Associate Professor Mark Bellingham
Associate Professor

Mark Bellingham

Email: 
Phone: 
+61 7 336 53122

Background

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones.

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice and in vivo preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Projects include :

  • Neurobiology of motor control
  • Motor neuron disease
  • Synaptic transmission in the cochlear nucleus
  • Potassium currents in the brainstem and cerebellum
  • Rhythmic control of breathing movements

Availability

Associate Professor Mark Bellingham is:
Available for supervision

Fields of research

Neurosciences Pharmacology and pharmaceutical sciences Veterinary sciences

Research interests

  • Synaptic transmission in the cochlear nucleus:

    <li>Electrophysiology of postsynaptic AMPA and NMDA receptors and their developmental regulation <li>Single cell RT-PCR with Drs. Joanne Lewohl and Peter Dodd (Biochemistry, UQ) to determine AMPA and NMDA receptor subunits <li>Developmental changes in and mechanisms of short term synaptic plasticity <li>Calcium imaging in single presynaptic terminals

  • Potassium currents in the brainstem and cerebellum:

    <li>Muscarinic receptor regulation of potassium channels in hypoglossal motor neurones - neuropharmacology and second messenger systems <li>Role of potassium channels in causing cerebellar ataxia in ATM protein knock-out mice (with Dr. Martin Lavin, QIMR) <li>Role of potassium channels in regulating transmitter release from presynaptic terminals contacting hypoglossal motor neurones

  • Rhythmic control of breathing movements:

    <li>Muscarinic responses of hypoglossal motor neurones and rhythm-generating network for breathing movements - may be involved in sleep apnoea and SIDS. <li>Role of ATP receptors in rhythmic breathing movements in normal and transgenic knockout mice (with Dr. Peter Noakes) <li>Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Search Professor Mark Bellingham’s works on UQ eSpace

124 works between 1988 and 2024
All (124) Journal Article (83) Book Chapter (4) Conference Publication (36) Other Outputs (1)

21 - 40 of 124 works

2017

Journal Article

Investigating methodological differences in the assessment of dendritic morphology of basolateral amygdala principal neurons – a comparison of Golgi-Cox and neurobiotin electroporation techniques

Klenowski, Paul M., Wright, Sophie E., Mu, Erica W.H., Noakes, Peter G., Lavidis, Nickolas A., Bartlett, Selena E., Bellingham, Mark C. and Fogarty, Matthew J. (2017). Investigating methodological differences in the assessment of dendritic morphology of basolateral amygdala principal neurons – a comparison of Golgi-Cox and neurobiotin electroporation techniques. Brain Sciences, 7 (12) 165, 1-12. doi: 10.3390/brainsci7120165

Investigating methodological differences in the assessment of dendritic morphology of basolateral amygdala principal neurons – a comparison of Golgi-Cox and neurobiotin electroporation techniques

2017

Journal Article

Capsaicin enhances glutamatergic synaptic transmission to neonatal rat hypoglossal motor neurons via a TRPV1-independent mechanism

Thakre, Prajwal P. and Bellingham, Mark C. (2017). Capsaicin enhances glutamatergic synaptic transmission to neonatal rat hypoglossal motor neurons via a TRPV1-independent mechanism. Frontiers in Cellular Neuroscience, 11 (383) 383, 383. doi: 10.3389/fncel.2017.00383

Capsaicin enhances glutamatergic synaptic transmission to neonatal rat hypoglossal motor neurons via a TRPV1-independent mechanism

2017

Journal Article

Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model

Fogarty, Matthew J., Mu, Erica W. H., Lavidis, Nickolas A., Noakes, Peter G. and Bellingham, Mark C. (2017). Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model. Frontiers in Neuroscience, 11 (NOV) 609, 1-16. doi: 10.3389/fnins.2017.00609

Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model

2017

Journal Article

Binge-like sucrose consumption reduces the dendritic length and complexity of principal neurons in the adolescent rat basolateral amygdala

Shariff, Masroor, Klenowski, Paul, Morgan, Michael, Patkar, Omkar, Mu, Erica, Bellingham, Mark, Belmer, Arnauld and Bartlett, Selena E. (2017). Binge-like sucrose consumption reduces the dendritic length and complexity of principal neurons in the adolescent rat basolateral amygdala. PLoS One, 12 (8) e0183063, e0183063. doi: 10.1371/journal.pone.0183063

Binge-like sucrose consumption reduces the dendritic length and complexity of principal neurons in the adolescent rat basolateral amygdala

