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Functional genomics and molecular physiology of nodules.

Professor Gresshoff is the Director of the ARC Centre of Excellence for Integrative Legume Research.

His main research interests are the following areas:

1) Functional genomic analysis of nodulation and nitrogen fixation in legumes:

• Molecular components of the control of nodulation (AON) in soybean and Lotus japonicus
• Analysis of ethylene and ABA insensitive legume mutants and transgenics
• Genetic transformation of soybean and Lotus
• Transcription analysis of legumes
• Analysis of acid soil effect on nodulation
• Analysis of Nodulation factor receptors NFR1 and NFR5 in soybean
• Mutational analysis of the GmNARK receptor kinase

2) Sustainable Biofuel Production from Legume Tree Pongamia pinnata:

• Analysis of genetic stability
• Fatty acid analysis
• Field trials
• Clonal propagation
• Gene and promoter discovery
• Functional genomics
• Genetic transformation

Professor Gresshoff is member of the editorial boards of several international journals (among others Molecular Plant, J. Plant Physiology, Symbiosis). He also is a member of the Advisory Committee of the OGTR as well as the Biofuel and Bioenergy Committee of RIRDC.

(she/her)

Dr. Laura Grogan is a qualified veterinarian, Senior Lecturer in Wildlife Science and Leader of the Biodiversity Health Research Team (https://www.biodiversity-health.org/) - a collaborative multiple-university research group focused on finding sustainable solutions for the most challenging threatening processes currently affecting biodiversity.

Dr. Grogan has a background in research on wildlife diseases, ecology and conservation. She's particularly interested in investigating the dynamics, relative importance, and impacts of infectious diseases among other threats affecting wildlife across both individual and population scales, to improve conservation management.

While she works across taxa and methodological approaches, her main study system currently involves the devastating amphibian fungal skin disease, chytridiomycosis, where at the individual scale she focuses on the pathogenesis and amphibian immune response to the disease, untangling the roles of resistance and tolerance in defense against infection. At the population and landscape scale she explores mechanisms underlying persistence in the face of endemic infection, focused on the endangered Fleay's barred frog. She also studies population and infection dynamics of chlamydiosis in koala using a mathematical modelling approach, exploring the relative benefits of different management approaches. In addition to working on amphibian and koala diseases, Laura is a keen birdwatcher, wildlife photographer and artist. She supervises projects across wildlife-related fields (predominantly vertebrates).

You can find out more about her research team here: www.biodiversity-health.org.

Dr. Grogan has been awarded around $1.3 million in research funding since 2018. In late 2019 she was awarded an Australian Research Council Discovery Early Career Researcher Award (DECRA; DE200100490), worth $426,742. This project, titled "Understanding infection tolerance to improve management of wildlife disease", commenced in late 2020. Dr. Grogan was identified as one of the four top-ranked science DECRA awardees by the Australian Academy of Science’s 2020 J G Russell Award, and was also recipient of the highest award of the Wildlife Disease Association Australasia Section with their 2019 Barry L Munday Recognition Award.

PhD and Honours projects are now available in the following areas (plus many more areas - please get in touch if you have an idea):

• Can frogs be ‘vaccinated’ by antifungal treatment of active infections to develop protective immunity to the devastating chytrid fungus? (Principal Supervisor)
• Establishing the conservation status of south-east Queensland’s amphibians - occupancy surveys and species distribution models (Principal Supervisor)
• Tadpoles as a reservoir of the lethal frog chytrid fungal disease – measuring sublethal effects on growth, time to metamorphosis and ability to forage (mouthpart loss) (Principal Supervisor)
• Impacts of chytrid fungus on the survival of juvenile endangered Fleay’s barred frogs, Mixophyes fleayi, and importance for population recruitment (Principal Supervisor)
• Measuring the infection resistance versus tolerance of barred frogs to the devastating chytrid fungal disease to improve management outcomes (Principal Supervisor)
• Mapping the impacts of fire-fighting chemicals on endangered frog habitats (Co-Supervisor)
• Bowra birds: what do long-term monitoring data reveal about bird communities in the semi-arid region? (Co-Supervisor)
• Impacts of fire-fighting chemicals on endangered frogs: Implications for conservation and management (Co-Supervisor)

