|
2026 Journal Article Understanding the relationship between knee alignment and osteoarthritis using genetic approaches: Findings from 58,203 UK Biobank ParticipantsJung, Mijin, Alomar, Faten, Chen, Shibo, Coveney, Clarissa R., Orr, Sarah, Mimpen, Jolet, Saunders, Fiona, Gregory, Jenny, Aspden, Richard, Harvey, Nicholas, Lindner, Claudia, Abram, Simon, Hammond, Chrissy, Zeggini, Eleftheria, Snelling, Sarah, Capellini, Terence, Rice, Sarah, Kemp, John, Tobias, Jon, Cootes, Timothy and Faber, Ben G. (2026). Understanding the relationship between knee alignment and osteoarthritis using genetic approaches: Findings from 58,203 UK Biobank Participants. Osteoarthritis and Cartilage, 34, S113-S114. doi: 10.1016/j.joca.2026.01.131 |
|
2026 Journal Article THE CLINICAL AND GENETIC PROFILES OF MACHINE LEARNING-DERIVED STRUCTURAL OSTEOARTHRITIS PHENOTYPESFaber, Ben G., Jung, Mijin, Ebsim, Raja, Saunders, Fiona, Hashmi, Asad, Scott, Sophie, Gregory, Jenny, Aspden, Richard, Harvey, Nicholas, Kemp, John, Smith, George Davey, Judge, Andy, Boer, Cindy, Lindner, Claudia, Cootes, Timothy, Collins, Jamie and Tobias, Jon (2026). THE CLINICAL AND GENETIC PROFILES OF MACHINE LEARNING-DERIVED STRUCTURAL OSTEOARTHRITIS PHENOTYPES. Osteoarthritis and Cartilage, 34, S251. doi: 10.1016/j.joca.2026.01.346 |
|
2026 Journal Article MASSIVELY PARALLEL REPORTER ASSAY (MPRA) IDENTIFIES ANCIENT, EVOLUTIONARILY IMPORTANT VARIANTS PERTINENT TO MUSCULOSKELETAL TRAITS AND DISEASECoveney, Clarissa R., Gananpathee, Danalaxshmi S., Okamoto, Alexander S., Amani, Marta A., Richard, Daniel, Jagoda, Evelyn, Jung, Mijin, Ebsim, Raja, Saunders, Fiona, Hashmi, Asad, Gregory, Jenny, Aspden, Richard, Lindner, Claudia, Cootes, Timothy, Kemp, John, Tobias, Jon, Faber, Ben G. and Capellini, Terence (2026). MASSIVELY PARALLEL REPORTER ASSAY (MPRA) IDENTIFIES ANCIENT, EVOLUTIONARILY IMPORTANT VARIANTS PERTINENT TO MUSCULOSKELETAL TRAITS AND DISEASE. Osteoarthritis and Cartilage, 34, S28. doi: 10.1016/j.joca.2026.01.014 |
|
2026 Journal Article DISCOVERY OF CORE GENES IN OSTEOARTHRITIS USING THE OMNIGENIC MODEL AND ZEBRAFISH VALIDATIONStewart, Rory, Iakovliev, Andrii, Collins, Fraser, Spiliopoulou, Athina, Kemp, John, Debari, Cosimo, McKeigue, Paul and Kague, Erika (2026). DISCOVERY OF CORE GENES IN OSTEOARTHRITIS USING THE OMNIGENIC MODEL AND ZEBRAFISH VALIDATION. Osteoarthritis and Cartilage, 34, S111-S112. doi: 10.1016/j.joca.2026.01.128 |
|
2026 Journal Article Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging StudySim, Marc, Webster, James, Smith, Cassandra, Saleem, Afsah, Gilani, Syed Zulqarnain, Toro-Huamanchumo, Carlos J., Suter, David, Figtree, Gemma, Lagendijk, Anne Karine, Duncan, Emma L., Schultz, Carl, Szulc, Pawel, Hung, Joseph, Lim, Wai H., Raina, Parminder, Bondonno, Nicola P., Woodman, Richard, Hodgson, Jonathan M., Kiel, Douglas P., Prince, Richard L., Leslie, William D., Kemp, John P., Harvey, Nicholas C., Schousboe, John T. and Lewis, Joshua R. (2026). Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging Study. JACC: Advances, 5 (3) 102570, 102570. doi: 10.1016/j.jacadv.2025.102570 |
|
2024 Journal Article The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fractureFaber, Benjamin G., Frysz, Monika, Zheng, Jaiyi, Lin, Huandong, Flynn, Kaitlyn A., Ebsim, Raja, Saunders, Fiona R., Beynon, Rhona, Gregory, Jennifer S., Aspden, Richard M., Harvey, Nicholas C., Lindner, Claudia, Cootes, Timothy, Evans, David M., Smith, George Davey, Gao, Xin, Wang, Sijia, Kemp, John P. and Tobias, Jonathan H. (2024). The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture. Human Molecular Genetics, 34 (3), 207-217. doi: 10.1093/hmg/ddae169 |
|
