Associate Professor Adam Ewing
Associate Professor

Adam Ewing

Email: 

Background

Dr Ewing leads the Translational Bioinformatics Group at the Mater Research Institute - UQ, located at the Translational Research Institute (TRI). His research interests follow a common theme of developing and applying computational methods to investigate genomic mutation in evolutionary and disease-related processes. Dr Ewing is a key collaborator on an array of projects spanning from basic research into clinical applications of Bioinformatics.

Availability

Associate Professor Adam Ewing is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Pennsylvania

Research interests

  • Computational methods for sequence analysis

Search Professor Adam Ewing’s works on UQ eSpace

66 works between 2005 and 2024
All (66) Journal Article (56) Book Chapter (1) Conference Publication (3) Book (1) Other Outputs (5)

41 - 60 of 66 works

2017

Journal Article

Analysis of LINE-1 elements in DNA from postmortem brains of individuals with schizophrenia

Doyle, Glenn A., Crist, Richard C., Karatas, Emre T., Hammond, Matthew J., Ewing, Adam D., Ferraro, Thomas N., Hahn, Chang-Gyu and Berrettini, Wade H. (2017). Analysis of LINE-1 elements in DNA from postmortem brains of individuals with schizophrenia. Neuropsychopharmacology, 42 (13), 2602-2611. doi: 10.1038/npp.2017.115

Analysis of LINE-1 elements in DNA from postmortem brains of individuals with schizophrenia

2017

Journal Article

Heritable L1 retrotransposition in the mouse primordial germline and early embryo

Richardson, Sandra R., Gerdes, Patricia, Gerhardt, Daniel J., Sanchez-Luque, Francisco J., Bodea, Gabriela-Oana, Muñoz-Lopez, Martin, Jesuadian, J. Samuel, Kempen, Marie-Jeanne H. C., Carreira, Patricia E., Jeddeloh, Jeffrey A., Garcia-Perez, Jose L., Kazazian Jr., Haig H., Ewing, Adam D. and Faulkner, Geoffrey J. (2017). Heritable L1 retrotransposition in the mouse primordial germline and early embryo. Genome Research, 27 (8), 1395-1405. doi: 10.1101/gr.219022.116

Heritable L1 retrotransposition in the mouse primordial germline and early embryo

2017

Journal Article

Reading LINEs within the cocaine addicted brain

Doyle, Glenn A. , Doucet-O'Hare, Tara T. , Hammond, Matthew J. , Crist, Richard C. , Ewing, Adam D. , Ferraro, Thomas N. , Mash, Deborah C. , Kazazian, Haig H. and Berrettini, Wade H. (2017). Reading LINEs within the cocaine addicted brain. Brain and Behavior, 7 (5) e00678, e00678. doi: 10.1002/brb3.678

Reading LINEs within the cocaine addicted brain

2017

Book Chapter

The mobilisation of processed transcripts in germline and somatic tissues

Ewing, Adam D. (2017). The mobilisation of processed transcripts in germline and somatic tissues. Human retrotransposons in health and disease. (pp. 95-106) edited by Gael Cristofari. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-48344-3_4

The mobilisation of processed transcripts in germline and somatic tissues

2016

Journal Article

Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M. and Faulkner, Geoffrey J. (2016). Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme. Mobile DNA, 7 (1) 21, 1-14. doi: 10.1186/s13100-016-0076-6

Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

2015

Journal Article

Transposable element detection from whole genome sequence data

Ewing, Adam D. (2015). Transposable element detection from whole genome sequence data. Mobile DNA, 6 (24) 24. doi: 10.1186/s13100-015-0055-3

Transposable element detection from whole genome sequence data

2015

Journal Article

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

Ewing, Adam D., Gacita, Anthony, Wood, Laura D., Ma, Florence, Xing, Dongmei, Kim, Min-Sik, Manda, Srikanth S., Abril, Gabriela, Pereira, Gavin, Makohon-Moore, Alvin, Looijenga, Leendert H.J., Gillis, Ad J.M., Hruban, Ralph H., Anders, Robert A., Romans, Katharine E., Pandey, Akhilesh, Iacobuzio-Donahue, Christine A., Vogelstein, Bert, Kinzler, Kenneth W., Kazazian, Haig H. and Solyom, Szilvia (2015). Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution. Genome Research, 25 (10), 1536-1545. doi: 10.1101/gr.196238.115

