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Harendra's research interests are in the area of synthetic pharmaceutical chemistry, pharmaceutics as applied to nano-carriers, and advanced non-viral drug/gene delivery system design, synthesis and evaluation. His team at PACE have been instrumental in developing highly versatile micro- & nanobubble formulations, which when used in-conjuction with ultrasound, pave the way for improved rates of 'on-demand' drug delivery and release in target tissue. Harendra also has a keen interest in developing bioresponsive drug/gene delivery systems with current engagement with pharma partners, globally, to commercialise his platforms. Separately, Dr Parekh has been developing a program to reformulate TCMs, in collaboration with researchers at a leading Chinese research institute; the outcomes of this work was aired across Asia in a BBC World News story, and showcased (TV & radio) by the Australian Academy of Science, National Touring Series.

BScPharm(Hon I), PhD (Nottingham)

Harendra completed his BSc in pharmacy (UK) and registered as a Pharmacist in 1998. He went onto undertake his PhD in Medicinal Chemistry at the University of Nottingham in the same year. Under the supervision of Dr B. Kellam and Dr. S. R. Chhabra he investigated the development of novel linkers for solid phase peptide and glycopeptide synthesis. Harendra was awarded his PhD in 2002, and after a short time working in community pharmacy in the UK relocated to Australia and took up a position as research officer in the School of Chemistry at UQ. He continues to be a member of the Royal Pharmaceutical Society of GB and is also registered with the AHPRA (pharmacist) in QLD.

During his post-doctoral tenure he explored the area of non-viral gene delivery via chemical synthesis of novel dendrimeric systems. Emphasis was on the treatment of age-related macular degeneration and in 2004 he received Uniquest's Trailblazer Prize for commercialisation potential. In May 2005 Dr Parekh was appointed Lecturer within the School of Pharmacy, and promoted to Senior Lecturer in 2011. He also holds adjunct positions at Manipal University (India), and the National University of Singapore's Nanoscience and Nanotechnology Institute (NNI).

Julie’s research is mainly focussed on gas-water-rock core reactivity at reservoir conditions using experimental, field, and geochemical modelling techniques. Recent projects have been in the application of carbon dioxide geological storage in which CO2 is captured and stored in formations generally contained by low permeability cap-rock. The safe containment of the injected CO2 and the potential changes to rock porosity, permeability, and water quality should be determined. Recent and current projects with a focus on a demonstration site in the Surat Basin (Precipice Sandstone) include the impacts of impurity or acid gases present in industrial CO2 streams (collaboration with D. Kirste, SFU), inducing carbonate precipitation (in collaboration with S. Golding), and understanding dissolved metal sources and fate. Julie has also worked closely with the CO2CRC, CTSCo, Glencore, SEAL, the NSW government, CI-NSW, and ANLEC R&D, and provided expert opinion to the Queensland Government, and input to Environmental Impacts Assessments.

Julie is currently working with landholders, the QLD regional government, RDMW, councils and industry to understand the sources of methane in aquifers of the Great Artesian Basin, especailly those overlying coal seam gas reservoirs (CSG) (with Arrow Energy, SANTOS, APLNG, H. Hoffman, K, Baublys).

Other projects include gas-water-rock or acid-rock reactivity that modify nano-porosity and gas flow in gas or oil bearing shales.

Julie Pearce graduated with an MCHEM (Hons) degree in Chemistry from the University of York, UK. She then moved to the University of Bristol to complete a Ph.D. in 2007 focusing on laser spectroscopic studies to understand the detailed reaction dynamics of atmospheric processes. From 2007 – 2009 she accepted a Japan Society for the Promotion of Science Postdoctoral Fellowship, hosted at Nagoya University, Japan. There she measured delta 13C and delta 18O isotopic signatures of CO2 simultaneously in real time in the atmosphere using a laser spectroscopic technique to understand anthropogenic and biogenic sources of CO2. After taking a career break to travel in 15 countries in Asia, she moved to Brisbane in 2010 where she is enjoying the surrounding natural beauty of Queensland.