2024 Journal Article Femoral neck width genetic risk score is a novel independent risk factor for hip fracturesTobias, Jonathan H., Nethander, Maria, Faber, Benjamin G., Heppenstall, Sophie V., Ebsim, Raja, Cootes, Tim, Lindner, Claudia, Saunders, Fiona R., Gregory, Jenny S., Aspden, Richard M., Harvey, Nicholas C., Kemp, John P., Frysz, Monika and Ohlsson, Claes (2024). Femoral neck width genetic risk score is a novel independent risk factor for hip fractures. Journal of Bone and Mineral Research, 39 (3), 241-251. doi: 10.1093/jbmr/zjae002 |
|
2023 Journal Article The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analysesFaber, Benjamin G., Frysz, Monika, Boer, Cindy G., Evans, Daniel S., Ebsim, Raja, Flynn, Kaitlyn A., Lundberg, Mischa, Southam, Lorraine, Hartley, April, Saunders, Fiona R., Lindner, Claudia, Gregory, Jennifer S., Aspden, Richard M., Lane, Nancy E., Harvey, Nicholas C., Evans, David M., Zeggini, Eleftheria, Davey Smith, George, Cootes, Timothy, Van Meurs, Joyce, Kemp, John P. and Tobias, Jonathan H. (2023). The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses. eBioMedicine, 95 104759, 104759. doi: 10.1016/j.ebiom.2023.104759 |
|
2023 Journal Article Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosisMedina-Gomez, Carolina, Mullin, Benjamin H., Chesi, Alessandra, Prijatelj, Vid, Kemp, John P., Shochat-Carvalho, Chen, Trajanoska, Katerina, Wang, Carol, Joro, Raimo, Evans, Tavia E., Schraut, Katharina E., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Zillikens, M. Carola, Zhu, Kun, Mook-Kanamori, Dennis O., Evans, Daniel S., Nethander, Maria, Knol, Maria J., Thorleifsson, Gudmar, Prokic, Ivana, Zemel, Babette, Broer, Linda, McGuigan, Fiona E., van Schoor, Natasja M., Reppe, Sjur, Pawlak, Mikolaj A., Ralston, Stuart H., van der Velde, Nathalie ... Rivadeneira, Fernando (2023). Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Communications Biology, 6 (1) 691, 1-12. doi: 10.1038/s42003-023-04869-0 |
|
2023 Journal Article A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adultsFaber, Benjamin G., Frysz, Monika, Hartley, April E., Ebsim, Raja, Boer, Cindy G., Saunders, Fiona R., Gregory, Jennifer S., Aspden, Richard M, Harvey, Nicholas C., Southam, Lorraine, Giles, William, Le Maitre, Christine L., Wilkinson, J. Mark, van Meurs, Joyce B. J., Zeggini, Eleftheria, Cootes, Timothy, Lindner, Claudia, Kemp, John P., Davey Smith, George and Tobias, Jonathan H. (2023). A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults. Arthritis and Rheumatology, 75 (6), 900-909. doi: 10.1002/art.42451 |
|
2023 Journal Article Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomizationZheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F.M., Yau, Michelle S., Hartley, April E., Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P, Frysz, Monika, Robinson, Jamie, Reppe, Sjur, Prijatelj, Vid, Gautvik, Kaare M., Falk, Louise, Maerz, Winfried, Gergei, Ingrid, Peyser, Patricia A, Kavousi, Maryam, de Vries, Paul S., Miller, Clint L., Bos, Maxime, van der Laan, Sander W., Malhotra, Rajeev, Herrmann, Markus, Scharnagl, Hubert, Kleber, Marcus, Dedoussis, George, Zeggini, Eleftheria ... Tobias, Jonathan H. (2023). Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization. Arthritis & Rheumatology, 75 (10), 1781-1792. doi: 10.1002/art.42538 |
|
2022 Journal Article Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer riskD’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w |
|
2022 Journal Article Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal diseaseBergen, Dylan J. M., Tong, Qiao, Shukla, Ankit, Newham, Elis, Zethof, Jan, Lundberg, Mischa, Ryan, Rebecca, Youlten, Scott E., Frysz, Monika, Croucher, Peter I., Flik, Gert, Richardson, Rebecca J., Kemp, John P., Hammond, Chrissy L. and Metz, Juriaan R. (2022). Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology, 20 (1) 21, 21. doi: 10.1186/s12915-021-01209-8 |
|
