Associate Professor Mark Bellingham
Associate Professor

Mark Bellingham

Email: 
Phone: 
+61 7 336 53122

Background

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones.

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice and in vivo preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Projects include :

  • Neurobiology of motor control
  • Motor neuron disease
  • Synaptic transmission in the cochlear nucleus
  • Potassium currents in the brainstem and cerebellum
  • Rhythmic control of breathing movements

Availability

Associate Professor Mark Bellingham is:
Available for supervision

Fields of research

Neurosciences Pharmacology and pharmaceutical sciences Veterinary sciences

Research interests

  • Synaptic transmission in the cochlear nucleus:

    <li>Electrophysiology of postsynaptic AMPA and NMDA receptors and their developmental regulation <li>Single cell RT-PCR with Drs. Joanne Lewohl and Peter Dodd (Biochemistry, UQ) to determine AMPA and NMDA receptor subunits <li>Developmental changes in and mechanisms of short term synaptic plasticity <li>Calcium imaging in single presynaptic terminals

  • Potassium currents in the brainstem and cerebellum:

    <li>Muscarinic receptor regulation of potassium channels in hypoglossal motor neurones - neuropharmacology and second messenger systems <li>Role of potassium channels in causing cerebellar ataxia in ATM protein knock-out mice (with Dr. Martin Lavin, QIMR) <li>Role of potassium channels in regulating transmitter release from presynaptic terminals contacting hypoglossal motor neurones

  • Rhythmic control of breathing movements:

    <li>Muscarinic responses of hypoglossal motor neurones and rhythm-generating network for breathing movements - may be involved in sleep apnoea and SIDS. <li>Role of ATP receptors in rhythmic breathing movements in normal and transgenic knockout mice (with Dr. Peter Noakes) <li>Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Search Professor Mark Bellingham’s works on UQ eSpace

124 works between 1988 and 2024
All (124) Journal Article (83) Book Chapter (4) Conference Publication (36) Other Outputs (1)

81 - 100 of 124 works

2004

Journal Article

Developmental expression of two-pore domain K+ channels, TASK-1 and TREK-1, in the rat cochlea

Kanjhan, Refik, Balke, Caroline, Housley, Gary, Bellingham, Mark and Noakes, Peter (2004). Developmental expression of two-pore domain K+ channels, TASK-1 and TREK-1, in the rat cochlea. Neuroreport, 15 (3), 437-441. doi: 10.1097/01.wnr.0000114978.66165.39

Developmental expression of two-pore domain K+ channels, TASK-1 and TREK-1, in the rat cochlea

2004

Conference Publication

Expression of two pore domain K channels TASK1 and TREK1, in the rat cochlea: implications for Tinnitus

Noakes, Peter G., Kanjhan, Refik, Balke, Caroline L., Nguyen, Thanh T., Housley, G. and Bellingham, Mark C. (2004). Expression of two pore domain K channels TASK1 and TREK1, in the rat cochlea: implications for Tinnitus. Australian Neuroscience Society Meeting 24th Annual Meeting, Melbourne, 27-30 January, 2004. Melbourne: Australian Neuroscience Society.

Expression of two pore domain K channels TASK1 and TREK1, in the rat cochlea: implications for Tinnitus

2004

Conference Publication

Locaization of TASK1 and TREK1 Two Pore Domain K Channels and P2Y2 and P2Y4 Receptors in Rat Hypoglossal Motoneurons

Bellingham, M. C., Kanjhan, R., Huang, L. C., Housley, G. D., Lipski, J., Funk, G. D. and Noakes, P. G. (2004). Locaization of TASK1 and TREK1 Two Pore Domain K Channels and P2Y2 and P2Y4 Receptors in Rat Hypoglossal Motoneurons. 24th Annual Meeting of the Australian Neuroscience Society, Melbourne, Australia, 27-30 January, 2004. Melbourne: Australian Neuroscience Inc.

Locaization of TASK1 and TREK1 Two Pore Domain K Channels and P2Y2 and P2Y4 Receptors in Rat Hypoglossal Motoneurons

2004

Journal Article

The effect of N-ethylmaleimide on transmitter release from the skeletal neuromuscular junction of Bufo marinus

Knight, D, Bellingham, MC and Lavidis, NA (2004). The effect of N-ethylmaleimide on transmitter release from the skeletal neuromuscular junction of Bufo marinus. Synapse, 53 (3), 151-158. doi: 10.1002/syn.20044

The effect of N-ethylmaleimide on transmitter release from the skeletal neuromuscular junction of Bufo marinus

2004

Conference Publication

A new marker for the meningeo-glial network: a two pore domain K channel TASK1

Kanjhan, R., Pow, D.V., Birt, J.B., Noakes, P.G. and Bellingham, M.C. (2004). A new marker for the meningeo-glial network: a two pore domain K channel TASK1. Australian Neuroscience Society - 24th Annual Meeting, Melbourne, Australia, 27-30 January, 2004. Amsterdam: Elsevier/North-Holland.

