Associate Professor Mark Bellingham
Associate Professor

Mark Bellingham

Email: 
Phone: 
+61 7 336 53122

Background

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones.

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice and in vivo preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Projects include :

  • Neurobiology of motor control
  • Motor neuron disease
  • Synaptic transmission in the cochlear nucleus
  • Potassium currents in the brainstem and cerebellum
  • Rhythmic control of breathing movements

Availability

Associate Professor Mark Bellingham is:
Available for supervision

Fields of research

Neurosciences Pharmacology and pharmaceutical sciences Veterinary sciences

Research interests

  • Synaptic transmission in the cochlear nucleus:

    <li>Electrophysiology of postsynaptic AMPA and NMDA receptors and their developmental regulation <li>Single cell RT-PCR with Drs. Joanne Lewohl and Peter Dodd (Biochemistry, UQ) to determine AMPA and NMDA receptor subunits <li>Developmental changes in and mechanisms of short term synaptic plasticity <li>Calcium imaging in single presynaptic terminals

  • Potassium currents in the brainstem and cerebellum:

    <li>Muscarinic receptor regulation of potassium channels in hypoglossal motor neurones - neuropharmacology and second messenger systems <li>Role of potassium channels in causing cerebellar ataxia in ATM protein knock-out mice (with Dr. Martin Lavin, QIMR) <li>Role of potassium channels in regulating transmitter release from presynaptic terminals contacting hypoglossal motor neurones

  • Rhythmic control of breathing movements:

    <li>Muscarinic responses of hypoglossal motor neurones and rhythm-generating network for breathing movements - may be involved in sleep apnoea and SIDS. <li>Role of ATP receptors in rhythmic breathing movements in normal and transgenic knockout mice (with Dr. Peter Noakes) <li>Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Search Professor Mark Bellingham’s works on UQ eSpace

124 works between 1988 and 2024
All (124) Journal Article (83) Book Chapter (4) Conference Publication (36) Other Outputs (1)

61 - 80 of 124 works

2011

Conference Publication

Pulsatile Growth Hormone Secretion in the SOD1G93A Mouse Model of ALS

Steyn, F.J., Ngo, S.T., Buckley, A.J., Leong, J.W., Veldhuis, J.D., McCombe, P.A., Chen, C. and Bellingham, M.C. (2011). Pulsatile Growth Hormone Secretion in the SOD1G93A Mouse Model of ALS. Endocrine Society of Australia Annual Scientific Meeting, Perth Convention and Exhibition Centre, Perth, Western Australia, 28-31 August.

Pulsatile Growth Hormone Secretion in the SOD1G93A Mouse Model of ALS

2011

Conference Publication

Estimation of Motor Unit Loss in Amyotrophic Lateral Sclerosis (ALS)

Ngo, S. T., Baumann, F., Pettitt, A. N., Ridall, P. G., Henderson, R. D., McCombe, P. A. and Bellingham, M. C. (2011). Estimation of Motor Unit Loss in Amyotrophic Lateral Sclerosis (ALS). Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand, 31 January -3 February 2011.

Estimation of Motor Unit Loss in Amyotrophic Lateral Sclerosis (ALS)

2011

Conference Publication

Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method

McCombe, P., Ngo, S., Bellingham, M., Pettitt, A. and Henderson, R. (2011). Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method. 63rd AAN Annual Meeting, Honolulu, HI, United States, 9-16 April 2011.

Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method

2011

Conference Publication

Pulsatile growth hormone secretion in the SOD1G93A mouse model of ALS resembles growth hormone deficiency in ALS patients

Ngo, S. T., Steyn, F. J., Buckley, A. J., Leong, J. W., Veldhuis, J. D., Chen, C., McCombe, P. A. and Bellingham, M. C. (2011). Pulsatile growth hormone secretion in the SOD1G93A mouse model of ALS resembles growth hormone deficiency in ALS patients. 22nd International ALS/MND Symposium, Sydney, Australia, 30 November - 2 December 2011.

Pulsatile growth hormone secretion in the SOD1G93A mouse model of ALS resembles growth hormone deficiency in ALS patients

2011

Conference Publication

Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method

McCombe, Pamela, Ngo, Shuyan, Bellingham, Mark, Pettitt, Anthony and Henderson, Robert (2011). Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method. 63rd Annual Meeting of the American-Academy-of-Neurology, Honolulu, HI, U.S.A., APR 09-16, 2011. Philadelphia, PA, U.S.A.: Lippincott Williams & Wilkins.