2017

Journal Article

Alterations in hypoglossal motor neurons due to GAD67 and VGAT deficiency in mice

Fogarty, Matthew J., Kanjhan, Refik, Yanagawa, Yuchio, Noakes, Peter G. and Bellingham, Mark C. (2017). Alterations in hypoglossal motor neurons due to GAD67 and VGAT deficiency in mice. Experimental Neurology, 289, 117-127. doi: 10.1016/j.expneurol.2016.12.004

Alterations in hypoglossal motor neurons due to GAD67 and VGAT deficiency in mice

2017

Conference Publication

Alfaxalone alters inhibitory but not excitatory synaptic transmission or action potential firing in rat hypoglossal motor neurons

Thakre, P. and Bellingham, M. (2017). Alfaxalone alters inhibitory but not excitatory synaptic transmission or action potential firing in rat hypoglossal motor neurons. ISN-ESN Meeting, Paris France, 20-24 August 2017. Chichester, West Sussex United Kingdom: Wiley.

Alfaxalone alters inhibitory but not excitatory synaptic transmission or action potential firing in rat hypoglossal motor neurons

2017

Conference Publication

Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders

Cardoso, Fernanda C., Bellingham, Mark C., King, Glenn F. and Lewis, Richard J. (2017). Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders

2016

Journal Article

Increased synaptic excitation and abnormal dendritic structure of prefrontal cortex layer V pyramidal neurons following prolonged binge-like consumption of ethanol

Klenowski, Paul M., Fogarty, Matthew J., Shariff, Masroor, Belmer, Arnauld, Bellingham, Mark C. and Bartlett, Selena E. (2016). Increased synaptic excitation and abnormal dendritic structure of prefrontal cortex layer V pyramidal neurons following prolonged binge-like consumption of ethanol. eNeuro, 3 (6) e0248, ENEURO.0248-16.2016. doi: 10.1523/eneuro.0248-16.2016

Increased synaptic excitation and abnormal dendritic structure of prefrontal cortex layer V pyramidal neurons following prolonged binge-like consumption of ethanol

2016

Journal Article

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

Fogarty, Matthew J., Klenowski, Paul M., Lee, John D., Drieberg-Thompson, Joy R., Bartlett, Selena E., Ngo, Shyuan T., Hilliard, Massimo A., Bellingham, Mark C. and Noakes, Peter G. (2016). Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. Scientific Reports, 6 (1) 37968, 37968. doi: 10.1038/srep37968

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

2016

Journal Article

Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 (4), 927-947. doi: 10.1189/jlb.4VMA0716-316R

Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage

2016

Journal Article

A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371

A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype

2016

Journal Article

Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Fogarty, Matthew J., Mu, Erica W. H., Noakes, Peter G., Lavidis, Nickolas A. and Bellingham, Mark C. (2016). Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 4 (77) 77, 1-21. doi: 10.1186/s40478-016-0347-y

Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

2016

Journal Article

Prolonged consumption of sucrose in a binge-like manner alters the morphology of medium spiny neurons in the nucleus accumbens shell

Klenowski, Paul M., Shariff, Masroor R., Belmer, Arnauld, Fogarty, Matthew J., Mu, Erica H. W., Bellingham, Mark C. and Bartlett, Selena E. (2016). Prolonged consumption of sucrose in a binge-like manner alters the morphology of medium spiny neurons in the nucleus accumbens shell. Frontiers in Behavioral Neuroscience, 10 (MAR) 54, 54.1-54.10. doi: 10.3389/fnbeh.2016.00054

Prolonged consumption of sucrose in a binge-like manner alters the morphology of medium spiny neurons in the nucleus accumbens shell

2016

Journal Article

The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice

Patkar, Omkar L., Belmer, Arnauld, Holgate, Joan Y., Tarren, Josephine R., Shariff, Masroor R., Morgan, Michael, Fogarty, Matthew J., Bellingham, Mark C., Bartlett, Selena E. and Klenowski, Paul M. (2016). The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice. Addiction Biology, 22 (3), 679-691. doi: 10.1111/adb.12359

The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice

2016

Journal Article

Glycinergic neurotransmission: A potent regulator of embryonic motor neuron dendritic morphology and synaptic plasticity

Fogarty, Matthew J., Kanjhan, Refik, Bellingham, Mark C. and Noakes, Peter G. (2016). Glycinergic neurotransmission: A potent regulator of embryonic motor neuron dendritic morphology and synaptic plasticity. Journal of Neuroscience, 36 (1), 80-87. doi: 10.1523/JNEUROSCI.1576-15.2016

