Dr Simon Worrall
Dr

Simon Worrall

Email: 
Phone: 
+61 7 336 54626

Background

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
  • Do keratin 8 or 18 mutants sensitise the liver to toxins?
  • Is an aberrant immune response involved in NSAID adverse reactions?
  • What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

Availability

Dr Simon Worrall is:
Not available for supervision

Fields of research

Clinical sciences Zoology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of St Andrews
  • Doctor of Philosophy, University of Nottingham

Search Professor Simon Worrall’s works on UQ eSpace

95 works between 1985 and 2024
All (95) Journal Article (52) Book Chapter (7) Conference Publication (35) Book (1)

1 - 20 of 95 works

2024

Journal Article

The Metabolic Syndrome: An Overview and Proposed Mechanisms

Thomaz, Fernanda Santos, John, Oliver Dean, Sinha, Payel, Shafie, Siti Raihanah and Worrall, Simon (2024). The Metabolic Syndrome: An Overview and Proposed Mechanisms. Obesities, 4 (3), 226-255. doi: 10.3390/obesities4030020

The Metabolic Syndrome: An Overview and Proposed Mechanisms

2022

Journal Article

Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats

Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats. Foods, 11 (21) 3435, 1-12. doi: 10.3390/foods11213435

Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats

2021

Journal Article

A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?

White, Hayden, Heffernan, Aaron J., Worrall, Simon, Grunsfeld, Alexander and Thomas, Matt (2021). A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?. Frontiers in Medicine, 8 740374, 740374. doi: 10.3389/fmed.2021.740374

A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?

2020

Journal Article

The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats

Thomaz, Fernanda S., Altemani, Faisal, Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats. Journal of Human Hypertension, 35 (2), 170-180. doi: 10.1038/s41371-020-0359-8

The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats

2020

Journal Article

Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats

Thomaz, Fernanda S., Tomsett, Kate I., Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats. Journal of Functional Foods, 67 103868, 103868. doi: 10.1016/j.jff.2020.103868

Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats

2018

Journal Article

Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro

Chakravarthy, Madhuri, AlShamaileh, Hadi, Huang, He, Tannenberg, Rudi K., Chen, Suxiang, Worrall, Simon, Dodd, Peter R. and Veedu, Rakesh N. (2018). Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical Communications, 54 (36), 4593-4596. doi: 10.1039/c8cc02256a

Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro

2018

Conference Publication

Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids

Worrall, S., Simmons, G., Mills, P., Rainger, J., Keates, H., Plan, M. and Nixon, P. F. (2018). Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids. 19th World Congress of International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Kyoto Japan, 9-13 September 2018. Hoboken, NJ United States: Wiley-Blackwell.

Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids

2015

Journal Article

Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking

Toselli, Francesca, Depaz, Iris M. Booth, Worrall, Simon, Etheridge, Naomi, Dodd, Peter R., Wilce, Peter A. and Gillam, Elizabeth M. J. (2015). Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. Alcoholism: Clinical and Experimental Research, 39 (5), 790-797. doi: 10.1111/acer.12697

Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking

2014

Conference Publication

Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption

Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451

Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption

2014

Conference Publication

Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking

Toselli, Francesca, Worrall, Simon, Wilce, Peter A., Dodd, Peter R. and Gillam, Elizabeth M. J. (2014). Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, 29 September - 03 October 2013. New York, NY United States: Informa Healthcare.

Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking

2014

Conference Publication

Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease

Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451

Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease

2013

Journal Article

Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status

White, Hayden, Venkatesh, Balasubramanian, Jones, Mark, Worrall, Simon, Chuah, Teong and Ordonez, Jenny (2013). Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status. Intensive Care Medicine, 39 (4), 727-733. doi: 10.1007/s00134-012-2790-y

Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status

2013

Book Chapter

The effect of diet on protein modification by ethanol metabolites

Worrall, Simon (2013). The effect of diet on protein modification by ethanol metabolites. Alcohol, nutrition, and health consequences. (pp. 111-130) edited by Ronald Ross Watson, Victor R. Preedy and Sherma Zibadi. New York, NY, United States: Springer. doi: 10.1007/978-1-62703-047-2_9

The effect of diet on protein modification by ethanol metabolites

2012

Conference Publication

Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration

Richards, S., Perry, A., Dodd, P. R. and Worrall, S. (2012). Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration. 16th World Congress of the International-Society for Biomedical Research on Alcoholism (ISBRA), Sapporo, Japan, 9-12 September 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1530-0277.2012.01917.x

Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration

2011

Book

Biochemistry for health professionals

Batmanian, Laura, Ridge, Justin and Worrall, Simon (2011). Biochemistry for health professionals. Chatswood, NSW, Australia: Elsevier Australia.

Biochemistry for health professionals

2009

Journal Article

Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain

Partadiredja, G., Worrall, S. and Bedi, K. S. (2009). Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain. Brain Research, 1285, 22-29. doi: 10.1016/j.brainres.2009.06.010

Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain

2008

Journal Article

Pre-weaning undernutrition alters the expression levels of reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain

Partadiredja, G., Worrall, S., Simpson, R. and Bedi, K. S. (2008). Pre-weaning undernutrition alters the expression levels of reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain. Brain Research, 1222, 69-78. doi: 10.1016/j.brainres.2008.05.046

Pre-weaning undernutrition alters the expression levels of reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain

2007

Conference Publication

Discussion

Eriksson, C. J. Peter, Preedy, Victor R., Albano, Emanuele, Salaspuro, Mikko, Seitz, Helmut K., Emery, Peter, Apte, Minoti V., Shukla, Shivendra D., Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Niemelä, Onni, Crabb, David W. and Ren, Jun (2007). Discussion.

Discussion

2007

Conference Publication

Discussion

Seitz, Helmut K., Deitrich, Richard A., Peter Eriksson, C. J., Apte, Minoti V., Preedy, Victor R., Morris, John B., Albano, Emanuele, Worrall, Simon, Emery, Peter, Ren, Jun, Crabb, David W., Salaspuro, Mikko, Quertemont, Etienne, Thornalley, Paul J., Rao, Radhakrishna K., Aranda, Agustin, Okamura, Tomonori, Shukla, Shivendra D., Niemelä, Onni and Jamal, Mostofa (2007). Discussion.

Discussion

2007

Conference Publication

Discussion

Worrall, Simon, Eriksson, C. J. Peter, Preedy, Victor R., Seitz, Helmut K., Salaspuro, Ville, Salaspuro, Mikko, Apte, Minoti V., Rao, Radhakrishna K., Morris, John B., Thornalley, Paul J. and Ren, Jun (2007). Discussion.

Discussion

Past funding

  • 2010
    Choroid Plexus Dysfunction the Pathogenesis of Alcohol Intoxication
    Open grant
  • 2006
    The Effect of Mutant Keratin Mutations and Polymorphisms on Hepatic Sensitivity of Oxidative Stress Induced by Chronic Ethanol Oxidation
    Australian Brewers' Foundation
    Open grant
  • 1999
    Oxidative stress in the human alcoholic brain
    Australian Brewers' Foundation
    Open grant
  • 1998
    Identification and Characterisation of Adducts from Ethanol Metabolites and Model Peptides
    ARC Australian Research Council (Small grants)
    Open grant
  • 1997
    The effect of chronic ethanol feeding of heptic gene expression in a rat model of alcholic liver disease
    University of Queensland New Staff Research Grant
    Open grant

Availability

Dr Simon Worrall is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

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