Dr. Wenyi Gu’s early education was conducted in China which include his undergraduate and master’s degrees in veterinary medicine. In 1996, he migrated to Australia and pursued his PhD study in biochemistry & molecular biology at the Australian National University (ANU). After a short period of work at John Curtin Medical School ANU as a junior scientist, he moved to Brisbane in 2001 for his post-doc at the University of Queensland and currently a post-doctoral research fellow at AIBN. He held a Peter Doherty Fellowship (2006-2009) and was further supported by NHMRC to spend 7 months at Harvard University as a visiting fellow in 2008. Since his post-doctoral research he has been working in the area of using RNAi to treat viral diseases and cancers. He also has a strong background in immunology and vaccine development.

Associate Professor Emma Hamilton-Williams’ career focuses on understanding how immune tolerance is disrupted leading to the development of the autoimmune disease type 1 diabetes. She received her PhD from the Australian National University in 2001, followed by postdoctoral training in Germany and the Scripps Research Institute in the USA.

In 2012, she started a laboratory at the Frazer Institute, University of Queensland where she investigates the gut microbiota as a potential trigger or therapy target for type 1 diabetes, as well as developing an immunotherapy for type 1 diabetes. The overall aim of her research is to find new ways to prevent or treat the underlying immune dysfunction causing autoimmunity.

She is Chief Scientific Officer for an Australia-wide pregnancy-birth cohort study of children at increased risk of type 1 diabetes, which aims to uncover the environmental drivers of this disease. Her laboratory uses big-data approaches including proteomics, metabolomics and metagenomics to understand the function of the gut microbiota linked to disease.

She recently conducted a clinical trial of a microbiome-targeting biotherapy aimed at restoring a healthy microbiome and immune tolerance, with an ultimate aim of preventing type 1 diabetes.

Dr Pingping Han is currently leading the Epigenetic Nanodiagnostics and Therapeutics Group within the Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3), at the UQ School of Dentistry. Dr Han received her PhD in Biomedical Engineering from the Queensland University of Technology (QUT) in 2014. Dr Han's current research focuses on three themes: a) salivary diagnostics for periodontal disease, b) “cell-free” regenerative therapy for periodontal tissue engineering and c) cellular nano-mechanics on different modified biomaterial substrates.

Dr April Hastwell is a plant molecular biologist with the School of Agriculture and Food Science at The University of Queensland, Australia. The focus of her research group is on roles of short signalling peptides in root development including in molecular networks controlling the beneficial legume-rhizobia symbiosis and nodule development.

Alesha Hatton is a postdoctoral research fellow specializing in statistical genetics and genetic epidemiology at the Institute for Molecular Bioscience, University of Queensland. Currently, her research focuses on understanding the genetic and environmental aetiology underlying complex traits through use of Mendelian randomization and statistical genetics methodologies. Her PhD was in systems genomics, applying quantitative genetics methods to investigate the role of DNA methylation in complex trait variation. Alesha has a bachelor’s degree in medical mathematics from the University of Wollongong (2016) and previously was employed as a statistician at the South Australian health and Medical Research Institute.

