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Dr

John Kemp

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Overview

Background

John Kemp is a senior research fellow at the University of Queensland. He first developed a keen interest in genetics while studying a Bachelor of Science at the University of Pretoria (RSA). After being awarded a first for his honours degree, he secured a scholarship from the University of Newcastle upon Tyne (UK) to study a master’s degree in medical genetics, which he subsequently completed with distinction. John was awarded a Wellcome Trust PhD studentship in molecular genetics and life-course epidemiology at the University of Bristol (UK). He duly completed his PhD, focussing on the genetics of osteoporosis (OP). His expertise lies in the genetic mapping of complex traits related to OP, and his research has yielded a step change in understanding the genetic architecture of OP. Through his extensive network of experts in functional genomics and murine genetics, he has mapped may OP loci to target genes and identified nine genes that represent new opportunities for drug development. These findings have since been published in top-tier journals such as Nature Genetics, and his contributions have been further recognised by the way of several international young investigator awards. His other interests include applying new statistical genetics methodologies to OP research, including approaches for causal modelling through Mendelian Randomization. John’s expertise extends beyond statistical genetics, as he has >6 years of experience performing advanced molecular genetics laboratory techniques and has used these to advance his OP research.

Availability

Dr John Kemp is:
Available for supervision

Qualifications

  • Masters (Coursework) of Science, Newcastle University
  • Doctor of Philosophy, University of Bristol

Research interests

  • Identifying pharmacological targets for osteoporosis intervention.

    Osteoporosis is a debilitating disease characterized by weak bones and increased risk of fracture. This research applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.

Works

Search Professor John Kemp’s works on UQ eSpace

140 works between 2009 and 2026

1 - 20 of 140 works

2026

Journal Article

Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging Study

Sim, Marc, Webster, James, Smith, Cassandra, Saleem, Afsah, Gilani, Syed Zulqarnain, Toro-Huamanchumo, Carlos J., Suter, David, Figtree, Gemma, Lagendijk, Anne Karine, Duncan, Emma L., Schultz, Carl, Szulc, Pawel, Hung, Joseph, Lim, Wai H., Raina, Parminder, Bondonno, Nicola P., Woodman, Richard, Hodgson, Jonathan M., Kiel, Douglas P., Prince, Richard L., Leslie, William D., Kemp, John P., Harvey, Nicholas C., Schousboe, John T. and Lewis, Joshua R. (2026). Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging Study. JACC: Advances, 5 (3) 102570, 102570. doi: 10.1016/j.jacadv.2025.102570

Automated Abdominal Aortic Calcification Scores and Atherosclerotic Cardiovascular Disease in the UK Biobank Imaging Study

2025

Conference Publication

AUTOMATED ABDOMINAL AORTIC CALCIFICATION EXTENT IS ASSOCIATED WITH MUSCLE COMPOSITION, STRENGTH AND SARCOPENIA: THE UK BIOBANK IMAGING STUDY

Gebre, A., Smith, C., Webster, J., Saleem, A., Gilani, S. Z., Duque, G., Duncan, E. L., Hong, N. K., Raina, P., Kiel, D. P., Kemp, J. P., Zhong, Y., Daly, R. M., Schousboe, J. T., Leslie, D., Prince, R. L., Harvey, N. C., Lewis, J. R. and Sim, M. (2025). AUTOMATED ABDOMINAL AORTIC CALCIFICATION EXTENT IS ASSOCIATED WITH MUSCLE COMPOSITION, STRENGTH AND SARCOPENIA: THE UK BIOBANK IMAGING STUDY. NEW YORK: SPRINGER.

AUTOMATED ABDOMINAL AORTIC CALCIFICATION EXTENT IS ASSOCIATED WITH MUSCLE COMPOSITION, STRENGTH AND SARCOPENIA: THE UK BIOBANK IMAGING STUDY

2024

Journal Article

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture

Faber, Benjamin G., Frysz, Monika, Zheng, Jaiyi, Lin, Huandong, Flynn, Kaitlyn A., Ebsim, Raja, Saunders, Fiona R., Beynon, Rhona, Gregory, Jennifer S., Aspden, Richard M., Harvey, Nicholas C., Lindner, Claudia, Cootes, Timothy, Evans, David M., Smith, George Davey, Gao, Xin, Wang, Sijia, Kemp, John P. and Tobias, Jonathan H. (2024). The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture. Human Molecular Genetics, 34 (3), 207-217. doi: 10.1093/hmg/ddae169

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture

2024

Conference Publication

Early findings from the Genetics of Osteoarthritis Endophenotypes Working Group: a genome-wide association meta-analysis of hip osteophytosis identifies IGFBP3

