Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

167 works between 2001 and 2024
All (167) Journal Article (137) Book Chapter (3) Conference Publication (26) Other Outputs (1)

81 - 100 of 167 works

2014

Journal Article

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

Smith, Craig M., Chua, Berenice E., Zhang, Cary, Walker, Andrew W., Haidar, Mouna, Hawkes, David, Shabanpoor, Fazel, Hossain, Mohammad Akhter, Wade, John D., Rosengren, K. Johan and Gundlach, Andrew L. (2014). Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice. Behavioural Brain Research, 268, 117-126. doi: 10.1016/j.bbr.2014.03.037

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

2014

Journal Article

Evolutionary origins of a bioactive peptide buried within preproalbumin

Elliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014). Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 (3), 981-995. doi: 10.1105/tpc.114.123620

Evolutionary origins of a bioactive peptide buried within preproalbumin

2014

Journal Article

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

Schroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Phillip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A. and Craik, David J. (2014). Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry and Biology, 21 (2), 284-294. doi: 10.1016/j.chembiol.2013.11.014

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

2014

Journal Article

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif

Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif

2014

Journal Article

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

2014

Journal Article

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

2014

Journal Article

Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni

Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558

Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni

2014

Journal Article

Semienzymatic cyclization of disulfide-rich peptides using sortase A

Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262

Semienzymatic cyclization of disulfide-rich peptides using sortase A

2014

Conference Publication

Structural Diversity of a Novel Family of Cyclic Plant Peptides

Rosengren, K. J., Elliott, A. G., Franke, B. and Mylne, J. S. (2014). Structural Diversity of a Novel Family of Cyclic Plant Peptides. 33rd European Peptide Symposium, Sofia Bulgaria, August 31 – September 5 2014. United Kingdom: John Wiley & Sons.

Structural Diversity of a Novel Family of Cyclic Plant Peptides

2014

Journal Article

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

2014

Conference Publication

Discovery of voltage-gated sodium channel inhibitors from tarantula venoms

Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

Discovery of voltage-gated sodium channel inhibitors from tarantula venoms

2014

Conference Publication

SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID

Brust, A., Gori, A., Wang, C-I A., Harvey, P. J., Rosengren, K. J., Gelmi, M. L., Longh, R., Lewis, R. J. and Alewood, P. F. (2014). SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID. 33rd European Peptide Symposium, Sofia, Bulgaria, 31 August – 5 September 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687

SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID

2014

Journal Article

Seed storage albumins: Biosynthesis, trafficking and structures

Mylne, Joshua S., Hara-Nishimura, Ikuko and Rosengren, K. Johan (2014). Seed storage albumins: Biosynthesis, trafficking and structures. Functional Plant Biology, 41 (7), 671-677. doi: 10.1071/FP14035

Seed storage albumins: Biosynthesis, trafficking and structures

2013

Journal Article

The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013)

Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013). Biopolymers, 102 (1), 136-136. doi: 10.1002/bip.22443

The Self-Association of the Cyclotide Kalata B2 in Solution is Guided by Hydrophobic Interactions (vol 100, pg 453, 2013)

2013

Journal Article

Relaxin-3/RXFP3 system regulates alcohol-seeking

Ryan,Philip J., Kastman, Hanna E., Krstew, Elena V., Rosengren, K. Johan, Hossain, Mohammed Akhter, Churilov, Leonid, Wade, John D., Gundlach, Andrew L. and Lawrence, Andrew J. (2013). Relaxin-3/RXFP3 system regulates alcohol-seeking. Proceedings of the National Academy of Sciences of the United States of America, 110 (51), 20789-20794. doi: 10.1073/pnas.1317807110

Relaxin-3/RXFP3 system regulates alcohol-seeking

2013

Journal Article

Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor

Daly, Norelle L., Thorstholm, Louise, Greenwood, Kathryn P., King, Gordon J., Rosengren, K. Johan, Heras, Begona, Martin, Jennifer L. and Craik, David J. (2013). Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. Journal of Biological Chemistry, 288 (50), 36141-36148. doi: 10.1074/jbc.M113.528240

Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor

2013

Journal Article

The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions

Rosengren, K. Johan, Daly, Norelle L., Harvey, Peta J. and Craik, David J. (2013). The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions. Peptide Science, Accepted Article (5), 1-16. doi: 10.1002/bip.22269

The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions

2013

Journal Article

The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity

Conibear, Anne C., Rosengren, K. Johan, Daly, Norelle L., Henriques, Sonia Troeira and Craik, David J. (2013). The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. Journal of Biological Chemistry, 288 (15), 10830-10840. doi: 10.1074/jbc.M113.451047

The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity

2013

Journal Article

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3

Bathgate, Ross A. D., Oh, Maria H. Y., Ling, W. J. Jason, Kaas, Quentin, Hossain, M. Akhter, Gooley, Paul R. and Rosengren, K. Johan (2013). Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3. Frontiers in Endocrinology, 4 (FEB) article 13. doi: 10.3389/fendo.2013.00013

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3

2013

Journal Article

Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor

Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Asa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2013). Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor. Journal of Biological Chemistry, 288 (3), 1814-1827. doi: 10.1074/jbc.M112.430785

Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

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Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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