Professor Lee Hickey is a plant breeder and crop geneticist within the Queensland Alliance for Agriculture and Food Innovation at The University of Queensland, Australia. He is an ARC Future Fellow and Director of the ARC Training Centre in Predictive Breeding. His own research group specialises in plant breeding innovation to support development of more productive food crops, such as wheat, barley and chickpea. He has a strong interest in the integration of breeding technologies, such as genomic prediction, AI, speed breeding and genome editing. His advice for speed breeding crops is sought internationally and the technology is now adopted by plant breeding programs worldwide, which is fast-tracking development of improved crop varieties for farmers. His research outcomes have featured in >90 refereed publications, including articles in high profile journals Nature Plants, Nature Protocols and Nature Biotechnology. Lee is a prolific science communicator and his research outcomes have appeared in mainstream media such as BBC World News, National Geographic, and the New York Times. He is passionate about training the next generation of plant breeders and currently mentors 18 PhD students, while 20 of his previous graduates now work for leading plant breeding companies and high-profile research institutes around the globe.

Check out the Hickey Lab website here

Follow Professor Lee Hickey on X: @DrHikov

Research interests

• Speed breeding techniques to reduce the length of breeding cycles
• Understanding the genetics of physiological traits that support yield in different environments
• Integrating breeding technologies to accelerate genetic gain in breeding programs
• Innovative genomic selection methodologies
• Identifying novel sources of disease resistance

Queensland Brain Institute

Dr Massimo A. Hilliard received his PhD in Biological Chemistry and Molecular Biology in 2001 from the University of Naples, Italy. His experimental work, performed at the Institute of Genetics and Biophysics of the CNR (Italian National Council of Research), was aimed at understanding the neuronal and genetic basis of aversive taste behavior (bitter taste) in C. elegans.

During his first postdoc at the University of California, San Diego, using the Ca2+ indicator Cameleon he published the first direct visualisation of chemosensory activity in C. elegans neurons. In his second postdoctoral work at the University of California, San Francisco and at The Rockefeller University, he switched from neuronal function to neuronal development, focusing in particular on how neurons establish and orient their polarity with respect to extracellular cues.

From September 2007, he is at the Queensland Brain Institute where he established an independent laboratory.

Valentin was awarded a PhD from the French National Institute of Higher Education in Agricultural Sciences and the University of Montpellier (France) in 2018. His thesis focused on methodological developments for genetic differentiation analysis in the Next Generation Sequencing era in a neutral and adaptive context. Since 2019, he works as a post-doctoral researcher at the University of Queensland in the Program in Complex Trait Genomics group under the supervision of Professor Peter Visscher. His current research focuses on studying the within and between-population genetic variation in human complex traits.

I graduated with Honours in Medicine from the University of the West Indies, Jamaica, in 1992. In 1997 I relocated to the UK where I specialised in Obstetrics & Gynaecology and was admitted as a Member of the Royal College of Obstetricians & Gynaecologists in 1999. In 2012 I gained dual accreditation as a Subspecialist in Reproductive Medicine & Surgery and was admitted to the European Specialist Register. In 2012, I was appointed Senior Lecturer and Consultant in Reproductive Medicine & Surgery at University College London (UCL) and UCL Hospitals where I was the clinical lead for IVF and Recurrent Miscarriage and the scientific lead for Mammalian Oocyte Research within UCL’s Institute for Women’s Health. In January 2014 I relocated to Australia after being recruited to UNSW through the DVCR’s Strategic Priority Funding Scheme. At UNSW I jointly set up and co-directed UNSW’s first oocyte biology research lab. In January 2016, following a competitive global search, I was appointed to the fully endowed Christopher Chen Chair in Reproductive Medicine at UQ where I currently head the Christopher Chen Oocyte Research Laboratory. Since relocating to Australia I have been awarded Fellowship of the Royal Australian NZ College of Obstetricians & Gynaecologists.

In parallel with clinical activity, I have developed an internationally leading research program investigating oocyte maturation and oocyte quality. My Ph.D was awarded in 2009 from the University of Newcastle-upon-Tyne (UK) and received a Dean’s commendation. My thesis investigated the regulation of chromosome segregation in mouse and human oocytes and was funded by a WellBeing of Women Research Training Fellowship. My post-doctoral research was undertaken at UCL funded by a prestigious Wellcome Trust Clinician Scientist Fellowship ($1.2 million). At UCL, I was one of the principal investigators in the cross-faculty Mammalian Oocyte and Embryo Research Laboratory. In my first 2 years in Australia, I have secured NHMRC funding as CIA worth over $1 million.

