Associate Professor Mark Bellingham
Associate Professor

Mark Bellingham

Email: 
Phone: 
+61 7 336 53122

Background

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones.

Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice and in vivo preparations, patch clamp techniques, imaging, molecular biology and computer modelling.

Projects include :

  • Neurobiology of motor control
  • Motor neuron disease
  • Synaptic transmission in the cochlear nucleus
  • Potassium currents in the brainstem and cerebellum
  • Rhythmic control of breathing movements

Availability

Associate Professor Mark Bellingham is:
Available for supervision

Fields of research

Neurosciences Pharmacology and pharmaceutical sciences Veterinary sciences

Research interests

  • Synaptic transmission in the cochlear nucleus:

    <li>Electrophysiology of postsynaptic AMPA and NMDA receptors and their developmental regulation <li>Single cell RT-PCR with Drs. Joanne Lewohl and Peter Dodd (Biochemistry, UQ) to determine AMPA and NMDA receptor subunits <li>Developmental changes in and mechanisms of short term synaptic plasticity <li>Calcium imaging in single presynaptic terminals

  • Potassium currents in the brainstem and cerebellum:

    <li>Muscarinic receptor regulation of potassium channels in hypoglossal motor neurones - neuropharmacology and second messenger systems <li>Role of potassium channels in causing cerebellar ataxia in ATM protein knock-out mice (with Dr. Martin Lavin, QIMR) <li>Role of potassium channels in regulating transmitter release from presynaptic terminals contacting hypoglossal motor neurones

  • Rhythmic control of breathing movements:

    <li>Muscarinic responses of hypoglossal motor neurones and rhythm-generating network for breathing movements - may be involved in sleep apnoea and SIDS. <li>Role of ATP receptors in rhythmic breathing movements in normal and transgenic knockout mice (with Dr. Peter Noakes) <li>Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

Search Professor Mark Bellingham’s works on UQ eSpace

124 works between 1988 and 2024
All (124) Journal Article (83) Book Chapter (4) Conference Publication (36) Other Outputs (1)

101 - 120 of 124 works

1999

Journal Article

Synaptic inhibition of cat phrenic motoneurons by internal intercostal nerve stimulation

Bellingham, M C (1999). Synaptic inhibition of cat phrenic motoneurons by internal intercostal nerve stimulation. Journal of neurophysiology, 82 (3), 1224-32. doi: 10.1152/jn.1999.82.3.1224

Synaptic inhibition of cat phrenic motoneurons by internal intercostal nerve stimulation

1999

Journal Article

Synaptic inhibition of cat phrenic motoneurons by internal intercostal nerve stimulation

Bellingham, MC (1999). Synaptic inhibition of cat phrenic motoneurons by internal intercostal nerve stimulation. Journal of Neurophysiology, 82 (3), 1224-1232.

Synaptic inhibition of cat phrenic motoneurons by internal intercostal nerve stimulation

1999

Journal Article

A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse

Bellingham, MC and Walmsley, B (1999). A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse. Neuron, 23 (1), 159-170. doi: 10.1016/S0896-6273(00)80762-X

A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse

1998

Journal Article

Driving respiration: The respiratory central pattern generator

Bellingham, MC (1998). Driving respiration: The respiratory central pattern generator. Clinical and Experimental Pharmacology and Physiology, 25 (10), 847-856. doi: 10.1111/j.1440-1681.1998.tb02166.x

Driving respiration: The respiratory central pattern generator

1998

Journal Article

Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat

Bellingham, MC, Lim, R and Walmsley, B (1998). Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat. Journal of Physiology, 511 (3), 861-869. doi: 10.1111/j.1469-7793.1998.861bg.x

Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat

1997

Journal Article

Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons

Baraban, SC, Bellingham, MC, Berger, AJ and Schwartzkroin, PA (1997). Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons. Journal of Physiology-London, 498 (3), 679-689. doi: 10.1113/jphysiol.1997.sp021892

Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons

1996

Journal Article

Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors

Bellingham, MC and Berger, AJ (1996). Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors. Journal of Neurophysiology, 76 (6), 3758-3770. doi: 10.1152/jn.1996.76.6.3758

Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors

1996

Journal Article

Presynaptic inhibition of glutamatergic synaptic transmission to rat motoneurons by serotonin