A new marker for the meningeo-glial network: a two pore domain K channel TASK1

2004

Journal Article

P2x(7)-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms

Ireland, M. F., Noakes, P. G. and Bellingham, M. C. (2004). P2x(7)-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms. Neuroscience, 128 (2), 269-280. doi: 10.1016/j.neuroscience.2004.06.014

P2x(7)-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms

2004

Conference Publication

Hypoglossal and spinal motor neural activity in gephyrin-deficient versus wild-type mice

Wong, L. M., Kanjhan, R., Bellingham, M. C. and Noakes, P. G. (2004). Hypoglossal and spinal motor neural activity in gephyrin-deficient versus wild-type mice. Australian Neuroscience Society, 24th Annual Meeeting, Melbourne, Australia, 27-30 January, 2004. Australia: Australian Neuroscience Society.

Hypoglossal and spinal motor neural activity in gephyrin-deficient versus wild-type mice

2003

Conference Publication

The Use of Cell Type Specific Knockout Mice to Study the Roles of Synaptic Signalling Molecules in the Nervous System

Noakes, P. G., Koshi, K., Frugier, T., White, M., Bellingham, M. and Mclennan I. (2003). The Use of Cell Type Specific Knockout Mice to Study the Roles of Synaptic Signalling Molecules in the Nervous System. Australian Neurological Society Annual Conference, Adelaide, 2003.

The Use of Cell Type Specific Knockout Mice to Study the Roles of Synaptic Signalling Molecules in the Nervous System

2003

Conference Publication

Motoneuron survival in the absence of GABA and glycine neurotransmission during embryonic development

Banks, G., Bellingham, M., Kneussel, M., Sullivan, M., Betz, H. and Noakes, P. (2003). Motoneuron survival in the absence of GABA and glycine neurotransmission during embryonic development. Australian Neuroscience Society 23rd Annual Meeting, Adelaide, 28-31 January, 2003. Australia: Australian Neuroscience Sociey.

Motoneuron survival in the absence of GABA and glycine neurotransmission during embryonic development

2003

Conference Publication

P2X7 receptors enhance excitatory central synaptic transmission

Birt, J., Ireland, M., Knight, D., Noakes, P. G. and Bellingham, M. (2003). P2X7 receptors enhance excitatory central synaptic transmission. Australian Neuroscience Society 23rd Annual Meeting, Adelaide, 28-31 January, 2003. Australia: Australian Neuroscience Sociey Inc..

P2X7 receptors enhance excitatory central synaptic transmission

2002

Conference Publication

Role of P2X7 receptors in transmitter release in mice

Knight, D., Ireland, M. F., Bellingham, M. C. and Noakes, P. G. (2002). Role of P2X7 receptors in transmitter release in mice. Society for Neuroscience Annual Meeting 2002, Orlando, Florida, 2-7 November, 2002. Washington , DC: Society for Neuroscience.

Role of P2X7 receptors in transmitter release in mice

2002

Journal Article

Contribution of cholinergic systems to state-dependent modulation of respiratory control

Bellingham, MC and Ireland, MF (2002). Contribution of cholinergic systems to state-dependent modulation of respiratory control. Respiratory Physiology & Neurobiology, 131 (1-2), 135-144. doi: 10.1016/S1569-9048(02)00043-5

Contribution of cholinergic systems to state-dependent modulation of respiratory control

2001

Conference Publication

Contribution of cholinergic systems to state-dependent modulation of respiratory networks

Bellingham, M. C., Funk, G. D., Ireland, M., Miles, G. B., Robinson, D. M. and Selvaratnam, S. R. (2001). Contribution of cholinergic systems to state-dependent modulation of respiratory networks. Neural Control of Breathing Satellite Meeting, Rotorua, New Zealand, 1-4 September, 2001. London, United Kingdom: BioMed Central. doi: 10.1186/rr112

Contribution of cholinergic systems to state-dependent modulation of respiratory networks

2001

Conference Publication

Rapid developmental regulation of presynaptic factors governing synaptic transmission and plasticity at central synapses

Bellingham, M. C. (2001). Rapid developmental regulation of presynaptic factors governing synaptic transmission and plasticity at central synapses. 14th Biennial Meeting of the Int. Society for Dev. Neuroscience, Sydney, 31/1 - 4/2 2002. United Kingdom: Pergamon.

