Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

167 works between 2001 and 2024
All (167) Journal Article (137) Book Chapter (3) Conference Publication (26) Other Outputs (1)

1 - 20 of 167 works

2024

Journal Article

Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5)

Wu, Hongkang, Hartono, Herodion A., Handley, Thomas N. G., Hoare, Bradley L., Rosengren, K. Johan, Chalmers, David K., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2024). Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5). Journal of Medicinal Chemistry, 67 (23), 20966-20979. doi: 10.1021/acs.jmedchem.4c01422

Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5)

2024

Journal Article

The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation

Budusan, Elena, Payne, Colton D., Gonzalez, Tye I., Obergrussberger, Alison, Becker, Nadine, Clark, Richard J., Rosengren, K. Johan, Rash, Lachlan D. and Cristofori-Armstrong, Ben (2024). The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation. Biochemical Pharmacology, 228 116175, 1-12. doi: 10.1016/j.bcp.2024.116175

The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation

2024

Journal Article

Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain

Wang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain. International Journal of Molecular Sciences, 25 (9) 4745, 4745. doi: 10.3390/ijms25094745

Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain

2024

Journal Article

Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues

Smallwood, Taylor B., Krumpe, Lauren R. H., Payne, Colton D., Klein, Victoria G., O'Keefe, Barry R., Clark, Richard J., Schroeder, Christina I. and Rosengren, K. Johan (2024). Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues. Chemical Science, 15 (33), 13227-13233. doi: 10.1039/d4sc01976h

Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues

2023

Journal Article

Side‐chain dynamics of the α<sub>1B</sub>‐adrenergic receptor determined by NMR via methyl relaxation

Baumann, Christian, Chiang, Wan‐Chin, Valsecchi, Renato, Jurt, Simon, Deluigi, Mattia, Schuster, Matthias, Rosengren, Karl Johan, Plückthun, Andreas and Zerbe, Oliver (2023). Side‐chain dynamics of the α1B‐adrenergic receptor determined by NMR via methyl relaxation. Protein Science, 32 (11) e4801, 1-18. doi: 10.1002/pro.4801

Side‐chain dynamics of the α<sub>1B</sub>‐adrenergic receptor determined by NMR via methyl relaxation

2023

Journal Article

Noncovalent peptide stapling using alpha-methyl-l-phenylalanine for α-helical peptidomimetics

Bathgate, Ross A. D., Praveen, Praveen, Sethi, Ashish, Furuya, Werner I., Dhingra, Rishi R., Kocan, Martina, Ou, Qinghao, Valkovic, Adam L., Gil-Miravet, Isis, Navarro-Sánchez, Mónica, Olucha-Bordonau, Francisco E., Gundlach, Andrew L., Rosengren, K. Johan, Gooley, Paul R., Dutschmann, Mathias and Hossain, Mohammed Akhter (2023). Noncovalent peptide stapling using alpha-methyl-l-phenylalanine for α-helical peptidomimetics. Journal of the American Chemical Society, 145 (37), 20242-20247. doi: 10.1021/jacs.3c02743

Noncovalent peptide stapling using alpha-methyl-l-phenylalanine for α-helical peptidomimetics

2023

Journal Article

Stretching peptides to generate small molecule β-strand mimics

Adams, Zoë C., Silvestri, Anthony P., Chiorean, Sorina, Flood, Dillon T., Balo, Brian P., Shi, Yifan, Holcomb, Matthew, Walsh, Shawn I., Maillie, Colleen A., Pierens, Gregory K., Forli, Stefano, Rosengren, K. Johan and Dawson, Philip E. (2023). Stretching peptides to generate small molecule β-strand mimics. ACS Central Science, 9 (4), 648-656. doi: 10.1021/acscentsci.2c01462

Stretching peptides to generate small molecule β-strand mimics

2023

Journal Article

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

2022

Journal Article

Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex

Goncalves Monteiro, Daniela Goncalves, Rishi, Gautam, Gorman, Declan M., Burnet, Guillaume, Aliyanto, Randy, Rosengren, K. Johan, Frazer, David M., Subramaniam, V. Nathan and Clark, Richard J. (2022). Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex. Molecules, 27 (19) 6581, 1-13. doi: 10.3390/molecules27196581

Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex

2022

Journal Article

Secondary structure transitions for a family of amyloidogenic, antimicrobial uperin 3 peptides in contact with sodium dodecyl sulfate

Prasad, Anup K., Tiwari, Chandni, Ray, Sourav, Holden, Stephanie, Armstrong, David A., Rosengren, K. Johan, Rodger, Alison, Panwar, Ajay S. and Martin, Lisandra L. (2022). Secondary structure transitions for a family of amyloidogenic, antimicrobial uperin 3 peptides in contact with sodium dodecyl sulfate. ChemPlusChem, 87 (1) e202100408, e202100408. doi: 10.1002/cplu.202100408

Secondary structure transitions for a family of amyloidogenic, antimicrobial uperin 3 peptides in contact with sodium dodecyl sulfate

