Overview
Background
Mechanisms of drug-induced liver damage.
Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.
Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.
- Does ethanol alter hepatic gene expression to cause liver damage?
- Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
- Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
- Do keratin 8 or 18 mutants sensitise the liver to toxins?
- Is an aberrant immune response involved in NSAID adverse reactions?
- What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?
Availability
- Dr Simon Worrall is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of St Andrews
- Doctor of Philosophy, University of Nottingham
Works
Search Professor Simon Worrall’s works on UQ eSpace
2002
Book Chapter
Alcohol and heart muscle proteins: With special reference to measurement of protein synthesis in vivo
Preedy, V. R., Dunn, M. J., Hunter, R., Mantle, D., Worrall, S. and Richardson, P. J. (2002). Alcohol and heart muscle proteins: With special reference to measurement of protein synthesis in vivo. Alcohol and Heart Disease. (pp. 197-211) CRC Press.
2002
Journal Article
The Mallory body as an aggresome: In vitro studies
Riley, N. E., Li, J., Worrall, S., Rothnagel, J. A., Swagell, C., van Leeuwen, F. W. and French, S. W. (2002). The Mallory body as an aggresome: In vitro studies. Experimental and Molecular Pathology, 72 (1), 17-23. doi: 10.1006/exmp.2001.2413
2001
Journal Article
Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region
Worrall, S., Niemela, O., Parkkila, S., Peters, T. J. and Preedy, V. R. (2001). Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region. European Journal of Clinical Investigation, 31 (8), 723-730. doi: 10.1046/j.1365-2362.2001.00848.x
2001
Journal Article
Recent advances in the pathology of alcoholic myopathy
Preedy, Victor R., Adachi, Junko, Peters, Timothy J., Worrall, Simon, Parkkila, Seppo, Niemela, Onni, Asamo, Migiwa, Ueno, Yasuhino, Takeda, Kunihiko, Yamauchi, Masayoshi, Sakamoto, Kazuhiko, Takagi, Masaru, Nakajima, Hisato and Toda, Gotaro (2001). Recent advances in the pathology of alcoholic myopathy. Alcoholism-clinical And Experimental Research, 25 (Supp 1), 54S-59S. doi: 10.1111/j.1530-0277.2001.tb02374.x
2001
Journal Article
The chemistry and biological effects of malondialdehyde-acetaldehyde adducts
Thiele, Geoffrey M., Worrall, Simon, Tuma, Dean J., Klassen, Lynell W., Wyatt, Todd A. and Nagata, Naruhiko (2001). The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. Alcoholism-clinical And Experimental Research, 25 (Supp 1), 218S-224S. doi: 10.1111/j.1530-0277.2001.tb02399.x
2001
Journal Article
Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation
Tuma, Dean J., Kearley, Mark L., Thiele, Geoffrey M., Worrall, Simon, Haver, Alvin, Klassen, Lynell W. and Sorrell, Michael F. (2001). Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation. Chemical Research In Toxicology, 14 (7), 822-832. doi: 10.1021/tx000222a
2001
Conference Publication
Pathogenic mechanisms in alcoholic myopathy
Preedy, VR, Peters, TJ, Adachi, J, Ahmed, S, Mantle, D, Niemela, O, Parkkila, S and Worrall, S (2001). Pathogenic mechanisms in alcoholic myopathy. International Titisee Symposium on Health Effects of Alcohol Intake, Titisee Germany, Dec 09-12, 1999. NEW YORK: MARCEL DEKKER.
2001
Journal Article
Protein modification in ethanol toxicity
Worrall, S. and Thiele, G.M. (2001). Protein modification in ethanol toxicity. Adverse Drug Reactions and Toxicological Reviews, 20 (3), 133-159.
2001
Book Chapter
Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake
Worrall, S. (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. New and Upcoming Markers of Alcohol Consumption. (pp. 94-110) edited by FM Wurst. Germany: Springer Verlag.
2001
Book Chapter
Alcohol and the heart in humans and animal models
Dunn, M. J., Patel, V. B., Preedy, V. R., Richardson, P. and Worrall, S. (2001). Alcohol and the heart in humans and animal models. Alcohol and Coffee Use in the Aging. (pp. 41-56) edited by Ronald R Watson. USA: CRC Press LLC. doi: 10.1201/9781420038941.ch3
2001
Book Chapter
Pathogenic Mechanisms in Alcoholic Myopathy
Preedy, Victor, Peters, Timothy, Adachi, Junko, Ahmed, Sohail, Mantle, David, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2001). Pathogenic Mechanisms in Alcoholic Myopathy. Alcohol in Health and Disease. (pp. 243-259) Boca Raton, FL United States: CRC Press. doi: 10.3109/9780203902172
2001
Conference Publication
Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake
Worrall, S (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. 11th World Congress of Psychiatry, Hamburg Germany, Aug 06-11, 1999. BERLIN 33: STEINKOPFF DARMSTADT.