I have placed leading papers on oocyte regulation in high impact journals such as Science, Developmental Cell, Genes & Development and Nature Cell Biology all of which have been cited by the Faculty of 1000 Experts. I have received numerous prizes and awards including the highly prestigious Medical Research Society Young Investigator Award (first and only award made to the specialty of O&G in the UK) and was the first of the UK Walport Clinical Lecturers in all specialties to attain Clinician Scientist status. I was one of the very few to have delivered the RCOG’s William Blair Bell Memorial Lecture whilst still a clinical trainee.

The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.

David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute

Dr Daniel Liang-Dar Hwang is a genetic epidemiologist and statistical geneticist by training. His research interests include sensory nutrition, causal modelling, and personalized nutrition. Dr Hwang applies statistical models to big data to understand genetic and environmental factors contributing to individual differences in taste and olfactory perception and their relationship with dietary behaviour and chronic conditions (See his research on taste perception in The Conversation). He develops methods for increasing statistical power for gene discovery, estimating intergenerational causal relationships, and personalized intervention. He also works with clinicians to investigate impaired chemosensory perception in cancer patients and COVID-19.

Daniel has a B.Sc from the National Taiwan University, majoring in Biochemical Science and Technology, and an M.Biotech from the University of Pennsylvania. Following graduation, he worked as a research technician in Danielle Reed's lab at the Monell Chemical Senses Center, where he first developed a keen interest in genetics and chemosensory perception. Later, he was awarded scholarships to complete an M.Sc in Nutrition at the University of Washington, under the supervision of Glen Duncan, and a PhD in Genetic Epidemiology at the QIMR Berghofer Medical Research Institute, under the supervision of Nicholas Martin and Margaret Wright. He then joined David Evans's group as a postdoc at the University of Queensland Diamantina Institute (now the Frazer Institute). Dr Hwang is an ARC DECRA Fellow at the Institute for Molecular Bioscience. He is also an Affiliated Scientist at the Monell Chemical Senses Center.

Dr Hwang has published more than 40 peer-reviewed publications. His work has been referred to in international health policy guidelines and a WHO report for the intervention of childhood obesity and in a global patent for personalized wine selection. He is on the editorial boards of BMC Medicine and Twin Research and Human Genetics. Dr Hwang is a Leadership Team member of the Global Consortium for Chemosensory Research, a global initiative to understand the relationship between smell loss and COVID-19 and foster the advancement of chemosensory science. He currently drives an international collaborative project to investigate the impact of COVID-19 vaccinations on long-COVID symptoms. Dr Hwang is a member of the National Committee for Nutrition of the Australian Academy of Science. He contributes to implementing the decadal plan for the science of nutrition in Australia.

Clara Jiang is a postdoctoral research fellow at the Institute for Molecular Bioscience, the University of Queensland. Clara’s research focuses on using genomic and transcriptomic analysis to investigate the genetic basis of cardiovascular and psychiatric disorders, with a particular focus on female health, as well as using statistical genomic approaches to explore possible opportunities for drug repurposing. Clara graduated from the University of Queensland with Bachelor of Advanced Science (First Class Honours) in 2017, and was awarded the University Medal. Clara was awarded her PhD at the University of Queensland in 2021, where she utilised bioinformatic approaches and molecular experiments to decipher the genetic aetiology of breast cancer, specifically the regulatory role of transposons or ‘jumping genes’ in modulating the transcriptional landscape in the cancer state. Clara is also a UQ Wellness ambassador and an advocate for promoting equity, diversity and inclusion in academia.

Prof. David Jordan is a sorghum breeder and geneticist with more than 20 years experience working in both the public and private sector.

