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Associate Professor François-René Bertin
Associate Professor

François-René Bertin

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Overview

Background

Dr François-René Bertin (DVM, MS, PhD, dipl.ACVIM (LAIM)) is an equine internist with expertise in clinical endocrinology.

François-René completed a Doctorate of Veterinary Medicine (University of Nantes, France), an American College of Veterinary Internal Medicine (ACVIM) residency in equine internal medicine (Purdue University, USA) and a PhD in physiology (McGill University, Canada). He moved to the School of Veterinary Science at UQ in 2016.

François-René’s research interests lie in the pathophysiology of hyperinsulinaemia-associated laminitis and the disorders of the equine hypothalamo-pituitary adrenocortical axis. Some of his current projects examine the regulators of pancreatic b-cell activity and the mechanisms of pituitary gland senescence. François-René has received awards from the School of Veterinary Science and the Faculty of Science for his contribution to Research and HDR student supervision.

François-René teaches equine internal medicine into the veterinary science and veterinary technology programs and coordinates the Equine Clinical Studies course. He has received Teaching and Learning Faculty Awards.

Availability

Associate Professor François-René Bertin is:
Available for supervision
Media expert

Qualifications

  • Doctoral Diploma of Veterinary Medicine, Université de Nantes
  • Masters (Coursework) of Science, Purdue University
  • Doctor of Philosophy, McGill University
  • Fellow, American College of Veterinary Internal Medicine, American College of Veterinary Internal Medicine

Research interests

  • Equine endocrinology

  • Pancreatic b-cell activity

    Understanding the mechanisms associated with hyperinsulinaemia and the development of equine laminitis.

  • Hypothalamo-pituitary adrenocortical axis senescence

    Understanding the age-associated changes of the equine pituitary gland.

  • Clinical diagnostic testing

    Improving diagnostic testing of endocrine disorders in horses.

Works

Search Professor François-René Bertin’s works on UQ eSpace

123 works between 2010 and 2024

1 - 20 of 123 works

Featured

2020

Journal Article

Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses

Horn, Remona, Stewart, Allison J., Jackson, Karen V., Dryburgh, Elizabeth L., Medina‐Torres, Carlos E. and Bertin, François‐René (2020). Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses. Journal of Veterinary Internal Medicine, 35 (1) jvim.16017, 560-570. doi: 10.1111/jvim.16017

Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses

Featured

2020

Book Chapter

Endocrine system

Kritchevsky, Janice E. and Bertin, François-René (2020). Endocrine system. Equine clinical medicine, surgery and reproduction. (pp. 901-922) edited by Munroe, Graham A.. Boca Raton, FL, United States: CRC Press Taylor & Francis Group.

Endocrine system

Featured

2020

Book

Equine endocrinology

Bertin, F. R. and Fraser, N. S. (2020). Equine endocrinology. Wallingford, United Kingdom: CABI. doi: 10.1079/9781789241099.0000

Equine endocrinology

Featured

2018

Journal Article

Factors associated with survival, laminitis and insulin dysregulation in horses diagnosed with equine pituitary pars intermedia dysfunction

Horn, R., Bamford, N. J., Afonso, T., Sutherland, M., Buckerfield, J., Tan, R. H. H., Secombe, C. J., Stewart, A. J. and Bertin, F. R. (2018). Factors associated with survival, laminitis and insulin dysregulation in horses diagnosed with equine pituitary pars intermedia dysfunction. Equine Veterinary Journal, 51 (4), 440-445. doi: 10.1111/evj.13041

Factors associated with survival, laminitis and insulin dysregulation in horses diagnosed with equine pituitary pars intermedia dysfunction

Featured

2017

Journal Article

The diagnosis of equine insulin dysregulation

Bertin, F. R. and de Laat, M. A. (2017). The diagnosis of equine insulin dysregulation. Equine Veterinary Journal, 49 (5), 570-576. doi: 10.1111/evj.12703

