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Associate Professor Deanne Whitworth
Associate Professor

Deanne Whitworth

Email: 
Phone: 
+61 7 54601 972

Overview

Background

I completed a BSc (Hons) and a PhD at the University of Melbourne before undertaking post-doctoral research at the University of California, Berkeley, and the University of Texas MD Anderson Cancer Center, Houston. My research focused on marsupial and eutherian developmental biology, going off piste a couple of times to work with spotted hyaenas and European moles. After 6 years in the US I returned to Australia to study Veterinary Science (BVSc) at the University of Queensland (UQ), going on to work in equine and small animal practice. A longing to get back into research lead to my current position as a Teaching & Research academic in the School of Veterinary Science, UQ. My lab has generated induced pluripotent stem cells (iPSCs) from dogs and horses that are being used to model diseases in vitro and as the basis for research into stem cell-based treatments for a variety of diseases. We have also produced iPSCs from the Tasmanian devil and the platypus, the first stem cells ever described from a marsupial and a monotreme, respectively, allowing us to pursue research directed at treating devil facial tumour disease, understanding marsupial and monotreme embryonic development, and the conservation of endangered species.

Education

  • BSc (Hons), University of Melbourne (1990)
  • PhD, University of Melbourne (1996)
  • BVSc (Hons), University of Queensland (2006)

Employment

  • Post-doctoral researcher, University of California, Berkeley, USA (1996-1997)
  • Post-doctoral researcher, MD Anderson Cancer Centre, Houston, Texas, USA (1997-2002)
  • Veterinary Surgeon (2006-present)
  • Lecturer, School of Veterinary Science, University of Queensland (2010-2017)
  • Affiliate Senior Research Fellow, Australian Institute for Bioengineering and Nanotechnology, University of Queensland (2016-present)
  • Senior Lecturer, School of Veterinary Science, University of Queensland (2017-2022)
  • Associate Professor, School of Veterinary Science, University of Queensland (2023-present)

Availability

Associate Professor Deanne Whitworth is:
Available for supervision
Media expert

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, University of Melbourne
  • Bachelor (Honours) of Veterinary Science, The University of Queensland

Research interests

  • Induced pluripotent stem cells from domestic and native Australian species

    Our research uses induced pluripotent stem cells (iPSCs) from domestic and native Australian species to address several key areas of research including regenerative medicine, reproduction, species conservation and mammalian evolution.

Works

Search Professor Deanne Whitworth’s works on UQ eSpace

51 works between 1992 and 2024

1 - 20 of 51 works

Featured

2022

Journal Article

Monodelphis domestica induced pluripotent stem cells reveal metatherian pluripotency architecture

Kumar, Satish, De Leon, Erica M., Granados, Jose, Whitworth, Deanne J. and VandeBerg, John L. (2022). Monodelphis domestica induced pluripotent stem cells reveal metatherian pluripotency architecture. International Journal of Molecular Sciences, 23 (20) 12623, 12623. doi: 10.3390/ijms232012623

Monodelphis domestica induced pluripotent stem cells reveal metatherian pluripotency architecture

Featured

2021

Journal Article

Innovations and advances in schistosome stem cell research

You, Hong, Jones, Malcolm K., Whitworth, Deanne J. and McManus, Donald P. (2021). Innovations and advances in schistosome stem cell research. Frontiers in Immunology, 12 599014, 1-9. doi: 10.3389/fimmu.2021.599014

Innovations and advances in schistosome stem cell research

Featured

2021

Journal Article

Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells

Shahsavari, Arash, Weeratunga, Prasanna, Ovchinnikov, Dmitry A. and Whitworth, Deanne J. (2021). Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells. Scientific Reports, 11 (1) 3486, 3486. doi: 10.1038/s41598-021-82856-3

Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells

Featured

2020

Journal Article

Laser assisted blastomere extrusion biopsy of in vitro produced cattle embryos—A potential high throughput, minimally invasive approach for sampling pre-morula and morula stage embryos

Tutt, Desmond A. R., Passaro, Claudia, Whitworth, Deanne J. and Holland, Michael K. (2020). Laser assisted blastomere extrusion biopsy of in vitro produced cattle embryos—A potential high throughput, minimally invasive approach for sampling pre-morula and morula stage embryos. Animal Reproduction Science, 219 106546, 106546. doi: 10.1016/j.anireprosci.2020.106546

Laser assisted blastomere extrusion biopsy of in vitro produced cattle embryos—A potential high throughput, minimally invasive approach for sampling pre-morula and morula stage embryos

Featured

2020

Journal Article

Blubber cortisol levels in humpback whales (Megaptera novaeangliae): a measure of physiological stress without effects from sampling

Mingramm, Fletcher M. J., Keeley, Tamara, Whitworth, Deanne J. and Dunlop, Rebecca A. (2020). Blubber cortisol levels in humpback whales (Megaptera novaeangliae): a measure of physiological stress without effects from sampling. General and Comparative Endocrinology, 291 113436, 113436. doi: 10.1016/j.ygcen.2020.113436

