Dr Simon Worrall
Dr

Simon Worrall

Email: 
Phone: 
+61 7 336 54626

Background

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
  • Do keratin 8 or 18 mutants sensitise the liver to toxins?
  • Is an aberrant immune response involved in NSAID adverse reactions?
  • What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

Availability

Dr Simon Worrall is:
Not available for supervision

Fields of research

Clinical sciences Zoology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of St Andrews
  • Doctor of Philosophy, University of Nottingham

Search Professor Simon Worrall’s works on UQ eSpace

95 works between 1985 and 2024
All (95) Journal Article (52) Book Chapter (7) Conference Publication (35) Book (1)

61 - 80 of 95 works

1998

Journal Article

Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system

Bailey, MJ, Worrall, S, de Jersey, J and Dickinson, RG (1998). Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system. Chemico-Biological Interactions, 115 (2), 153-166. doi: 10.1016/S0009-2797(98)00071-4

Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system

1998

Journal Article

Bracken fern carcinogenesis: Multiple intravenous doses of activated ptaquiloside induce DNA adducts, monocytosis, increased TNF alpha levels, and mammary gland carcinoma in rats

Shahin, Mahmood, Smith, Barry L., Worral, Simon, Moore, Michael R., Seawright, Alan A. and Prakash, Arungundrum S. (1998). Bracken fern carcinogenesis: Multiple intravenous doses of activated ptaquiloside induce DNA adducts, monocytosis, increased TNF alpha levels, and mammary gland carcinoma in rats. Biochemical And Biophysical Research Communications, 244 (1), 192-197. doi: 10.1006/bbrc.1998.8240

Bracken fern carcinogenesis: Multiple intravenous doses of activated ptaquiloside induce DNA adducts, monocytosis, increased TNF alpha levels, and mammary gland carcinoma in rats

1998

Journal Article

Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats

Pennington, H.L., Wilce, P.A. and Worrall, S. (1998). Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats. Alcoholism-clinical And Experimental Research, 22 (8), 1713-1718. doi: 10.1097/00000374-199811000-00014

Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats

1998

Journal Article

H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats

Shahin, M., Moore, M. R., Worrall, S., Smith, B. L., Seawright, A. A. and Prakash, A. S. (1998). H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats. Biochemical And Biophysical Research Communications, 250 (2), 491-497. doi: 10.1006/bbrc.1998.9341

H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats

1998

Journal Article

Comparison of carbohydrate-deficient transferrin, immunoglobulin A antibodies reactive with acetaldehyde-modified protein and acetaldehyde-modified albumin with conventional markers of alcohol consumption

Worrall, S, de Jersey, J, Wilce, PA, Seppa, K, Hurme, L and Sillanaukee, P (1998). Comparison of carbohydrate-deficient transferrin, immunoglobulin A antibodies reactive with acetaldehyde-modified protein and acetaldehyde-modified albumin with conventional markers of alcohol consumption. Alcoholism-clinical And Experimental Research, 22 (9), 1921-1926. doi: 10.1111/j.1530-0277.1998.tb05899.x

Comparison of carbohydrate-deficient transferrin, immunoglobulin A antibodies reactive with acetaldehyde-modified protein and acetaldehyde-modified albumin with conventional markers of alcohol consumption

1998

Journal Article

A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats

Pennington, H.L., Wilce, P.A. and Worrall, S. (1998). A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats. Alcoholism: Clinical and Experimental Research, 22 (7), 1525-1530. doi: 10.1097/00000374-199810000-00023

A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats

1997

Journal Article

Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis

Pennington, H.L., Hall, P.D., Wilce, P.A. and Worrall, S. (1997). Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. Journal of Gastroenterology And Hepatology, 12 (4), 305-313. doi: 10.1111/j.1440-1746.1997.tb00426.x

Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis

1996

Journal Article

Relationship between alcohol intake and immunoglobulin A immunoreactivity with acetaldehyde-modified bovine serum albumin

