Overview
Background
Dr Ewing leads the Translational Bioinformatics Group at the Mater Research Institute - UQ, located at the Translational Research Institute (TRI). His research interests follow a common theme of developing and applying computational methods to investigate genomic mutation in evolutionary and disease-related processes. Dr Ewing is a key collaborator on an array of projects spanning from basic research into clinical applications of Bioinformatics.
Availability
- Associate Professor Adam Ewing is:
- Available for supervision
Qualifications
- Doctor of Philosophy, University of Pennsylvania
Research interests
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Computational methods for sequence analysis
Works
Search Professor Adam Ewing’s works on UQ eSpace
2024
Conference Publication
Genomic variation in symptom expression in men with castrate resistant prostate cancer
Good, Phillip, Foster, Karyn, Greer, Ristan, Oliveira, Niara, Vayne-Bossert, Petra, Ewing, Adam and Hardy, Janet (2024). Genomic variation in symptom expression in men with castrate resistant prostate cancer. ANZSPM 2024 Biennial Conference, Adelaide, SA, United States, 5-8 September 2024. London, United Kingdom: BMJ Group. doi: 10.1136/spcare-2024-anzspm.61
2024
Journal Article
Molecular genetic analysis of candidate genes for glutaric aciduria type II in a cohort of patients from Queensland, Australia
Demetriou, Kalliope, Nisbet, Janelle, Coman, David, Ewing, Adam D., Phillips, Liza, Smith, Sally, Lipke, Michelle, Inwood, Anita, Spicer, Janette, Atthow, Catherine, Wilgen, Urs, Robertson, Thomas, McWhinney, Avis, Swenson, Rebecca, Espley, Brayden, Snowdon, Brianna, McGill, James J. and Summers, Kim M. (2024). Molecular genetic analysis of candidate genes for glutaric aciduria type II in a cohort of patients from Queensland, Australia. Molecular Genetics and Metabolism, 142 (4) 108516, 108516. doi: 10.1016/j.ymgme.2024.108516
2024
Journal Article
LINE-1 retrotransposons contribute to mouse PV interneuron development
Bodea, Gabriela O., Botto, Juan M., Ferreiro, Maria E., Sanchez-Luque, Francisco J., de los Rios Barreda, Jose, Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Jansz, Natasha, Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Da Costa Guevara, Darwin J., Cumner, Linda, Bell, Charles C., Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H. C., Love, Chloe J., Saha, Karabi, Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2024). LINE-1 retrotransposons contribute to mouse PV interneuron development. Nature Neuroscience, 27 (7), 1-34. doi: 10.1038/s41593-024-01650-2
2024
Journal Article
Placentae of small appropriately-grown-for-gestational-age neonates exhibit sexually dimorphic transcriptomic changes representative of placental insufficiency
Ewing, Adam, O'Callaghan, Jessica L., McCracken, Sharon, Ellery, Stacy, Lappas, Martha, Holland, Olivia J., Perkins, Anthony, Saif, Zarqa and Clifton, Vicki L. (2024). Placentae of small appropriately-grown-for-gestational-age neonates exhibit sexually dimorphic transcriptomic changes representative of placental insufficiency. Placenta, 149, 37-43. doi: 10.1016/j.placenta.2024.02.003
2023
Journal Article
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Cheng, Kevin C. L., Frost, Jennifer M., Sánchez-Luque, Francisco J., García-Canãdas, Marta, Taylor, Darren, Yang, Wan R., Irayanar, Branavy, Sampath, Swetha, Patani, Hemalvi, Agger, Karl, Helin, Kristian, Ficz, Gabriella, Burns, Kathleen H., Ewing, Adam, García-Pérez, José L. and Branco, Miguel R. (2023). Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation. Epigenetics and Chromatin, 16 (1) 39, 1-16. doi: 10.1186/s13072-023-00514-6
2023
Journal Article
Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development