2021

Journal Article

Barrettides: a peptide family specifically produced by the deep-sea sponge Geodia barretti

Steffen, Karin, Laborde, Quentin, Gunasekera, Sunithi, Payne, Colton D., Rosengren, K. Johan, Riesgo, Ana, Göransson, Ulf and Cárdenas, Paco (2021). Barrettides: a peptide family specifically produced by the deep-sea sponge Geodia barretti. Journal of Natural Products, 84 (12) acs.jnatprod.1c00938, 3138-3146. doi: 10.1021/acs.jnatprod.1c00938

Barrettides: a peptide family specifically produced by the deep-sea sponge Geodia barretti

2021

Journal Article

Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding

Survery, Sabeen, Hurtig, Fredrik, Haq, Syed Razaul, Eriksson, Jens, Guy, Lionel, Rosengren, K. Johan, Lindås, Ann-Christin and Chi, Celestine N. (2021). Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding. Communications Biology, 4 (1) 1024, 1-14. doi: 10.1038/s42003-021-02543-x

Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding

2021

Journal Article

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

Payne, Colton D., Vadlamani, Grishma, Hajiaghaalipour, Fatemeh, Muhammad, Taj, Fisher, Mark F., Andersson, Håkan S., Göransson, Ulf, Clark, Richard J., Bond, Charles S., Mylne, Joshua S. and Rosengren, K. Johan (2021). Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides. RSC Chemical Biology, 2 (6), 1682-1691. doi: 10.1039/d1cb00155h

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

2021

Journal Article

A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4

Clark, Richard J., Phan, Thanh Huyen, Song, Angela, Ouellette, André J., Conibear, Anne C. and Rosengren, K. Johan (2021). A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4. Peptide Science, 114 (1) e24250. doi: 10.1002/pep2.24250

A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4

2021

Journal Article

Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo

Gorman, Declan M., Li, Xaria X., Payne, Colton D., Cui, Cedric S., Lee, John D., Rosengren, K. Johan, Woodruff, Trent M. and Clark, Richard J. (2021). Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo. ACS Pharmacology and Translational Science, 4 (6) acsptsci.1c00199, 1808-1817. doi: 10.1021/acsptsci.1c00199

Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo

2021

Journal Article

Structural characterization of the PawL-derived peptide family, an ancient subfamily of orbitides

Payne, Colton D., Fisher, Mark F., Mylne, Joshua S. and Rosengren, K. Johan (2021). Structural characterization of the PawL-derived peptide family, an ancient subfamily of orbitides. Journal of Natural Products, 84 (11) acs.jnatprod.1c00672, 2914-2922. doi: 10.1021/acs.jnatprod.1c00672

Structural characterization of the PawL-derived peptide family, an ancient subfamily of orbitides

2021

Journal Article

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo

Smallwood, Taylor B., Navarro, Severine, Cristofori-Armstrong, Ben, Watkins, Thomas S., Tungatt, Katie, Ryan, Rachael Y.M., Haigh, Oscar L., Lutzky, Viviana P., Mulvenna, Jason P., Rosengren, K. Johan, Loukas, Alex, Miles, John J. and Clark, Richard J. (2021). Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. Journal of Biological Chemistry, 297 (1) 100834, 1-14. doi: 10.1016/j.jbc.2021.100834

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo

2021

Journal Article

A chameleonic macrocyclic peptide with drug delivery applications

Payne, Colton D., Franke, Bastian, Fisher, Mark F., Hajiaghaalipour, Fatemeh, McAleese, Courtney E., Song, Angela, Eliasson, Carl, Zhang, Jingjing, Jayasena, Achala S., Vadlamani, Grishma, Clark, Richard J., Minchin, Rodney F., Mylne, Joshua S. and Rosengren, K. Johan (2021). A chameleonic macrocyclic peptide with drug delivery applications. Chemical Science, 12 (19), 6670-6683. doi: 10.1039/d1sc00692d

A chameleonic macrocyclic peptide with drug delivery applications

2021

Conference Publication

Structure-function of the spider peptide ProTx-III

Zhao, Tianjiao, Rosengren, Johan K., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Structure-function of the spider peptide ProTx-III. Venom to Drugs, Daydream Island, QLD Australia, 15-19 March 2021.

Structure-function of the spider peptide ProTx-III

2021

Journal Article

Pursuing orally bioavailable hepcidin analogues via cyclic N-methylated mini-hepcidins

Goncalves Monteiro, Daniela, van Dijk, Johannes W. A., Aliyanto, Randy, Fung, Eileen, Nemeth, Elizabeta, Ganz, Tomas, Rosengren, Johan and Clark, Richard J. (2021). Pursuing orally bioavailable hepcidin analogues via cyclic N-methylated mini-hepcidins. Biomedicines, 9 (2) 164, 1-14. doi: 10.3390/biomedicines9020164

Pursuing orally bioavailable hepcidin analogues via cyclic N-methylated mini-hepcidins

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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