Worrall, S, deJersey, J, Wilce, PA, Seppa, K, Hurme, L and Sillanaukee, P (1996). Relationship between alcohol intake and immunoglobulin A immunoreactivity with acetaldehyde-modified bovine serum albumin. Alcoholism-Clinical and Experimental Research, 20 (5), 836-840. doi: 10.1111/j.1530-0277.1996.tb05260.x

Relationship between alcohol intake and immunoglobulin A immunoreactivity with acetaldehyde-modified bovine serum albumin

1996

Journal Article

The formation and stability of imidazolidinone adducts from acetaldehyde and model peptides - A kinetic study with implications for protein modification in alcohol abuse

Fowles, LF, Beck, E, Worrall, S, Shanley, BC and deJersey, J (1996). The formation and stability of imidazolidinone adducts from acetaldehyde and model peptides - A kinetic study with implications for protein modification in alcohol abuse. Biochemical Pharmacology, 51 (10), 1259-1267. doi: 10.1016/0006-2952(95)02408-5

The formation and stability of imidazolidinone adducts from acetaldehyde and model peptides - A kinetic study with implications for protein modification in alcohol abuse

1995

Journal Article

Rat Serum-Albumin Modified by Diflunisal Acyl Glucuronide Is Immunogenic in Rats

Worrall, S and Dickinson, RG (1995). Rat Serum-Albumin Modified by Diflunisal Acyl Glucuronide Is Immunogenic in Rats. Life Sciences, 56 (22), 1921-1930. doi: 10.1016/0024-3205(95)00167-5

Rat Serum-Albumin Modified by Diflunisal Acyl Glucuronide Is Immunogenic in Rats

1995

Journal Article

Studies On the Reactivity of Acyl Glucuronides .8. Generation of An Antiserum for the Detection of Diflunisal-Modified Proteins in Diflunisal-Dosed Rats

Williams, AM, Worrall, S, Dejersey, J and Dickinson, RG (1995). Studies On the Reactivity of Acyl Glucuronides .8. Generation of An Antiserum for the Detection of Diflunisal-Modified Proteins in Diflunisal-Dosed Rats. Biochemical Pharmacology, 49 (2), 209-217. doi: 10.1016/S0006-2952(94)00408-0

Studies On the Reactivity of Acyl Glucuronides .8. Generation of An Antiserum for the Detection of Diflunisal-Modified Proteins in Diflunisal-Dosed Rats

1994

Journal Article

Distribution and Turnover of Acetaldehyde-Modified Proteins in Liver and Blood of Ethanol-Fed Rats

Nicholls, RM, Fowles, LF, Worrall, S, Dejersey, J and Wilce, PA (1994). Distribution and Turnover of Acetaldehyde-Modified Proteins in Liver and Blood of Ethanol-Fed Rats. Alcohol and Alcoholism, 29 (2), 149-157. doi: 10.1093/oxfordjournals.alcalc.a045501

Distribution and Turnover of Acetaldehyde-Modified Proteins in Liver and Blood of Ethanol-Fed Rats

1994

Journal Article

Anti-Acetaldehyde Adduct Antibodies Generated by Ethanol-Fed Rats React with Reduced and Unreduced Acetaldehyde-Modified Proteins

Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1994). Anti-Acetaldehyde Adduct Antibodies Generated by Ethanol-Fed Rats React with Reduced and Unreduced Acetaldehyde-Modified Proteins. Alcohol and Alcoholism, 29 (1), 43-50. doi: 10.1093/oxfordjournals.alcalc.a045483

Anti-Acetaldehyde Adduct Antibodies Generated by Ethanol-Fed Rats React with Reduced and Unreduced Acetaldehyde-Modified Proteins

1994

Journal Article

The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.

Worrall S. and Wilce P.A. (1994). The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., 2, 447-451.

The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.

1994

Journal Article

Studies on the usefulness of acetaldehyde-modified proteins and associated antibodies as markers of alcohol abuse.

