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Dr John Kemp
Dr

John Kemp

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Overview

Background

John Kemp is a senior research fellow at the University of Queensland. He first developed a keen interest in genetics while studying a Bachelor of Science at the University of Pretoria (RSA). After being awarded a first for his honours degree, he secured a scholarship from the University of Newcastle upon Tyne (UK) to study a master’s degree in medical genetics, which he subsequently completed with distinction. John was awarded a Wellcome Trust PhD studentship in molecular genetics and life-course epidemiology at the University of Bristol (UK). He duly completed his PhD, focussing on the genetics of osteoporosis (OP). His expertise lies in the genetic mapping of complex traits related to OP, and his research has yielded a step change in understanding the genetic architecture of OP. Through his extensive network of experts in functional genomics and murine genetics, he has mapped may OP loci to target genes and identified nine genes that represent new opportunities for drug development. These findings have since been published in top-tier journals such as Nature Genetics, and his contributions have been further recognised by the way of several international young investigator awards. His other interests include applying new statistical genetics methodologies to OP research, including approaches for causal modelling through Mendelian Randomization. John’s expertise extends beyond statistical genetics, as he has >6 years of experience performing advanced molecular genetics laboratory techniques and has used these to advance his OP research.

Availability

Dr John Kemp is:
Not available for supervision

Qualifications

  • Masters (Coursework) of Science, Newcastle University
  • Doctor of Philosophy, University of Bristol

Research interests

  • Identifying pharmacological targets for osteoporosis intervention.

    Osteoporosis is a debilitating disease characterized by weak bones and increased risk of fracture. This research applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.

Works

Search Professor John Kemp’s works on UQ eSpace

130 works between 2009 and 2024

1 - 20 of 130 works

2024

Conference Publication

Variation In Hip Shape Amongst The General Population Is Unlikely To Have A Causal Effect On The Development Hip Osteoarthritis: Findings From A GWAS Meta-analysis And Mendelian Randomisation Study

Faber, Ben G., Frysz, Monika, Zheng, Jiayi, Lin, Huandong, Flynn, Kaitlyn, Ebsim, Raja, Saunders, Fiona, Beynon, Rhona, Gregory, Jenny, Aspden, Richard, Harvey, Nicholas, Lindner, Claudia, Cootes, Tim, Smith, George Davey, Evans, David, Gao, Xin, Wang, Sijia, Kemp, John and Tobias, Jon (2024). Variation In Hip Shape Amongst The General Population Is Unlikely To Have A Causal Effect On The Development Hip Osteoarthritis: Findings From A GWAS Meta-analysis And Mendelian Randomisation Study. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.02.688

Variation In Hip Shape Amongst The General Population Is Unlikely To Have A Causal Effect On The Development Hip Osteoarthritis: Findings From A GWAS Meta-analysis And Mendelian Randomisation Study

2024

Conference Publication

Early findings from the Genetics of Osteoarthritis Endophenotypes Working Group: a genome-wide association meta-analysis of hip osteophytosis identifies IGFBP3

Faber, Ben G., Arbeeva, Liubov, Zheng, Jiayi, Beynon, Rhona, Jung, Mijin, Agricola, Rintje, Nelson, Amanda E., Golightly, Yvonne M., Wang, Sijia, Kemp, John, Tobias, Jon, Meurs, Joyce v. and Boer, Cindy (2024). Early findings from the Genetics of Osteoarthritis Endophenotypes Working Group: a genome-wide association meta-analysis of hip osteophytosis identifies IGFBP3. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.02.715

Early findings from the Genetics of Osteoarthritis Endophenotypes Working Group: a genome-wide association meta-analysis of hip osteophytosis identifies IGFBP3

2024

Journal Article

Femoral neck width genetic risk score is a novel independent risk factor for hip fractures