Research Interests

• Advanced Drug Delivery and Nanomedicine 1.Advanced drug delivery methods (controlled release dosage forms such as tablets, granules and microspheres) 2. Biomaterials as next generation adjuvant for vaccine delivery 3. Surface modified nanomaterials (Silica, Polymer, Liposomes) 4. Programmable nanoparticales for oral drug delivery and targeting 5. Translocation of nanoparticles after oral drug delivery (In-vitro and In-vivo)

Qualifications

• Master of Pharmaceutical Science, Gujarat University
• Bachelor of Pharmacy, Gujarat University

This is an automatically generated university page - my real website is https://people.smp.uq.edu.au/BenPowell/

I am a Principal Investigator (PI) and a senior research officer (SRO) at Mater research – UQ with excellent clinical and research laboratory skills and expertise in conducting and analyzing laboratory assays and resolving complex research and clinical laboratory problems. I can describe myself as determined, reliable, studious, conscientious, attentive, industrious, diligent, and focused on the timely, quality completion of all lab procedures. I am able to work well under pressure and time constraints within high-volume environments both independently and in collaboration within a team. I am also a highly self-motivated and career-oriented individual with a genuine interest in addressing cancer molecular mechanisms with the goal of developing novel cancer therapeutics and immunotherapy focusing on tumor microenvironment, immunoregulation and signaling pathways in cancer and metastasis.

Cassandra is a Senior Research Fellow at QAEHS, joining the group in 2019. She completed her PhD at the University of Birmingham in 2014 where her research focussed on determining how humans are exposed to flame retardants from their indoor environments. Following her PhD she completed a Postdoctoral Fellowship at Environment and Climate Change Canada where she was the principal researcher for the Global Atmospheric Passive Sampling (GAPS) Network, researching chemicals of concern in the atmosphere. Following her Postdoctoral Fellowship she worked for the Oil Sands Monitoring Program in Canada, assisting with facilitating a multi-stakeholder funding program for assessing environmental impact of Oil Sands operations, before returning to Australia in 2019.

At QAEHS she is the project lead investigating human exposure to microplastics and developing new methods for detecting micro and nanoplastics in human matrices. Her other research interests include the impact of tyre road wear particles and the chemical additives they contain on urban water ways, and developing novel biomonitoring methods for assessing human exposure to chemicals of concern (e.g. silicone wristbands and breast implants).

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Dr Ben Ross is a chemist with interests in medicinal chemistry, computer-aided drug design, virtual screening, synthetic chemistry, enzyme inhibitors, ion channel modulators, antivirals, amyloid diseases, neurodegenerative diseases, and cancer.

Follow Dr Ben Ross and his team on Twitter: @RossChemLab ||| Google Scholar: Benjamin P. Ross ||| ResearcherID: A-9573-2012 ||| ORCID: 0000-0002-1899-8484 ||| Scopus Author ID:7401608823 ||| Group Web Page: www.drbenross.com

Research Interests

The main focus of Dr Ben Ross's research is the application of computer-aided drug design and synthetic chemistry to create new drug candidates for cancer, viral infections, and neurodegenerative diseases such as Alzheimer’s disease. His team's novel molecules are evaluated using a variety of biochemical, biophysical, and cell-based screening assays, as well as animal models of disease, both within their lab and in partnership with local and international collaborators. Consideration of drug-likeness is an integral part of the design process, since good ADMET properties are crucial for their molecules to reach the clinic.