Worrall S., Jersey J.D., Wilce P.A., Seppa K. and Sillanaukee P. (1994). Studies on the usefulness of acetaldehyde-modified proteins and associated antibodies as markers of alcohol abuse.. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., 2, 503-507.

Studies on the usefulness of acetaldehyde-modified proteins and associated antibodies as markers of alcohol abuse.

1993

Journal Article

Antibodies From Alcoholics, Ethanol-Fed Rats and a Rabbit Immunized with Proteins Modified by Acetaldehyde In-Vitro React with Liver Cytosolic Proteins From Ethanol-Fed Rats

Worrall, S, Dejersey, J and Wilce, PA (1993). Antibodies From Alcoholics, Ethanol-Fed Rats and a Rabbit Immunized with Proteins Modified by Acetaldehyde In-Vitro React with Liver Cytosolic Proteins From Ethanol-Fed Rats. Alcohol and Alcoholism, 28 (5), 513-519. doi: 10.1093/oxfordjournals.alcalc.a045427

Antibodies From Alcoholics, Ethanol-Fed Rats and a Rabbit Immunized with Proteins Modified by Acetaldehyde In-Vitro React with Liver Cytosolic Proteins From Ethanol-Fed Rats

1993

Journal Article

Acetaldehyde-Protein Interactions - Are They Involved in the Pathogenesis of Alcoholic Liver-Disease

Worrall, S, Dejersey, J, Nicholls, R and Wilce, P (1993). Acetaldehyde-Protein Interactions - Are They Involved in the Pathogenesis of Alcoholic Liver-Disease. Digestive Diseases, 11 (4-5), 265-277. doi: 10.1159/000171418

Acetaldehyde-Protein Interactions - Are They Involved in the Pathogenesis of Alcoholic Liver-Disease

1992

Journal Article

Modification of Proteins and Other Biological Molecules by Acetaldehyde - Adduct Structure and Functional-Significance

Nicholls, R, Dejersey, J, Worrall, S and Wilce, P (1992). Modification of Proteins and Other Biological Molecules by Acetaldehyde - Adduct Structure and Functional-Significance. International Journal of Biochemistry, 24 (12), 1899-1906. doi: 10.1016/0020-711X(92)90285-9

Modification of Proteins and Other Biological Molecules by Acetaldehyde - Adduct Structure and Functional-Significance

1992

Journal Article

Studies On the Reactivity of Acyl Glucuronides .3. Glucuronide-Derived Adducts of Valproic Acid and Plasma-Protein and Anti-Adduct Antibodies in Humans

Williams, AM, Worrall, S, Dejersey, J and Dickinson, RG (1992). Studies On the Reactivity of Acyl Glucuronides .3. Glucuronide-Derived Adducts of Valproic Acid and Plasma-Protein and Anti-Adduct Antibodies in Humans. Biochemical Pharmacology, 43 (4), 745-755. doi: 10.1016/0006-2952(92)90239-F

Studies On the Reactivity of Acyl Glucuronides .3. Glucuronide-Derived Adducts of Valproic Acid and Plasma-Protein and Anti-Adduct Antibodies in Humans

1991

Journal Article

Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins

Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1991). Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 261-264.

Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins

Past funding

  • 2010
    Choroid Plexus Dysfunction the Pathogenesis of Alcohol Intoxication
    Open grant
  • 2006
    The Effect of Mutant Keratin Mutations and Polymorphisms on Hepatic Sensitivity of Oxidative Stress Induced by Chronic Ethanol Oxidation
    Australian Brewers' Foundation
    Open grant
  • 1999
    Oxidative stress in the human alcoholic brain
    Australian Brewers' Foundation
    Open grant
  • 1998
    Identification and Characterisation of Adducts from Ethanol Metabolites and Model Peptides
    ARC Australian Research Council (Small grants)
    Open grant
  • 1997
    The effect of chronic ethanol feeding of heptic gene expression in a rat model of alcholic liver disease
    University of Queensland New Staff Research Grant
    Open grant

Availability

Dr Simon Worrall is:
Not available for supervision

Supervision history

Completed supervision

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