The diagnosis of equine insulin dysregulation

Featured

2013

Journal Article

Comparison of a two-step insulin-response test to conventional insulin-sensitivity testing in horses

Bertin, F. R. and Sojka-Kritchevsky, J. E. (2013). Comparison of a two-step insulin-response test to conventional insulin-sensitivity testing in horses. Domestic Animal Endocrinology, 44 (1), 19-25. doi: 10.1016/j.domaniend.2012.07.003

Comparison of a two-step insulin-response test to conventional insulin-sensitivity testing in horses

2024

Journal Article

Value of measuring markers of lipid metabolism in horses during an oral glucose test

Zemek, Claire H. K., Kemp, Kate L. and Bertin, François‐René (2024). Value of measuring markers of lipid metabolism in horses during an oral glucose test. Journal of Veterinary Internal Medicine. doi: 10.1111/jvim.17199

Value of measuring markers of lipid metabolism in horses during an oral glucose test

2024

Journal Article

Extracellular RNA Induces Neutrophil Recruitment Via Toll‐Like Receptor 3 During Venous Thrombosis After Vascular Injury

Najem, Maria Y., Rys, Ryan N., Laurance, Sandrine, Bertin, François‐René, Gourdou‐Latyszenok, Virginie, Gourhant, Lénaïck, Le Gall, Lauriane, Le Corre, Rozenn, Couturaud, Francis, Blostein, Mark D. and Lemarié, Catherine A. (2024). Extracellular RNA Induces Neutrophil Recruitment Via Toll‐Like Receptor 3 During Venous Thrombosis After Vascular Injury. Journal of the American Heart Association, 13 (15) ARTN e034492, e034492. doi: 10.1161/jaha.124.034492

Extracellular RNA Induces Neutrophil Recruitment Via Toll‐Like Receptor 3 During Venous Thrombosis After Vascular Injury

2024

Journal Article

Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation

Kemp, Kate L., Skinner, Jazmine E. and Bertin, François‐René (2024). Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation. Journal of Veterinary Internal Medicine, 38 (2), 1177-1184. doi: 10.1111/jvim.17013

Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation

2024

Book

Concise textbook of equine clinical practice book 5 : Nervous system, eyes, cardiovascular disorders and haemolymphatic system

Beasley, Erin, Munroe, Graham, Bertin, François-René and Munroe, Graham (2024). Concise textbook of equine clinical practice book 5 : Nervous system, eyes, cardiovascular disorders and haemolymphatic system. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781003451921

Concise textbook of equine clinical practice book 5 : Nervous system, eyes, cardiovascular disorders and haemolymphatic system

2024

Journal Article

Epidemiological investigation of insulin dysregulation in Shetland and Welsh ponies in Australia

Clark, Brianna L., Norton, Elaine M., Bamford, Nicholas J., Randhawa, Imtiaz A. S., Kemp, Kate L., McCue, Molly E., Bertin, François‐René and Stewart, Allison J. (2024). Epidemiological investigation of insulin dysregulation in Shetland and Welsh ponies in Australia. Equine Veterinary Journal, 56 (2), 281-290. doi: 10.1111/evj.14044

Epidemiological investigation of insulin dysregulation in Shetland and Welsh ponies in Australia

2023

Book

Concise textbook of equine clinical practice book 4: Liver, endocrine, urinary, skin and wounds

Munroe, Graham, Bertin, François-René, Cruz, Antonio, Durham, Andy and Knottenbelt, Derek (2023). Concise textbook of equine clinical practice book 4: Liver, endocrine, urinary, skin and wounds. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781003453666

Concise textbook of equine clinical practice book 4: Liver, endocrine, urinary, skin and wounds

2023

Journal Article

Lipid disorders in horses and foals

Bertin, François-René (2023). Lipid disorders in horses and foals. UK-Vet Equine, 7 (6), 248-253. doi: 10.12968/ukve.2023.7.6.248

Lipid disorders in horses and foals

2023

Journal Article

Clinical implications of imprecise sampling time for 10‐ and 30‐min thyrotropin‐releasing hormone stimulation tests in horses

