Overview
Background
Dr. Yuanhao Yang is a senior research fellow at Mater Research Institute, with high-level expertise in computational and statistical genetics and genomics. His research field focuses on understanding the genetic and genomic etiology of human complex traits and common diseases, such as multiple sclerosis, depression and autism, through large-scale genetic/genomic and multi-omics data, including 1) revealing the genetic architecture of complex traits and common diseases using advanced genome-wide association study (GWAS)-based quantitative genetics methods; and 2) identifying potential relationships between disease risk and cellular genotypes/pathways using single-cell RNA sequence/spatial transcriptomics data and technology.
Availability
- Dr Yuanhao Yang is:
- Available for supervision
Qualifications
- Bachelor of Biotechnology, Sun Yat-sen University
- Masters (Coursework) of Biostatistics, The University of Manchester
- Doctor of Philosophy, Queensland University of Technology
Works
Search Professor Yuanhao Yang’s works on UQ eSpace
2024
Journal Article
β-resorcylic acid released by Limosilactobacillus reuteri protects against cisplatin-induced ovarian toxicity and infertility
Feng, Yinglin, Zheng, Huimin, Yin, Chunhua, Liang, Dong, Zhang, Siyou, Chen, Jingrui, Mai, Feihong, Lan, Zixin, Zhu, Menglin, Mai, Zhensheng, Shen, Sj, Jayawardana, Thisun, Wu, Rong, Tang, Wenli, Zhang, Renfang, He, Xiaoyun, Zheng, Shanshan, Hu, Qian, Han, Yubin, Yang, Yuanhao, Gong, Shenhai, Wang, Zhang, El-Omar, Emad M., Luo, Wei, Chen, Xueqin, Chen, Guoqiang, Li, Pan and Chen, Xia (2024). β-resorcylic acid released by Limosilactobacillus reuteri protects against cisplatin-induced ovarian toxicity and infertility. Cell Reports Medicine, 5 (8) 101678, 101678. doi: 10.1016/j.xcrm.2024.101678
2024
Journal Article
Brain cell-type shifts in Alzheimer’s disease, autism, and schizophrenia interrogated using methylomics and genetics
Yap, Chloe X., Vo, Daniel D., Heffel, Matthew G., Bhattacharya, Arjun, Wen, Cindy, Yang, Yuanhao, Kemper, Kathryn E., Zeng, Jian, Zheng, Zhili, Zhu, Zhihong, Hannon, Eilis, Vellame, Dorothea Seiler, Franklin, Alice, Caggiano, Christa, Wamsley, Brie, Geschwind, Daniel H., Zaitlen, Noah, Gusev, Alexander, Pasaniuc, Bogdan, Mill, Jonathan, Luo, Chongyuan and Gandal, Michael J. (2024). Brain cell-type shifts in Alzheimer’s disease, autism, and schizophrenia interrogated using methylomics and genetics. Science Advances, 10 (21) adn7655. doi: 10.1126/sciadv.adn7655
2024
Journal Article
Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications
Qi, Mengling, Zhang, Haoyang, Xiu, Xuehao, He, Dan, Cooper, David N., Yang, Yuanhao and Zhao, Huiying (2024). Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications. Human Genetics. doi: 10.1007/s00439-024-02661-6
2023
Journal Article
Inferring the genetic relationship between brain imaging-derived phenotypes and risk of complex diseases by Mendelian randomization and genome-wide colocalization
Lin, Siying, Zhang, Haoyang, Qi, Mengling, Cooper, David N., Yang, Yuedong, Yang, Yuanhao and Zhao, Huiying (2023). Inferring the genetic relationship between brain imaging-derived phenotypes and risk of complex diseases by Mendelian randomization and genome-wide colocalization. NeuroImage, 279 120325, 120325. doi: 10.1016/j.neuroimage.2023.120325
2023
Journal Article
Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer
