Overview
Background
I am a Group Leader at Mater Research Institute, heading the Developmental Molecular Genetics Lab. My team investigates the dynamic interplay between mobile DNA sequences and mammalian genomes, with a primary focus on the retrotransposon Long Interspersed Element 1 (L1). L1 sequences are “selfish” genetic entities, which must insert new copies (retrotranspose) in the genomes of cells that will contribute to the next generation. This evolutionary drive sets up a perpetual conflict between L1 propagation and genome stability, which plays out in pluripotent embryonic cells as well as in cells of the developing germline. My ongoing research is focused on elucidating the developmental timing of heritable L1 retrotransposition, and understanding how L1 activity is controlled in these critical niches. I am interested in the capacity of L1 retrotransposition events to generate genetic diversity and drive genome evolution, as well as their contribution to somatic and germline genetic mosaicism and their potential to cause human genetic disease and reproductive dysfunction.
Availability
- Dr Sandra Richardson is:
- Available for supervision
Works
Search Professor Sandra Richardson’s works on UQ eSpace
Featured
2017
Journal Article
Heritable L1 retrotransposition in the mouse primordial germline and early embryo
Richardson, Sandra R., Gerdes, Patricia, Gerhardt, Daniel J., Sanchez-Luque, Francisco J., Bodea, Gabriela-Oana, Muñoz-Lopez, Martin, Jesuadian, J. Samuel, Kempen, Marie-Jeanne H. C., Carreira, Patricia E., Jeddeloh, Jeffrey A., Garcia-Perez, Jose L., Kazazian Jr., Haig H., Ewing, Adam D. and Faulkner, Geoffrey J. (2017). Heritable L1 retrotransposition in the mouse primordial germline and early embryo. Genome Research, 27 (8), 1395-1405. doi: 10.1101/gr.219022.116
2024
Journal Article
LINE-1 retrotransposons contribute to mouse PV interneuron development
Bodea, Gabriela O., Botto, Juan M., Ferreiro, Maria E., Sanchez-Luque, Francisco J., de los Rios Barreda, Jose, Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Jansz, Natasha, Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Da Costa Guevara, Darwin J., Cumner, Linda, Bell, Charles C., Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H. C., Love, Chloe J., Saha, Karabi, Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2024). LINE-1 retrotransposons contribute to mouse PV interneuron development. Nature Neuroscience, 27 (7), 1-34. doi: 10.1038/s41593-024-01650-2
2024
Journal Article
Every repeat is unique: Exploring the genomic impact of human L1 retrotransposons at locus-specific resolution
Workman, Stephanie and Richardson, Sandra R. (2024). Every repeat is unique: Exploring the genomic impact of human L1 retrotransposons at locus-specific resolution. Cell Genomics, 4 (2) 100504, 100504. doi: 10.1016/j.xgen.2024.100504
2023
Journal Article
Safe Babies, Safe Moms: a multifaceted, trauma informed care initiative
Patchen, Loral, Mccullers, Asli, Beach, Charmain, Browning, Melanie, Porter, Shy, Danielson, Aimee, Asegieme, Evelyn, Richardson, S. Roxana, Jost, Ali, Jensen, Caitlin Schille and Ahmed, Naheed (2023). Safe Babies, Safe Moms: a multifaceted, trauma informed care initiative. Maternal and Child Health Journal, 28 (1), 31-37. doi: 10.1007/s10995-023-03840-z
2023
Journal Article
Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development
Gerdes, Patricia, Chan, Dorothy, Lundberg, Mischa, Sanchez-Luque, Francisco J., Bodea, Gabriela O., Ewing, Adam D., Faulkner, Geoffrey J. and Richardson, Sandra R. (2023). Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development. Genome Research, 33 (9), 1465-1481. doi: 10.1101/gr.278003.123
2022
Journal Article
Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells
Gerdes, Patricia, Lim, Sue Mei, Ewing, Adam D., Larcombe, Michael R., Chan, Dorothy, Sanchez-Luque, Francisco J., Walker, Lucinda, Carleton, Alexander L., James, Cini, Knaupp, Anja S., Carreira, Patricia E., Nefzger, Christian M., Lister, Ryan, Richardson, Sandra R., Polo, Jose M. and Faulkner, Geoffrey J. (2022). Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nature Communications, 13 (1) 7470, 1-18. doi: 10.1038/s41467-022-35180-x
2022
Journal Article
Somatic retrotransposition in the developing rhesus macaque brain
Billon, Victor, Sanchez-Luque, Francisco J, Rasmussen, Jay, Bodea, Gabriela O, Gerhardt, Daniel J, Gerdes, Patricia, Cheetham, Seth W, Schauer, Stephanie N, Ajjikuttira, Prabha, Meyer, Thomas J, Layman, Cora E, Nevonen, Kimberly A, Jansz, Natasha, Garcia-Perez, Jose L, Richardson, Sandra R, Ewing, Adam D, Carbone, Lucia and Faulkner, Geoffrey J (2022). Somatic retrotransposition in the developing rhesus macaque brain. Genome Research, 32 (7), gr.276451.121-1314. doi: 10.1101/gr.276451.121
2022
Journal Article
LINE-1 retrotransposon activation intrinsic to interneuron development
Bodea, Gabriela O., Ferreiro, Maria E., Sanchez-Luque, Francisco J., Botto, Juan M., Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H.C., Love, Chloe J., Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2022). LINE-1 retrotransposon activation intrinsic to interneuron development.
