Overview
Background
Dr. Yuanhao Yang is a senior research fellow at Mater Research Institute, with high-level expertise in computational and statistical genetics and genomics. His research field focuses on understanding the genetic and genomic etiology of human complex traits and common diseases, such as multiple sclerosis, depression and autism, through large-scale genetic/genomic and multi-omics data, including 1) revealing the genetic architecture of complex traits and common diseases using advanced genome-wide association study (GWAS)-based quantitative genetics methods; and 2) identifying potential relationships between disease risk and cellular genotypes/pathways using single-cell RNA sequence/spatial transcriptomics data and technology.
Availability
- Dr Yuanhao Yang is:
- Available for supervision
Qualifications
- Bachelor of Biotechnology, Sun Yat-sen University
- Masters (Coursework) of Biostatistics, The University of Manchester
- Doctor of Philosophy, Queensland University of Technology
Works
Search Professor Yuanhao Yang’s works on UQ eSpace
2022
Journal Article
MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis
Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010
2021
Journal Article
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
Yang, Yuanhao, Musco, Hannah, Simpson-Yap, Steve, Zhu, Zhihong, Wang, Ying, Lin, Xin, Zhang, Jiawei, Taylor, Bruce, Gratten, Jacob and Zhou, Yuan (2021). Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases. Nature Communications, 12 (1) 5641, 5641. doi: 10.1038/s41467-021-25768-0
2021
Journal Article
Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract
Zhang, Haoyang, Xiu, Xuehao, Xue, Angli, Yang, Yuedong, Yang, Yuanhao and Zhao, Huiying (2021). Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract. International Journal of Epidemiology, 50 (6), 2024-2037. doi: 10.1093/ije/dyab175
2021
Journal Article
Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank
Yap, Chloe X., Alvares, Gail A., Henders, Anjali K., Lin, Tian, Wallace, Leanne, Farrelly, Alaina, McLaren, Tiana, Berry, Jolene, Vinkhuyzen, Anna A. E., Trzaskowski, Maciej, Zeng, Jian, Yang, Yuanhao, Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren, Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Visscher, Peter M., Dawson, Paul A., Dissanayake, Cheryl ... Gratten, Jacob (2021). Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank. Molecular Autism, 12 (1) 12, 12. doi: 10.1186/s13229-020-00407-5
2019
Conference Publication
Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothers
Gratten, Jacob, Yang, Yuanhao, Trzaskowski, Maciej, Kemper, Kathryn, Yengo, Loic, Zheng, Zhili, Zhang, Futao, Zhu, Zhihong, Mcrae, Allan, Yang, Jian, Wray, Naomi and Visscher, Peter (2019). Common genetic variation explains a high proportion of the elevated risk of psychiatric disorders in children of younger mothers. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2018.08.167
2018
Journal Article
Imprint of assortative mating on the human genome
Yengo, Loic, Robinson, Matthew R., Keller, Matthew C., Kemper, Kathryn E., Yang, Yuanhao, Trzaskowski, Maciej, Gratten, Jacob, Turley, Patrick, Cesarini, David, Benjamin, Daniel J., Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2018). Imprint of assortative mating on the human genome. Nature Human Behaviour, 2 (12), 948-954. doi: 10.1038/s41562-018-0476-3
2018
Journal Article
Molecular genetic overlap between migraine and major depressive disorder
Yang, Yuanhao, Zhao, Huiying, Boomsma, Dorret I., Ligthart, Lannie, Belin, Andrea C., Smith, George Davey, Esko, Tonu, Freilinger, Tobias M., Hansen, Thomas Folkmann, Ikram, M. Arfan, Kallela, Mikko, Kubisch, Christian, Paraskevi, Christofidou, Strachan, David P., Wessman, Maija, International Headache Genetics Consortium, van den Maagdenberg, Arn M. J. M., Terwindt, Gisela M. and Nyholt, Dale R. (2018). Molecular genetic overlap between migraine and major depressive disorder. European Journal of Human Genetics, 26 (8), 1202-1216. doi: 10.1038/s41431-018-0150-2
2017
Journal Article
Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks
Zhao, Huiying, Nyholt, Dale R., Yang, Yuanhao, Wang, Jihua and Yang, Yuedong (2017). Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks. Scientific Reports, 7 (1) 3512. doi: 10.1038/s41598-017-03826-2
2017
Journal Article
A continuum of genetic liability for minor and major depression
Corfield, E. C., Yang, Y., Martin, N. G. and Nyholt, D. R. (2017). A continuum of genetic liability for minor and major depression. Translational Psychiatry, 7 (5) e1131, e1131-e1131. doi: 10.1038/tp.2017.99
2016
Journal Article
Familial aggregation of migraine and depression: insights from a large Australian twin sample
Yang, Yuanhao, Zhao, Huiying, Heath, Andrew C., Madden, Pamela A. F., Martin, Nicholas G. and Nyholt, Dale R. (2016). Familial aggregation of migraine and depression: insights from a large Australian twin sample. Twin Research and Human Genetics, 19 (4), 312-321. doi: 10.1017/thg.2016.43
2016
Journal Article
Shared genetic factors underlie migraine and depression
Yang, Yuanhao, Zhao, Huiying, Heath, Andrew C., Madden, Pamela A. F., Martin, Nicholas G. and Nyholt, Dale R. (2016). Shared genetic factors underlie migraine and depression. Twin Research and Human Genetics, 19 (4), 341-350. doi: 10.1017/thg.2016.46
2016
Journal Article
Genetic epidemiology of migraine and depression
Yang, Yuanhao, Ligthart, Lannie, Terwindt, Gisela M., Boomsma, Dorret I., Rodriguez-Acevedo, Astrid J. and Nyholt, Dale R. (2016). Genetic epidemiology of migraine and depression. Cephalalgia, 36 (7), 679-691. doi: 10.1177/0333102416638520
Funding
Current funding
Supervision
Availability
- Dr Yuanhao Yang is:
- Available for supervision
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Available projects
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Understanding mechanisms underlying multiple sclerosis using large-scale multi-omics
Improve understanding of the pathophysiology of multiple sclerosis onset and progression by integrating large-scale multi-omics data (i.e. epigenomics, transcriptomics, proteomics) using cutting-edge statistical methods.
Supervision history
Current supervision
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Doctor Philosophy
Cellular genomics of Parkinson's disease
Associate Advisor
Other advisors: Dr Quan Nguyen, Dr Allan McRae, Honorary Professor Jake Gratten
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Doctor Philosophy
Multiomics of common co-occurring conditions in autism spectrum disorder
Associate Advisor
Other advisors: Dr Allan McRae, Honorary Professor Jake Gratten
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Doctor Philosophy
Applying long-read sequencing technologies to cancer genomes
Associate Advisor
Other advisors: Dr Jodi Saunus, Dr Sandra Richardson, Associate Professor Adam Ewing
Media
Enquiries
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