Biography

Ben Ross graduated with a First-Class Honours Degree in Chemistry (1999) and then moved to the UQ School of Pharmacy where he gained a Doctorate in the field of Medicinal Chemistry (2004). He worked in the School of Molecular and Microbial Sciences as a Postdoctoral Research Fellow with Dr Ross McGeary for two years (2004-2006) during which he completed the synthesis of a variety of biologically useful molecules. In June 2006 Ben was appointed to a Lectureship within the UQ School of Pharmacy. In the first half of 2012 he was a Guest Researcher in the Department of Biochemistry and Structural Biology, Lund University, Sweden. In 2013 Ben was promoted to Senior Lecturer at UQ. A general theme of his research is medicinal chemistry, specifically the application of synthetic chemistry and molecular modeling to discover novel molecules with application as drugs or tools for research. Ben's team has published extensively in journals having a moderate-to-high impact factor in their specialised area of research (e.g. Journal of Medicinal Chemistry, Nanoscale, Food Chemistry).

Selected Primary Research Articles

Bifunctional Succinylated ε-Polylysine Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon. C.T.H. Nguyen, R.I. Webb, L.K. Lambert, E. Strounina, E.C. Lee, M.-O. Parat, M.A. McGuckin, A. Popat, P.J. Cabot, B.P. Ross*. ACS Applied Materials & Interfaces 2017, 9, 9470-9483. doi:10.1021/acsami.7b00411 (2016 JIF 7.5, Quartile 1)

Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening. S.N. Dighe, G.S. Deora, E. De la Mora, F. Nachon, S. Chan, M.-O. Parat, X. Brazzolotto*, B.P. Ross*. Journal of Medicinal Chemistry 2016, 59, 7683-7689. doi:10.1021/acs.jmedchem.6b00356 (Featured on the front cover of the journal: http://pubs.acs.org/toc/jmcmar/59/16) (2016 JIF 6.3, Quartile 1)

GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses. E.C. Lee, N. Davis-Poynter*, C.T.H. Nguyen, A.A. Peters, G.R. Monteith, E. Strouina, A. Popat*, B.P. Ross*. Nanoscale 2016, 8, 16192-16196. doi:10.1039/C6NR03878F (2016 JIF 7.4, Quartile 1)

Metal chelation, radical scavenging and inhibition of Aβ42 fibrillation by food constituents in relation to Alzheimer’s disease. S. Chan, S. Kantham, V.M. Rao, M.K. Palanivelu, H.L. Pham, P.N. Shaw, R.P. McGeary, B.P. Ross*. Food Chemistry 2016, 199, 185-194. doi:10.1016/j.foodchem.2015.11.118 (2016 JIF 4.5, Quartile 1)

"Click" Assembly of Glycoclusters and Discovery of a Trehalose Analogue that Retards Aβ40 Aggregation and Inhibits Aβ40-induced Neurotoxicity. H. Rajaram, M.K. Palanivelu, T.V. Arumugam, V.M. Rao, P.N. Shaw, R.P. McGeary, B.P. Ross*. Bioorganic & Medicinal Chemistry Letters 2014, 24, 4523-4528. doi:10.1016/j.bmcl.2014.07.077 (2014 JIF 2.4, Quartile 3)

Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres. A. Popat, B.P. Ross, J.Liu, S. Jambhrunkar, F. Kleitz*, S.Z. Qiao*. Angewandte Chemie International Edition 2012, 51, 12486-12489. doi:10.1002/anie.201206416 (2010 JIF 13.7, Quartile 1)

PhD vacancies - PhD opportunities

Australian and international students with backgrounds in chemistry, biochemistry, and pharmacy are encouraged to contact Dr Ben Ross to discuss possible Honours or PhD projects and scholarships.

Sources of funding include: UQ Scholarships; NHMRC Postgraduate Scholarships; Endeavour Scholarships and Fellowships; Malaysia Ministry of Higher Education (MOHE) Scholarships; Ministry of Education Saudi Arabia; and the China Scholarship Council (CSC), as well as many other funding schemes. Contact Dr Ben Ross via email to discuss the best strategy to obtain a scholarship.