2022 Journal Article Limb development genes underlie variation in human fingerprint patternsLi, Jinxi, Glover, James D., Zhang, Haiguo, Peng, Meifang, Tan, Jingze, Mallick, Chandana Basu, Hou, Dan, Yang, Yajun, Wu, Sijie, Liu, Yu, Peng, Qianqian, Zheng, Shijie C., Crosse, Edie I., Medvinsky, Alexander, Anderson, Richard A., Brown, Helen, Yuan, Ziyu, Zhou, Shen, Xu, Yanqing, Kemp, John P., Ho, Yvonne Y.W., Loesch, Danuta Z., Wang, Lizhong, Li, Yingxiang, Tang, Senwei, Wu, Xiaoli, Walters, Robin G., Lin, Kuang, Meng, Ruogu ... Wang, Sijia (2022). Limb development genes underlie variation in human fingerprint patterns. Cell, 185 (1), 95-112.e18. doi: 10.1016/j.cell.2021.12.008 |
|
2022 Journal Article Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic healthWang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Åsvold, Bjørn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2022). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Hypertension, 79 (1), 170-177. doi: 10.1161/hypertensionaha.121.17701 |
|
2021 Journal Article Dnmt3a-mutated clonal hematopoiesis promotes osteoporosisKim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E., Słabicki, Mikołaj, Kemp, John P., Bick, Alexander, Gibson, Christopher J., Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J., Wong, Waihay J., Cohen, Drew N., Uddin, Md Mesbah, Shin, Wesley J., Pirruccello, James, Tsai, Jonathan M., Agrawal, Mridul, Kiel, Douglas P., Bouxsein, Mary L., Richards, J. Brent, Evans, David M., Wein, Marc N., Charles, Julia F., Jaiswal, Siddhartha, Natarajan, Pradeep and Ebert, Benjamin L. (2021). Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Journal of Experimental Medicine, 218 (12) e20211872. doi: 10.1084/jem.20211872 |
|
2021 Journal Article Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal diseaseYoulten, Scott E., Kemp, John P., Logan, John G., Ghirardello, Elena J., Sergio, Claudio M., Dack, Michael R. G., Guilfoyle, Siobhan E., Leitch, Victoria D., Butterfield, Natalie C., Komla-Ebri, Davide, Chai, Ryan C., Corr, Alexander P., Smith, James T., Mohanty, Sindhu T., Morris, John A., McDonald, Michelle M., Quinn, Julian M. W., McGlade, Amelia R., Bartonicek, Nenad, Jansson, Matt, Hatzikotoulas, Konstantinos, Irving, Melita D., Beleza-Meireles, Ana, Rivadeneira, Fernando, Duncan, Emma, Richards, J. Brent, Adams, David J., Lelliott, Christopher J., Brink, Robert ... Croucher, Peter I. (2021). Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Nature Communications, 12 (1) 2444, 1-21. doi: 10.1038/s41467-021-22517-1 |
|
2021 Journal Article Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))McDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R.G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M.W., Youlten, Scott E. ... Phan, Tri Giang (2021). Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002)). Cell, 184 (7), 1940-1940. doi: 10.1016/j.cell.2021.03.010 |
|
2021 Journal Article Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorptionMcDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R. G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M. W., Youlten, Scott E. ... Phan, Tri Giang (2021). Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. Cell, 184 (5), 1330-1347. doi: 10.1016/j.cell.2021.02.002 |
|
2021 Journal Article Genome-wide association study of circulating interleukin 6 levels identifies novel lociAhluwalia, Tarunveer S., Prins, Bram P., Abdollahi, Mohammadreza, Armstrong, Nicola J., Aslibekyan, Stella, Bain, Lisa, Jefferis, Barbara, Baumert, Jens, Beekman, Marian, Ben-Shlomo, Yoav, Bis, Joshua C., Mitchell, Braxton D., de Geus, Eco, Delgado, Graciela E., Marek, Diana, Eriksson, Joel, Kajantie, Eero, Kanoni, Stavroula, Kemp, John P., Lu, Chen, Marioni, Riccardo E., McLachlan, Stela, Milaneschi, Yuri, Nolte, Ilja M., Petrelis, Alexandros M., Porcu, Eleonora, Sabater-Lleal, Maria, Naderi, Elnaz, Seppälä, Ilkka ... CHARGE Inflammation Working Group (2021). Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 30 (5), 393-409. doi: 10.1093/hmg/ddab023 |