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

2015

Journal Article

Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection

Ewing, Adam D., Houlahan, Kathleen E., Hu, Yin, Ellrott, Kyle, Caloian, Cristian, Yamaguchi, Takafumi N., Bare, J. Christopher, P'Ng, Christine, Waggott, Daryl, Sabelnykova, Veronica Y., ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen, Michael R., Norman, Thea C., Haussler, David, Friend, Stephen H., Stolovitzky, Gustavo, Margolin, Adam A., Stuart, Joshua M. and Boutros, Paul C. (2015). Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection. Nature Methods, 12 (7), 623-630. doi: 10.1038/nmeth.3407

Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection

2015

Journal Article

Ubiquitous L1 mosaicism in hippocampal neurons

Upton, Kyle R., Gerhardt, Daniel J., Jesuadian, J. Samuel, Richardson, Sandra R., Sanchez-Luque, Francisco J., Bodea, Gabriela O., Ewing, Adam D., Salvador-Palomeque, Carmen, van der Knaap, Mario S., Brennan, Paul M., Vanderver, Adeline and Faulkner, Geoffrey J. (2015). Ubiquitous L1 mosaicism in hippocampal neurons. Cell, 161 (2), 228-239. doi: 10.1016/j.cell.2015.03.026

Ubiquitous L1 mosaicism in hippocampal neurons

2014

Journal Article

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

Jacobs, Frank M. J., Greenberg, David, Ngan Nguyen, Haeussler, Maximilian, Ewing, Adam D., Katzman, Sol, Paten, Benedict, Salama, Sofie R. and Haussler, David (2014). An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. Nature, 516 (7530), 242-245. doi: 10.1038/nature13760

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

2014

Journal Article

Lying up a nation: Zora neale hurston and the local uses of diaspora

Ewing, Adam (2014). Lying up a nation: Zora neale hurston and the local uses of diaspora. Callaloo, 37 (1), 130-147. doi: 10.1353/cal.2014.0015

Lying up a nation: Zora neale hurston and the local uses of diaspora

2014

Journal Article

RADIA: RNA and DNA integrated analysis for somatic mutation detection

Radenbaugh, Amie J., Ma, Singer, Ewing, Adam, Stuart, Joshua M., Collisson, Eric A., Zhu, Jingchun and Haussler, David (2014). RADIA: RNA and DNA integrated analysis for somatic mutation detection. PLoS ONE, 9 (11) e111516, e111516.1-e111516.11. doi: 10.1371/journal.pone.0111516

RADIA: RNA and DNA integrated analysis for somatic mutation detection

2014

Book

The age of Garvey: How a Jamaican activist created a mass movement and changed global Black politics

Ewing, Adam (2014). The age of Garvey: How a Jamaican activist created a mass movement and changed global Black politics. Princeton University Press.

The age of Garvey: How a Jamaican activist created a mass movement and changed global Black politics

2014

Journal Article

Global optimization of somatic variant identification in cancer genomes with a global community challenge

Boutros, Paul C., Ewing, Adam D., Ellrott, Kyle, Norman, Thea C., Dang, Kristen K., Hu, Yin, Kellen, Michael R., Suver, Christine, Bare, J. Christopher, Stein, Lincoln D., Spellman, Paul T., Stolovitzky, Gustavo, Friend, Stephen H., Margolin, Adam A. and Stuart, Joshua M. (2014). Global optimization of somatic variant identification in cancer genomes with a global community challenge. Nature Genetics, 46 (4), 318-319. doi: 10.1038/ng.2932

Global optimization of somatic variant identification in cancer genomes with a global community challenge

2013

Journal Article

Caribbean labour politics in the age of Garvey, 1918-1938

Ewing, Adam (2013). Caribbean labour politics in the age of Garvey, 1918-1938. Race and Class, 55 (1), 23-45. doi: 10.1177/0306396813486586

Caribbean labour politics in the age of Garvey, 1918-1938

2013

Journal Article

Retrotransposition of gene transcripts leads to structural variation in mammalian genomes

Ewing, Adam D., Ballinger, Tracy J., Earl, Dent, Harris, Christopher C., Ding, Li, Wilson, Richard K. and Haussler, David (2013). Retrotransposition of gene transcripts leads to structural variation in mammalian genomes. Genome Biology, 14 (3) R22. doi: 10.1186/gb-2013-14-3-r22