Teaching and Service Activities

Dr Ben Ross is the Research Higher Degrees Coordinator for the School of Pharmacy, and an Academic Advisor for Year 2 of the BPharm(Hons) program. He also coordinates and teaches within the following undergraduate BPharm(Hons) courses:

PHRM2021 Dosage Form Design A1;

PHRM2022 Dosage Form Design A2;

PHRM2040 Drug Discovery A1;

PHRM2041 Drug Discovery A2 - Course Coordinator;

PHRM3021 Dosage Form Design B1.

Dr Narottam Saha is specialized in the area of environmental analytical chemistry and geochemistry, with Bachelors and Masters Degrees in Applied Chemistry and Chemical Technology, a second Masters Degree (Distinction) in Environmental Sciences ( University of East Anglia, UEA, UK), and PhD in geochemistry (The University of Queensland). In his Masters study, Saha received a commonwealth scholarship, one of the most prestigious international scholarship schemes, for Master Degree in Environmental Sciences, with special emphasis on Clumped Isotope geochemistry and climate science. In 2014, Saha received Australia’s federal government scholarship (IPRS) for undertaking his PhD degree. Saha’s research achievements were well recognised with awards of Stanley Gray Fellowship from Institute of Marine Engineering, Science & Technology (IMarEST, UK) for coral reef research and National Science and Information & Communication Technology (NSICT) Fellowship (2010) from Government of Bangladesh for heavy metal pollution research.

His multidisciplinary research experiences include biogeochemistry of heavy metals, assessment of carcinogenic and non-carcinogenic risks for the population exposed to heavy metals, clumped isotopes geochemistry in recovering palaeo-climate history and developing trace element proxies in coral carbonate skeleton to trace historical gradients of inshore coastal water quality. His PhD research highlights the potential of self-referencing rare earth elements over traditional trace elemental proxies for reconstructing marine water quality, degradation of which is considered as one of the major threats in declining the Great Barrier Reef (GBR) coral community. He has been the first to have discovered a noble V/Ca proxy, which is decoupled from other commonly used runoff proxies, for monitoring historical catchment clearing and firing in coastal areas. His discovery has direct relevance to environmental protection for reefs in the GBR through promoting better land management with improved water quality.

Stephen is currently a Postdoctoral Research Fellow in the Bernhardt group at the University of Queensland. His current research is focused on the theory of nonequilibrium statistical mechanics and molecular dynamics.

Stephen completed a double degree in electrical engineering and physics at James Cook University, followed by a PhD in physics, also at James Cook University, under the supervision of Prof. Ronald White and Dr Bronson Philippa, as well as the University of Queensland's Prof. Paul Burn and Prof. Alan Mark. His PhD focused on using kinetic Monte-Carlo simulations of charge and exciton dynamics, coupled with atomistic molecular dynamics deposition simulations to establish a better understanding of structure-property relationships in organic semiconductors, particularly organic light-emitting diodes.

Dr Viviene Santiago is a Postdoctoral Research Fellow in the Natural Toxins group within the Centre for Animal Science, Queensland Alliance for Agriculture and Food Innovation (QAAFI) and is based at the Health and Food Sciences Precinct (Coopers Plains). With a robust foundation in organic and analytical chemistry, her research primarily focuses on natural products chemistry from terrestrial, marine, and microbial sources.

Dr Santiago joined QAAFI as a Postdoctoral Research Fellow in 2023. Her current research involves developing a delivery system for bioactive compounds aimed at reducing enteric methane emissions in cattle and exploring atypical sugars in novel foods such as stingless bee honey. Over the years, she has cultivated a keen interest in utilising liquid chromatography-mass spectrometry (LC-MS) and molecular networking techniques to investigate chemical diversity from different sources such as natural toxins in certain plants and atypical sugars in stingless bee honey.

Dr Santiago earned her Ph.D. from The University of Queensland, where her dissertation focused on applying advanced molecular networking techniques, such as the Global Natural Products Social Molecular Networking (GNPS), to explore the chemical diversity of Australian microbes. Her academic journey also includes a Master’s and a Bachelor’s degree in Chemistry from the University of the Philippines – Diliman. These academic experiences have equipped her with a comprehensive understanding of natural products chemistry, enabling her to make significant contributions to both academia and industry.