Faber, Ben G., Arbeeva, Liubov, Zheng, Jiayi, Beynon, Rhona, Jung, Mijin, Agricola, Rintje, Nelson, Amanda E., Golightly, Yvonne M., Wang, Sijia, Kemp, John, Tobias, Jon, Meurs, Joyce v. and Boer, Cindy (2024). Early findings from the Genetics of Osteoarthritis Endophenotypes Working Group: a genome-wide association meta-analysis of hip osteophytosis identifies IGFBP3. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.02.715

Early findings from the Genetics of Osteoarthritis Endophenotypes Working Group: a genome-wide association meta-analysis of hip osteophytosis identifies IGFBP3

2024

Conference Publication

Variation In Hip Shape Amongst The General Population Is Unlikely To Have A Causal Effect On The Development Hip Osteoarthritis: Findings From A GWAS Meta-analysis And Mendelian Randomisation Study

Faber, Ben G., Frysz, Monika, Zheng, Jiayi, Lin, Huandong, Flynn, Kaitlyn, Ebsim, Raja, Saunders, Fiona, Beynon, Rhona, Gregory, Jenny, Aspden, Richard, Harvey, Nicholas, Lindner, Claudia, Cootes, Tim, Smith, George Davey, Evans, David, Gao, Xin, Wang, Sijia, Kemp, John and Tobias, Jon (2024). Variation In Hip Shape Amongst The General Population Is Unlikely To Have A Causal Effect On The Development Hip Osteoarthritis: Findings From A GWAS Meta-analysis And Mendelian Randomisation Study. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.02.688

Variation In Hip Shape Amongst The General Population Is Unlikely To Have A Causal Effect On The Development Hip Osteoarthritis: Findings From A GWAS Meta-analysis And Mendelian Randomisation Study

2024

Conference Publication

Variation in hip shape amongst the general population is unlikely to have a causal effect on the development hip osteoarthritis: findings from a GWAS meta-analysis and Mendelian randomisation study

Faber, Ben G., Frysz, Monika, Zheng, Jiayi, Lin, Huandong, Flynn, Kaitlyn, Ebsim, Raja, Saunders, Fiona, Beynon, Rhona, Gregory, Jenny, Aspden, Richard, Harvey, Nicholas, Lindner, Claudia, Cootes, Tim, Smith, George Davey, Evans, David, Gao, Xin, Wang, Sijia, Kemp, John and Tobias, Jon (2024). Variation in hip shape amongst the general population is unlikely to have a causal effect on the development hip osteoarthritis: findings from a GWAS meta-analysis and Mendelian randomisation study. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier.

Variation in hip shape amongst the general population is unlikely to have a causal effect on the development hip osteoarthritis: findings from a GWAS meta-analysis and Mendelian randomisation study

2024

Journal Article

Femoral neck width genetic risk score is a novel independent risk factor for hip fractures

Tobias, Jonathan H., Nethander, Maria, Faber, Benjamin G., Heppenstall, Sophie V., Ebsim, Raja, Cootes, Tim, Lindner, Claudia, Saunders, Fiona R., Gregory, Jenny S., Aspden, Richard M., Harvey, Nicholas C., Kemp, John P., Frysz, Monika and Ohlsson, Claes (2024). Femoral neck width genetic risk score is a novel independent risk factor for hip fractures. Journal of Bone and Mineral Research, 39 (3), 241-251. doi: 10.1093/jbmr/zjae002

Femoral neck width genetic risk score is a novel independent risk factor for hip fractures

2023

Conference Publication

Identification of genetic risk factors for hip osteoarthritis acting through altered hip shape: findings from a genome-wide association meta-analysis of 43,485 individuals

Faber, Benjamin, Frysz, Monika, Zheng, Jiayi, Lin, Huandong, Ebsim, Raja, Saunders, Fiona, Gregory, Jenny, Aspden, Richard, Harvey, Nicholas, Lindner, Claudia, Cootes, Tim, Wang, Sijia, Kemp, John and Tobias, Jonathan (2023). Identification of genetic risk factors for hip osteoarthritis acting through altered hip shape: findings from a genome-wide association meta-analysis of 43,485 individuals. Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Vancouver Canada, Oct 13-16, 2023. OXFORD: OXFORD UNIV PRESS.

Identification of genetic risk factors for hip osteoarthritis acting through altered hip shape: findings from a genome-wide association meta-analysis of 43,485 individuals

2023

Conference Publication

Multiscale Analysis Identifies Cell Types and Genes Associated with Bone Mineral Density

Chai, Ryan C., Lundberg, Mischa, Frysz, Monika, Bassett, J. H. Duncan, Williams, Graham R., Croucher, Peter I. and Kemp, John P. (2023). Multiscale Analysis Identifies Cell Types and Genes Associated with Bone Mineral Density. Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Vancouver Canada, Oct 13-16, 2023. OXFORD: OXFORD UNIV PRESS.

