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Associate Professor Deanne Whitworth
Associate Professor

Deanne Whitworth

Email: 
Phone: 
+61 7 54601 972

Overview

Background

I completed a BSc (Hons) and a PhD at the University of Melbourne before undertaking post-doctoral research at the University of California, Berkeley, and the University of Texas MD Anderson Cancer Center, Houston. My research focused on marsupial and eutherian developmental biology. After 6 years in the US I returned to Australia to study Veterinary Science (BVSc) at the University of Queensland (UQ), going on to work in equine and small animal practice. A longing to get back into research lead to my current position as a Teaching & Research academic in the School of Veterinary Science, UQ. My lab has generated induced pluripotent stem cells (iPSCs) from dogs and horses that are being used to model diseases in vitro and as the basis for research into stem cell-based treatments for a variety of diseases. We have also produced iPSCs from the Tasmanian devil and the platypus, the first stem cells ever described from a marsupial and a monotreme, respectively, allowing us to pursue research directed at treating devil facial tumour disease, understanding marsupial and monotreme embryonic development, and the conservation of endangered species.

Education

  • BSc (Hons), University of Melbourne (1990)
  • PhD, University of Melbourne (1996)
  • BVSc (Hons), University of Queensland (2006)

Employment

  • Post-doctoral researcher, University of California, Berkeley, USA (1996-1997)
  • Post-doctoral researcher, MD Anderson Cancer Centre, Houston, Texas, USA (1997-2002)
  • Veterinary Surgeon (2006-present)
  • Lecturer, School of Veterinary Science, University of Queensland (2010-2017)
  • Affiliate Senior Research Fellow, Australian Institute for Bioengineering and Nanotechnology, University of Queensland (2016-present)
  • Senior Lecturer, School of Veterinary Science, University of Queensland (2017-2022)
  • Associate Professor, School of Veterinary Science, University of Queensland (2023-present)

Availability

Associate Professor Deanne Whitworth is:
Available for supervision
Media expert

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, University of Melbourne
  • Bachelor (Honours) of Veterinary Science, The University of Queensland

Research interests

  • Induced pluripotent stem cells from domestic and native Australian species

    Our research uses induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) from domestic and native Australian species to address several key areas of research including regenerative medicine, reproduction, species conservation and mammalian evolution.

Works

Search Professor Deanne Whitworth’s works on UQ eSpace

52 works between 1992 and 2024

21 - 40 of 52 works

Featured

2014

Journal Article

Stem cell therapies for treating osteoarthritis: prescient or premature?

Whitworth, Deanne J. and Banks, Tania A. (2014). Stem cell therapies for treating osteoarthritis: prescient or premature?. The Veterinary Journal, 202 (3), 416-424. doi: 10.1016/j.tvjl.2014.09.024

Stem cell therapies for treating osteoarthritis: prescient or premature?

Featured

2014

Journal Article

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 (2), 251-261. doi: 10.1016/j.scr.2014.05.006

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Featured

2014

Journal Article

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print (24), 3021-3033. doi: 10.1089/scd.2013.0634

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Featured

2014

Journal Article

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014). Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles (13), 1-9. doi: 10.1089/scd.2013.0461

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Featured

2012

Journal Article

Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012). Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 (12), 2288-2297. doi: 10.1089/scd.2011.0608

Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts

Featured

2008

Journal Article

Overtraining syndrome in horses

McGowan, C. M. and Whitworth, D. J. (2008). Overtraining syndrome in horses. Comparative Exercise Physiology, 5 (2), 57-65. doi: 10.1017/S1478061508979202

Overtraining syndrome in horses

Featured

2004

Journal Article

Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression

Pask, Andrew J., Whitworth, Deanne, J., Mao Chai-An, Wei, Kei-Jun, Sankovic, Natasha, Graves, Jennifer A. M., Shaw, Geoffrey, Renfree, Marilyn B. and Behringer, Richard R. (2004). Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression. Biology of Reproduction, 70 (1), 160-167. doi: 10.1095/biolreprod.103.020016

Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression

Featured

2001

Journal Article

Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial

Whitworth, D. J., Pask, A. J., Shaw, G., Marshall Graves, J. A., Behringer, R. R. and Renfree, M. B. (2001). Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial. Gene, 277 (1-2), 209-219. doi: 10.1016/S0378-1119(01)00677-1

Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial

Featured

2001

Journal Article

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

Bi, Weimin, Huang, Wendong, Whitworth, Deanne J., Deng, Jian Min, Zhang, Zhaoping, Behringer, Richard R. and de Crombrugghe, Benoit (2001). Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proceedings of the National Academy of Sciences of the United States of America, 98 (12), 6698-6703. doi: 10.1073/pnas.111092198

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

Featured

2001

Book Chapter

The transgenic mouse in studies of mammalian sexual differentiation.

Whitworth, Deanne J. and Behringer, Richard R. (2001). The transgenic mouse in studies of mammalian sexual differentiation.. Transgenics in Endocrinology. (pp. 19-39) edited by Martin M. Matzuk, Chester W. Brown, T. Rajendra Kumar and P. Michael Conn. Totowa, NJ, U.S.A.: Humana Press.

The transgenic mouse in studies of mammalian sexual differentiation.

