Dr Simon Worrall
Dr

Simon Worrall

Email: 
Phone: 
+61 7 336 54626

Background

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
  • Do keratin 8 or 18 mutants sensitise the liver to toxins?
  • Is an aberrant immune response involved in NSAID adverse reactions?
  • What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

Availability

Dr Simon Worrall is:
Not available for supervision

Fields of research

Clinical sciences Zoology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of St Andrews
  • Doctor of Philosophy, University of Nottingham

Search Professor Simon Worrall’s works on UQ eSpace

95 works between 1985 and 2024
All (95) Journal Article (52) Book Chapter (7) Conference Publication (35) Book (1)

81 - 95 of 95 works

1991

Journal Article

Acetaldehyde-modified proteins and associated antibodies in ethanol-fed rats

Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1991). Acetaldehyde-modified proteins and associated antibodies in ethanol-fed rats. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 255-260.

Acetaldehyde-modified proteins and associated antibodies in ethanol-fed rats

1991

Journal Article

Antibodies Against Acetaldehyde-Modified Epitopes - An Elevated Iga Response in Alcoholics

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Antibodies Against Acetaldehyde-Modified Epitopes - An Elevated Iga Response in Alcoholics. European Journal of Clinical Investigation, 21 (1), 90-95. doi: 10.1111/j.1365-2362.1991.tb01364.x

Antibodies Against Acetaldehyde-Modified Epitopes - An Elevated Iga Response in Alcoholics

1991

Journal Article

Detection of Stable Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Detection of Stable Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. Alcohol and Alcoholism, 26 (4), 437-444. doi: 10.1093/oxfordjournals.alcalc.a045136

Detection of Stable Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats

1991

Conference Publication

Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.

Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats

1991

Conference Publication

Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.

Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins

1990

Journal Article

Antibodies against acetaldehyde-modified epitopes: Presence in alcoholic, non-alcoholic liver disease and control subjects

Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1990). Antibodies against acetaldehyde-modified epitopes: Presence in alcoholic, non-alcoholic liver disease and control subjects. Alcohol and Alcoholism, 25 (5), 509-517. doi: 10.1093/oxfordjournals.alcalc.a045044

Antibodies against acetaldehyde-modified epitopes: Presence in alcoholic, non-alcoholic liver disease and control subjects

1990

Conference Publication

Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. LONDON: PORTLAND PRESS. doi: 10.1042/bst0180678

Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats

1990

Journal Article

Antibodies Against Acetaldehyde-Modified Epitopes - Presence in Alcoholic, Nonalcoholic Liver-Disease and Control Subjects

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Antibodies Against Acetaldehyde-Modified Epitopes - Presence in Alcoholic, Nonalcoholic Liver-Disease and Control Subjects. Alcohol and Alcoholism, 25 (5), 509-517.

Antibodies Against Acetaldehyde-Modified Epitopes - Presence in Alcoholic, Nonalcoholic Liver-Disease and Control Subjects

1989

Journal Article

Ethanol Induces the Production of Antibodies to Acetaldehyde-Modified Epitopes in Rats

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1989). Ethanol Induces the Production of Antibodies to Acetaldehyde-Modified Epitopes in Rats. Alcohol and Alcoholism, 24 (3), 217-223. doi: 10.1093/oxfordjournals.alcalc.a044898

Ethanol Induces the Production of Antibodies to Acetaldehyde-Modified Epitopes in Rats

1988

Journal Article

Purification of Brain D2 Dopamine Receptor

Williamson, RA, Worrall, S, Chazot, PL and Strange, PG (1988). Purification of Brain D2 Dopamine Receptor. Embo Journal, 7 (13), 4129-4133. doi: 10.1002/j.1460-2075.1988.tb03307.x

Purification of Brain D2 Dopamine Receptor

1988

Journal Article

Partial-Purification of the D-2 Dopamine Receptor From Bovine Caudate-Nucleus

Williamson, RA, Worrall, S, Chazot, PL and Strange, PG (1988). Partial-Purification of the D-2 Dopamine Receptor From Bovine Caudate-Nucleus. Biochemical Society Transactions, 16 (4), 450-452. doi: 10.1042/bst0160450

Partial-Purification of the D-2 Dopamine Receptor From Bovine Caudate-Nucleus

1987

Conference Publication

Partial-Purification of D2 Dopamine-Receptors From Bovine Brain

Williamson, RA, Worrall, S and Strange, PG (1987). Partial-Purification of D2 Dopamine-Receptors From Bovine Brain. LONDON: WALTER DE GRUYTER & CO. doi: 10.1042/bst0151155

Partial-Purification of D2 Dopamine-Receptors From Bovine Brain

1986

Conference Publication

Purification of D2-Dopamine Receptors From Bovine Brain

Worrall, S, Williamson, RA and Strange, PG (1986). Purification of D2-Dopamine Receptors From Bovine Brain. LONDON: PORTLAND PRESS. doi: 10.1042/bst0141138

Purification of D2-Dopamine Receptors From Bovine Brain

1986

Conference Publication

Partial-Purification of D2-Dopamine Receptors From Bovine Brain

Worrall, S, Williamson, R and Strange, PG (1986). Partial-Purification of D2-Dopamine Receptors From Bovine Brain. BERLIN: PORTLAND PRESS.

Partial-Purification of D2-Dopamine Receptors From Bovine Brain

1985

Journal Article

Isolation and Characterization of D2-Dopamine Receptors

Strange, PG, Abbott, WM, Juszczak, R and Worrall, S (1985). Isolation and Characterization of D2-Dopamine Receptors. Biochemical Society Transactions, 13 (6), 1099-1100. doi: 10.1042/bst0131099

Isolation and Characterization of D2-Dopamine Receptors

Past funding

  • 2010
    Choroid Plexus Dysfunction the Pathogenesis of Alcohol Intoxication
    Open grant
  • 2006
    The Effect of Mutant Keratin Mutations and Polymorphisms on Hepatic Sensitivity of Oxidative Stress Induced by Chronic Ethanol Oxidation
    Australian Brewers' Foundation
    Open grant
  • 1999
    Oxidative stress in the human alcoholic brain
    Australian Brewers' Foundation
    Open grant
  • 1998
    Identification and Characterisation of Adducts from Ethanol Metabolites and Model Peptides
    ARC Australian Research Council (Small grants)
    Open grant
  • 1997
    The effect of chronic ethanol feeding of heptic gene expression in a rat model of alcholic liver disease
    University of Queensland New Staff Research Grant
    Open grant

Availability

Dr Simon Worrall is:
Not available for supervision

Supervision history

Completed supervision

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