Associate Professor Adam Ewing
Associate Professor

Adam Ewing

Email: 

Background

Dr Ewing leads the Translational Bioinformatics Group at the Mater Research Institute - UQ, located at the Translational Research Institute (TRI). His research interests follow a common theme of developing and applying computational methods to investigate genomic mutation in evolutionary and disease-related processes. Dr Ewing is a key collaborator on an array of projects spanning from basic research into clinical applications of Bioinformatics. In particular, his interests include the genomics and epigenomics of epithelial tumours including those arising in prostate, pancreatic, and breast cancer.

Availability

Associate Professor Adam Ewing is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Pennsylvania

Research interests

  • Computational methods for sequence analysis

  • Epithelial tumours

  • Placental genomics

Search Professor Adam Ewing’s works on UQ eSpace

69 works between 2005 and 2026
All (69) Book (1) Journal Article (61) Other Outputs (2) Conference Publication (4) Book Chapter (1)

21 - 40 of 69 works

2022

Journal Article

LINE-1 retrotransposon activation intrinsic to interneuron development

Bodea, Gabriela O., Ferreiro, Maria E., Sanchez-Luque, Francisco J., Botto, Juan M., Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H.C., Love, Chloe J., Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2022). LINE-1 retrotransposon activation intrinsic to interneuron development.

LINE-1 retrotransposon activation intrinsic to interneuron development

2022

Other Outputs

Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans

Lockett, Jack , Saif, Zarqa, Nolan, Brendan J., Keshvari, Sahar, Cesana-Nigro, Nicole, Ewing, Adam, Inder, Warrick J. and Clifton, Vicki L. (2022). Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans. The University of Queensland. (Dataset) doi: 10.48610/ee0c38e

Glucocorticoid activity regulates glucocorticoid receptor isoform expression and downstream gene transcription in humans

2021

Conference Publication

Maternal clinical characteristics have unique effects on placental function that are distinct based on fetal growth

O'Callaghan, Jessica, Clifton, Vicki, Prentis, Peter, Ewing, Adam and Pelzer, Elise (2021). Maternal clinical characteristics have unique effects on placental function that are distinct based on fetal growth. Meeting of the International Federation of Placenta Associations, Auckland, New Zealand, 30 August - 2 September 2021. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2021.07.194

Maternal clinical characteristics have unique effects on placental function that are distinct based on fetal growth

2021

Journal Article

An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden

Rasmussen, Jay, Ewing, Adam D., Bodea, Liviu‐Gabriel, Bodea, Gabriela O., Gearing, Marla and Faulkner, Geoffrey J. (2021). An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden. Brain Pathology, 32 (3) e13018, e13018. doi: 10.1111/bpa.13018

An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden

2021

Journal Article

No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing

Smits, Nathan, Rasmussen, Jay, Bodea, Gabriela O., Amarilla, Alberto A., Gerdes, Patricia, Sanchez-Luque, Francisco J., Ajjikuttira, Prabha, Modhiran, Naphak, Liang, Benjamin, Faivre, Jamila, Deveson, Ira W., Khromykh, Alexander A., Watterson, Daniel, Ewing, Adam D. and Faulkner, Geoffrey J. (2021). No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing. Cell Reports, 36 (7) 109530, 109530. doi: 10.1016/j.celrep.2021.109530

No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing

2021

Journal Article

Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptome

Troskie, Robin-Lee, Jafrani, Yohaann, Mercer, Tim R., Ewing, Adam D., Faulkner, Geoffrey J. and Cheetham, Seth W. (2021). Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptome. Genome Biology, 22 (1) 146, 1-15. doi: 10.1186/s13059-021-02369-0

Long-read cDNA sequencing identifies functional pseudogenes in the human transcriptome

2021

Journal Article

Microdeletion of 9q22.3: a patient with minimal deletion size associated with a severe phenotype