Glycinergic neurotransmission: A potent regulator of embryonic motor neuron dendritic morphology and synaptic plasticity

2016

Journal Article

Emerging roles of filopodia and dendritic spines in motoneuron plasticity during development and disease

Kanjhan, Refik, Noakes, Peter G. and Bellingham, Mark C. (2016). Emerging roles of filopodia and dendritic spines in motoneuron plasticity during development and disease. Neural Plasticity, 2016 3423267, 3423267.1-3423267.31. doi: 10.1155/2016/3423267

Emerging roles of filopodia and dendritic spines in motoneuron plasticity during development and disease

2016

Conference Publication

Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia

Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, C. S., Bellingham, M., Noakes, P., Lim, Y. C., Barnett, N., Dingwall, S., Wolvetang, E., Mashimo, T., Roberts, T. and Lavin, M. (2016). Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia

2015

Journal Article

Developmental changes in the morphology of mouse hypoglossal motor neurons

Kanjhan, Refik, Fogarty, Matthew J., Noakes, Peter G. and Bellingham, Mark C. (2015). Developmental changes in the morphology of mouse hypoglossal motor neurons. Brain Structure and Function, 221 (7), 1-32. doi: 10.1007/s00429-015-1130-8

Developmental changes in the morphology of mouse hypoglossal motor neurons

2015

Journal Article

Structural and functional characterization of dendritic arbors and GABaergic synaptic inputs on interneurons and principal cells in the rat basolateral amygdala

Klenowski, Paul M., Fogarty, Matthew J., Belmer, Arnauld, Noakes, Peter G., Bellingham, Mark C. and Bartlett, Selena E. (2015). Structural and functional characterization of dendritic arbors and GABaergic synaptic inputs on interneurons and principal cells in the rat basolateral amygdala. Journal of Neurophysiology, 114 (2), 942-957. doi: 10.1152/jn.00824.2014

Structural and functional characterization of dendritic arbors and GABaergic synaptic inputs on interneurons and principal cells in the rat basolateral amygdala

2015

Conference Publication

Hippocampal influence on the respiratory and cardiovascular system

Ajayi, I., Mills, P., Bellingham, M., Silburn, P. and Subramanian, H. (2015). Hippocampal influence on the respiratory and cardiovascular system. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, Aug 23-27, 2015. HOBOKEN: WILEY-BLACKWELL.

Hippocampal influence on the respiratory and cardiovascular system

Current funding

  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Linking synaptic hyperexcitability to corticospinal neuron death in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    In search of novel MND therapeutics: Investigating the role of selective KATP channel activators on cortical hyperexcitability, corticospinal circuit degeneration, and cortical bioenergetics
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Orexin/Hypocretin Receptors in Self- Administration and Stress-Induced Reinstatement of Ethanol Seeking (NHMRC Project Grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2014 - 2015
    Respiratory motor dysfunction and treatment in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Sleep disturbance and cholinergic degeneration in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    A multi-channel, multi-animal facility for recording brain and muscle activity in awake behaving animals
    NHMRC Equipment Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2010
    Plant derived odours reducing the adverse affects of chronic stress on the hiccocampus
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006
    Glutamate receptors and ion currents controlling in vivo excitability of motor neurons resistant and susceptible to death in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2004
    Mechanisms underlying motor neurone death due to glutamate-receptor evoked calcium influx
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    Interactions between phenome and genome at developing CNS synapses during synaptic refinement
    ARC Discovery Projects
    Open grant
  • 2002
    Cholinergic modulation of central respiratory activity
    UQ External Support Enabling Grant
    Open grant
  • 2002 - 2003
    Epigenetic and genetic factors involved in regulation of developmental changes in central synaptic transmission
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Mechanisms underlying motor neuron death due to glutamate receptor-evoked calcium influx in vitro
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2001
    Fast photometric measurement of calcium entry into single central synaptic terminals
    Ramaciotti Foundation
    Open grant
  • 2000
    (1) Quantifying the relationship betwen presynaptic calcium influx and transmitter release at a single central synapse. (2) The cellular basis for cholinergic control of respiratory muscle activity.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000 - 2001
    Mechanisms controlling transmitter release at a central synapse
    ARC Australian Research Fellowship/QEII F/ship
    Open grant
  • 2000
    Quantifying the Relationship Between Presynaptic Calcium Influx and Transmitter Release at a Single Central Synapse.
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Associate Professor Mark Bellingham is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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