Featured

2000

Journal Article

A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse

Bishop, Colin E., Whitworth, Deanne J., Qin, Yanjun, Agoulnik, Alexander I., Agoulnik, Irina A., Harrison, Wilbur R., Behringer, Richard R. and Overbeek, Paul A. (2000). A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nature Genetics, 26 (4), 490-494. doi: 10.1038/82652

A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse

Featured

2000

Journal Article

Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta

Whitworth, Deanne J., Hunt, Leigh and Licht, Paul (2000). Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta. General and Comparative Endocrinology, 118 (2), 354-358. doi: 10.1006/gcen.2000.7474

Widespread expression of the mRNA encoding a novel vitamin D/thyroxine dual binding protein in the turtle Trachemys scripta

Featured

1999

Journal Article

High specificity of Müllerian-inhibiting substance signaling in vivo

Mishina, Y., Whitworth, D. J., Racine, C. and Behringer, R. R.. (1999). High specificity of Müllerian-inhibiting substance signaling in vivo. Endocrinology, 140 (5), 2084-2088. doi: 10.1210/en.140.5.2084

High specificity of Müllerian-inhibiting substance signaling in vivo

Featured

1999

Journal Article

Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea

Whitworth, Deanne J., Licht, Paul, Racey, Paul A. and Glickman, Stephen E. (1999). Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea. Biology of Reproduction, 60 (2), 413-418. doi: 10.1095/biolreprod60.2.413

Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea

Featured

1998

Journal Article

XX germ cells: The difference between an ovary and a testis

Whitworth, Deanne J. (1998). XX germ cells: The difference between an ovary and a testis. Trends in Endocrinology and Metabolism, 9 (1), 2-6. doi: 10.1016/S1043-2760(98)00002-2

XX germ cells: The difference between an ovary and a testis

Featured

1997

Journal Article

Müllerian duct regression in a marsupial, the tammar wallaby

Whitworth, Deanne J., Shaw, Geoffrey and Renfree Marilyn B. (1997). Müllerian duct regression in a marsupial, the tammar wallaby. Anatomy And Embryology, 196 (1), 39-46. doi: 10.1007/s004290050078

Müllerian duct regression in a marsupial, the tammar wallaby

Featured

1997

Book Chapter

Sexual determination and differentiation in the marsupial Macropus eugenii

Shaw, Geoffrey, Harry, Jenny L., Whitworth, Deanne J. and Renfree, Marilyn B. (1997). Sexual determination and differentiation in the marsupial Macropus eugenii. Marsupial biology : Recent research, new perspectives. (pp. 132-141) edited by N. R. Saunders and L. A. Hinds. Sydney, NSW, Australia: University of NSW Press.

Sexual determination and differentiation in the marsupial Macropus eugenii

Featured

1996

Journal Article

Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro

Whitworth, Deanne J., Shaw, Geoffrey and Renfree, Marilyn B. (1996). Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro. Development (Cambridge), 122 (12), 4057-4063.

Gonadal sex reversal of the developing marsupial ovary in vivo and in vitro

2018

Conference Publication

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry, Wolvetang, Ernst and Whitworth, Deanne (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

2018

Conference Publication

Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential

Shahsavari, A., Ovchinnikov, D., Wolvetang, E. and Whitworth, D. (2018). Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.

Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential

Funding

Current funding

  • 2023 - 2025
    Saving the endangered Spectacled flying fox from annual tick paralysis mortality events:
    Threatened Species Research Grants
    Open grant

Past funding

  • 2019 - 2020
    The generation of spermatogonial stem cells from equine induced pluripotent stem cells for the correction of genetic diseases and the restoration of fertility in geldings
    John & Mary Kibble Trust
    Open grant
  • 2019 - 2020
    Automated immunohistochemical analysis module for the expansion of research and clinical diagnostic capabilities at UQ
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2020
    Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential
    Morris Animal Foundation
    Open grant
  • 2017 - 2019
    Effect of induced pluripotent stem cell-derived mesenchymal stem cells on facial tumour cells from the Tasmanian devil (Sarcophillus harrisii)
    Annandale Bequest
    Open grant
  • 2015 - 2016
    Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential in canine disease
    Research Donation Generic
    Open grant
  • 2014 - 2018
    The role of gap junction channels, growth factors and cytokines in the diseased canine cornea
    Canine Research Foundation
    Open grant
  • 2014 - 2018
    The role of gap junction channels, growth factors, and cytokines in the diseased canine cornea
    Peter & Mary Ellen Stone Memorial Fund
    Open grant
  • 2014 - 2018
    A stem cell-based approach to the treatment of devil facial tumour disease in the Tasmanian devil (Sarcophilus harrisii)
    Morris Animal Foundation
    Open grant
  • 2014
    Establishment of a core facility in reproductive technology including cell micromanipulation and stem cells to improve research capacity and benefit animal health at the Gatton campus
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    In vitro-derived mesenchymal cells as a therapeutic resource for treating osteoarthritis - a clinical trial
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2012 - 2013
    Canine induced pluripotent stem cells as a resource for treating canine osteoarthritis
    John & Mary Kibble Trust
    Open grant
  • 2011 - 2012
    Canine Induced Pluripotent Stem Cells as a Resource for Treating Canine Osteoarthritis
    John & Mary Kibble Trust
    Open grant
  • 2011 - 2012
    Canine Induced Pluripotent Stem Cells as a Resource for Treating Canine Osteoarthritis
    Australian Companion Animal Health Foundation
    Open grant
  • 2010 - 2011
    Canine induced pluripotent stem cells as a resource for treating canine osteoarthritis
    John & Mary Kibble Trust
    Open grant
  • 2010 - 2011
    Canine Induced Pluripotent Stem Cells as a Resource for Treating Canine Osteoarthritis
    UQ New Staff Research Start-Up Fund
    Open grant

Supervision

Availability

Associate Professor Deanne Whitworth is:
Available for supervision

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Available projects

  • Projects working with marsupial (Tasmanian devil) and horse stem cells are currently available

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Associate Professor Deanne Whitworth directly for media enquiries about:

  • regenerative medicine
  • stem cells
  • stem cells in animals
  • use of stem cells in veterinary medicine

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au