I obtained a Diploma in Chemistry from the University of Bern in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (UQ) in 1993 to carry out research towards a PhD in Biochemistry(supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at UQ under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period, I was awarded Fellowships from both the Wellcome Trust and UQ. In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Senior Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)Physical Chemistry at UQ. In 2006 I was promoted to Senior Lecturer. Following the award of a UQ Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2008), and between 2011 and 2013 I was also on a fractional professorial appointment (50%) at Maynooth University, Ireland. From 2013 to 2017 I held a Future Fellowship from the Australian Research Council, and during this period I was promoted to Full Professor at UQ (2015). I also hold affiliate professorships in the Sustainable Minerals Institute and the Australian Institute for Bioengineering and Nanotechnology, both located at UQ.

I have successfully focused my research on the investigation of enzyme-catalysed reactions, their optimisation for applications in biotechnology and the synthesis of small molecules that mimic their structure and catalytic function (i.e. biomimetics). I advanced understanding of the contribution of metals to enzyme-catalysed reactions and employed state-of-the-art technologies (e.g. cryo-EM, ancestral gene reconstruction) to develop enzyme inhibitors as leads for novel biocides (herbicides, fungicides, antibacterial compounds) and engineer enzymes with enhanced catalytic properties for industrial applications in the advanced manufacturing sector (i.e. cell-free enzyme cascades, next-gen fertilisers). My work into enzyme mechanisms, regulation and engineering received international acclaim evidenced by invitations to provide plenary and keynote lectures and review articles in prestigious journals. I have published over 250 peer-reviewed articles, including over 40 papers in the ACS staple (J. Am. Chem. Soc, ACS Catalysis, ACS Sus. Chem. Eng., Inorg. Chem, Chem. Rev., Acc. Chem. Rev.) as well as landmark studies in Nature, Nature Catalysis, Nature Communications and Proc. Natl. Acad. Sci. (USA). For my leadership in enzymology I was awarded a Future Fellowship by the Australian Research Council, a Foundation Research Excellence Award by UQ and, most recently, the prestigious role as Ambassador for the Technical University of Munich (TUM), an honour bestowed upon me also for my leading role in building an extensive network of collaborations between UQ and TUM in the areas of bioengineering and bioeconomy. The network has since evolved into the Global Bioeconomy Alliance.

My research interests are in the field of Chemistry education, particularly how students learn in the chemistry laboratory.

I teach biological inorganic chemistry at a second and Masters level, as well as a broad range of topics in first year chemistry. I also teach the ethics of chemistry in second year.

Nick Shaw was appointed to the School as Professor in January 2004 and undertook the role of Head of School of Pharmacy at UQ from 1st July 2004 until 31st December 2014. Nick is a pharmacist, graduating PhD from the University of Manchester in 1985 and was a member of the academic staff of the University of Nottingham from 1985-2003. He was appointed a Fellow of the Royal Society of Chemistry in 1994 and a Fellow of the Royal Pharmaceutical Society in 2010. He previously founded and chaired the Council of Pharmacy Schools (Australia and New Zealand); he is the chair of the APC Accreditation Committee and was the chair of the Australian Pharmacy Liaison Forum in 2011. He has taught across a range of subjects to the second and third years of the BPharm (Hons) course at UQ. Nick has supervised and co-supervised over 45 PhD and research Masters students.

In 2013 Nick was awarded the Pharmaceutical Society of Australia’s Bowl of Hygeia for services to the profession.

Dr. Denis Shishin,

• Bachelor of Science and Master of Science in Chemistry from Moscow State University (Diploma with Honors)
• PhD in Metallurgical Engineering from University of Montreal, Canada
• 2014 - Current: Research Fellow in Pyrometallurgy Innovation Centre (PYROSEARCH) of the University of Queensland