Multiscale Analysis Identifies Cell Types and Genes Associated with Bone Mineral Density

2023

Conference Publication

Femoral Neck Width Genetic Risk Score Is A Novel Independent Risk Factor For Hip Fractures

Tobias, Jonathan H., Nethander, Maria, Faber, Benjamin F., Heppenstall, Sophie, Ebsim, Raja, Cootes, Timothy, Lidner, Claudia, Saunders, Fiona R., Gregory, Jenny S., Aspden, Richard M., Harvey, Nick C., Kemp, John, Frysz, Monika and Ohlsson, Claes (2023). Femoral Neck Width Genetic Risk Score Is A Novel Independent Risk Factor For Hip Fractures. Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Vancouver Canada, Oct 13-16, 2023. OXFORD: OXFORD UNIV PRESS.

Femoral Neck Width Genetic Risk Score Is A Novel Independent Risk Factor For Hip Fractures

2023

Journal Article

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses

Faber, Benjamin G., Frysz, Monika, Boer, Cindy G., Evans, Daniel S., Ebsim, Raja, Flynn, Kaitlyn A., Lundberg, Mischa, Southam, Lorraine, Hartley, April, Saunders, Fiona R., Lindner, Claudia, Gregory, Jennifer S., Aspden, Richard M., Lane, Nancy E., Harvey, Nicholas C., Evans, David M., Zeggini, Eleftheria, Davey Smith, George, Cootes, Timothy, Van Meurs, Joyce, Kemp, John P. and Tobias, Jonathan H. (2023). The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses. eBioMedicine, 95 104759, 104759. doi: 10.1016/j.ebiom.2023.104759

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses

2023

Journal Article

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Medina-Gomez, Carolina, Mullin, Benjamin H., Chesi, Alessandra, Prijatelj, Vid, Kemp, John P., Shochat-Carvalho, Chen, Trajanoska, Katerina, Wang, Carol, Joro, Raimo, Evans, Tavia E., Schraut, Katharina E., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Zillikens, M. Carola, Zhu, Kun, Mook-Kanamori, Dennis O., Evans, Daniel S., Nethander, Maria, Knol, Maria J., Thorleifsson, Gudmar, Prokic, Ivana, Zemel, Babette, Broer, Linda, McGuigan, Fiona E., van Schoor, Natasja M., Reppe, Sjur, Pawlak, Mikolaj A., Ralston, Stuart H., van der Velde, Nathalie ... Rivadeneira, Fernando (2023). Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Communications Biology, 6 (1) 691, 1-12. doi: 10.1038/s42003-023-04869-0

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

2023

Journal Article

A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults

Faber, Benjamin G., Frysz, Monika, Hartley, April E., Ebsim, Raja, Boer, Cindy G., Saunders, Fiona R., Gregory, Jennifer S., Aspden, Richard M, Harvey, Nicholas C., Southam, Lorraine, Giles, William, Le Maitre, Christine L., Wilkinson, J. Mark, van Meurs, Joyce B. J., Zeggini, Eleftheria, Cootes, Timothy, Lindner, Claudia, Kemp, John P., Davey Smith, George and Tobias, Jonathan H. (2023). A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults. Arthritis and Rheumatology, 75 (6), 900-909. doi: 10.1002/art.42451

A GWAS meta‐analysis of alpha angle suggests cam‐type morphology may be a specific feature of hip osteoarthritis in older adults

2023

Journal Article

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization

Zheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F.M., Yau, Michelle S., Hartley, April E., Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P, Frysz, Monika, Robinson, Jamie, Reppe, Sjur, Prijatelj, Vid, Gautvik, Kaare M., Falk, Louise, Maerz, Winfried, Gergei, Ingrid, Peyser, Patricia A, Kavousi, Maryam, de Vries, Paul S., Miller, Clint L., Bos, Maxime, van der Laan, Sander W., Malhotra, Rajeev, Herrmann, Markus, Scharnagl, Hubert, Kleber, Marcus, Dedoussis, George, Zeggini, Eleftheria ... Tobias, Jonathan H. (2023). Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization. Arthritis & Rheumatology, 75 (10), 1781-1792. doi: 10.1002/art.42538

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome‐wide association meta‐analysis followed by Mendelian randomization

2023

Conference Publication

Expanded genome-wide association study meta-analysis of hip and spine BMD identifies ∼45 novel loci and uncovers widespread pleiotropy

Lu, Haojie, Frysz, Monika, Lu, Tianyuan, Ohlsson, Claes, Rivadeneira, Fernando, Tobias, Jonathan, Richards, Brent, Kiel, Douglas P., Kemp, John P. and Medina-Gomez, Carolina (2023). Expanded genome-wide association study meta-analysis of hip and spine BMD identifies ∼45 novel loci and uncovers widespread pleiotropy. Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Austin Tx, Sep 09-12, 2022. HOBOKEN: WILEY.