Rapid developmental regulation of presynaptic factors governing synaptic transmission and plasticity at central synapses

2001

Conference Publication

Motoneuron cell death, branching and muscle activity in agrin-deficient mice

Noakes, P. G., Banks, G., Choy, P. T., Lavidis, N. A. and Bellingham, M. C. (2001). Motoneuron cell death, branching and muscle activity in agrin-deficient mice. 31st Annual Meeting of the Society for Neuroscience, San Diego, 10-15 November 2001. USA: Society for Neuroscience.

Motoneuron cell death, branching and muscle activity in agrin-deficient mice

2001

Conference Publication

Developmental changes in short-term synaptic plasticity at a central auditory synapse

Bellingham, M. C. (2001). Developmental changes in short-term synaptic plasticity at a central auditory synapse. 21st Meeting of the Australian Neuroscience Society, Brisbane, 28-31 January 2001. Sydney: ANS.

Developmental changes in short-term synaptic plasticity at a central auditory synapse

2000

Journal Article

Australian Neuroscience Society--20th Annual Meeting. 30 January-2 February 2000, Melbourne, Australia

Bellingham, M. C. (2000). Australian Neuroscience Society--20th Annual Meeting. 30 January-2 February 2000, Melbourne, Australia. IDrugs : the investigational drugs journal, 3 (5), 490-2.

Australian Neuroscience Society--20th Annual Meeting. 30 January-2 February 2000, Melbourne, Australia

2000

Conference Publication

Effect of N-Ethylmaleimide on transmitter release at the skeletal neuromuscular junction of Bufo Marinus

Knight, D., Bellingham, M. C. and Lavidis, N. A. (2000). Effect of N-Ethylmaleimide on transmitter release at the skeletal neuromuscular junction of Bufo Marinus. Society for Neuroscience, New Orleans, LA, USA, 4-9 November 2000. USA: Society for Neuroscience.

Effect of N-Ethylmaleimide on transmitter release at the skeletal neuromuscular junction of Bufo Marinus

2000

Journal Article

Australian Neuroscience Society - 20th Annual Meeting

Bellingham, M. C. (2000). Australian Neuroscience Society - 20th Annual Meeting. IDrugs, 3 (5), 490-492.

Australian Neuroscience Society - 20th Annual Meeting

2000

Conference Publication

Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination

Bellingham, Mark C. and Funk, Greg D. (2000). Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination. Australian Neuroscience Society Symposium on Nervous Control of Breathing, Hobart, Australia, January/February 1999. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1046/j.1440-1681.2000.03192.x

Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination

Current funding

  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Linking synaptic hyperexcitability to corticospinal neuron death in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    In search of novel MND therapeutics: Investigating the role of selective KATP channel activators on cortical hyperexcitability, corticospinal circuit degeneration, and cortical bioenergetics
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Orexin/Hypocretin Receptors in Self- Administration and Stress-Induced Reinstatement of Ethanol Seeking (NHMRC Project Grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2014 - 2015
    Respiratory motor dysfunction and treatment in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Sleep disturbance and cholinergic degeneration in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    A multi-channel, multi-animal facility for recording brain and muscle activity in awake behaving animals
    NHMRC Equipment Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2010
    Plant derived odours reducing the adverse affects of chronic stress on the hiccocampus
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006
    Glutamate receptors and ion currents controlling in vivo excitability of motor neurons resistant and susceptible to death in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2004
    Mechanisms underlying motor neurone death due to glutamate-receptor evoked calcium influx
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    Interactions between phenome and genome at developing CNS synapses during synaptic refinement
    ARC Discovery Projects
    Open grant
  • 2002
    Cholinergic modulation of central respiratory activity
    UQ External Support Enabling Grant
    Open grant
  • 2002 - 2003
    Epigenetic and genetic factors involved in regulation of developmental changes in central synaptic transmission
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Mechanisms underlying motor neuron death due to glutamate receptor-evoked calcium influx in vitro
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2001
    Fast photometric measurement of calcium entry into single central synaptic terminals
    Ramaciotti Foundation
    Open grant
  • 2000
    (1) Quantifying the relationship betwen presynaptic calcium influx and transmitter release at a single central synapse. (2) The cellular basis for cholinergic control of respiratory muscle activity.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000 - 2001
    Mechanisms controlling transmitter release at a central synapse
    ARC Australian Research Fellowship/QEII F/ship
    Open grant
  • 2000
    Quantifying the Relationship Between Presynaptic Calcium Influx and Transmitter Release at a Single Central Synapse.
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Associate Professor Mark Bellingham is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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