Blubber cortisol levels in humpback whales (Megaptera novaeangliae): a measure of physiological stress without effects from sampling

Featured

2020

Journal Article

Induced pluripotent stem cell-derived mesenchymal stem cells from the Tasmanian devil (Sarcophilus harrisii) express immunomodulatory factors and a tropism toward devil facial tumor cells

Weeratunga, Prasanna, Shahsavari, Arash, Fennis, Evelien, Wolvetang, Ernst J., Ovchinnikov, Dmitry A. and Whitworth, Deanne J. (2020). Induced pluripotent stem cell-derived mesenchymal stem cells from the Tasmanian devil (Sarcophilus harrisii) express immunomodulatory factors and a tropism toward devil facial tumor cells. Stem Cells and Development, 29 (1), 25-37. doi: 10.1089/scd.2019.0203

Induced pluripotent stem cell-derived mesenchymal stem cells from the Tasmanian devil (Sarcophilus harrisii) express immunomodulatory factors and a tropism toward devil facial tumor cells

Featured

2020

Journal Article

The influence of physiological status on the reproductive behaviour of humpback whales (Megaptera novaeangliae)

Mingramm, F. M.J., Keeley, T., Whitworth, D. J. and Dunlop, R. A. (2020). The influence of physiological status on the reproductive behaviour of humpback whales (Megaptera novaeangliae). Hormones and Behavior, 117 104606, 104606. doi: 10.1016/j.yhbeh.2019.104606

The influence of physiological status on the reproductive behaviour of humpback whales (Megaptera novaeangliae)

Featured

2019

Journal Article

Relationships between blubber and respiratory vapour steroid hormone concentrations in humpback whales (Megaptera novaeangliae)

Mingramm, Fletcher M. J., Keeley, Tamara, Whitworth, Deanne J. and Dunlop, Rebecca A. (2019). Relationships between blubber and respiratory vapour steroid hormone concentrations in humpback whales (Megaptera novaeangliae). Aquatic Mammals, 45 (5), 465-477. doi: 10.1578/AM.45.5.2019.465

Relationships between blubber and respiratory vapour steroid hormone concentrations in humpback whales (Megaptera novaeangliae)

Featured

2019

Journal Article

Evaluation of respiratory vapour and blubber samples for use in endocrine assessments of bottlenose dolphins (Tursiops spp.)

Mingramm, F.M.J., Dunlop, R.A., Blyde, D., Whitworth, D.J. and Keeley, T. (2019). Evaluation of respiratory vapour and blubber samples for use in endocrine assessments of bottlenose dolphins (Tursiops spp.). General and Comparative Endocrinology, 274, 37-49. doi: 10.1016/j.ygcen.2018.12.015

Evaluation of respiratory vapour and blubber samples for use in endocrine assessments of bottlenose dolphins (Tursiops spp.)

Featured

2019

Journal Article

Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme

Whitworth, Deanne J., Limnios, Ioannis J., Gauthier, Marie-Emilie, Weeratunga, Prasanna, Ovchinnikov, Dmitry A., Baillie, Gregory, Grimmond, Sean M., Graves, Jennifer A. Marshall and Wolvetang, Ernst J. (2019). Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme. Stem Cells and Development, 28 (3), 151-164. doi: 10.1089/scd.2018.0179

Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme

Featured

2019

Journal Article

Lifetime extension of humpback whale skin fibroblasts and their response to lipopolysaccharide (LPS) and a mixture of polychlorinated biphenyls (Aroclor)

Burkard, Michael, Bengtson Nash, Susan, Gambaro, Gessica, Whitworth, Deanne and Schirmer, Kristin (2019). Lifetime extension of humpback whale skin fibroblasts and their response to lipopolysaccharide (LPS) and a mixture of polychlorinated biphenyls (Aroclor). Cell Biology and Toxicology, 35 (4), 387-398. doi: 10.1007/s10565-018-09457-1

Lifetime extension of humpback whale skin fibroblasts and their response to lipopolysaccharide (LPS) and a mixture of polychlorinated biphenyls (Aroclor)

Featured

2018

Journal Article

Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns

Alateeq, Suad, Ovchinnikov, Dmitry, Tracey, Timothy, Whitworth, Deanne, Al-Rubaish, Abdullah, Al-Ali, Amein and Wolvetang, Ernst (2018). Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. APL Bioengineering, 2 (4) 046103, 046103. doi: 10.1063/1.5048625

Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns

Featured

2018

Journal Article

Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases

Fortuna, Patrick R. J., Bielefeldt-Ohmann, Helle, Ovchinnikov, Dmitry A., Wolvetang, Ernst Jurgen and Whitworth, Deanne Jeanette (2018). Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases. Stem Cells and Development, 27 (10), 704-715. doi: 10.1089/scd.2017.0106

Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases

Featured

2018

Journal Article

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Whitworth, Deanne J. (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Stem Cells and Development, 27 (2), 112-122. doi: 10.1089/scd.2017.0224

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Featured

2016

Journal Article

The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials

Whitworth, Deanne J. and Pask, Andrew J. (2016). The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials. Seminars in Cell and Developmental Biology, 56, 117-121. doi: 10.1016/j.semcdb.2016.01.006

The X factor: X chromosome dosage compensation in the evolutionarily divergent monotremes and marsupials

Featured

2015

Journal Article

Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment

Burkard, Michael, Whitworth, Deanne, Schirmer, Kristin and Nash, Susan B. (2015). Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment. Aquatic Toxicology, 167, 240-247. doi: 10.1016/j.aquatox.2015.08.005

Establishment of the first humpback whale fibroblast cell lines and their application in chemical risk assessment

Featured

2014

Journal Article

Stem cell therapies for treating osteoarthritis: prescient or premature?

