Overview
Background
Mechanisms of drug-induced liver damage.
Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.
Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.
- Does ethanol alter hepatic gene expression to cause liver damage?
- Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
- Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
- Do keratin 8 or 18 mutants sensitise the liver to toxins?
- Is an aberrant immune response involved in NSAID adverse reactions?
- What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?
Availability
- Dr Simon Worrall is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of St Andrews
- Doctor of Philosophy, University of Nottingham
Works
Search Professor Simon Worrall’s works on UQ eSpace
2007
Conference Publication
Discussion
Crabb, David W., Seitz, Helmut K., Emery, Peter, Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Shukla, Shivendra D., Apte, Minoti V., Deitrich, Richard A., Salaspuro, Mikko, Yin, Shih-Jiun, Ren, Jun, Okamura, Tomonori, Eriksson, C. J. Peter, Preedy, Victor R. and Albano, Emanuele (2007). Discussion.
2007
Conference Publication
Discussion
Preedy, Victor R., Peter Eriksson, C. J., Morris, John B., Salaspuro, Mikko, Emery, Peter, Thornalley, Paul J., Seitz, Helmut K., Rao, Radhakrishna K., Worrall, Simon, Apte, Minoti V., Okamura, Tomonori and Yin, Shih-Jiun (2007). Discussion.
2007
Conference Publication
Discussion
Deitrich, Richard A., Crabb, David W., Salaspuro, Mikko, Peter Eriksson, C. J., Apte, Minoti V., Emery, Peter, Niemelä, Onni, Worrall, Simon, Thornalley, Paul J., Albano, Emanuele, Seitz, Helmut K. and Shukla, Shivendra D. (2007). Discussion.
2007
Conference Publication
Discussion
Thornalley, Paul J., Worrall, Simon, Niemelä, Onni, Rao, Radhakrishna K., Preedy, Victor R., Apte, Minoti V., Albano, Emanuele and Seitz, Helmut K. (2007). Discussion.
2007
Conference Publication
Discussion
Quertemont, Etienne, Jamal, Mostofa, Peter Eriksson, C. J., Preedy, Victor R., Worrall, Simon, Deitrich, Richard A., Yin, Shih-Jiun and Apte, Minoti V. (2007). Discussion.
2007
Conference Publication
General discussion
Worrall, Simon (2007). General discussion. Symposium on Acetaldehyde-related pathology: Bridging the Trans-disciplinary Divide, London, UK, 5-7 September 2006. Chichester, UK: John Wiley.
2006
Conference Publication
Cellular and molecular changes in rat models of alcoholic cardiomyopathy
Preedy, Victor R., Hashimoto, Kijiro, Hirano, Makoto, Hunter, Ross, Nakahara, Tatsuo, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2006). Cellular and molecular changes in rat models of alcoholic cardiomyopathy. World Congress on Alcohol Research, Sydney, Australia, 10-13 Septmeber 2006. Hoboken, NJ, United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/j.1530-0277.2006.00197.x
2006
Conference Publication
Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration
Perry, Anthony, Dodd, Peter R. and Worrall, Simon (2006). Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration. 29th Annual Meeting of the Research Society on Alcoholism ( RSA 2006), Baltimore, MD, USA, 23rd- 29th June, 2006. Maryland: John Wiley & Sons, Inc. doi: 10.1111/j.1530-0277.2006.00150.x
2006
Conference Publication
Hepatic adduct levels do not predict the levels of extrahepatic modification
Worrall, Simon (2006). Hepatic adduct levels do not predict the levels of extrahepatic modification. World Congress on Alcohol Research (ISBRA 2006), Sydney, Australia, 10 - 13 September 2006. Oxford: Blackwell Publishing. doi: 10.1111/j.1530-0277.2006.00197.x
2006
Conference Publication
Detection of elevated protein modification in alcoholic cerebellar degeneration
Perry, Anthony, Dodd, Peter and Worrall, Simon (2006). Detection of elevated protein modification in alcoholic cerebellar degeneration. 29th Annual Meeting of Research Society on Alcoholism, Sydney, Australia, 10-13 September, 2006. Maryland, USA: Blackwell. doi: 10.1111/j.1530-0277.2006.00197.x
2005
Journal Article
Protein adduct species in muscle and liver of rats following acute ethanol administration
Patel, Vinood B., Worrall, Simon, Emery, Peter W. and Preedy, Victor R. (2005). Protein adduct species in muscle and liver of rats following acute ethanol administration. Alcohol and Alcoholism, 40 (6), 485-493. doi: 10.1093/alcalc/agh196
2005
Book Chapter
Modification of proteins by reactive ethanol metabolites: Adduct structure, functional and pathological consequences
Worrall, S. and Thiele, G.M. (2005). Modification of proteins by reactive ethanol metabolites: Adduct structure, functional and pathological consequences. Comprehensive Handbook of Alcohol Related Pathology Vol. 3. (pp. 1209-1222) edited by V.R. Preedy and R.R. Watson. Great Britain: Elsevier. doi: 10.1016/B978-012564370-2/50094-5
2005
Conference Publication
Recent advances in alcohol-induced adduct formation
Freeman, Thomas L., Tuma, Dean J., Thiele, Geoffrey M., Klassen, Lynell W., Worrall, Simon, Niemela, Onni, Parkkila, Seppo, Emery, Peter W. and Preedy, Victor R. (2005). Recent advances in alcohol-induced adduct formation. 12th International Congress of the International Society for Biomedical Research on Alcoholism, Heidelberg, Germany, 29 September-2 October 2004. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/01.ALC.0000171484.52201.52
2004
Conference Publication
Adduct chemistry and mechanisms of adduct formation.