Ewing, Adam D., Cheetham, Seth W., McGill, James J., Sharkey, Michael, Walker, Rick, West, Jennifer A., West, Malcolm J. and Summers, Kim M. (2021). Microdeletion of 9q22.3: a patient with minimal deletion size associated with a severe phenotype. American Journal of Medical Genetics Part A, 185 (7) ajmg.a.62224, 2070-2083. doi: 10.1002/ajmg.a.62224

Microdeletion of 9q22.3: a patient with minimal deletion size associated with a severe phenotype

2020

Journal Article

Nanopore sequencing enables comprehensive transposable element epigenomic profiling

Ewing, Adam D., Smits, Nathan, Sanchez-Luque, Francisco J., Faivre, Jamila, Brennan, Paul M., Richardson, Sandra R., Cheetham, Seth W. and Faulkner, Geoffrey J. (2020). Nanopore sequencing enables comprehensive transposable element epigenomic profiling. Molecular Cell, 80 (5), 915-928.e5. doi: 10.1016/j.molcel.2020.10.024

Nanopore sequencing enables comprehensive transposable element epigenomic profiling

2020

Journal Article

Multiscale imaging of basal cell dynamics in the functionally mature mammary gland

Stevenson, Alexander J., Vanwalleghem, Gilles, Stewart, Teneale A., Condon, Nicholas D., Lloyd-Lewis, Bethan, Marino, Natascia, Putney, James W., Scott, Ethan K., Ewing, Adam D. and Davis, Felicity M. (2020). Multiscale imaging of basal cell dynamics in the functionally mature mammary gland. Proceedings of the National Academy of Sciences, 117 (43), 1-11. doi: 10.1073/pnas.2016905117

Multiscale imaging of basal cell dynamics in the functionally mature mammary gland

2020

Journal Article

Whole genome investigation of an atypical autism case identifies a novel ANOS1 mutation with subsequent diagnosis of Kallmann syndrome

Dawson, Paul A., Lee, Soohyun, Ewing, Adam D., Prins, Johannes B. and Heussler, Helen S. (2020). Whole genome investigation of an atypical autism case identifies a novel ANOS1 mutation with subsequent diagnosis of Kallmann syndrome. Molecular Genetics and Metabolism Reports, 23 100593, 100593. doi: 10.1016/j.ymgmr.2020.100593

Whole genome investigation of an atypical autism case identifies a novel ANOS1 mutation with subsequent diagnosis of Kallmann syndrome

2020

Journal Article

Modulation of placental gene expression in small-for-gestational-age infants

O’Callaghan, Jessica L., Clifton, Vicki L., Prentis, Peter, Ewing, Adam, Miller, Yvette D. and Pelzer, Elise S. (2020). Modulation of placental gene expression in small-for-gestational-age infants. Genes, 11 (1) 80, 80. doi: 10.3390/genes11010080

Modulation of placental gene expression in small-for-gestational-age infants

2020

Journal Article

A community effort to create standards for evaluating tumor subclonal reconstruction

Salcedo, Adriana, Tarabichi, Maxime, Espiritu, Shadrielle Melijah G., Deshwar, Amit G., David, Matei, Wilson, Nathan M., Dentro, Stefan, Wintersinger, Jeff A., Liu, Lydia Y., Ko, Minjeong, Sivanandan, Srinivasan, Zhang, Hongjiu, Zhu, Kaiyi, Ou Yang, Tai-Hsien, Chilton, John M., Buchanan, Alex, Lalansingh, Christopher M., P’ng, Christine, Anghel, Catalina V., Umar, Imaad, Lo, Bryan, Zou, William, Jha, Alokkumar, Huang, Tanxiao, Yang, Tsun-Po, Peifer, Martin, Sahinalp, Cenk, Malikic, Salem, Vázquez-García, Ignacio ... Boutros, Paul C. (2020). A community effort to create standards for evaluating tumor subclonal reconstruction. Nature Biotechnology, 38 (1), 97-107. doi: 10.1038/s41587-019-0364-z