2000
Journal Article
Experimental heart muscle damage in alcohol feeding is associated with increased amounts of reduced-and unreduced-acetaldehyde and malondialdehyde-acetaldehyde protein adducts
Worrall, Simon, Richardson, Peter J. and Preedy, Victor R. (2000). Experimental heart muscle damage in alcohol feeding is associated with increased amounts of reduced-and unreduced-acetaldehyde and malondialdehyde-acetaldehyde protein adducts. Addiction Biology, 5 (4), 421-427. doi: 10.1111/j.1369-1600.2000.tb00211.x
2000
Conference Publication
Studies on protein modification by ethanol metabolites in alcohol abuse
Worrall, S. (2000). Studies on protein modification by ethanol metabolites in alcohol abuse. Joint Meeting of ASCEPT and the British Pharmacological Society, Monash University, Melbourne, 3-6 December 2000. Melbourne, Vic: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists.
2000
Conference Publication
The effect of keratin mutants on hepatocytes metabolising ethanol in culture
Swagell, C. D., Rothnagel, J. A. and Worrall, S. (2000). The effect of keratin mutants on hepatocytes metabolising ethanol in culture. 10th Congress of the International Society for Biomedical Research on Alcoholism: ISBRA 2000, Yokohama, Japan, 2-8 July 2000.
2000
Journal Article
Comparison of the formation of proteins modified by direct and indirect ethanol metabolites in the liver and blood of rats fed the lieber-decarli liquid diet
Worrall, S, de Jersey, J and Wilce, PA (2000). Comparison of the formation of proteins modified by direct and indirect ethanol metabolites in the liver and blood of rats fed the lieber-decarli liquid diet. Alcoholism and Alcoholism, 35 (2), 164-170. doi: 10.1093/alcalc/35.2.164
2000
Conference Publication
Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat
Niemlea, O., Parkkila, S. and Worrall, S. (2000). Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat. 10th Congress of the International Society for Biomedical Research on Alcoholism, Yokohama, Japan, 2-8 July, 2000.
2000
Conference Publication
The formation and clearance of MAA adducts in ethanol-fed rats
Worrall, Simon (2000). The formation and clearance of MAA adducts in ethanol-fed rats. 10th Congress of the International Society for Biomedical Reseach on Alcoholism, Yokohama, Japan, 2-8 July, 2000. doi: 10.1111/(ISSN)1530-0277
1999
Journal Article
Tumor necrosis factor-a at presentation in 60 cases of spontaneous canine acute pancreatitis
Ruaux, C., Pennington, H., Worrall, S. and Atwell, R. B. (1999). Tumor necrosis factor-a at presentation in 60 cases of spontaneous canine acute pancreatitis. Veterinary Immunology and Immunopathology, 72 (3-4), 369-376. doi: 10.1016/S0165-2427(99)00108-7
1998
Journal Article
H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats (vol 250, pg 491, 1998)
Shahin, M, Moore, MR, Worrall, S, Smith, BL, Seawright, AA and Prakash, AS (1998). H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats (vol 250, pg 491, 1998). Biochemical and Biophysical Research Communications, 251 (2), 668-668. doi: 10.1006/bbrc.1998.9424
Funding
Past funding
Supervision
Availability
- Dr Simon Worrall is:
- Not available for supervision
Supervision history
Completed supervision
-
2020
Doctor Philosophy
The influence of Wasabi (Wasabia japonica) on obesity and metabolic syndrome
Principal Advisor
-
2015
Master Philosophy
Analysis of acyl coenzyme A: cholesterol acyltransferase (ACAT) expression in human tissues
Principal Advisor
-
2004
Doctor Philosophy
CYTOTOXIC EFFECTS OF PYRROLIZIDINE ALKALOIDS
Principal Advisor
-
2013
Doctor Philosophy
Characterisation of the expression of indole-metabolising cytochrome P450 enzymes in the human brain
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2008
Doctor Philosophy
Genetic mapping and pharmacological analysis of phosphine toxicity and resistance pathways in Caenorhabditis elegans
Associate Advisor
Other advisors: Associate Professor Paul Ebert
-
2004
Doctor Philosophy
THE INITIATION OF AUTO-IMMUNE REACTIONS ON ANTI-CONVULSANT INDUCED HYPERSENSITIVITY: THE ROLE OF CYTOCHROME P450 ENZYMES
Associate Advisor
Other advisors: Professor Elizabeth Gillam
Media
Enquiries
For media enquiries about Dr Simon Worrall's areas of expertise, story ideas and help finding experts, contact our Media team: