Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

166 works between 2001 and 2024
All (166) Journal Article (136) Book Chapter (3) Conference Publication (26) Other Outputs (1)

21 - 40 of 166 works

2021

Journal Article

Investigation of receptor heteromers using NanoBRET ligand binding

Johnstone, Elizabeth K. M., See, Heng B., Abhayawardana, Rekhati S., Song, Angela, Rosengren, K. Johan, Hill, Stephen J. and Pfleger, Kevin D. G. (2021). Investigation of receptor heteromers using NanoBRET ligand binding. International Journal of Molecular Sciences, 22 (3) 1082, 1-16. doi: 10.3390/ijms22031082

Investigation of receptor heteromers using NanoBRET ligand binding

2021

Journal Article

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

Niederacher, Gerhard, Urwin, Debra, Dijkwel, Yasmin, Tremethick, David J., Rosengren, K. Johan, Becker, Christian F. W. and Conibear, Anne C. (2021). Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology, 2 (2), 537-550. doi: 10.1039/d0cb00175a

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

2021

Journal Article

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding

Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding

2020

Journal Article

Insights into the interaction of LVV-hemorphin-7 with angiotensin II type 1 receptor

Ali, Amanat, Johnstone, Elizabeth K. M., Baby, Bincy, See, Heng B., Song, Angela, Rosengren, K. Johan, Pfleger, Kevin D. G., Ayoub, Mohammed Akli and Vijayan, Ranjit (2020). Insights into the interaction of LVV-hemorphin-7 with angiotensin II type 1 receptor. International Journal of Molecular Sciences, 22 (1) 209, 209-14. doi: 10.3390/ijms22010209

Insights into the interaction of LVV-hemorphin-7 with angiotensin II type 1 receptor

2020

Journal Article

Recifin A, initial example of the Tyr-lock peptide structural family, is a selective allosteric inhibitor of Tyrosyl-DNA phosphodiesterase I

Krumpe, Lauren R. H., Wilson, Brice A. P., Marchand, Christophe, Sunassee, Suthananda N., Bermingham, Alun, Wang, Wenjie, Price, Edmund, Guszczynski, Tad, Kelley, James A., Gustafson, Kirk R., Pommier, Yves, Rosengren, K. Johan, Schroeder, Christina I. and O'Keefe, Barry R. (2020). Recifin A, initial example of the Tyr-lock peptide structural family, is a selective allosteric inhibitor of Tyrosyl-DNA phosphodiesterase I. Journal of the American Chemical Society, 142 (50), 21178-21188. doi: 10.1021/jacs.0c10418

Recifin A, initial example of the Tyr-lock peptide structural family, is a selective allosteric inhibitor of Tyrosyl-DNA phosphodiesterase I

2020

Journal Article

Defining the familial fold of the vicilin-buried peptide family

Payne, Colton D., Vadlamani, Grishma, Fisher, Mark F., Zhang, Jingjing, Clark, Richard J., Mylne, Joshua S. and Rosengren, K. Johan (2020). Defining the familial fold of the vicilin-buried peptide family. Journal of Natural Products, 83 (10), 3030-3040. doi: 10.1021/acs.jnatprod.0c00594

Defining the familial fold of the vicilin-buried peptide family

2020

Journal Article

Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue

Praveen, Praveen, Tailhades, Julien, Rosengren, K. Johan, Liu, Mengjie, Wade, John D., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2020). Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue. ACS Medicinal Chemistry Letters, 11 (11) acsmedchemlett.0c00456, 2336-2340. doi: 10.1021/acsmedchemlett.0c00456

Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue

2020

Journal Article

The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Fisher, Mark F., Payne, Colton D., Chetty, Thaveshini, Crayn, Darren M., Berkowitz, Oliver, Whelan, James, Rosengren, K. Johan and Mylne, Joshua S. (2020). The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides. Journal of Biological Chemistry, 295 (42), 14510-14521. doi: 10.1074/jbc.ra120.014781

The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

2020

Journal Article

Exploring the use of helicogenic amino acids for optimising single chain relaxin-3 peptide agonists