Comparison of Motor Units Number Estimation by Bayesian Statistical MUNE with Histological Counting of Motor Unit Numbers: Validation of the Method

2011

Conference Publication

Comparison of motor unit number estimation by Bayesian statistical MUNE with histological counting of motor unit numbers

Ngo, S. T., Bellingham, M. C., Pettitt, A. N., Ridall, P. G., Henderson, R. D. and McCombe, P. A. (2011). Comparison of motor unit number estimation by Bayesian statistical MUNE with histological counting of motor unit numbers. 22nd International ALS/MND Symposium, Sydney, Australia, 30 November - 2 December 2011.

Comparison of motor unit number estimation by Bayesian statistical MUNE with histological counting of motor unit numbers

2010

Journal Article

The two-pore domain K+ channel TASK-1 is closely associated with brain barriers and meninges

Kanjhan, Refik, Pow, David V., Noakes, Peter G. and Bellingham, Mark C. (2010). The two-pore domain K+ channel TASK-1 is closely associated with brain barriers and meninges. Journal of Molecular Histology, 41 (6), 315-323. doi: 10.1007/s10735-010-9293-3

The two-pore domain K+ channel TASK-1 is closely associated with brain barriers and meninges

2010

Conference Publication

Bayesian Motor Unit Number Estimation in the SOD1G93A mouse

Ngo, S.T., Bellingham, M.C., Baumann, F., Pettitt, A.N., Ridall, P.G., Henderson, R.D. and McCombe, P.A. (2010). Bayesian Motor Unit Number Estimation in the SOD1G93A mouse. Forum of European Neuroscience, AMSTERDAM NETHERLANDS, 3/7/2010-7/7/2010.

Bayesian Motor Unit Number Estimation in the SOD1G93A mouse

2008

Journal Article

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

van Zundert, B., Peuscher, M. H., Hynynen, M., Chen, A., Neve, R. L., Brown, R. H., Constantine-Paton, M. and Bellingham, M. C. (2008). Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis. Journal of Neuroscience, 28 (43), 10864-10874. doi: 10.1523/JNEUROSCI.1340-08.2008

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

2007

Journal Article

GABA-deficient mice produce regional alterations in motoneuron survival during neural development

Noakes, P. G., Smallcombe, K., Arata, A., Obata, A., Davies, J. and Bellingham, M. C. (2007). GABA-deficient mice produce regional alterations in motoneuron survival during neural development. The Society for Neuroscience Abstracts, 27 (33).

GABA-deficient mice produce regional alterations in motoneuron survival during neural development

2007

Journal Article

Using group learning to promote integration and cooperative learning between Asian and Australian second-year Veterinary Science students

Mills, P.C., Woodall, P.F., Bellingham, M.C., Noad, M.J. and Lloyd, S. (2007). Using group learning to promote integration and cooperative learning between Asian and Australian second-year Veterinary Science students. Journal of Veterinary Medical Education, 34 (3), 350-355. doi: 10.3138/jvme.34.3.350

Using group learning to promote integration and cooperative learning between Asian and Australian second-year Veterinary Science students

2006

Journal Article

Differential expression of the NMDA NR2B receptor subunit in motoneuron populations susceptible and resistant to amyotrophic lateral sclerosis

Fuller, Paula I., Reddrop, Courtney, Rodger, Jennifer, Bellingham, Mark C. and Phillips, Jacqueline K. (2006). Differential expression of the NMDA NR2B receptor subunit in motoneuron populations susceptible and resistant to amyotrophic lateral sclerosis. Neuroscience Letters, 399 (1-2), 157-161. doi: 10.1016/j.neulet.2006.01.051

Differential expression of the NMDA NR2B receptor subunit in motoneuron populations susceptible and resistant to amyotrophic lateral sclerosis

2006

Conference Publication

Decrease in spontaneous activity and cell death of the brachial motoneurons in GAD67-deficient mouse embryo

Arata, A., Obata, K., Davies, J., Bellingham, M. and Noakes, P. G. (2006). Decrease in spontaneous activity and cell death of the brachial motoneurons in GAD67-deficient mouse embryo. 29th Annual Meeting of the Japan Neuroscience Society, Kyoto, Japan, 19-21 July 2006. Clare: Elsevier Ireland Ltd. doi: 10.1016/j.neures.2006.04.004

Decrease in spontaneous activity and cell death of the brachial motoneurons in GAD67-deficient mouse embryo

2006

Journal Article

Developmental regulation of the neuromotor circuit: peripheral and central synaptic influences in motoneuron numbers and innervation of muscle

Noakes, P. G., Smallcombe, K. L., Kanjhan, R., Arata, A., Banks, G., Obata, K., Betz, H. and Bellingham, M. C. (2006). Developmental regulation of the neuromotor circuit: peripheral and central synaptic influences in motoneuron numbers and innervation of muscle. Proceedings of the Australian Society for Biochemistry and Molecular Biology, 38, SYM-57-03-SYM-57-03.

