Overview
Background
I completed my PhD in the Molecular and Cellular Biology Program at the Federal University of Parana (UFPR – Curitiba, Brazil). My PhD research focused on developing new treatments based on chemically modified heparins for preventing melanoma metastatic spread in different experimental models. During my PhD, I also performed an international exchange with Prof. Nicholas Huntington and Dr. Fernando Guimaraes at the Walter and Eliza Hall Institute (WEHI, Melbourne) to elucidate the mechanisms of how these new compounds can impact innate immunity, particularly in activation of natural killer (NK) cells. My current postdoctoral interests at the Translational Innate Immunotherapy Laboratory (TI2) at UQDI focuses on understanding the impact of tumour microenvironment (TME)-mediated regulation of NK cell tumoricidal immunity, and how to take advantage of this new knowledge to model and develop new immune-cellular interventions to fight cancer. My projects now take advantage of multi-disciplinary approaches combining cutting edge molecular/immune/stem cell biology and systems biology to build on and create innovative solutions for complex clinical challenges.
Availability
- Dr Gustavo Rodrigues Rossi is:
- Available for supervision
Qualifications
- Doctor of Philosophy, unknown
Works
Search Professor Gustavo Rodrigues Rossi’s works on UQ eSpace
2024
Journal Article
The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy
McCulloch, Timothy R, Rossi, Gustavo R, Miranda‐Hernandez, Socorro, Valencia‐Hernandez, Ana Maria, Alim, Louisa, Belle, Clemence J, Krause, Andrew, Zacchi, Lucia F, Lam, Pui Yeng, Nakamura, Kyohei, Kupz, Andreas, Wells, Timothy J and Souza‐Fonseca‐Guimaraes, Fernando (2024). The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy. Immunology & Cell Biology. doi: 10.1111/imcb.12794
2024
Journal Article
TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancer
Wong, Joshua K.M., McCulloch, Timothy R., Alim, Louisa, Omer, Natacha, Mehdi, Ahmed M., Tuong, Zewen Kelvin, Bonfim-Melo, Alexis, Chung, Eric, Nicol, Alice, Simpson, Fiona, Rhee, Handoo, Rossi, Gustavo Rodrigues and Souza-Fonseca-Guimaraes, Fernando (2024). TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancer. eBioMedicine, 104 105176, 105176. doi: 10.1016/j.ebiom.2024.105176
2024
Journal Article
Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis
Tu, Cui, Buckle, Irina, Leal Rojas, Ingrid, Rossi, Gustavo Rodrigues, Sester, David P, Moore, Andrew S, Radford, Kristen, Guillerey, Camille and Souza‐Fonseca‐Guimaraes, Fernando (2024). Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis. Clinical & Translational Immunology, 13 (3) e1501, e1501. doi: 10.1002/cti2.1501
2023
Journal Article
Development of physiologically relevant skin organoids from human induced pluripotent stem cells
Shafiee, Abbas, Sun, Jane, Ahmed, Imaan A., Phua, Felicia, Rossi, Gustavo R., Lin, Cheng‐Yu, Souza‐Fonseca‐Guimaraes, Fernando, Wolvetang, Ernst J., Brown, Jason and Khosrotehrani, Kiarash (2023). Development of physiologically relevant skin organoids from human induced pluripotent stem cells. Small, 20 (16) e2304879, 1-14. doi: 10.1002/smll.202304879
2023
Conference Publication
TIGIT limits anti-bacterial immunity and is a potential target for immunotherapy
Souza-Fonseca-Guimaraes, Fernando, Rossi, Gustavo Rodrigues, Wells, Timothy and McCulloch, Timothy Ryan (2023). TIGIT limits anti-bacterial immunity and is a potential target for immunotherapy. IMMUNOLOGY2023™ Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: The American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.64.14
2023
Journal Article
Fucoidan from Spatoglossum schröederi promotes B16-F10 malignancy features modulation and antimelanoma in vivo activities