For the last decade he has led the public sorghum pre-breeding program in Australia which is a partnership between the University of Queensland (UQ), The Queensland Department of Agriculture and Fisheries (DAF) and the Grains research and Develop Corporation (GRDC). This is a long running and successful research effort with a reputation for integrating across disciplines and linking research efforts from the strategic to the applied. Breeding lines from this program are widely used commercially in Australia and internationally with 100% of the commercial sorghum grown in Australia having genetics from the program. At the same time the research group continues to produce research papers at the forefront of sorghum research.

In recent years he had led projects focused on improving the lives of resource poor farmers in Africa that rely on sorghum.

I am a computational biologist with a centre-wide research role in the ARC Centre of Excellence for Plant Success in Nature and Agriculture, based here at UQ. I spend my time researching new computational techniques for predicting complex quantitative traits by integrating multiple layers of 'omics data (amongst dozens of other things!).

Areas of interest:

• Machine Learning, AI and high performance computing to learn and exploit functional connectivity in biological data
• Gene Expressions networks
• Multiplex networks, information propagation and perturbation
• Genomic Prediction

My goal is to aid crop and forestry breeders in selecting parental lines more accurately, which gives us a pathway to improving certain plant species. I also spend time developing new data analysis techniques that are being applied to human disease and conditions such as Autism and substance addiction.

David completed his PhD at Australian National University in 2017, focusing on the genome-wide basis of foliar terpene variation in Eucalyptus. He then undertook a postdoc at Oak Ridge National Laboratory, a US Dept of Energy lab with a focus on big data. After a stint as a staff scientist at Oak Ridge, David arrived at the Centre of Excellence in 2023 in the role of a Senior Research Fellow.

Dr Kemper is a postdoctoral fellow in statistical genetics. She joined UQ in 2016 after obtaining a PhD and postdoctoral experience at the University of Melbourne (2006-2016). Her expertise and research interests span a range of topics in quantitative genetics, including genomic prediction, modelling the epidemiological consequences of genetic change in disease and population genetics. Current research areas include:

• genetic analysis of longitudinal traits
• estimation of non-additive genetic effects
• genomic prediction in admixed populations

I am a developmental neuroscientist and bioinformatician interested in the molecular evolution of the mammalian brain. I completed a PhD on the molecular development of vasculature in the primate retina at the Australian National University, followed by a postdoctoral position at the Institut de la Vision in France that was supported by a NHMRC CJ Martin fellowship, where I investigated the role of guidance factors in the formation of commissural neurons within the mammalian hindbrain. My current research focuses on the development and evolution of the mammalian forebrain, in particular understanding the regulatory mechanisms and molecular evolutionary processes that control specification of cortical neuron subtypes.

Researcher Biography

Dr Snehlata Kumari is the head of skin inflammation and immunity laboratory at the Frazer Institute, the University of Queensland in Brisbane, Australia. She is a board member of the Australasian Society for Dermatology Research (ASDR).

After PhD and post-doctoral training in Germany, she is heading her research group with a focus on elucidating molecular mechanisms and underlying signalling pathways regulating inflammation. She has discovered novel mechanisms by which NF-kappaB, TNF, necroptotic and apoptotic signalling pathways control skin homeostasis and inflammation and published in top-tier journals such as Nature and Immunity.

Her scientific contributions received recognition from the global immunology and dermatology scientific communities including the German National Academy of Sciences, German Research Foundation (SFB), European Society for Dermatological Research, and the 2021 Christina Fleishmann Award for the Young Women Investigator from the International Cytokine and Interferon Society, USA

Overall aims and research focus

- Understanding molecular mechanisms of epithelial and immune cell communication in skin homeostasis and immunity.

- Elucidating signalling pathways and cytokines/chemokine interactions to develop novel drug targets and strategies to treat skin diseases such as Psoriasis, Hidradenitis Suppurative, Atopic Dermatitis.