Developmental regulation of the neuromotor circuit: peripheral and central synaptic influences in motoneuron numbers and innervation of muscle

2006

Conference Publication

A lack of GABA produces regional alterations in motoneuron activity, motoneuron survival and innervation of mice during neural development

Noakes, Peter G., Smallcombe, Karen, Davis, Jonathan and Bellingham, Mark C. (2006). A lack of GABA produces regional alterations in motoneuron activity, motoneuron survival and innervation of mice during neural development. ComBio 2006, Brisbane, Australia, 24-28 September, 2006. Online:

A lack of GABA produces regional alterations in motoneuron activity, motoneuron survival and innervation of mice during neural development

2006

Journal Article

Postnatal developmental expression of the PDZ scaffolds Na+-H+ exchanger regulatory factors 1 and 2 in the rat cochlea

Kanjhan, Refik, Hryciw, Deanne H., Yun, C. Chris, Bellingham, Mark C. and Poronnik, Philip (2006). Postnatal developmental expression of the PDZ scaffolds Na+-H+ exchanger regulatory factors 1 and 2 in the rat cochlea. Cell And Tissue Research, 323 (1), 53-70. doi: 10.1007/s00441-005-0051-x

Postnatal developmental expression of the PDZ scaffolds Na+-H+ exchanger regulatory factors 1 and 2 in the rat cochlea

2005

Journal Article

Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner

Kanjhan, R., Coulson, E. J., Adams, D. J. and Bellingham, M. C. (2005). Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. Journal of Pharmacology And Experimental Therapeutics, 314 (3), 1353-1361. doi: 10.1124/jpet.105.085928

Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner

2005

Journal Article

Erratum: Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation

Banks, Glen B., Kanjhan, Refik, Wiese, Stefan, Kneussel, Matthias, Wong, Loke M., O'Sullivan, Gregory, Sendtner, Michael, Bellingham, Mark C., Betz, Heinrich and Noakes, Peter G. (2005). Erratum: Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. Journal of Neuroscience, 25 (11), 3018-3021.

Erratum: Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation

2005

Journal Article

Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation

Banks, GB, Kanjhan, R, Wiese, S, Kneussel, M, Wong, LM, O'Sullivan, G, Sendtner, M, Bellingham, MC, Betz, H and Noakes, PG (2005). Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. Journal of Neuroscience, 25 (5), 1249-1259. doi: 10.1523/JNEUROSCI.1786-04.2005

Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation

2004

Journal Article

Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum

Kanjhan, Refik, Anselme, Amy, Noakes, Peter and Bellingham, Mark (2004). Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum. Neuroreport, 15 (8), 1321-1324. doi: 10.1097/01.wnr.0000127462.15985.dc

Postnatal changes in TASK-1 and TREK-1 expression in rat brain stem and cerebellum

Current funding

  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Linking synaptic hyperexcitability to corticospinal neuron death in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    In search of novel MND therapeutics: Investigating the role of selective KATP channel activators on cortical hyperexcitability, corticospinal circuit degeneration, and cortical bioenergetics
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Orexin/Hypocretin Receptors in Self- Administration and Stress-Induced Reinstatement of Ethanol Seeking (NHMRC Project Grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2014 - 2015
    Respiratory motor dysfunction and treatment in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Sleep disturbance and cholinergic degeneration in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    A multi-channel, multi-animal facility for recording brain and muscle activity in awake behaving animals
    NHMRC Equipment Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2010
    Plant derived odours reducing the adverse affects of chronic stress on the hiccocampus
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006
    Glutamate receptors and ion currents controlling in vivo excitability of motor neurons resistant and susceptible to death in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2004
    Mechanisms underlying motor neurone death due to glutamate-receptor evoked calcium influx
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    Interactions between phenome and genome at developing CNS synapses during synaptic refinement
    ARC Discovery Projects
    Open grant
  • 2002
    Cholinergic modulation of central respiratory activity
    UQ External Support Enabling Grant
    Open grant
  • 2002 - 2003
    Epigenetic and genetic factors involved in regulation of developmental changes in central synaptic transmission
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Mechanisms underlying motor neuron death due to glutamate receptor-evoked calcium influx in vitro
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2001
    Fast photometric measurement of calcium entry into single central synaptic terminals
    Ramaciotti Foundation
    Open grant
  • 2000
    (1) Quantifying the relationship betwen presynaptic calcium influx and transmitter release at a single central synapse. (2) The cellular basis for cholinergic control of respiratory muscle activity.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000 - 2001
    Mechanisms controlling transmitter release at a central synapse
    ARC Australian Research Fellowship/QEII F/ship
    Open grant
  • 2000
    Quantifying the Relationship Between Presynaptic Calcium Influx and Transmitter Release at a Single Central Synapse.
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Associate Professor Mark Bellingham is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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