Tobias, Jonathan H., Nethander, Maria, Faber, Benjamin G., Heppenstall, Sophie V., Ebsim, Raja, Cootes, Tim, Lindner, Claudia, Saunders, Fiona R., Gregory, Jenny S., Aspden, Richard M., Harvey, Nicholas C., Kemp, John P., Frysz, Monika and Ohlsson, Claes (2024). Femoral neck width genetic risk score is a novel independent risk factor for hip fractures. Journal of Bone and Mineral Research, 39 (3), 241-251. doi: 10.1093/jbmr/zjae002

Femoral neck width genetic risk score is a novel independent risk factor for hip fractures

2023

Journal Article

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses

Faber, Benjamin G., Frysz, Monika, Boer, Cindy G., Evans, Daniel S., Ebsim, Raja, Flynn, Kaitlyn A., Lundberg, Mischa, Southam, Lorraine, Hartley, April, Saunders, Fiona R., Lindner, Claudia, Gregory, Jennifer S., Aspden, Richard M., Lane, Nancy E., Harvey, Nicholas C., Evans, David M., Zeggini, Eleftheria, Davey Smith, George, Cootes, Timothy, Van Meurs, Joyce, Kemp, John P. and Tobias, Jonathan H. (2023). The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses. eBioMedicine, 95 104759, 104759. doi: 10.1016/j.ebiom.2023.104759

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses

2023

Journal Article

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Medina-Gomez, Carolina, Mullin, Benjamin H., Chesi, Alessandra, Prijatelj, Vid, Kemp, John P., Shochat-Carvalho, Chen, Trajanoska, Katerina, Wang, Carol, Joro, Raimo, Evans, Tavia E., Schraut, Katharina E., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Zillikens, M. Carola, Zhu, Kun, Mook-Kanamori, Dennis O., Evans, Daniel S., Nethander, Maria, Knol, Maria J., Thorleifsson, Gudmar, Prokic, Ivana, Zemel, Babette, Broer, Linda, McGuigan, Fiona E., van Schoor, Natasja M., Reppe, Sjur, Pawlak, Mikolaj A., Ralston, Stuart H., van der Velde, Nathalie ... Rivadeneira, Fernando (2023). Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Communications Biology, 6 (1) 691, 1-12. doi: 10.1038/s42003-023-04869-0

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

2023

Journal Article

A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults

Faber, Benjamin G., Frysz, Monika, Hartley, April E., Ebsim, Raja, Boer, Cindy G., Saunders, Fiona R., Gregory, Jennifer S., Aspden, Richard M, Harvey, Nicholas C., Southam, Lorraine, Giles, William, Le Maitre, Christine L., Wilkinson, J. Mark, van Meurs, Joyce B. J., Zeggini, Eleftheria, Cootes, Timothy, Lindner, Claudia, Kemp, John P., Davey Smith, George and Tobias, Jonathan H. (2023). A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults. Arthritis and Rheumatology, 75 (6), 900-909. doi: 10.1002/art.42451

A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults

2023

Journal Article

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization

Zheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F.M., Yau, Michelle S., Hartley, April E., Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P, Frysz, Monika, Robinson, Jamie, Reppe, Sjur, Prijatelj, Vid, Gautvik, Kaare M., Falk, Louise, Maerz, Winfried, Gergei, Ingrid, Peyser, Patricia A, Kavousi, Maryam, de Vries, Paul S., Miller, Clint L., Bos, Maxime, van der Laan, Sander W., Malhotra, Rajeev, Herrmann, Markus, Scharnagl, Hubert, Kleber, Marcus, Dedoussis, George, Zeggini, Eleftheria ... Tobias, Jonathan H. (2023). Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization. Arthritis & Rheumatology, 75 (10), 1781-1792. doi: 10.1002/art.42538

