
Overview
Background
I completed a BSc (Hons) and a PhD at the University of Melbourne before undertaking post-doctoral research at the University of California, Berkeley, and the University of Texas MD Anderson Cancer Center, Houston. My research focused on marsupial and eutherian developmental biology. After 6 years in the US I returned to Australia to study Veterinary Science (BVSc) at the University of Queensland (UQ), going on to work in equine and small animal practice. A longing to get back into research lead to my current position as a Teaching & Research academic in the School of Veterinary Science, UQ. My lab has generated induced pluripotent stem cells (iPSCs) from dogs and horses that are being used to model diseases in vitro and as the basis for research into stem cell-based treatments for a variety of diseases. We have also produced iPSCs from the Tasmanian devil and the platypus, the first stem cells ever described from a marsupial and a monotreme, respectively, allowing us to pursue research directed at treating devil facial tumour disease, understanding marsupial and monotreme embryonic development, and the conservation of endangered species.
Education
- BSc (Hons), University of Melbourne (1990)
- PhD, University of Melbourne (1996)
- BVSc (Hons), University of Queensland (2006)
Employment
- Post-doctoral researcher, University of California, Berkeley, USA (1996-1997)
- Post-doctoral researcher, MD Anderson Cancer Centre, Houston, Texas, USA (1997-2002)
- Veterinary Surgeon (2006-present)
- Lecturer, School of Veterinary Science, University of Queensland (2010-2017)
- Affiliate Senior Research Fellow, Australian Institute for Bioengineering and Nanotechnology, University of Queensland (2016-present)
- Senior Lecturer, School of Veterinary Science, University of Queensland (2017-2022)
- Associate Professor, School of Veterinary Science, University of Queensland (2023-present)
Availability
- Associate Professor Deanne Whitworth is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Melbourne
- Doctor of Philosophy, University of Melbourne
- Bachelor (Honours) of Veterinary Science, The University of Queensland
Research interests
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Induced pluripotent stem cells from domestic and native Australian species
Our research uses induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) from domestic and native Australian species to address several key areas of research including regenerative medicine, reproduction, species conservation and mammalian evolution.
Works
Search Professor Deanne Whitworth’s works on UQ eSpace
Featured
2014
Journal Article
Stem cell therapies for treating osteoarthritis: prescient or premature?
Whitworth, Deanne J. and Banks, Tania A. (2014). Stem cell therapies for treating osteoarthritis: prescient or premature?. The Veterinary Journal, 202 (3), 416-424. doi: 10.1016/j.tvjl.2014.09.024
Featured
2014
Journal Article
Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro
Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 (2), 251-261. doi: 10.1016/j.scr.2014.05.006
Featured
2014
Journal Article
Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway
Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print (24), 3021-3033. doi: 10.1089/scd.2013.0634
Featured
2014
Journal Article
Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts
Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014). Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles (13), 1-9. doi: 10.1089/scd.2013.0461
Featured
2012
Journal Article
Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts
Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012). Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 (12), 2288-2297. doi: 10.1089/scd.2011.0608
Featured
2008
Journal Article
Overtraining syndrome in horses
McGowan, C. M. and Whitworth, D. J. (2008). Overtraining syndrome in horses. Comparative Exercise Physiology, 5 (2), 57-65. doi: 10.1017/S1478061508979202
Featured
2004
Journal Article
Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression
Pask, Andrew J., Whitworth, Deanne, J., Mao Chai-An, Wei, Kei-Jun, Sankovic, Natasha, Graves, Jennifer A. M., Shaw, Geoffrey, Renfree, Marilyn B. and Behringer, Richard R. (2004). Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression. Biology of Reproduction, 70 (1), 160-167. doi: 10.1095/biolreprod.103.020016
Featured
2001
Journal Article
Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial
Whitworth, D. J., Pask, A. J., Shaw, G., Marshall Graves, J. A., Behringer, R. R. and Renfree, M. B. (2001). Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial. Gene, 277 (1-2), 209-219. doi: 10.1016/S0378-1119(01)00677-1
Featured
2001
Journal Article
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization
Bi, Weimin, Huang, Wendong, Whitworth, Deanne J., Deng, Jian Min, Zhang, Zhaoping, Behringer, Richard R. and de Crombrugghe, Benoit (2001). Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proceedings of the National Academy of Sciences of the United States of America, 98 (12), 6698-6703. doi: 10.1073/pnas.111092198
Featured
2001
Book Chapter
The transgenic mouse in studies of mammalian sexual differentiation.
Whitworth, Deanne J. and Behringer, Richard R. (2001). The transgenic mouse in studies of mammalian sexual differentiation.. Transgenics in Endocrinology. (pp. 19-39) edited by Martin M. Matzuk, Chester W. Brown, T. Rajendra Kumar and P. Michael Conn. Totowa, NJ, U.S.A.: Humana Press.