Singer, JH, Bellingham, MC and Berger, AJ (1996). Presynaptic inhibition of glutamatergic synaptic transmission to rat motoneurons by serotonin. Journal of Neurophysiology, 76 (2), 799-807. doi: 10.1152/jn.1996.76.2.799

Presynaptic inhibition of glutamatergic synaptic transmission to rat motoneurons by serotonin

1996

Conference Publication

Postnatal development of hypoglossal motoneuron intrinsic properties

Berger, A. J., Bayliss, D. A., Bellingham, M. C., Umemiya, M. and Viana, F. (1996). Postnatal development of hypoglossal motoneuron intrinsic properties.

Postnatal development of hypoglossal motoneuron intrinsic properties

1995

Journal Article

Adenosinergic Modulation of Respiratory Neurons and Hypoxic Responses in the Anesthetized Cat

Schmidt, C, Bellingham, MC and Richter, DW (1995). Adenosinergic Modulation of Respiratory Neurons and Hypoxic Responses in the Anesthetized Cat. Journal of Physiology-London, 483 (3), 769-781. doi: 10.1113/jphysiol.1995.sp020621

Adenosinergic Modulation of Respiratory Neurons and Hypoxic Responses in the Anesthetized Cat

1995

Book Chapter

Postnatal development of hypoglossal motoneuron intrinsic properties

Berger, A. J., Bayliss, D. A., Bellingham, M. C., Umemiya, M. and Viana, F. (1995). Postnatal development of hypoglossal motoneuron intrinsic properties. Control of the Cardiovascular and Respiratory Systems in Health and Disease. (pp. 63-71) edited by C. Tissa Kappagoda and Marc P. Kaufman. Singapore, Singapore: Springer Singapore. doi: 10.1007/978-1-4615-1895-2_7

Postnatal development of hypoglossal motoneuron intrinsic properties

1994

Journal Article

Activity-Related Ph Changes in Respiratory Neurons and Glial-Cells of Cats

Ballanyi, K, Muckenhoff, K, Bellingham, MC, Okada, Y, Scheid, P and Richter, DW (1994). Activity-Related Ph Changes in Respiratory Neurons and Glial-Cells of Cats. Neuroreport, 6 (1), 33-36. doi: 10.1097/00001756-199412300-00010

Activity-Related Ph Changes in Respiratory Neurons and Glial-Cells of Cats

1994

Journal Article

Adenosine suppresses excitatory glutamatergic inputs to rat hypoglossal motoneurons in vitro

Bellingham, MC and Berger, AJ (1994). Adenosine suppresses excitatory glutamatergic inputs to rat hypoglossal motoneurons in vitro. Neuroscience Letters, 177 (1-2), 143-146. doi: 10.1016/0304-3940(94)90065-5

Adenosine suppresses excitatory glutamatergic inputs to rat hypoglossal motoneurons in vitro

1994

Journal Article

Pontine respiratory neurons in anesthetized cats

Dick, TE, Bellingham, MC and Richter, DW (1994). Pontine respiratory neurons in anesthetized cats. Brain Research, 636 (2), 259-269. doi: 10.1016/0006-8993(94)91025-1

Pontine respiratory neurons in anesthetized cats

1994

Journal Article

Characteristics and Postnatal-Development of a Hyperpolarization-Activated Inward Current in Rat Hypoglossal Motoneurons In-Vitro

Bayliss, DA, Viana, F, Bellingham, MC and Berger, AJ (1994). Characteristics and Postnatal-Development of a Hyperpolarization-Activated Inward Current in Rat Hypoglossal Motoneurons In-Vitro. Journal of Neurophysiology, 71 (1), 119-128. doi: 10.1152/jn.1994.71.1.119

Characteristics and Postnatal-Development of a Hyperpolarization-Activated Inward Current in Rat Hypoglossal Motoneurons In-Vitro

1994

Journal Article

pH changes in respiratory neurons: A phenomenon at the search of a function

Ballanyi, K., Mückenhoff, K., Bellingham, M. C., Okada, Y., Scheid, P. and Rioter, D. W. (1994). pH changes in respiratory neurons: A phenomenon at the search of a function. NeuroReport, 6 (1). doi: 10.1097/00001756-199412300-00001

pH changes in respiratory neurons: A phenomenon at the search of a function

1993

Journal Article

Late Expiratory Inhibition of Stage-2 Expiratory Neurons in the Cat - a Correlate of Expiratory Termination