Bellan, D.L., Bini, I.H., Santi, F.C., Rossi, G.R., Biscaia, S.M.P., Maximo, A.I., Reis, M.B., Simas, F.F., Oliveira, C.C., Winnischofer, S.M.B., Leme, D.M., Chammas, R., Rocha, H.A.O. and Trindade, E.S. (2023). Fucoidan from Spatoglossum schröederi promotes B16-F10 malignancy features modulation and antimelanoma in vivo activities. Algal Research, 72 103134, 1-12. doi: 10.1016/j.algal.2023.103134
2023
Journal Article
Differential regulation of natural killer cells by tumor necrosis factor receptors 1 and 2
McCulloch, Timothy R., Rossi, Gustavo Rodrigues, Lam, Allie, Wong, Joshua, Kane, Lawrence P, Herold, Marco, Wells, Timothy and Souza-Fonseca-Guimaraes, Fernando (2023). Differential regulation of natural killer cells by tumor necrosis factor receptors 1 and 2. The Journal of Immunology, 210 (S1), 72.28-72.28. doi: 10.4049/jimmunol.210.supp.72.28
2023
Journal Article
IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin ... Tang, Benjamin (2023). IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Frontiers in Immunology, 13 1060438, 1-14. doi: 10.3389/fimmu.2022.1060438
2022
Journal Article
A simple method to evaluate the toxic effects of Prorocentrum lima extracts to fish (sea bass) kidney cells
da Silva, Cesar Aparecido, Mafra, Luiz Laureno, Rossi, Gustavo Rodrigues, da Silva Trindade, Edvaldo and Matias, William Gerson (2022). A simple method to evaluate the toxic effects of Prorocentrum lima extracts to fish (sea bass) kidney cells. Toxicology in Vitro, 85 105476, 1-8. doi: 10.1016/j.tiv.2022.105476
2022
Journal Article
Nanobiomaterials to modulate natural killer cell responses for effective cancer immunotherapy
Raza, Aun, Rossi, Gustavo Rodrigues, Janjua, Taskeen Iqbal, Souza-Fonseca-Guimaraes, Fernando and Popat, Amirali (2022). Nanobiomaterials to modulate natural killer cell responses for effective cancer immunotherapy. Trends in Biotechnology, 41 (1), 77-92. doi: 10.1016/j.tibtech.2022.06.011
2022
Journal Article
TGF-β and CIS inhibition overcomes NK cell suppression to restore anti-tumor immunity
Souza-Fonseca Guimaraes, Fernando, Rossi, Gustavo R., Dagley, Laura F., Foroutan, Momeneh, McCulloch, Timothy R., Yousef, Jumana, Park, Hae-Young, Gunter, Jennifer H., Beavis, Paul A., Lin, Cheng-Yu, Hediyeh-zadeh, Soroor, Camilleri, Tania, Davis, Melissa J. and Huntington, Nicholas D. (2022). TGF-β and CIS inhibition overcomes NK cell suppression to restore anti-tumor immunity. Cancer Immunology Research, 10 (9), 1047-1054. doi: 10.1158/2326-6066.cir-21-1052
2022
Journal Article
CIS and TGF ‐β regulatory pathways influence immunity to bacterial infection
McCulloch, Timothy R., Rossi, Gustavo R., Schreuder, Jaring, Belz, Gabrielle T., Wells, Timothy J. and Souza‐Fonseca‐Guimaraes, Fernando (2022). CIS and TGF ‐β regulatory pathways influence immunity to bacterial infection. Immunology, 167 (1), 54-63. doi: 10.1111/imm.13516
2022
Journal Article
Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures
Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021
2021
Journal Article
Enhancing natural killer cell targeting of pediatric sarcoma
Omer, Natacha, Nicholls, Wayne, Ruegg, Bronte, Souza-Fonseca-Guimaraes, Fernando and Rossi, Gustavo Rodrigues (2021). Enhancing natural killer cell targeting of pediatric sarcoma. Frontiers in Immunology, 12 791206, 791206. doi: 10.3389/fimmu.2021.791206
2021
Journal Article
Electrospun polyvinyl-alcohol/gum arabic nanofibers: biomimetic platform for in vitro cell growth and cancer nanomedicine delivery
Serio, Francesca, da Cruz, Anderson Fraga, Chandra, Anil, Nobile, Concetta, Rossi, Gustavo Rodrigues, D'Amone, Eliana, Gigli, Giuseppe, del Mercato, Loretta Laureana and de Oliveira, Carolina Camargo (2021). Electrospun polyvinyl-alcohol/gum arabic nanofibers: biomimetic platform for in vitro cell growth and cancer nanomedicine delivery. International Journal of Biological Macromolecules, 188, 764-773. doi: 10.1016/j.ijbiomac.2021.08.069
2021
Journal Article
Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas
Gonçalves, Jenifer P., da Cruz, Anderson F., Nunes, Ábner M., Meneghetti, Mario R., de Barros, Heloise R., Borges, Beatriz S., de Medeiros, Lia C.A.S., Soares, Maurilio J., dos Santos, Mayara P., Grassi, Marco T., Rossi, Gustavo R., Bellan, Daniel L., Biscaia, Stellee M.P., Cristal, Aline M., Buzzo, João L.A., Ribeiro, Yasmin C., Acco, Alexandra, Cardoso, Mateus B., Simas, Fernanda F., Trindade, Edvaldo S., Riegel-Vidotti, Izabel C. and de Oliveira, Carolina C. (2021). Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas. International Journal of Biological Macromolecules, 185, 551-561. doi: 10.1016/j.ijbiomac.2021.06.172
2021
Journal Article
Production of a novel recombinant brown spider hyaluronidase in baculovirus-infected insect cells
De-Bona, Elidiana, Chaves-Moreira, Daniele, Batista, Thiago Beltrami Dias, Justa, Hanna Câmara da, Rossi, Gustavo Rodrigues, Antunes, Bruno Cesar, Matsubara, Fernando Hitomi, Minozzo, João Carlos, Wille, Ana Carolina Martins, Veiga, Silvio Sanches, Senff-Ribeiro, Andrea and Gremski, Luiza Helena (2021). Production of a novel recombinant brown spider hyaluronidase in baculovirus-infected insect cells. Enzyme and Microbial Technology, 146 109759, 1-13. doi: 10.1016/j.enzmictec.2021.109759
2020
Journal Article
Green does not always mean go: a sulfated galactan from Codium isthmocladum green seaweed reduces melanoma metastasis through direct regulation of malignancy features
Bellan, D.L., Biscaia, S.M.P., Rossi, G.R., Cristal, A.M., Gonçalves, J.P., Oliveira, C.C., Simas, F.F., Sabry, D.A., Rocha, H.A.O., Franco, C.R.C., Chammas, R., Gillies, R.J. and Trindade, E.S. (2020). Green does not always mean go: a sulfated galactan from Codium isthmocladum green seaweed reduces melanoma metastasis through direct regulation of malignancy features. Carbohydrate Polymers, 250 116869, 116869. doi: 10.1016/j.carbpol.2020.116869
2020
Journal Article
Beyond gold nanoparticles cytotoxicity: potential to impair metastasis hallmarks
Pendiuk Gonçalves, Jenifer, Fraga da Cruz, Anderson, Ribeiro de Barros, Heloise, Santana Borges, Beatriz, Almeida Soares de Medeiros, Lia Carolina, Soares, Maurilio José, Padovan dos Santos, Mayara, Grassi, Marco Tadeu, Chandra, Anil, del Mercato, Loretta Laureana, Rodrigues Rossi, Gustavo, da Silva Trindade, Edvaldo, Riegel-Vidotti, Izabel Cristina and Camargo de Oliveira, Carolina (2020). Beyond gold nanoparticles cytotoxicity: potential to impair metastasis hallmarks. European Journal of Pharmaceutics and Biopharmaceutics, 157, 221-232. doi: 10.1016/j.ejpb.2020.10.019
2020
Journal Article
The antitumor effect of heparin is not mediated by direct NK cell activation
Rossi, Gustavo R., Gonçalves, Jenifer P., McCulloch, Timothy, Delconte, Rebecca B., Hennessy, Robert J., Huntington, Nicholas D., Trindade, Edvaldo S. and Souza-Fonseca-Guimaraes, Fernando (2020). The antitumor effect of heparin is not mediated by direct NK cell activation. Journal of Clinical Medicine, 9 (8) 2666, 2666-11. doi: 10.3390/jcm9082666
Supervision
Availability
- Dr Gustavo Rodrigues Rossi is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Immune regulation through bi-directional interactions between subsets of Natural Killer cells and Dendritic cells.
Associate Advisor
Other advisors: Professor Andrew Barbour, Dr Arutha Kulasinghe, Dr Camille Guillerey, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Enhancement of natural killer cell function for therapeutic targeting and elimination of metastatic breast cancer
Associate Advisor
Other advisors: Associate Professor Fiona Simpson, Associate Professor Fernando Guimaraes
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Doctor Philosophy
KIR-mismatched NK-cells graft-versus-paediatric sarcoma effect
Associate Advisor
Other advisors: Associate Professor Wayne Nicholls, Associate Professor Fernando Guimaraes
Media
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