Featured
2000
Journal Article
A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse
Bishop, Colin E., Whitworth, Deanne J., Qin, Yanjun, Agoulnik, Alexander I., Agoulnik, Irina A., Harrison, Wilbur R., Behringer, Richard R. and Overbeek, Paul A. (2000). A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nature Genetics, 26 (4), 490-494. doi: 10.1038/82652
Featured
2000
Journal Article
Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta
Whitworth, Deanne J., Hunt, Leigh and Licht, Paul (2000). Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta. General and Comparative Endocrinology, 118 (2), 354-358. doi: 10.1006/gcen.2000.7474
Featured
1999
Journal Article
High specificity of Müllerian-inhibiting substance signaling in vivo
Mishina, Y., Whitworth, D. J., Racine, C. and Behringer, R. R.. (1999). High specificity of Müllerian-inhibiting substance signaling in vivo. Endocrinology, 140 (5), 2084-2088. doi: 10.1210/en.140.5.2084
Featured
1999
Journal Article
Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea
Whitworth, Deanne J., Licht, Paul, Racey, Paul A. and Glickman, Stephen E. (1999). Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea. Biology of Reproduction, 60 (2), 413-418. doi: 10.1095/biolreprod60.2.413
Featured
1998
Journal Article
XX germ cells: The difference between an ovary and a testis
Whitworth, Deanne J. (1998). XX germ cells: The difference between an ovary and a testis. Trends in Endocrinology and Metabolism, 9 (1), 2-6. doi: 10.1016/S1043-2760(98)00002-2
Featured
1997
Journal Article
Müllerian duct regression in a marsupial, the tammar wallaby
Whitworth, Deanne J., Shaw, Geoffrey and Renfree Marilyn B. (1997). Müllerian duct regression in a marsupial, the tammar wallaby. Anatomy And Embryology, 196 (1), 39-46. doi: 10.1007/s004290050078
Featured
1997
Book Chapter
Sexual determination and differentiation in the marsupial Macropus eugenii
Shaw, Geoffrey, Harry, Jenny L., Whitworth, Deanne J. and Renfree, Marilyn B. (1997). Sexual determination and differentiation in the marsupial Macropus eugenii. Marsupial biology : Recent research, new perspectives. (pp. 132-141) edited by N. R. Saunders and L. A. Hinds. Sydney, NSW, Australia: University of NSW Press.
Featured
1996
Journal Article
Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro
Whitworth, Deanne J., Shaw, Geoffrey and Renfree, Marilyn B. (1996). Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro. Development (Cambridge), 122 (12), 4057-4063.
2018
Conference Publication
Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency
Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry, Wolvetang, Ernst and Whitworth, Deanne (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.
2018
Conference Publication
Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential
Shahsavari, A., Ovchinnikov, D., Wolvetang, E. and Whitworth, D. (2018). Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.
Funding
Current funding
Supervision
Availability
- Associate Professor Deanne Whitworth is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Projects working with marsupial (Tasmanian devil) and horse stem cells are currently available
Supervision history
Current supervision
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Doctor Philosophy
Genetic engineering in Tasmanian devil stem cells to deliver targeted anti-tumour activity against devil facial tumour cells
Principal Advisor
Other advisors: Associate Professor Gry Boe-Hansen
-
Doctor Philosophy
In vitro modelling and treatment of laminitis using equine stem cells
Principal Advisor
Other advisors: Associate Professor Francois-Rene Bertin, Dr Albert Sole Guitart
-
Doctor Philosophy
The Oncogenic and Immunosuppresive Potency of Novel Flying Fox Gammaretrovirus : Uncover The Species-Shifting of Bat Virus Origin
Associate Advisor
Other advisors: Professor Joanne Meers, Dr Lee McMichael
Completed supervision
-
2020
Doctor Philosophy
A pre-clinical trial using bio-material-based delivery of in vitro-derived mesenchymal stem cells to effect cartilage repair in a canine model of osteoarthritis
Principal Advisor
Other advisors: Professor Ernst Wolvetang
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2020
Doctor Philosophy
A stem cell-based approach to the treatment of devil facial tumour disease (DFTD) in the Tasmanian devil (Sarcophilus harrisii)
Principal Advisor
Other advisors: Professor Ernst Wolvetang
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2018
Doctor Philosophy
Multi-matrix endocrine analysis of cetaceans: Development and examination of reproductive and adrenal monitoring techniques
Associate Advisor
Other advisors: Associate Professor Rebecca Dunlop
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2018
Doctor Philosophy
Improving Efficiency of Embryo Technologies to Expedite Livestock Genetic Gain
Associate Advisor
-
2016
Doctor Philosophy
CRISPR/Cas9-mediated traceless gene correction and activation of the HBB locus in iPSCs with the beta thalassaemia mutation
Associate Advisor
Other advisors: Professor Ernst Wolvetang
Media
Enquiries
Contact Associate Professor Deanne Whitworth directly for media enquiries about:
- regenerative medicine
- stem cells
- stem cells in animals
- use of stem cells in veterinary medicine
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