Gerdes, Patricia, Chan, Dorothy, Lundberg, Mischa, Sanchez-Luque, Francisco J., Bodea, Gabriela O., Ewing, Adam D., Faulkner, Geoffrey J. and Richardson, Sandra R. (2023). Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development. Genome Research, 33 (9), 1465-1481. doi: 10.1101/gr.278003.123
2023
Journal Article
Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes
Leung, Sherman S., Lenchik, Nataliya, Mathews, Clayton, Pugliese, Alberto, McCarthy, Domenica A., Le Bagge, Selena, Ewing, Adam, Harris, Mark, Radford, Kristen J., Borg, Danielle J., Gerling, Ivan and Forbes, Josephine M. (2023). Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes. Scientific Reports, 13 (1) 12948, 1-15. doi: 10.1038/s41598-023-39243-x
2023
Journal Article
Resolution of melanoma to PD-1 blockade but simultaneous rapid progression of concomitant chronic lymphocytic leukemia
Burgess, Melinda, Keane, Colm, Tobin, Joshua W. D., Law, Soi Cheng, Griffin, Alison, Gill, Devinder, Ewing, Adam D., Atkinson, Victoria, Mollee, Peter, Sabdia, Muhammed B., Saunders, Nicholas and Gandhi, Maher K. (2023). Resolution of melanoma to PD-1 blockade but simultaneous rapid progression of concomitant chronic lymphocytic leukemia. Acta Haematologica, 146 (2), 166-171. doi: 10.1159/000527631
2022
Journal Article
Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells
Gerdes, Patricia, Lim, Sue Mei, Ewing, Adam D., Larcombe, Michael R., Chan, Dorothy, Sanchez-Luque, Francisco J., Walker, Lucinda, Carleton, Alexander L., James, Cini, Knaupp, Anja S., Carreira, Patricia E., Nefzger, Christian M., Lister, Ryan, Richardson, Sandra R., Polo, Jose M. and Faulkner, Geoffrey J. (2022). Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nature Communications, 13 (1) 7470, 1-18. doi: 10.1038/s41467-022-35180-x
2022
Journal Article
Sex-dependent differential transcript expression in the placenta of growth restricted infants
O'Callaghan, Jessica L., Clifton, Vicki L., Prentis, Peter, Ewing, Adam, Saif, Zarqa and Pelzer, Elise S. (2022). Sex-dependent differential transcript expression in the placenta of growth restricted infants. Placenta, 128, 1-8. doi: 10.1016/j.placenta.2022.08.004
2022
Journal Article
Somatic retrotransposition in the developing rhesus macaque brain
Billon, Victor, Sanchez-Luque, Francisco J, Rasmussen, Jay, Bodea, Gabriela O, Gerhardt, Daniel J, Gerdes, Patricia, Cheetham, Seth W, Schauer, Stephanie N, Ajjikuttira, Prabha, Meyer, Thomas J, Layman, Cora E, Nevonen, Kimberly A, Jansz, Natasha, Garcia-Perez, Jose L, Richardson, Sandra R, Ewing, Adam D, Carbone, Lucia and Faulkner, Geoffrey J (2022). Somatic retrotransposition in the developing rhesus macaque brain. Genome Research, 32 (7), gr.276451.121-1314. doi: 10.1101/gr.276451.121
2022
Journal Article
Methylartist: tools for visualizing modified bases from nanopore sequence data
Cheetham, Seth W., Kindlova, Michaela and Ewing, Adam D. (2022). Methylartist: tools for visualizing modified bases from nanopore sequence data. Bioinformatics, 38 (11), 3109-3112. doi: 10.1093/bioinformatics/btac292
2022
Journal Article
A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci
van Bree, Elisabeth J, Guimarães, Rita L F P, Lundberg, Mischa, Blujdea, Elena R, Rosenkrantz, Jimi L, White, Fred T G, Poppinga, Josse, Ferrer-Raventós, Paula, Schneider, Anne-Fleur E, Clayton, Isabella, Haussler, David, Reinders, Marcel J T, Holstege, Henne, Ewing, Adam D, Moses, Colette and Jacobs, Frank M J (2022). A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci. Genome research, 32 (4), 656-670. doi: 10.1101/gr.275515.121
2022
Journal Article
LINE-1 retrotransposon activation intrinsic to interneuron development
Bodea, Gabriela O., Ferreiro, Maria E., Sanchez-Luque, Francisco J., Botto, Juan M., Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H.C., Love, Chloe J., Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2022). LINE-1 retrotransposon activation intrinsic to interneuron development.