Vorster, Dante M., Wang, Wenqing, Kemp, Kate L., Bamford, Nicholas J. and Bertin, François‐René (2023). Clinical implications of imprecise sampling time for 10‐ and 30‐min thyrotropin‐releasing hormone stimulation tests in horses. Equine Veterinary Journal, 56 (2), 291-298. doi: 10.1111/evj.13991

Clinical implications of imprecise sampling time for 10‐ and 30‐min thyrotropin‐releasing hormone stimulation tests in horses

2023

Journal Article

Diagnosis and management of thyroid disorders and thyroid hormone supplementation in adult horses and foals

Bertin, François-René, Frank, Nicholas, Breuhaus, Babetta A., Schott, Harold C. and Kritchevsky, Janice E. (2023). Diagnosis and management of thyroid disorders and thyroid hormone supplementation in adult horses and foals. Equine Veterinary Journal, 56 (2), 243-252. doi: 10.1111/evj.13981

Diagnosis and management of thyroid disorders and thyroid hormone supplementation in adult horses and foals

2023

Journal Article

Evaluation of field-testing protocols to diagnose insulin dysregulation in ponies using a Bayesian approach

Clark, B. L., Stewart, A. J., Kemp, K. L., Bamford, N. J. and Bertin, F.-R. (2023). Evaluation of field-testing protocols to diagnose insulin dysregulation in ponies using a Bayesian approach. The Veterinary Journal, 298-299 106019, 106019. doi: 10.1016/j.tvjl.2023.106019

Evaluation of field-testing protocols to diagnose insulin dysregulation in ponies using a Bayesian approach

2023

Conference Publication

Breed differences in plasma adrenocorticotropic hormone concentrations among healthy horses and ponies

Bamford, Nicholas J., Stewart, Allison J., El-Hage, Charlie M., Bertin, Francois-Rene and Bailey, Simon R. (2023). Breed differences in plasma adrenocorticotropic hormone concentrations among healthy horses and ponies. Australian and New Zealand College of Veterinary Scientists, Gold Coast, QLD, Australia, 27-29 July 2023.

Breed differences in plasma adrenocorticotropic hormone concentrations among healthy horses and ponies

2023

Conference Publication

Epidemiological investigation of insulin dysregulation in Shetland and Welsh ponies in Australia

Clark, Brianna, Norton, Elaine, Bamford, Nicholas, Randhawa, Imtiaz, Kemp, Kate, McCue, Molly, Bertin, Francois-Rene and Stewart, Allison (2023). Epidemiological investigation of insulin dysregulation in Shetland and Welsh ponies in Australia. Bain Fallon Equine Veterinarians of Australia, Sunshine Coast, QLD, Australia, 17 July 2023.

Epidemiological investigation of insulin dysregulation in Shetland and Welsh ponies in Australia

2023

Journal Article

Equine Crofton weed (Ageratina spp.) pneumotoxicity: What do we know and what do we need to know?

Shapter, Frances Marie, Granados-Soler, José Luis, Stewart, Allison J., Bertin, Francois Rene and Allavena, Rachel (2023). Equine Crofton weed (Ageratina spp.) pneumotoxicity: What do we know and what do we need to know?. Animals, 13 (13) 2082, 1-15. doi: 10.3390/ani13132082

Equine Crofton weed (Ageratina spp.) pneumotoxicity: What do we know and what do we need to know?

2023

Conference Publication

Investigation of plasma leptin concentrations in association with obesity and laminitis status in ponies

Clark, Brianna L., Vaughn, Sarah A., Stewart, Allison J., Kemp, Kate L., Bamford, Nicholas J., Hart, Kelsey A. and Bertin, Francois-Rene (2023). Investigation of plasma leptin concentrations in association with obesity and laminitis status in ponies. American College of Veterinary Internal Medicine Forum, Philadelphia, PA, United States, 15-17 June 2023. Hoboken, NJ, United States: Wiley-Blackwell Publishing.