Retrotransposition of gene transcripts leads to structural variation in mammalian genomes

2013

Journal Article

Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles

Mandal, Prabhat K., Ewing, Adam D., Hancks, Dustin C. and Kazazian, Haig H., Jr. (2013). Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles. Human Molecular Genetics, 22 (18) ddt225, 3730-3748. doi: 10.1093/hmg/ddt225

Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles

2012

Journal Article

Extensive somatic L1 retrotransposition in colorectal tumors

Solyom, Szilvia, Ewing, Adam D., Rahrmann, Eric P., Doucet, Tara, Nelson, Heather H., Burns, Michael B., Harris, Reuben S., Sigmon, David F., Casella, Alex, Erlanger, Bracha, Wheelan, Sarah, Upton, Kyle R., Shukla, Ruchi, Faulkner, Geoffrey J., Largaespada, David A. and Kazazian, Haig H. (2012). Extensive somatic L1 retrotransposition in colorectal tumors. Genome Research, 22 (12), 2328-2338. doi: 10.1101/gr.145235.112

Extensive somatic L1 retrotransposition in colorectal tumors

2012

Journal Article

Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon

Solyom, Szilvia, Ewing, Adam D., Hancks, Dustin C., Takeshima, Yasuhiro, Awano, Hiroyuki, Matsuo, Masafumi and Kazazian, Haig H., Jr. (2012). Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon. Human Mutation, 33 (2), 369-371. doi: 10.1002/humu.21663

Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon

2011

Journal Article

Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans

Ewing, Adam D. and Kazazian, Haig H., Jr. (2011). Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans. Genome Research, 21 (6), 985-990. doi: 10.1101/gr.114777.110

Whole-genome resequencing allows detection of many rare LINE-1 insertion alleles in humans

Current funding

  • 2024 - 2029
    Building mRNA Cancer Vaccines for Australia.
    MRFF - National Critical Infrastructure Initiative
    Open grant

Past funding

  • 2021 - 2024
    Mobile DNA activity in the mammalian primordial germline
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long-read genetic and epigenetic profiling in lung cancer for precision medicine
    Priority-driven Collaborative Cancer Research Scheme
    Open grant
  • 2020 - 2024
    The history of the human genome and the mechanisms of genomic disease
    NHMRC MRFF Investigator Grant
    Open grant
  • 2017 - 2018
    Unlocking the cellular determinants of retrotransposition
    ARC Discovery Projects
    Open grant
  • 2015
    Functional annotation of structural variants in human genetic disease
    UQ Early Career Researcher
    Open grant
  • 2015 - 2018
    The functional impact of new genes acquired through retrotransposition
    ARC Discovery Early Career Researcher Award
    Open grant

Availability

Associate Professor Adam Ewing is:
Available for supervision

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Available projects

  • Developing software to support Cancer Genomics

Supervision history

Current supervision

  • Doctor Philosophy

    Genomic and epigenomic correlates of prostate cancer therapy

    Principal Advisor

  • Doctor Philosophy

    Applying long-read sequencing technologies to cancer genomes

    Principal Advisor

    Other advisors: Dr Jodi Saunus, Dr Yuanhao Yang, Dr Sandra Richardson

  • Doctor Philosophy

    Genomic and epigenomic correlates of prostate cancer therapy

    Principal Advisor

  • Doctor Philosophy

    Epigenomic determinants of chemotherapy response in triple-negative breast cancer

    Associate Advisor

    Other advisors: Professor Chris Pyke, Dr Jodi Saunus

  • Master Philosophy

    Developing Companion Biomarkers Application in Follicular Lymphoma

    Associate Advisor

    Other advisors: Professor Maher Gandhi, Dr Joshua Tobin

  • Doctor Philosophy

    Longitudinal evaluation of glucocorticoid receptor isoforms and glucocorticoid responsive genes in medical patients on prednisolone.

    Associate Advisor

    Other advisors: Associate Professor Warrick Inder

  • Doctor Philosophy

    Mobile DNA Activity in the Mammalian Primordial Germline

    Associate Advisor

    Other advisors: Professor Josephine Bowles, Dr Sandra Richardson

  • Doctor Philosophy

    Epigenomic determinants of chemotherapy response in triple-negative breast cancer

    Associate Advisor

    Other advisors: Professor Chris Pyke, Dr Jodi Saunus

Completed supervision

Enquiries

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