Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

167 works between 2001 and 2024
All (167) Journal Article (137) Book Chapter (3) Conference Publication (26) Other Outputs (1)

101 - 120 of 167 works

2012

Journal Article

Structural characterization of the cyclic cystine ladder motif of θ-defensins

Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48), 9718-9726. doi: 10.1021/bi301363a

Structural characterization of the cyclic cystine ladder motif of θ-defensins

2012

Journal Article

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2

Scott, Daniel J., Rosengren, K. Johan and Bathgate, Ross A. D. (2012). The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2. Molecular Endocrinology, 26 (11), 1896-1906. doi: 10.1210/me.2012-1188

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2

2012

Journal Article

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

Chan, Linda J., Rosengren, K. Johan, Layfield, Sharon L., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed A. and Wade, John D. (2012). Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin. Journal of Biological Chemistry, 287 (49), 41152-41164. doi: 10.1074/jbc.M112.409284

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

2012

Journal Article

Circular proteins from plants and fungi

Goransson, Ulf, Burman, Robert, Gunasekera, Sunithi, Stromstedt, Adam A. and Rosengren, K. Johan (2012). Circular proteins from plants and fungi. Journal of Biological Chemistry, 287 (32), 27001-27006. doi: 10.1074/jbc.R111.300129

Circular proteins from plants and fungi

2012

Journal Article

Extensive polymorphism in the porcine Toll-like receptor 10 gene

Bergman, I.-M., Edman, K., Ekdahl, K. N., Rosengren, K. J. and Edfors, I. (2012). Extensive polymorphism in the porcine Toll-like receptor 10 gene. International Journal of Immunogenetics, 39 (1), 68-76. doi: 10.1111/j.1744-313X.2011.01057.x

Extensive polymorphism in the porcine Toll-like receptor 10 gene

2012

Journal Article

The structural determinants of insulin-like peptide 3 activity

Bathgate, Ross A. D., Zhang, Soude, Hughes, Richard A., Rosengren, K. Johan and Wade, John D. (2012). The structural determinants of insulin-like peptide 3 activity. Frontiers in Endocrinology, 3 (FEB) Article 11, 11.1-11.10. doi: 10.3389/fendo.2012.00011

The structural determinants of insulin-like peptide 3 activity

2012

Conference Publication

Novel single-chain ligands for the relaxin-3 receptor RXFP3

Rosengren, K. J., Haugaard-Kedstroem, L. M., Jones, M., Clark, R. J. and Bathgate, R. A. D. (2012). Novel single-chain ligands for the relaxin-3 receptor RXFP3. 32nd European Peptide Symposium "Peptides 2012", Athens, Greece, 02-07 September 2012. West Sussex, United Kingdom: John Wiley and Sons. doi: 10.1002/psc.2448

Novel single-chain ligands for the relaxin-3 receptor RXFP3

2012

Journal Article

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance

Andersson, Hakan S., Figueredo, Sharel M., Haugaard-Kedstrom, Linda M., Bengtsson, Elina, Daly, Norelle L., Qu, Xiaoqing, Craik, David J., Ouellette, Andre J. and Rosengren, K. Johan (2012). The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids, 43 (4), 1471-1483. doi: 10.1007/s00726-012-1220-3

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance

2012

Conference Publication

The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor

Ragnarsson, Lotten, Wang, Ching-I. Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2012). The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.137

The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor

2011

Journal Article

The minimal active structure of human relaxin-2

Hossain, Mohammed Akhter, Rosengren, K. Johan, Samuel, Chrishan S., Shabanpoor, Fazel, Chan, Linda J., Bathgate, Ross A. D. and Wade, John D. (2011). The minimal active structure of human relaxin-2. Journal of Biological Chemistry, 286 (43), 37555-37565. doi: 10.1074/jbc.M111.282194

The minimal active structure of human relaxin-2

2011

Journal Article

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

Henriques, Sónia Troeira, Huang, Yen-Hua, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Secondo, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, David J. (2011). Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. Journal of Biological Chemistry, 286 (27), 24231-24241. doi: 10.1074/jbc.M111.253393

Decoding the membrane activity of the cyclotide kalata B1: The importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

2011

Journal Article

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011). The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 (19), 4077-4086. doi: 10.1021/bi2004153

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

2011

Journal Article

Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3

Haugaard-Kedström, Linda M., Shabanpoor, Fazel, Hossain, Mohammed Akhter, Clark, Richard J., Ryan, Philip J., Craik, David J., Gundlach, Andrew L., Wade, John D., Bathgate, Ross A. D. and Rosengren, K. Johan (2011). Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3. Journal of the American Chemical Society, 133 (13), 4965-4974. doi: 10.1021/ja110567j

Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3

2011

Journal Article

NMR and protein structure in drug design: Application to cyclotides and conotoxins

Daly, Norelle L., Rosengren, K. Johan, Henriques, Sonia Troeira and Craik, David J. (2011). NMR and protein structure in drug design: Application to cyclotides and conotoxins. European Biophysics Journal, 40 (4), 359-370. doi: 10.1007/s00249-011-0672-9

NMR and protein structure in drug design: Application to cyclotides and conotoxins

2011

Conference Publication

Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions

Henriques, Sonia Troeira, Huang, Yen-Boa, Rosengren, K. Johan, Franquelim, Henri G., Carvalho, Filomena A., Johnson, Adam, Sonza, Second, Tachedjian, Gilda, Castanho, Miguel A. R. B., Daly, Norelle L. and Craik, I. David J. (2011). Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions. 22nd American Peptide Symposium, San Diego, California, 25-30 June 2011 . Hoboken, NJ, United States: John Wiley & Sons.

Differences in bactericidal, hemolytic and anti-HIV efficiencies of the cyclotide kalata B1 are explained by distinct cell membrane compositions

2010

Journal Article

Peptide rope tricks

Rosengren, K. Johan and Craik, David J. (2010). Peptide rope tricks. Chimica Oggi, 28 (6), 28-32.

Peptide rope tricks

2010

Conference Publication

Structural characterization of the relaxin-3IINSL5 chimera peptide: A selective RXFP3 and RXFP4 agonist

Haugaard-Kedström, M., Hossain, M. A., Daly, N. L., Bathgate, R. A. D., Wade, J. D., Craik, D. J. and Rosengren, K. J. (2010). Structural characterization of the relaxin-3IINSL5 chimera peptide: A selective RXFP3 and RXFP4 agonist. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Bognor Regis, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1301

Structural characterization of the relaxin-3IINSL5 chimera peptide: A selective RXFP3 and RXFP4 agonist

2010

Journal Article

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis

Plan, Manuel R, Rosengren, K Johan, Sando, Lillian, Daly, Norelle L and Craik, David J (2010). Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. Biopolymers, 94 (5), 647-658. doi: 10.1002/bip.21409

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis

2010

Journal Article

European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes

Bergman, Ingrid-Maria, Rosengren, Johan K., Edman, Kjell and Edfors, Inger (2010). European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes. Immunogenetics, 62 (1), 49-52. doi: 10.1007/s00251-009-0409-4

European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes

2010

Conference Publication

Characterisation of the human INSL5 solution structure

Haugaard-Kedstrom, M., Hossain, M. A., Daly, N. L., Bathgate, R. A. D., Craik, D. J., Wade, J. D. and Rosengren, K. J. (2010). Characterisation of the human INSL5 solution structure. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Bognor Regis, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

Characterisation of the human INSL5 solution structure

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

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Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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