A community effort to create standards for evaluating tumor subclonal reconstruction

2019

Journal Article

CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin

He, Yaowu, Davies, Claire M., Harrington, Brittney S., Hellmers, Linh, Sheng, Yonghua, Broomfield, Amy, McGann, Thomas, Bastick, Kate, Zhong, Laurie, Wu, Andy, Maresh, Grace, McChesney, Shannon, Yau Wong, Kuan, Adams, Mark N., Sullivan, Ryan C., Palmer, James S., Burke, Lez J., Ewing, Adam D., Zhang, Xin, Margolin, David, Li, Li, Lourie, Rohan, Matsika, Admire, Srinivasan, Bhuvana, McGuckin, Michael A., Lumley, John W. and Hooper, John D. (2019). CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene, 39 (1), 219-233. doi: 10.1038/s41388-019-0983-3

CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin

2019

Journal Article

LINE-1 Evasion of epigenetic repression in humans

Sanchez-Luque, Francisco J., Kempen, Marie-Jeanne H.C., Gerdes, Patricia, Vargas-Landin, Dulce B., Richardson, Sandra R., Troskie, Robin-Lee, Jesuadian, J. Samuel, Cheetham, Seth W., Carreira, Patricia E., Salvador-Palomeque, Carmen, García-Cañadas, Marta, Muñoz-Lopez, Martin, Sanchez, Laura, Lundberg, Mischa, Macia, Angela, Heras, Sara R., Brennan, Paul M., Lister, Ryan, Garcia-Perez, Jose L., Ewing, Adam D. and Faulkner, Geoffrey J. (2019). LINE-1 Evasion of epigenetic repression in humans. Molecular Cell, 75 (3), 590-604.e12. doi: 10.1016/j.molcel.2019.05.024

LINE-1 Evasion of epigenetic repression in humans

2019

Journal Article

Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation

Salvador-Palomeque, Carmen, Sanchez-Luque, Francisco J., Fortuna, Patrick R. J., Ewing, Adam D., Wolvetang, Ernst J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2019). Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation. Molecular and Cellular Biology, 39 (7) e00499-18, 1-19. doi: 10.1128/mcb.00499-18

Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation

2019

Journal Article

Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the border collie dog breed

Pugh, Carys A., Farrell, Lindsay L., Carlisle, Ailsa J., Bush, Stephen J., Ewing, Adam, Trejo-Reveles, Violeta, Matika, Oswald, de Kloet, Arne, Walsh, Caitlin, Bishop, Stephen C., Prendergast, James G. D., Rainger, Joe, Schoenebeck, Jeffrey J. and Summers, Kim M. (2019). Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the border collie dog breed. G3: Genes, Genomes, Genetics, 9 (3), 943-954. doi: 10.1534/g3.118.200944

Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the border collie dog breed

2018

Journal Article

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

Lee, Anna Y., Ewing, Adam D., Ellrott, Kyle, Hu, Yin, Houlahan, Kathleen E., Bare, J. Christopher, Espiritu, Shadrielle Melijah G., Huang, Vincent, Dang, Kristen, Chong, Zechen, Caloian, Cristian, Yamaguchi, Takafumi N., Kellen, Michael R., Chen, Ken, Norman, Thea C., Friend, Stephen H., Guinney, Justin, Stolovitzky, Gustavo, Haussler, David, Margolin, Adam A., Stuart, Joshua M. and Boutros, Paul C. (2018). Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection. Genome Biology, 19 (1) 188, 188. doi: 10.1186/s13059-018-1539-5

