar, Peter and Bartlett, Selena E. (2013). Investigating the Contribution of Beta1 Adrenoceptors in the Development of Alcohol Dependence. The Australasian Professional Society on Alcohol and other Drugs Conference, Brisbane, Australia, 24 -27 November 2013. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/dar.12077

Investigating the Contribution of Beta1 Adrenoceptors in the Development of Alcohol Dependence

2013

Book Chapter

Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice

Ngo, Shyuan T. and Bellingham, Mark C. (2013). Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice. Stimulation and inhibition of neurons. (pp. 225-235) edited by Pilowsky, Paul M., Farnham, Melissa M. J. and Fong, Angelina Y.. New York, NY United States: Humana Press. doi: 10.1007/978-1-62703-233-9_13

Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice

2013

Conference Publication

A method for the three-dimensional reconstruction and quantification of dendrites and synaptic inputs in Neurobiotin(TM)-filled glycine- and GABAA receptor clustering deficient neurons post functional assessment

Fogarty, M. J., Hammond, L. A., Kanjhan, R., Bellingham, M. C. and Noakes, P. G. (2013). A method for the three-dimensional reconstruction and quantification of dendrites and synaptic inputs in Neurobiotin(TM)-filled glycine- and GABAA receptor clustering deficient neurons post functional assessment. Neuroscience 2013: 43rd Annual Meeting of the Society for Neuroscience, San Diago, CA, United States, 9-13 November, 2012.

A method for the three-dimensional reconstruction and quantification of dendrites and synaptic inputs in Neurobiotin(TM)-filled glycine- and GABAA receptor clustering deficient neurons post functional assessment

2013

Book Chapter

Neurobiotin electroporation for combined structural and functional analysis of neurons in developing mouse brain slices

Kanjhan, Refik and Bellingham, Mark C. (2013). Neurobiotin electroporation for combined structural and functional analysis of neurons in developing mouse brain slices. Stimulation and inhibition of neurons. (pp. 151-165) edited by Pilowsky, Paul M., Farnham, Melissa M. J. and Fong, Angelina Y.. New York, NY, United States: Humana Press. doi: 10.1007/978-1-62703-233-9_9

Neurobiotin electroporation for combined structural and functional analysis of neurons in developing mouse brain slices

2013

Conference Publication

The role of beta1 adrenoceptors in the development of alcohol dependence

Klenowski, P. M., Holgate, J., Bellingham, M., Molenaar, P. and Bartlett, S. (2013). The role of beta1 adrenoceptors in the development of alcohol dependence. Neuroscience 2013: 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA, USA, 9-13 November, 2013.

The role of beta1 adrenoceptors in the development of alcohol dependence

2012

Journal Article

Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro

Ireland, Matthew F., Funk, Gregory D. and Bellingham, Mark C. (2012). Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro. Journal of Applied Physiology, 113 (7), 1024-1039. doi: 10.1152/japplphysiol.00699.2011

Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro

2012

Journal Article

The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1(G93A) mice

Ngo, S. T., Baumann, F., Ridall, P. G., Pettitt, A. N., Henderson, R. D., Bellingham, M. C. and McCombe, P. A. (2012). The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1(G93A) mice. Clinical Neurophysiology, 123 (10), 2080-2091. doi: 10.1016/j.clinph.2012.01.028

The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1(G93A) mice

2012

Conference Publication

Plant derived chemicals alleviate the effects of chronic stress on neuronal morphology and synaptic plasticity of hippocampal neurons

Butt, E. A., Bellingham, M. C. and Lavidis, N. A. (2012). Plant derived chemicals alleviate the effects of chronic stress on neuronal morphology and synaptic plasticity of hippocampal neurons. Neuroscience 2012: 42nd Annual Meeting of the Society for Neuroscience, New Orleans, LA, USA, 13-17 October, 2012. Washington, DC, United States: Society for Neuroscience.

Plant derived chemicals alleviate the effects of chronic stress on neuronal morphology and synaptic plasticity of hippocampal neurons

2012

Journal Article

Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis

Steyn, F. J., Ngo, S. T, Lee, J. D., Leong, J. W., Buckley, A. J., Veldhuis, J. D., McCombe, P. A., Chen, C. and Bellingham, M. C. (2012). Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Endocrinology, 153 (8), 3735-3746. doi: 10.1210/en.2011-2171

Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis

2011

Journal Article

Penetratin peptide potentiates endogenous calcium-activated chloride currents in Xenopus oocytes

Kanjhan, Refik and Bellingham, Mark C. (2011). Penetratin peptide potentiates endogenous calcium-activated chloride currents in Xenopus oocytes. Journal of Membrane Biology, 241 (1), 21-29. doi: 10.1007/s00232-011-9359-5

Penetratin peptide potentiates endogenous calcium-activated chloride currents in Xenopus oocytes

2011

Journal Article

A review of the neural mechanisms of action and clinical efficiency of Riluzole in treating Amyotrophic Lateral Sclerosis: What have we learned in the last decade?

Bellingham, Mark C. (2011). A review of the neural mechanisms of action and clinical efficiency of Riluzole in treating Amyotrophic Lateral Sclerosis: What have we learned in the last decade?. CNS Neuroscience and Therapeutics, 17 (1), 4-31. doi: 10.1111/j.1755-5949.2009.00116.x

A review of the neural mechanisms of action and clinical efficiency of Riluzole in treating Amyotrophic Lateral Sclerosis: What have we learned in the last decade?

Current funding

  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Linking synaptic hyperexcitability to corticospinal neuron death in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    In search of novel MND therapeutics: Investigating the role of selective KATP channel activators on cortical hyperexcitability, corticospinal circuit degeneration, and cortical bioenergetics
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Orexin/Hypocretin Receptors in Self- Administration and Stress-Induced Reinstatement of Ethanol Seeking (NHMRC Project Grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2014 - 2015
    Respiratory motor dysfunction and treatment in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Sleep disturbance and cholinergic degeneration in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    A multi-channel, multi-animal facility for recording brain and muscle activity in awake behaving animals
    NHMRC Equipment Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2010
    Plant derived odours reducing the adverse affects of chronic stress on the hiccocampus
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006
    Glutamate receptors and ion currents controlling in vivo excitability of motor neurons resistant and susceptible to death in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2004
    Mechanisms underlying motor neurone death due to glutamate-receptor evoked calcium influx
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    Interactions between phenome and genome at developing CNS synapses during synaptic refinement
    ARC Discovery Projects
    Open grant
  • 2002
    Cholinergic modulation of central respiratory activity
    UQ External Support Enabling Grant
    Open grant
  • 2002 - 2003
    Epigenetic and genetic factors involved in regulation of developmental changes in central synaptic transmission
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Mechanisms underlying motor neuron death due to glutamate receptor-evoked calcium influx in vitro
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2001
    Fast photometric measurement of calcium entry into single central synaptic terminals
    Ramaciotti Foundation
    Open grant
  • 2000
    (1) Quantifying the relationship betwen presynaptic calcium influx and transmitter release at a single central synapse. (2) The cellular basis for cholinergic control of respiratory muscle activity.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000 - 2001
    Mechanisms controlling transmitter release at a central synapse
    ARC Australian Research Fellowship/QEII F/ship
    Open grant
  • 2000
    Quantifying the Relationship Between Presynaptic Calcium Influx and Transmitter Release at a Single Central Synapse.
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Associate Professor Mark Bellingham is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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