Whitworth, Deanne J. and Banks, Tania A. (2014). Stem cell therapies for treating osteoarthritis: prescient or premature?. The Veterinary Journal, 202 (3), 416-424. doi: 10.1016/j.tvjl.2014.09.024

Stem cell therapies for treating osteoarthritis: prescient or premature?

Featured

2014

Journal Article

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 (2), 251-261. doi: 10.1016/j.scr.2014.05.006

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Featured

2014

Journal Article

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print (24), 3021-3033. doi: 10.1089/scd.2013.0634

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Featured

2014

Journal Article

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014). Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles (13), 1-9. doi: 10.1089/scd.2013.0461

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Funding

Current funding

  • 2023 - 2025
    Saving the endangered Spectacled flying fox from annual tick paralysis mortality events:
    Threatened Species Research Grants
    Open grant

Past funding

  • 2019 - 2020
    The generation of spermatogonial stem cells from equine induced pluripotent stem cells for the correction of genetic diseases and the restoration of fertility in geldings
    John & Mary Kibble Trust
    Open grant
  • 2019 - 2020
    Automated immunohistochemical analysis module for the expansion of research and clinical diagnostic capabilities at UQ
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2020
    Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential
    Morris Animal Foundation
    Open grant
  • 2017 - 2019
    Effect of induced pluripotent stem cell-derived mesenchymal stem cells on facial tumour cells from the Tasmanian devil (Sarcophillus harrisii)
    Annandale Bequest
    Open grant
  • 2015 - 2016
    Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential in canine disease
    Research Donation Generic
    Open grant
  • 2014 - 2018
    The role of gap junction channels, growth factors and cytokines in the diseased canine cornea
    Canine Research Foundation
    Open grant
  • 2014 - 2018
    The role of gap junction channels, growth factors, and cytokines in the diseased canine cornea
    Peter & Mary Ellen Stone Memorial Fund
    Open grant
  • 2014 - 2018
    A stem cell-based approach to the treatment of devil facial tumour disease in the Tasmanian devil (Sarcophilus harrisii)
    Morris Animal Foundation
    Open grant
  • 2014
    Establishment of a core facility in reproductive technology including cell micromanipulation and stem cells to improve research capacity and benefit animal health at the Gatton campus
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    In vitro-derived mesenchymal cells as a therapeutic resource for treating osteoarthritis - a clinical trial
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2012 - 2013
    Canine induced pluripotent stem cells as a resource for treating canine osteoarthritis
    John & Mary Kibble Trust
    Open grant
  • 2011 - 2012
    Canine Induced Pluripotent Stem Cells as a Resource for Treating Canine Osteoarthritis
    John & Mary Kibble Trust
    Open grant
  • 2011 - 2012
    Canine Induced Pluripotent Stem Cells as a Resource for Treating Canine Osteoarthritis
    Australian Companion Animal Health Foundation
    Open grant
  • 2010 - 2011
    Canine induced pluripotent stem cells as a resource for treating canine osteoarthritis
    John & Mary Kibble Trust
    Open grant
  • 2010 - 2011
    Canine Induced Pluripotent Stem Cells as a Resource for Treating Canine Osteoarthritis
    UQ New Staff Research Start-Up Fund
    Open grant

Supervision

Availability

Associate Professor Deanne Whitworth is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Projects working with marsupial (Tasmanian devil) and horse stem cells are currently available

Supervision history

Current supervision

  • Doctor Philosophy

    Genetic engineering in Tasmanian devil stem cells to deliver targeted anti-tumour activity against devil facial tumour cells

    Principal Advisor

    Other advisors: Dr Gry Boe-Hansen

  • Doctor Philosophy

    In vitro modelling and treatment of laminitis using equine stem cells

    Principal Advisor

    Other advisors: Associate Professor François-René Bertin, Dr Albert Sole Guitart

  • Doctor Philosophy

    The Oncogenic and Immunosuppresive Potency of Novel Flying Fox Gammaretrovirus : Uncover The Species-Shifting of Bat Virus Origin

    Associate Advisor

    Other advisors: Professor Joanne Meers, Dr Lee McMichael

Completed supervision

Media

Enquiries

Contact Associate Professor Deanne Whitworth directly for media enquiries about:

  • regenerative medicine
  • stem cells
  • stem cells in animals
  • use of stem cells in veterinary medicine

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au