Lee, Han Siean, Wang, Shu Hui, Daniel, James T., Hossain, Mohammed Akhter, Clark, Richard J., Bathgate, Ross A. D. and Rosengren, K. Johan (2020). Exploring the use of helicogenic amino acids for optimising single chain relaxin-3 peptide agonists. Biomedicines, 8 (10) 415, 1-16. doi: 10.3390/biomedicines8100415

Exploring the use of helicogenic amino acids for optimising single chain relaxin-3 peptide agonists

2020

Journal Article

Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability

Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan and Göransson, Ulf (2020). Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability. Frontiers in Microbiology, 11 168, 168. doi: 10.3389/fmicb.2020.00168

Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability

2020

Journal Article

Development of relaxin-3 agonists and antagonists based on grafted disulfide-stabilized scaffolds

Lee, Han Siean, Postan, Michael, Song, Angela, Clark, Richard J., Bathgate, Ross A. D., Haugaard-Kedström, Linda M. and Rosengren, K. Johan (2020). Development of relaxin-3 agonists and antagonists based on grafted disulfide-stabilized scaffolds. Frontiers in Chemistry, 8 87, 87. doi: 10.3389/fchem.2020.00087

Development of relaxin-3 agonists and antagonists based on grafted disulfide-stabilized scaffolds

2020

Book Chapter

Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy

Schroeder, Christina I. and Rosengren, K. Johan (2020). Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy. Snake and spider toxins: methods and protocols. (pp. 129-162) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-9845-6_7

Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy

2019

Journal Article

The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins

Bleackley, Mark R., Dawson, Charlotte S., Payne, Jennifer A.E., Harvey, Peta J., Rosengren, K. Johan, Quimbar, Pedro, Garcia-Ceron, Donovan, Lowe, Rohan, Bulone, Vincent, van der Weerden, Nicole L, Craik, David J. and Anderson, Marilyn A. (2019). The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. The Cell Surface, 5 100026, 100026. doi: 10.1016/j.tcsw.2019.100026

The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins

2019

Journal Article

An orbitide from Ratibida columnifera seed containing 16 amino acid residues

Fisher, Mark F., Payne, Colton D., Rosengren, K. Johan and Mylne, Joshua S. (2019). An orbitide from Ratibida columnifera seed containing 16 amino acid residues. Journal of Natural Products, 82 (8) acs.jnatprod.9b00111, 2152-2158. doi: 10.1021/acs.jnatprod.9b00111

An orbitide from Ratibida columnifera seed containing 16 amino acid residues

2019

Journal Article

Random coil shifts of posttranslationally modified amino acids

Conibear, Anne C., Rosengren, K. Johan, Becker, Christian F. W. and Kaehlig, Hanspeter (2019). Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR, 73 (10-11), 587-599. doi: 10.1007/s10858-019-00270-4

Random coil shifts of posttranslationally modified amino acids

2019

Journal Article

An ancient peptide family buried within vicilin precursors

Zhang, Jingjing, Payne, Colton D., Pouvreau, Benjamin, Schaefer, Hanno, Fisher, Mark F., Taylor, Nicolas L., Berkowitz, Oliver, Whelan, James, Rosengren, K. Johan and Mylne, Joshua S. (2019). An ancient peptide family buried within vicilin precursors. ACS Chemical Biology, 14 (5) acschembio.9b00167, 979-993. doi: 10.1021/acschembio.9b00167

An ancient peptide family buried within vicilin precursors

2019

Conference Publication

Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]

Zhao, Tianjiao, Rosengren, K. Johan, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]

2019

Conference Publication

Detection and characterisation of GPCR heteromers using NanoBRET ligand binding

Johnstone, E. K., See, H. B., Abhayawardana, R. S., Song, A., Rosengren, K. J., Hill, S. J. and Pfleger, K. D. (2019). Detection and characterisation of GPCR heteromers using NanoBRET ligand binding. British-Pharmacology-Society Meeting (Pharmacology), London, United Kingdom, 18-20 December 2018. Oxford, United Kingdom: John Wiley & Sons .

Detection and characterisation of GPCR heteromers using NanoBRET ligand binding

2018

Journal Article

Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate

Minchin, Rodney F., Rosengren, K. Johan, Burow, Rachel and Butcher, Neville J. (2018). Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochemical Pharmacology, 158, 153-160. doi: 10.1016/j.bcp.2018.10.013

Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate

2018

Journal Article

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2024
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

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Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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