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

2018

Journal Article

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

Maung, Kyaw Ze Ya, Leo, Paul J., Bassal, Mahmoud, Casolari, Debora A., Gray, James X., Bray, Sarah C., Pederson, Stephen, Singhal, Deepak, Samaraweera, Saumya E., Nguyen, Tran, Cildir, Gökhan, Marshall, Mhairi, Ewing, Adam, Duncan, Emma L., Brown, Matthew A., Saal, Russell, Tergaonkar, Vinay, To, Luen Bik, Marlton, Paula, Gill, Devinder, Lewis, Ian, Deans, Andrew J., Brown, Anna L., D’Andrea, Richard J. and Gonda, Thomas J. (2018). Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia. Blood Cancer Journal, 8 (6) 50, 50. doi: 10.1038/s41408-018-0090-7

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

2018

Journal Article

Human-specific NOTCH2NL genes affect notch signaling and cortical neurogenesis

Fiddes, Ian T., Lodewijk, Gerrald A., Mooring, Meghan, Bosworth, Colleen M., Ewing, Adam D., Mantalas, Gary L., Novak, Adam M., van den Bout, Anouk, Bishara, Alex, Rosenkrantz, Jimi L., Lorig-Roach, Ryan, Field, Andrew R., Haeussler, Maximilian, Russo, Lotte, Bhaduri, Aparna, Nowakowski, Tomasz J., Pollen, Alex A., Dougherty, Max L., Nuttle, Xander, Addor, Marie-Claude, Zwolinski, Simon, Katzman, Sol, Kriegstein, Arnold, Eichler, Evan E., Salama, Sofie R., Jacobs, Frank M.J. and Haussler, David (2018). Human-specific NOTCH2NL genes affect notch signaling and cortical neurogenesis. Cell, 173 (6), 1356-1369. doi: 10.1016/j.cell.2018.03.051

Human-specific NOTCH2NL genes affect notch signaling and cortical neurogenesis

2018

Journal Article

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

Schauer, Stephanie N., Carreira, Patricia E., Shukla, Ruchi, Gerhardt, Daniel J., Gerdes, Patricia, Sanchez-Luque, Francisco J., Nicoli, Paola, Kindlova, Michaela, Ghisletti, Serena, Santos, Alexandre Dos, Rapoud, Delphine, Samuel, Didier, Faivre, Jamila, Ewing, Adam D., Richardson, Sandra R. and Faulkner, Geoffrey J. (2018). L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis. Genome Research, 28 (5), 639-653. doi: 10.1101/gr.226993.117

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

Current funding

  • 2026 - 2027
    Improving early detection of pancreatic cancer by exploring the faulty methylation of the pre-cancerous tissue
    Early Detection
    Open grant
  • 2026 - 2028
    Mechanisms contributing to placental insufficiency and adverse neonatal outcomes across the birthweight centile continuum
    Open grant
  • 2025 - 2028
    A role for mobile DNA in unexplained female infertility
    NHMRC MRFF Infertility Pregnancy Loss and Menopause
    Open grant
  • 2024 - 2029
    Building mRNA Cancer Vaccines for Australia.
    MRFF - National Critical Infrastructure Initiative
    Open grant

Past funding

  • 2021 - 2024
    Mobile DNA activity in the mammalian primordial germline
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Long-read genetic and epigenetic profiling in lung cancer for precision medicine
    Priority-driven Collaborative Cancer Research Scheme
    Open grant
  • 2020 - 2024
    The history of the human genome and the mechanisms of genomic disease
    NHMRC MRFF Investigator Grant
    Open grant
  • 2017 - 2018
    Unlocking the cellular determinants of retrotransposition
    ARC Discovery Projects
    Open grant
  • 2015
    Functional annotation of structural variants in human genetic disease
    UQ Early Career Researcher
    Open grant
  • 2015 - 2018
    The functional impact of new genes acquired through retrotransposition
    ARC Discovery Early Career Researcher Award
    Open grant

Availability

Associate Professor Adam Ewing is:
Available for supervision

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Available projects

  • Developing software to support Cancer Genomics

Supervision history

Current supervision

Completed supervision

Enquiries

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