Freeman, TL, Klassen, LW, Worrall, S, Sorrell, MF, Tuma, DJ and Thiele, GM (2004). Adduct chemistry and mechanisms of adduct formation.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00363
2004
Conference Publication
Adduct formation in the liver.
Worrall, S (2004). Adduct formation in the liver.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00365
2004
Conference Publication
Liver adduct formation does not predict adduct levels in extrahepatic tissues.
Worrall, S (2004). Liver adduct formation does not predict adduct levels in extrahepatic tissues.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00010
2004
Conference Publication
Alcoholic skeletal muscle myopathy: A role for protein adducts?
Preedy, VR, Emery, P, Niemela, O, Parkkila, S, Peters, TJ and Worrall, S (2004). Alcoholic skeletal muscle myopathy: A role for protein adducts?. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00367
2004
Book Chapter
The effect of diet on protein modification by ethanol metabolites in tissues damaged in chronic alcohol abuse
Worrall, S. (2004). The effect of diet on protein modification by ethanol metabolites in tissues damaged in chronic alcohol abuse. Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake. (pp. 219-248) edited by R. R. Watson and V. R. Preedy. Florida: CRC Press. doi: 10.1201/9780203507636.ch13
2003
Journal Article
Generation of aldehyde-derived protein modifications in ethanol-exposed heart
Niemela, O., Parkkila, S., Worrall, S., Emery, P. W. and Preedy, V. R. (2003). Generation of aldehyde-derived protein modifications in ethanol-exposed heart. Alcoholism-clinical And Experimental Research, 27 (12), 1987-1992. doi: 10.1097/01.ALC.0000099260.58926.F2
2002
Journal Article
Free radicals in alcoholic myopathy: Indices of damage and preventive studies
Preedy, Victor R., Adachi, Junko, Asano, Migiwa, Koll, Michael, Mantle, David, Niemela, Onni, Parkkila, Seppo, Paice, Alistair G., Peters, Timothy, Rajendram, Rajkumar, Seitz, Helmut, Ueno, Yasuhiro and Worrall, Simon (2002). Free radicals in alcoholic myopathy: Indices of damage and preventive studies. Free Radical Biology And Medicine, 32 (8), 683-687. doi: 10.1016/S0891-5849(01)00794-8
Funding
Past funding
Supervision
Availability
- Dr Simon Worrall is:
- Not available for supervision
Supervision history
Completed supervision
-
2020
Doctor Philosophy
The influence of Wasabi (Wasabia japonica) on obesity and metabolic syndrome
Principal Advisor
-
2015
Master Philosophy
Analysis of acyl coenzyme A: cholesterol acyltransferase (ACAT) expression in human tissues
Principal Advisor
-
2004
Doctor Philosophy
CYTOTOXIC EFFECTS OF PYRROLIZIDINE ALKALOIDS
Principal Advisor
-
2013
Doctor Philosophy
Characterisation of the expression of indole-metabolising cytochrome P450 enzymes in the human brain
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2008
Doctor Philosophy
Genetic mapping and pharmacological analysis of phosphine toxicity and resistance pathways in Caenorhabditis elegans
Associate Advisor
Other advisors: Associate Professor Paul Ebert
-
2004
Doctor Philosophy
THE INITIATION OF AUTO-IMMUNE REACTIONS ON ANTI-CONVULSANT INDUCED HYPERSENSITIVITY: THE ROLE OF CYTOCHROME P450 ENZYMES
Associate Advisor
Other advisors: Professor Elizabeth Gillam
Media
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