2022
Other Outputs
Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans
Lockett, Jack , Saif, Zarqa, Nolan, Brendan J., Keshvari, Sahar, Cesana-Nigro, Nicole, Ewing, Adam, Inder, Warrick J. and Clifton, Vicki L. (2022). Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans. The University of Queensland. (Dataset) doi: 10.48610/ee0c38e
2021
Conference Publication
Maternal clinical characteristics have unique effects on placental function that are distinct based on fetal growth
O'Callaghan, Jessica, Clifton, Vicki, Prentis, Peter, Ewing, Adam and Pelzer, Elise (2021). Maternal clinical characteristics have unique effects on placental function that are distinct based on fetal growth. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2021.07.194
2021
Journal Article
An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden
Rasmussen, Jay, Ewing, Adam D., Bodea, Liviu‐Gabriel, Bodea, Gabriela O., Gearing, Marla and Faulkner, Geoffrey J. (2021). An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden. Brain Pathology, 32 (3) e13018, e13018. doi: 10.1111/bpa.13018
2021
Journal Article
No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing
Smits, Nathan, Rasmussen, Jay, Bodea, Gabriela O., Amarilla, Alberto A., Gerdes, Patricia, Sanchez-Luque, Francisco J., Ajjikuttira, Prabha, Modhiran, Naphak, Liang, Benjamin, Faivre, Jamila, Deveson, Ira W., Khromykh, Alexander A., Watterson, Daniel, Ewing, Adam D. and Faulkner, Geoffrey J. (2021). No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing. Cell Reports, 36 (7) 109530, 109530. doi: 10.1016/j.celrep.2021.109530
2021
Journal Article
Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptome
Troskie, Robin-Lee, Jafrani, Yohaann, Mercer, Tim R., Ewing, Adam D., Faulkner, Geoffrey J. and Cheetham, Seth W. (2021). Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptome. Genome Biology, 22 (1) 146, 1-15. doi: 10.1186/s13059-021-02369-0
2021
Journal Article
Microdeletion of 9q22.3: a patient with minimal deletion size associated with a severe phenotype
Ewing, Adam D., Cheetham, Seth W., McGill, James J., Sharkey, Michael, Walker, Rick, West, Jennifer A., West, Malcolm J. and Summers, Kim M. (2021). Microdeletion of 9q22.3: a patient with minimal deletion size associated with a severe phenotype. American Journal of Medical Genetics Part A, 185 (7) ajmg.a.62224, 2070-2083. doi: 10.1002/ajmg.a.62224
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Adam Ewing is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Developing software to support Cancer Genomics
Supervision history
Current supervision
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Doctor Philosophy
Genomic and epigenomic correlates of prostate cancer therapy
Principal Advisor
Other advisors: Honorary Professor John Hooper
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Doctor Philosophy
Applying long-read sequencing technologies to cancer genomes
Principal Advisor
Other advisors: Dr Jodi Saunus, Dr Yuanhao Yang, Dr Sandra Richardson
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Doctor Philosophy
Longitudinal evaluation of glucocorticoid receptor isoforms and glucocorticoid responsive genes in medical patients on prednisolone.
Associate Advisor
Other advisors: Associate Professor Warrick Inder, Honorary Professor Vicki Clifton
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Doctor Philosophy
Epigenomic determinants of chemotherapy response in triple-negative breast cancer
Associate Advisor
Other advisors: Professor Chris Pyke, Dr Jodi Saunus
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Doctor Philosophy
Mobile DNA Activity in the Mammalian Primordial Germline
Associate Advisor
Other advisors: Associate Professor Josephine Bowles, Dr Sandra Richardson
Completed supervision
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2023
Doctor Philosophy
Investigating a possible causal relationship between bone mineral density, osteoarthritis, and chronic pain
Associate Advisor
Other advisors: Dr Daniel Hwang, Dr John Kemp
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2023
Doctor Philosophy
Nanopore Sequencing for Mobile Element Research: The Long and Short of It
Associate Advisor
Other advisors: Dr Seth Cheetham, Professor Geoff Faulkner
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2022
Doctor Philosophy
Functional coding and noncoding pseudogenes in the human genome
Associate Advisor
Other advisors: Professor Geoff Faulkner, Dr Seth Cheetham
Media
Enquiries
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