Expanded genome-wide association study meta-analysis of hip and spine BMD identifies ∼45 novel loci and uncovers widespread pleiotropy

2023

Conference Publication

Describing the genetic architecture of hip shape: findings from UK Biobank

Frysz, Monika, Faber, Benjamin, Ebsim, Raja, Saunders, Fiona S., Gregory, Jenny S., Aspden, Richard M., Harvey, Nicholas C., Lindner, Claudia, Cootes, Timothy, Kemp, John P. and Tobias, Jon (2023). Describing the genetic architecture of hip shape: findings from UK Biobank. HOBOKEN: WILEY.

Describing the genetic architecture of hip shape: findings from UK Biobank

2022

Journal Article

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

D’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

2022

Conference Publication

A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank

Faber, B., Frysz, M., Ebsim, R., Lundberg, M., Southam, L., Hartley, A., Saunders, F.R., Lindner, C., Gregory, J.S., Aspden, R.M., Harvey, N.C., Zeggini, E., Smith, G. Davey, Cootes, T., Kemp, J.P. and Tobias, J.H. (2022). A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank. 2022 OARSI World Congress on Osteoarthritis, Online, 7-10 April 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2022.02.051

A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank

2022

Journal Article

Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease

Bergen, Dylan J. M., Tong, Qiao, Shukla, Ankit, Newham, Elis, Zethof, Jan, Lundberg, Mischa, Ryan, Rebecca, Youlten, Scott E., Frysz, Monika, Croucher, Peter I., Flik, Gert, Richardson, Rebecca J., Kemp, John P., Hammond, Chrissy L. and Metz, Juriaan R. (2022). Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology, 20 (1) 21, 21. doi: 10.1186/s12915-021-01209-8

Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease

2022

Journal Article

Limb development genes underlie variation in human fingerprint patterns

Li, Jinxi, Glover, James D., Zhang, Haiguo, Peng, Meifang, Tan, Jingze, Mallick, Chandana Basu, Hou, Dan, Yang, Yajun, Wu, Sijie, Liu, Yu, Peng, Qianqian, Zheng, Shijie C., Crosse, Edie I., Medvinsky, Alexander, Anderson, Richard A., Brown, Helen, Yuan, Ziyu, Zhou, Shen, Xu, Yanqing, Kemp, John P., Ho, Yvonne Y.W., Loesch, Danuta Z., Wang, Lizhong, Li, Yingxiang, Tang, Senwei, Wu, Xiaoli, Walters, Robin G., Lin, Kuang, Meng, Ruogu ... Wang, Sijia (2022). Limb development genes underlie variation in human fingerprint patterns. Cell, 185 (1), 95-112.e18. doi: 10.1016/j.cell.2021.12.008

Limb development genes underlie variation in human fingerprint patterns

Funding

Current funding

  • 2025 - 2029
    Using human genetics, single cell transcriptomics and animal models to accelerate drug development for patients with osteoporosis.
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2027
    Identifying genetic and lifestyle determinants of abdominal aortic calcification that predispose to cardiovascular disease (MRFF Cardiovascular Health Mission Grant administered by Edith Cowan Uni)
    Edith Cowan University
    Open grant

Past funding

  • 2021 - 2025
    Identifying drug targets for osteoporosis by synthesising murine single cell transcriptomics with data from human genetic association studies [ASBMR Rising Star Award]
    ASBMR Rising Star Award
    Open grant
  • 2020 - 2024
    Identifying pharmacological targets for osteoporosis intervention using whole genome and exome sequencing of bone related phenotypes
    NHMRC Investigator Grants
    Open grant
  • 2019 - 2023
    Using large scale genome-wide association studies to identify pharmacological targets for osteoporosis intervention
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Identifying molecular genetic pathways and modifiable risk factors that underpin osteoporosis pathogenesis through genome-wide association and Mendelian randomization
    UQ Development Fellowships
    Open grant

Supervision

Availability

Dr John Kemp is:
Available for supervision

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Available projects

  • Identifying cellular and genetic determinants of osteoporosis and related co-morbidities

    Osteoporosis is a debilitating disease characterized by brittle bones and increased risk of fracture. This project applies innovative statistical and molecular genetic methods to the world’s largest study of osteoporosis in order to identify genes, proteins and metabolites that may in the future serve as pharmacological targets to restore lost bone and prevent fracture.

Supervision history

Current supervision

  • Doctor Philosophy

    Using single cell transcriptomics, gene-mapping, and animal models to accelerate drug discovery for patients with osteoporosis

    Principal Advisor

    Other advisors: Dr Nicole Warrington

Completed supervision

Media

Enquiries

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