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization

2022

Journal Article

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

D’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

2022

Conference Publication

A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank

Faber, B., Frysz, M., Ebsim, R., Lundberg, M., Southam, L., Hartley, A., Saunders, F.R., Lindner, C., Gregory, J.S., Aspden, R.M., Harvey, N.C., Zeggini, E., Smith, G. Davey, Cootes, T., Kemp, J.P. and Tobias, J.H. (2022). A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank. 2022 OARSI World Congress on Osteoarthritis, Online, 7-10 April 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2022.02.051

A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank

2022

Journal Article

Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease

Bergen, Dylan J. M., Tong, Qiao, Shukla, Ankit, Newham, Elis, Zethof, Jan, Lundberg, Mischa, Ryan, Rebecca, Youlten, Scott E., Frysz, Monika, Croucher, Peter I., Flik, Gert, Richardson, Rebecca J., Kemp, John P., Hammond, Chrissy L. and Metz, Juriaan R. (2022). Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology, 20 (1) 21, 21. doi: 10.1186/s12915-021-01209-8

Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease

2022

Journal Article

Limb development genes underlie variation in human fingerprint patterns

Li, Jinxi, Glover, James D., Zhang, Haiguo, Peng, Meifang, Tan, Jingze, Mallick, Chandana Basu, Hou, Dan, Yang, Yajun, Wu, Sijie, Liu, Yu, Peng, Qianqian, Zheng, Shijie C., Crosse, Edie I., Medvinsky, Alexander, Anderson, Richard A., Brown, Helen, Yuan, Ziyu, Zhou, Shen, Xu, Yanqing, Kemp, John P., Ho, Yvonne Y.W., Loesch, Danuta Z., Wang, Lizhong, Li, Yingxiang, Tang, Senwei, Wu, Xiaoli, Walters, Robin G., Lin, Kuang, Meng, Ruogu ... Wang, Sijia (2022). Limb development genes underlie variation in human fingerprint patterns. Cell, 185 (1), 95-112.e18. doi: 10.1016/j.cell.2021.12.008

Limb development genes underlie variation in human fingerprint patterns

2022

Journal Article

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

Wang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Åsvold, Bjørn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2022). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Hypertension, 79 (1), 170-177. doi: 10.1161/hypertensionaha.121.17701

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

2021

Conference Publication

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

Wang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Asvold, Bjorn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2021). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Behavior Genetics Association 51st Annual Meeting, Online (Zoom), 29 June 2021. New York, United States: Springer.

Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health

2021

Journal Article

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

Kim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E., Słabicki, Mikołaj, Kemp, John P., Bick, Alexander, Gibson, Christopher J., Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J., Wong, Waihay J., Cohen, Drew N., Uddin, Md Mesbah, Shin, Wesley J., Pirruccello, James, Tsai, Jonathan M., Agrawal, Mridul, Kiel, Douglas P., Bouxsein, Mary L., Richards, J. Brent, Evans, David M., Wein, Marc N., Charles, Julia F., Jaiswal, Siddhartha, Natarajan, Pradeep and Ebert, Benjamin L. (2021). Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Journal of Experimental Medicine, 218 (12) e20211872. doi: 10.1084/jem.20211872

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

2021

Journal Article

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Youlten, Scott E., Kemp, John P., Logan, John G., Ghirardello, Elena J., Sergio, Claudio M., Dack, Michael R. G., Guilfoyle, Siobhan E., Leitch, Victoria D., Butterfield, Natalie C., Komla-Ebri, Davide, Chai, Ryan C., Corr, Alexander P., Smith, James T., Mohanty, Sindhu T., Morris, John A., McDonald, Michelle M., Quinn, Julian M. W., McGlade, Amelia R., Bartonicek, Nenad, Jansson, Matt, Hatzikotoulas, Konstantinos, Irving, Melita D., Beleza-Meireles, Ana, Rivadeneira, Fernando, Duncan, Emma, Richards, J. Brent, Adams, David J., Lelliott, Christopher J., Brink, Robert ... Croucher, Peter I. (2021). Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Nature Communications, 12 (1) 2444, 1-21. doi: 10.1038/s41467-021-22517-1

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

2021

Journal Article

Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))

McDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R.G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M.W., Youlten, Scott E. ... Phan, Tri Giang (2021). Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002)). Cell, 184 (7), 1940-1940. doi: 10.1016/j.cell.2021.03.010

Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))

2021

Journal Article

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

McDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R. G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M. W., Youlten, Scott E. ... Phan, Tri Giang (2021). Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. Cell, 184 (5), 1330-1347. doi: 10.1016/j.cell.2021.02.002

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

2021

Journal Article

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Ahluwalia, Tarunveer S., Prins, Bram P., Abdollahi, Mohammadreza, Armstrong, Nicola J., Aslibekyan, Stella, Bain, Lisa, Jefferis, Barbara, Baumert, Jens, Beekman, Marian, Ben-Shlomo, Yoav, Bis, Joshua C., Mitchell, Braxton D., de Geus, Eco, Delgado, Graciela E., Marek, Diana, Eriksson, Joel, Kajantie, Eero, Kanoni, Stavroula, Kemp, John P., Lu, Chen, Marioni, Riccardo E., McLachlan, Stela, Milaneschi, Yuri, Nolte, Ilja M., Petrelis, Alexandros M., Porcu, Eleonora, Sabater-Lleal, Maria, Naderi, Elnaz, Seppälä, Ilkka ... CHARGE Inflammation Working Group (2021). Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 30 (5), 393-409. doi: 10.1093/hmg/ddab023

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

2021

Journal Article

Opportunities and challenges in functional genomics research in osteoporosis: report From a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020

Tobias, Jonathan H., Duncan, Emma L., Kague, Erika, Hammond, Chrissy L., Gregson, Celia L., Bassett, Duncan, Williams, Graham R., Min, Josine L., Gaunt, Tom R., Karasik, David, Ohlsson, Claes, Rivadeneira, Fernando, Edwards, James R., Hannan, Fadil M., Kemp, John P., Gilbert, Sophie J., Alonso, Nerea, Hassan, Neelam, Compston, Juliet E. and Ralston, Stuart H. (2021). Opportunities and challenges in functional genomics research in osteoporosis: report From a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in Endocrinology, 11 630875, 630875. doi: 10.3389/fendo.2020.630875

Opportunities and challenges in functional genomics research in osteoporosis: report From a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020

2020

Journal Article

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun ... Morgan, Linda (2020). Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications, 11 (1) 5976, 5976. doi: 10.1038/s41467-020-19733-6

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Funding

Current funding

  • 2025 - 2029
    Using human genetics, single cell transcriptomics and animal models to accelerate drug development for patients with osteoporosis.
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2026
    Identifying genetic and lifestyle determinants of abdominal aortic calcification that predispose to cardiovascular disease (MRFF Cardiovascular Health Mission Grant administered by Edith Cowan Uni)
    Edith Cowan University
    Open grant
  • 2021 - 2025
    Identifying drug targets for osteoporosis by synthesising murine single cell transcriptomics with data from human genetic association studies [ASBMR Rising Star Award]
    ASBMR Rising Star Award
    Open grant

Past funding

  • 2020 - 2024
    Identifying pharmacological targets for osteoporosis intervention using whole genome and exome sequencing of bone related phenotypes
    NHMRC Investigator Grants
    Open grant
  • 2019 - 2023
    Using large scale genome-wide association studies to identify pharmacological targets for osteoporosis intervention
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Identifying molecular genetic pathways and modifiable risk factors that underpin osteoporosis pathogenesis through genome-wide association and Mendelian randomization
    UQ Development Fellowships
    Open grant

Supervision

Availability

Dr John Kemp is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Identifying genetic and cellular determinants of musculoskeletal disorders

    Principal Advisor

    Other advisors: Dr Nicole Warrington

  • Doctor Philosophy

    Identifying genetic and cellular determinants of musculoskeletal disorders

    Principal Advisor

    Other advisors: Dr Nicole Warrington

Completed supervision

Media

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