Investigation of plasma leptin concentrations in association with obesity and laminitis status in ponies

Funding

Current funding

  • 2024 - 2025
    Role of plasma extracellular vesicles in equine metabolic syndrome (EMS) condition
    Research Donation Generic
    Open grant
  • 2023 - 2024
    The role of dopamine in intestinal inflammation and oxidation in horses with pituitary pars intermedia dysfunction
    Research Donation Generic
    Open grant
  • 2018 - 2026
    Hendra virus antibody titres in foals derived from maternal antibodies and in response to vaccination
    John & Mary Kibble Trust
    Open grant

Past funding

  • 2022 - 2024
    Determination of proteomic and lipidomic profiles of horses with Equine Metabolic Syndrome and hyperinsulinemia-associated laminitis
    Boehringer Ingelheim Vetmedica GmbH
    Open grant
  • 2022 - 2023
    Controlling Insulin Dysregulation with Sirolimus (Grayson-Jockey Club Research Foundation administered by UPenn).
    University of Pennsylvania
    Open grant
  • 2021 - 2022
    Epidemiological and genetic evaluation of insulin dysregulation in ponies
    Resident Research Grants
    Open grant
  • 2020 - 2021
    Part 2 - Efficacy clinical trial of new oral pergolide in horses
    Luoda Pharma Pty Ltd
    Open grant
  • 2020 - 2023
    Dopamine as a new diagnostic tool for horses with pituitary pars intermedia dysfunction and its effect on the equine intestinal microbiota
    Australian Companion Animal Health Foundation
    Open grant
  • 2019 - 2023
    Evaluation of a Genetic test for Equine Metabolic Syndrome in Ponies
    Research Donation Generic
    Open grant
  • 2019 - 2023
    Investigating insulin and glucose dynamics in horses with Equine Metabolic Syndrome receiving Phenylbutazone
    Morris Animal Foundation
    Open grant
  • 2019 - 2022
    Endocrine profiles and reproduction performance in mares
    Research Donation Generic
    Open grant
  • 2019 - 2020
    Automated immunohistochemical analysis module for the expansion of research and clinical diagnostic capabilities at UQ
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2020
    Improvement of insulin stability in horses at risk of Equine Metabolic Syndrome
    John & Mary Kibble Trust
    Open grant
  • 2018
    Efficacy clinical trial of an herbal formulation to treat equine insect bite hypersensitivity
    Red Healer
    Open grant
  • 2018
    Assessment of value of a combined thyrotropin-releasing hormone stimulation test and 2-step insulin response test to diagnose Equine Pituitary Pars Intermedia Dysfunction and Equine Metabolic Syndrome
    UQ Early Career Researcher
    Open grant
  • 2017 - 2021
    Stability of equine adrenocorticotropic hormone (ACTH) under conditions encountered by Australian veterinarians
    Boehringer Ingelheim Pty Ltd
    Open grant
  • 2017 - 2018
    Establishment of seasonal reference intervals for adrenocorticotropic hormone (ACTH) concentrations for horses in Southern Queensland
    Research Donation Generic
    Open grant

Supervision

Availability

Associate Professor François-René Bertin is:
Available for supervision

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Available projects

  • Insulin dysregulation

    Insulin dysregulation is the hallmark of equine metabolic syndrome and has received attention because of its direct association with laminitis. In the absence of an adequate treatment for laminitis, our research focuses on the mechanisms leading to laminitis as well as on the early detection of individuals at risk of developing laminitis.

  • Hypothalamus-pituitary-adrenal dysfunctions

    The hypothalamo-pituitary-adrenal axis is a major regulator of homeostasis. With sickness or with age, this axis can be dysregulated leading to critical illness-related corticosteroid insufficiency or to pituitary pars intermedia dysfunction (PPID) respectively. The latter is a common condition of older horses that can result in laminitis and our research focuses on the detection and management of horses developping PPID.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

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