Gough, Madeline, Liu, Cheng, Srinivasan, Bhuvana, Wilkinson, Lisa, Dunk, Louisa, Yang, Yuanhao, Schreiber, Veronika, Tuffaha, Haitham, Kryza, Thomas, Hooper, John D., Lakhani, Sunil R. and Snell, Cameron E. (2023). Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer. Histopathology, 83 (4), 647-656. doi: 10.1111/his.15000
2023
Journal Article
Novel plasma and brain proteins that are implicated in multiple sclerosis
Lin, Xin, Yang, Yuanhao, Gresle, Melissa, Cuellar-Partida, Gabriel, Han, Xikun, Stankovich, Jim, Fuh-Ngwa, Valery, Charlesworth, Jac, Burdon, Kathryn P, Butzkueven, Helmut, Taylor, Bruce V, Zhou, Yuan and AusLong/Ausimmune Investigators Group Steve Simpson-Yap (2023). Novel plasma and brain proteins that are implicated in multiple sclerosis. Brain, 146 (6) awac420, 2464-2475. doi: 10.1093/brain/awac420
2023
Conference Publication
HER2 in situ hybridization testing in breast cancer: applying algorithm-assisted assessment to reduce interobserver variability in difficult cases
Gough, Madeline, Liu, Cheng, Srinivasan, Bhuvana, Wilkinson, Lisa, Dunk, Louisa, Yang, Yuanhao, Tuffaha, Haitham, Kryza, Thomas, Hooper, John D., Lakhani, Sunil R. and Snell, Cameron Edward (2023). HER2 in situ hybridization testing in breast cancer: applying algorithm-assisted assessment to reduce interobserver variability in difficult cases. 2023 ASCO Annual Meeting, Chicago, IL United States, 2-6 June 2023. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2023.41.16_suppl.e13561
2023
Journal Article
Interactions between the lipidome and genetic and environmental factors in autism
Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Giles, Corey, Huynh, Kevin, Nguyen, Anh, Wallace, Leanne, McLaren, Tiana, Yang, Yuanhao, Hernandez, Leanna M., Gandal, Michael J., Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Strike, Lachlan T. ... The Busselton Health Study Investigators (2023). Interactions between the lipidome and genetic and environmental factors in autism. Nature Medicine, 29 (4), 936-949. doi: 10.1038/s41591-023-02271-1
2023
Journal Article
Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer's disease using EEG technology
Jiao, Bin, Li, Rihui, Zhou, Hui, Qing, Kunqiang, Liu, Hui, Pan, Hefu, Lei, Yanqin, Fu, Wenjin, Wang, Xiaoan, Xiao, Xuewen, Liu, Xixi, Yang, Qijie, Liao, Xinxin, Zhou, Yafang, Fang, Liangjuan, Dong, Yanbin, Yang, Yuanhao, Jiang, Haiyan, Huang, Sha and Shen, Lu (2023). Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer's disease using EEG technology. Alzheimer's Research and Therapy, 15 (1) 32, 32. doi: 10.1186/s13195-023-01181-1
2023
Journal Article
The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders
Yang, Yuanhao, Zhou, Yuan, Nyholt, Dale R., Yap, Chloe X., Tannenberg, Rudolph K., Wang, Ying, Wu, Yang, Zhu, Zhihong, Taylor, Bruce V. and Gratten, Jacob (2023). The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders. Cell Genomics, 3 (2) 100249, 100249. doi: 10.1016/j.xgen.2022.100249
2023
Journal Article
Genetically determined serum serine level has a novel causal effect on multiple sclerosis risk and predicts disability progression
Lin, Xin, Yang, Yuanhao, Fuh-Ngwa, Valery, Yin, Xianyong, Simpson-Yap, Steve, van der Mei, Ingrid, Broadley, Simon A, Ponsonby, Anne-Louise, Burdon, Kathryn P, Taylor, Bruce V, Zhou, Yuan and Ausimmune/ AusLong Investigators Group (2023). Genetically determined serum serine level has a novel causal effect on multiple sclerosis risk and predicts disability progression. Journal of Neurology, Neurosurgery and Psychiatry, 94 (7) jnnp-2022-330259, 1-6. doi: 10.1136/jnnp-2022-330259
2023
Journal Article
GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection
Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022