Klages, S, Bellingham, MC and Richter, DW (1993). Late Expiratory Inhibition of Stage-2 Expiratory Neurons in the Cat - a Correlate of Expiratory Termination. Journal of Neurophysiology, 70 (4), 1307-1315. doi: 10.1152/jn.1993.70.4.1307

Late Expiratory Inhibition of Stage-2 Expiratory Neurons in the Cat - a Correlate of Expiratory Termination

1993

Journal Article

Meßsystem zur Bestimmung schneller intrazellulärer pH-Signale

Mückenhoff, K., Schreiber, S., Kawai, A., Scheid, P., Ballanyi, K., Bellingham, M. and Richter, D. W. (1993). Meßsystem zur Bestimmung schneller intrazellulärer pH-Signale. Biomedizinische Technik, 38 (s1), 307-308. doi: 10.1515/bmte.1993.38.s1.307

Meßsystem zur Bestimmung schneller intrazellulärer pH-Signale

1992

Conference Publication

Maintenance of the Respiratory Rhythm During Normoxia and Hypoxia

Richter, DW, Bellingham, MC and Schmidt, C (1992). Maintenance of the Respiratory Rhythm During Normoxia and Hypoxia. 5Th Oxford Conf On Control of Breathing and its Modelling Perspective, Fuji Japan, Sep 17-19, 1991. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.

Maintenance of the Respiratory Rhythm During Normoxia and Hypoxia

1992

Journal Article

Morphology and electrophysiology of superior laryngeal nerve afferents and postsynaptic neurons in the medulla oblongata of the cat

Bellingham, MC and Lipski, J (1992). Morphology and electrophysiology of superior laryngeal nerve afferents and postsynaptic neurons in the medulla oblongata of the cat. Neuroscience, 48 (1), 205-216. doi: 10.1016/0306-4522(92)90349-7

Morphology and electrophysiology of superior laryngeal nerve afferents and postsynaptic neurons in the medulla oblongata of the cat

Current funding

  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant

Past funding

  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Linking synaptic hyperexcitability to corticospinal neuron death in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    In search of novel MND therapeutics: Investigating the role of selective KATP channel activators on cortical hyperexcitability, corticospinal circuit degeneration, and cortical bioenergetics
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Orexin/Hypocretin Receptors in Self- Administration and Stress-Induced Reinstatement of Ethanol Seeking (NHMRC Project Grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2014 - 2015
    Respiratory motor dysfunction and treatment in an animal model of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Sleep disturbance and cholinergic degeneration in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Molecular Stereology Facility Upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    A multi-channel, multi-animal facility for recording brain and muscle activity in awake behaving animals
    NHMRC Equipment Grant
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2010
    Plant derived odours reducing the adverse affects of chronic stress on the hiccocampus
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006
    Glutamate receptors and ion currents controlling in vivo excitability of motor neurons resistant and susceptible to death in ALS
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2004
    Mechanisms underlying motor neurone death due to glutamate-receptor evoked calcium influx
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    Interactions between phenome and genome at developing CNS synapses during synaptic refinement
    ARC Discovery Projects
    Open grant
  • 2002
    Cholinergic modulation of central respiratory activity
    UQ External Support Enabling Grant
    Open grant
  • 2002 - 2003
    Epigenetic and genetic factors involved in regulation of developmental changes in central synaptic transmission
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Mechanisms underlying motor neuron death due to glutamate receptor-evoked calcium influx in vitro
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2001
    Fast photometric measurement of calcium entry into single central synaptic terminals
    Ramaciotti Foundation
    Open grant
  • 2000
    (1) Quantifying the relationship betwen presynaptic calcium influx and transmitter release at a single central synapse. (2) The cellular basis for cholinergic control of respiratory muscle activity.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2000 - 2001
    Mechanisms controlling transmitter release at a central synapse
    ARC Australian Research Fellowship/QEII F/ship
    Open grant
  • 2000
    Quantifying the Relationship Between Presynaptic Calcium Influx and Transmitter Release at a Single Central Synapse.
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Associate Professor Mark Bellingham is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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