2020
Journal Article
Nanopore sequencing enables comprehensive transposable element epigenomic profiling
Ewing, Adam D., Smits, Nathan, Sanchez-Luque, Francisco J., Faivre, Jamila, Brennan, Paul M., Richardson, Sandra R., Cheetham, Seth W. and Faulkner, Geoffrey J. (2020). Nanopore sequencing enables comprehensive transposable element epigenomic profiling. Molecular Cell, 80 (5), 915-928.e5. doi: 10.1016/j.molcel.2020.10.024
2019
Journal Article
LINE-1 Evasion of epigenetic repression in humans
Sanchez-Luque, Francisco J., Kempen, Marie-Jeanne H.C., Gerdes, Patricia, Vargas-Landin, Dulce B., Richardson, Sandra R., Troskie, Robin-Lee, Jesuadian, J. Samuel, Cheetham, Seth W., Carreira, Patricia E., Salvador-Palomeque, Carmen, García-Cañadas, Marta, Muñoz-Lopez, Martin, Sanchez, Laura, Lundberg, Mischa, Macia, Angela, Heras, Sara R., Brennan, Paul M., Lister, Ryan, Garcia-Perez, Jose L., Ewing, Adam D. and Faulkner, Geoffrey J. (2019). LINE-1 Evasion of epigenetic repression in humans. Molecular Cell, 75 (3), 590-604.e12. doi: 10.1016/j.molcel.2019.05.024
2019
Journal Article
Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation
Salvador-Palomeque, Carmen, Sanchez-Luque, Francisco J., Fortuna, Patrick R. J., Ewing, Adam D., Wolvetang, Ernst J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2019). Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation. Molecular and Cellular Biology, 39 (7) e00499-18, 1-19. doi: 10.1128/mcb.00499-18
2018
Journal Article
Heritable L1 retrotransposition events during development: understanding their origins: examination of heritable, endogenous L1 retrotransposition in mice opens up exciting new questions and research directions
Richardson, Sandra R. and Faulkner, Geoffrey J. (2018). Heritable L1 retrotransposition events during development: understanding their origins: examination of heritable, endogenous L1 retrotransposition in mice opens up exciting new questions and research directions. BioEssays, 40 (6) 1700189, e1700189. doi: 10.1002/bies.201700189
2018
Journal Article
L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis
Schauer, Stephanie N., Carreira, Patricia E., Shukla, Ruchi, Gerhardt, Daniel J., Gerdes, Patricia, Sanchez-Luque, Francisco J., Nicoli, Paola, Kindlova, Michaela, Ghisletti, Serena, Santos, Alexandre Dos, Rapoud, Delphine, Samuel, Didier, Faivre, Jamila, Ewing, Adam D., Richardson, Sandra R. and Faulkner, Geoffrey J. (2018). L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis. Genome Research, 28 (5), 639-653. doi: 10.1101/gr.226993.117
2018
Journal Article
L1 retrotransposon heterogeneity in ovarian tumor cell evolution
Nguyen, Thu H. M., Carreira, Patricia E., Sanchez-Luque, Francisco J., Schauer, Stephanie N., Fagg, Allister C., Richardson, Sandra R., Davies, Claire M., Jesuadian, J. Samuel, Kempen, Marie-Jeanne H. C., Troskie, Robin-Lee, James, Cini, Beaven, Elizabeth A., Wallis, Tristan P., Coward, Jermaine I. G., Chetty, Naven P., Crandon, Alexander J., Venter, Deon J., Armes, Jane E., Perrin, Lewis C., Hooper, John D., Ewing, Adam D., Upton, Kyle R. and Faulkner, Geoffrey J. (2018). L1 retrotransposon heterogeneity in ovarian tumor cell evolution. Cell Reports, 23 (13), 3730-3740. doi: 10.1016/j.celrep.2018.05.090
2017
Book Chapter
Analysis of somatic LINE-1 insertions in neurons