2023
Journal Article
Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans
Lu, Zhiya, Zhang, Haoyang, Yang, Yuanhao and Zhao, Huiying (2023). Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans. Human Genetics, 142 (7), 965-980. doi: 10.1007/s00439-023-02573-x
2022
Journal Article
Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians
Xiu, Xuehao, Zhang, Haoyang, Xue, Angli, Cooper, David N., Yan, Li, Yang, Yuedong, Yang, Yuanhao and Zhao, Huiying (2022). Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians. BMC Medicine, 20 (1) 300, 1-16. doi: 10.1186/s12916-022-02476-0
2022
Journal Article
Integrating Genetic Structural Variations and Whole-Genome Sequencing Into Clinical Neurology
Lin, Xin, Yang, Yuanhao, Melton, Phillip E., Singh, Vikrant, Simpson-Yap, Steve, Burdon, Kathryn P., Taylor, Bruce V. and Zhou, Yuan (2022). Integrating Genetic Structural Variations and Whole-Genome Sequencing Into Clinical Neurology. Neurology: Genetics, 8 (4) e200005, 1-12. doi: 10.1212/NXG.0000000000200005
2022
Journal Article
MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis
Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010
2021
Journal Article
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
Yang, Yuanhao, Musco, Hannah, Simpson-Yap, Steve, Zhu, Zhihong, Wang, Ying, Lin, Xin, Zhang, Jiawei, Taylor, Bruce, Gratten, Jacob and Zhou, Yuan (2021). Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases. Nature Communications, 12 (1) 5641, 5641. doi: 10.1038/s41467-021-25768-0
2021
Journal Article
Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract
Zhang, Haoyang, Xiu, Xuehao, Xue, Angli, Yang, Yuedong, Yang, Yuanhao and Zhao, Huiying (2021). Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract. International Journal of Epidemiology, 50 (6), 2024-2037. doi: 10.1093/ije/dyab175
2021
Journal Article
Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank
Yap, Chloe X., Alvares, Gail A., Henders, Anjali K., Lin, Tian, Wallace, Leanne, Farrelly, Alaina, McLaren, Tiana, Berry, Jolene, Vinkhuyzen, Anna A. E., Trzaskowski, Maciej, Zeng, Jian, Yang, Yuanhao, Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren, Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Visscher, Peter M., Dawson, Paul A., Dissanayake, Cheryl ... Gratten, Jacob (2021). Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank. Molecular Autism, 12 (1) 12, 12. doi: 10.1186/s13229-020-00407-5
2019
Conference Publication
Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothers
Gratten, Jacob, Yang, Yuanhao, Trzaskowski, Maciej, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, Zhang, Futao, Zhu, Zhihong, Mcrae, Allan, Yang, Jian, Wray, Naomi and Visscher, Peter (2019). Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothers. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2018.08.167
Funding
Current funding
Supervision
Availability
- Dr Yuanhao Yang is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Multiomics of common co-occurring conditions in autism spectrum disorder
Associate Advisor
Other advisors: Dr Allan McRae, Honorary Professor Jake Gratten
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Doctor Philosophy
Applying long-read sequencing technologies to cancer genomes
Associate Advisor
Other advisors: Dr Jodi Saunus, Dr Sandra Richardson, Associate Professor Adam Ewing
-
Doctor Philosophy
Cellular genomics of Parkinson's disease
Associate Advisor
Other advisors: Dr Quan Nguyen, Dr Allan McRae, Honorary Professor Jake Gratten
Media
Enquiries
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