Sanchez-Luque, Francisco J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2017). Analysis of somatic LINE-1 insertions in neurons. Genomic mosaicism in neurons and other cell types. (pp. 219-251) edited by José María Frade and Fred H. Gage. New York, United States: Humana Press. doi: 10.1007/978-1-4939-7280-7_12
2016
Journal Article
TET enzymes: double agents in the transposable element-host genome conflict
Gerdes, Patricia, Richardson, Sandra R. and Faulkner, Geoffrey J. (2016). TET enzymes: double agents in the transposable element-host genome conflict. Genome Biology, 17 (1) 259. doi: 10.1186/s13059-016-1124-8
2016
Journal Article
Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme
Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M. and Faulkner, Geoffrey J. (2016). Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme. Mobile DNA, 7 (1) 21, 1-14. doi: 10.1186/s13100-016-0076-6
2016
Journal Article
Transposable elements in the mammalian embryo: pioneers surviving through stealth and service
Gerdes, Patricia, Richardson, Sandra R., Mager, Dixie L. and Faulkner, Geoffrey J. (2016). Transposable elements in the mammalian embryo: pioneers surviving through stealth and service. Genome Biology, 17 (1) 100. doi: 10.1186/s13059-016-0965-5
2016
Book Chapter
LINE-1 cultured cell retrotransposition assay
Kopera, Huira C., Larson, Peter A., Moldovan, John B., Richardson, Sandra R., Liu, Ying and Moran, John V. (2016). LINE-1 cultured cell retrotransposition assay. Transposons and retrotransposons: methods and protocols. (pp. 139-156) edited by Jose L. Garcia-Pérez. New York, NY, United States: Humana Press . doi: 10.1007/978-1-4939-3372-3_10
2016
Book Chapter
Retrotransposon capture sequencing (RC-Seq): a targeted, high-throughput approach to resolve somatic L1 retrotransposition in humans
Sanchez-Luque, Francisco J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2016). Retrotransposon capture sequencing (RC-Seq): a targeted, high-throughput approach to resolve somatic L1 retrotransposition in humans. Transposons and retrotranspons: methods and protocols. (pp. 47-77) edited by Jose L. Garcia-Pérez. New York, NY, United States: Springer. doi: 10.1007/978-1-4939-3372-3_4
Supervision
Availability
- Dr Sandra Richardson is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Mobile DNA Activity in the Mammalian Primordial Germline
Principal Advisor
Other advisors: Associate Professor Josephine Bowles, Associate Professor Adam Ewing
-
Doctor Philosophy
Jumping Genes in Mammalian Development
Principal Advisor
Other advisors: Professor Geoff Faulkner
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Doctor Philosophy
Applying long-read sequencing technologies to cancer genomes
Associate Advisor
Other advisors: Dr Jodi Saunus, Dr Yuanhao Yang, Associate Professor Adam Ewing
-
Doctor Philosophy
Visualising genetic mosaicism during development
Associate Advisor
Other advisors: Dr Gabriela-Oana Bodea, Professor Geoff Faulkner
Completed supervision
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2021
Doctor Philosophy
Mobilisation and Regulation of L1 Retrotransposons in Mammalian Development
Associate Advisor
Other advisors: Professor Michael Piper, Professor Geoff Faulkner
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2019
Doctor Philosophy
L1 is dynamic during neurogenesis
Associate Advisor
Other advisors: Professor Ernst Wolvetang, Professor Geoff Faulkner
Media
Enquiries
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